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Volumn 7, Issue , 2014, Pages 331-340

Linking obesity with type 2 diabetes: The role of T-bet

Author keywords

Diabetes; IFN ; Immune system; Insulin resistance; Obesity; T bet; Th1; Type

Indexed keywords

CRYOPYRIN; GAMMA INTERFERON; INTERLEUKIN 1BETA; INTERLEUKIN 6; TRANSCRIPTION FACTOR T BET; TUMOR NECROSIS FACTOR ALPHA;

EID: 84905023529     PISSN: None     EISSN: 11787007     Source Type: Journal    
DOI: 10.2147/DMSO.S51432     Document Type: Review
Times cited : (32)

References (93)
  • 1
    • 4444228888 scopus 로고    scopus 로고
    • who. int [homepage on the Internet]. World Health Organization [updated May 2014; cited January 20, 2014]. Available from. Accessed May 21, 2014
    • who. int [homepage on the Internet]. Obesity and overweight. World Health Organization; 2013 [updated May 2014; cited January 20, 2014]. Available from: http: //www.who.int/mediacentre/factsheets/fs311/en/. Accessed May 21, 2014.
    • (2013) Obesity and overweight
  • 2
    • 84861119529 scopus 로고    scopus 로고
    • Obesity and severe obesity forecasts through 2030
    • Finkelstein EA, Khavjou OA, Thompson H, et al. Obesity and severe obesity forecasts through 2030. Am J Prev Med. 2012; 42(6): 563-570.
    • (2012) Am J Prev Med. , vol.42 , Issue.6 , pp. 563-570
    • Finkelstein, E.A.1    Khavjou, O.A.2    Thompson, H.3
  • 3
    • 84855857509 scopus 로고    scopus 로고
    • diabetes. niddk. nih. gov [homepage on the Internet]. National Diabetes Information Clearinghouse [updated April 2, 2014; cited January 20, 2014]. Available from. Accessed May 21, 2014
    • diabetes. niddk. nih. gov [homepage on the Internet]. Diabetes overview. National Diabetes Information Clearinghouse; 2008 [updated April 2, 2014; cited January 20, 2014]. Available from: http: //diabetes.niddk. nih.gov/dm/pubs/overview/. Accessed May 21, 2014.
    • (2008) Diabetes overview
  • 4
    • 51349156218 scopus 로고    scopus 로고
    • Insulin sensitivity: Modulation by nutrients and inflammation
    • Schenk S, Saberi M, Olefsky JM. Insulin sensitivity: modulation by nutrients and inflammation. J Clin Invest. 2008; 118(9): 2992-3002.
    • (2008) J Clin Invest. , vol.118 , Issue.9 , pp. 2992-3002
    • Schenk, S.1    Saberi, M.2    Olefsky, J.M.3
  • 5
    • 9444242665 scopus 로고    scopus 로고
    • Five stages of evolving beta-cell dysfunction during progression to diabetes
    • Weir GC, Bonner-Weir S. Five stages of evolving beta-cell dysfunction during progression to diabetes. Diabetes. 2004; 53 Suppl 3: S16-S21.
    • (2004) Diabetes , vol.53 , Issue.SUPPL. 3
    • Weir, G.C.1    Bonner-Weir, S.2
  • 7
    • 0035856980 scopus 로고    scopus 로고
    • Biochemistry and molecular cell biology of diabetic complications
    • Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature. 2001; 414(6865): 813-820.
    • (2001) Nature. , vol.414 , Issue.6865 , pp. 813-820
    • Brownlee, M.1
  • 8
    • 84868095524 scopus 로고    scopus 로고
    • Overview of animal models of obesity
    • Chapter 5: Unit5.61
    • Lutz TA, Woods SC. Overview of animal models of obesity. Curr Protoc Pharmacol. 2012; Chapter 5: Unit5.61.
    • (2012) Curr Protoc Pharmacol
    • Lutz, T.A.1    Woods, S.C.2
  • 9
    • 33745861300 scopus 로고    scopus 로고
    • Inflammation and insulin resistance
    • Shoelson SE, Lee J, Goldfine AB. Inflammation and insulin resistance. J Clin Invest. 2006; 116(7): 1793-1801.
    • (2006) J Clin Invest. , vol.116 , Issue.7 , pp. 1793-1801
    • Shoelson, S.E.1    Lee, J.2    Goldfine, A.B.3
  • 10
    • 84857861919 scopus 로고    scopus 로고
    • Mechanisms for insulin resistance: Common threads and missing links
    • Samuel VT, Shulman GI. Mechanisms for insulin resistance: common threads and missing links. Cell. 2012; 148(5): 852-871.
    • (2012) Cell. , vol.148 , Issue.5 , pp. 852-871
    • Samuel, V.T.1    Shulman, G.I.2
  • 11
    • 33244464562 scopus 로고    scopus 로고
    • Critical nodes in signalling pathways: Insights into insulin action
    • Taniguchi CM, Emanuelli B, Kahn CR. Critical nodes in signalling pathways: insights into insulin action. Nat Rev Mol Cell Biol. 2006; 7(2): 85-96.
    • (2006) Nat Rev Mol Cell Biol. , vol.7 , Issue.2 , pp. 85-96
    • Taniguchi, C.M.1    Emanuelli, B.2    Kahn, C.R.3
  • 12
    • 0030669392 scopus 로고    scopus 로고
    • A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulininduced tyrosine phosphorylation
    • Paz K, Hemi R, LeRoith D, et al. A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulininduced tyrosine phosphorylation. J Biol Chem. 1997; 272(47): 29911-29918.
    • (1997) J Biol Chem. , vol.272 , Issue.47 , pp. 29911-29918
    • Paz, K.1    Hemi, R.2    LeRoith, D.3
  • 13
    • 14644427890 scopus 로고    scopus 로고
    • Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB
    • Cai D, Yuan M, Frantz DF, et al. Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nat Med. 2005; 11(2): 183-190.
    • (2005) Nat Med. , vol.11 , Issue.2 , pp. 183-190
    • Cai, D.1    Yuan, M.2    Frantz, D.F.3
  • 14
    • 0037153158 scopus 로고    scopus 로고
    • A central role for JNK in obesity and insulin resistance
    • Hirosumi J, Tuncman G, Chang L, et al. A central role for JNK in obesity and insulin resistance. Nature. 2002; 420(6913): 333-336.
    • (2002) Nature. , vol.420 , Issue.6913 , pp. 333-336
    • Hirosumi, J.1    Tuncman, G.2    Chang, L.3
  • 15
    • 0036830636 scopus 로고    scopus 로고
    • SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2
    • Rui L, Yuan M, Frantz D, Shoelson S, White MF. SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2. J Biol Chem. 2002; 277(44): 42394-42398.
    • (2002) J Biol Chem. , vol.277 , Issue.44 , pp. 42394-42398
    • Rui, L.1    Yuan, M.2    Frantz, D.3    Shoelson, S.4    White, M.F.5
  • 16
    • 0344035946 scopus 로고    scopus 로고
    • Insulin down-regulates insulin receptor substrate-2 expression through the phosphatidylinositol 3-kinase/Akt pathway
    • Hirashima Y, Tsuruzoe K, Kodama S, et al. Insulin down-regulates insulin receptor substrate-2 expression through the phosphatidylinositol 3-kinase/Akt pathway. J Endocrinol. 2003; 179(2): 253-266.
    • (2003) J Endocrinol. , vol.179 , Issue.2 , pp. 253-266
    • Hirashima, Y.1    Tsuruzoe, K.2    Kodama, S.3
  • 17
    • 79961004321 scopus 로고    scopus 로고
    • Signalling by insulin and IGF receptors: Supporting acts and new players
    • Siddle K. Signalling by insulin and IGF receptors: supporting acts and new players. J Mol Endocrinol. 2011; 47(1): R1-R10.
    • (2011) J Mol Endocrinol. , vol.47 , Issue.1
    • Siddle, K.1
  • 18
    • 15944406764 scopus 로고    scopus 로고
    • PHLPP: A phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth
    • Gao T, Furnari F, Newton AC. PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Mol Cell. 2005; 18(1): 13-24.
    • (2005) Mol Cell. , vol.18 , Issue.1 , pp. 13-24
    • Gao, T.1    Furnari, F.2    Newton, A.C.3
  • 19
    • 0038242819 scopus 로고    scopus 로고
    • TRB3: A tribbles homolog that inhibits Akt/PKB activation by insulin in liver
    • Du K, Herzig S, Kulkarni RN, Montminy M. TRB3: a tribbles homolog that inhibits Akt/PKB activation by insulin in liver. Science. 2003; 300(5625): 1574-1577.
    • (2003) Science. , vol.300 , Issue.5625 , pp. 1574-1577
    • Du, K.1    Herzig, S.2    Kulkarni, R.N.3    Montminy, M.4
  • 20
    • 84860482342 scopus 로고    scopus 로고
    • A ceramide-centric view of insulin resistance
    • Chavez JA, Summers SA. A ceramide-centric view of insulin resistance. Cell Metab. 2012; 15(5): 585-594.
    • (2012) Cell Metab. , vol.15 , Issue.5 , pp. 585-594
    • Chavez, J.A.1    Summers, S.A.2
  • 21
    • 0033588253 scopus 로고    scopus 로고
    • Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate
    • Schmitz-Peiffer C, Craig DL, Biden TJ. Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate. J Biol Chem. 1999; 274(34): 24202-24210.
    • (1999) J Biol Chem. , vol.274 , Issue.34 , pp. 24202-24210
    • Schmitz-Peiffer, C.1    Craig, D.L.2    Biden, T.J.3
  • 22
    • 79955776595 scopus 로고    scopus 로고
    • A single prior bout of exercise protects against palmitate-induced insulin resistance despite an increase in total ceramide content
    • Thrush AB, Harasim E, Chabowski A, Gulli R, Stefanyk L, Dyck DJ. A single prior bout of exercise protects against palmitate-induced insulin resistance despite an increase in total ceramide content. Am J Physiol Regul Integr Comp Physiol. 2011; 300(5): R1200-R1208.
    • (2011) Am J Physiol Regul Integr Comp Physiol. , vol.300 , Issue.5
    • Thrush, A.B.1    Harasim, E.2    Chabowski, A.3    Gulli, R.4    Stefanyk, L.5    Dyck, D.J.6
  • 23
    • 0038532298 scopus 로고    scopus 로고
    • A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids
    • Chavez JA, Knotts TA, Wang LP, et al. A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids. J Biol Chem. 2003; 278(12): 10297-10303.
    • (2003) J Biol Chem. , vol.278 , Issue.12 , pp. 10297-10303
    • Chavez, J.A.1    Knotts, T.A.2    Wang, L.P.3
  • 24
    • 33748755008 scopus 로고    scopus 로고
    • Toll-like receptor-2 is essential for the development of palmitate-induced insulin resistance in myotubes
    • Senn JJ. Toll-like receptor-2 is essential for the development of palmitate-induced insulin resistance in myotubes. J Biol Chem. 2006; 281(37): 26865-26875.
    • (2006) J Biol Chem. , vol.281 , Issue.37 , pp. 26865-26875
    • Senn, J.J.1
  • 25
    • 33847332202 scopus 로고    scopus 로고
    • Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance
    • Holland WL, Brozinick JT, Wang LP, et al. Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance. Cell Metab. 2007; 5(3): 167-179.
    • (2007) Cell Metab. , vol.5 , Issue.3 , pp. 167-179
    • Holland, W.L.1    Brozinick, J.T.2    Wang, L.P.3
  • 26
    • 21244442275 scopus 로고    scopus 로고
    • Acid ceramidase overexpression prevents the inhibitory effects of saturated fatty acids on insulin signaling
    • Chavez JA, Holland WL, Bär J, Sandhoff K, Summers SA. Acid ceramidase overexpression prevents the inhibitory effects of saturated fatty acids on insulin signaling. J Biol Chem. 2005; 280(20): 20148-20153.
    • (2005) J Biol Chem. , vol.280 , Issue.20 , pp. 20148-20153
    • Chavez, J.A.1    Holland, W.L.2    Bär, J.3    Sandhoff, K.4    Summers, S.A.5
  • 27
    • 0036300538 scopus 로고    scopus 로고
    • Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha
    • Itani SI, Ruderman NB, Schmieder F, Boden G. Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha. Diabetes. 2002; 51(7): 2005-2011.
    • (2002) Diabetes. , vol.51 , Issue.7 , pp. 2005-2011
    • Itani, S.I.1    Ruderman, N.B.2    Schmieder, F.3    Boden, G.4
  • 28
    • 0032813243 scopus 로고    scopus 로고
    • Tissue and isoform-selective activation of protein kinase C in insulin-resistant obese Zucker rats-effects of feeding
    • Qu X, Seale JP, Donnelly R. Tissue and isoform-selective activation of protein kinase C in insulin-resistant obese Zucker rats-effects of feeding. J Endocrinol. 1999; 162(2): 207-214.
    • (1999) J Endocrinol. , vol.162 , Issue.2 , pp. 207-214
    • Qu, X.1    Seale, J.P.2    Donnelly, R.3
  • 29
    • 8544244084 scopus 로고    scopus 로고
    • PKC-theta knockout mice are protected from fat-induced insulin resistance
    • Kim JK, Fillmore JJ, Sunshine MJ, et al. PKC-theta knockout mice are protected from fat-induced insulin resistance. J Clin Invest. 2004; 114(6): 823-827.
    • (2004) J Clin Invest. , vol.114 , Issue.6 , pp. 823-827
    • Kim, J.K.1    Fillmore, J.J.2    Sunshine, M.J.3
  • 30
    • 79151478555 scopus 로고    scopus 로고
    • Type 2 diabetes as an inflammatory disease
    • Donath MY, Shoelson SE. Type 2 diabetes as an inflammatory disease. Nat Rev Immunol. 2011; 11(2): 98-107.
    • (2011) Nat Rev Immunol. , vol.11 , Issue.2 , pp. 98-107
    • Donath, M.Y.1    Shoelson, S.E.2
  • 31
    • 84878785347 scopus 로고    scopus 로고
    • Immunological goings-on in visceral adipose tissue
    • Mathis D. Immunological goings-on in visceral adipose tissue. Cell Metab. 2013; 17(6): 851-859.
    • (2013) Cell Metab. , vol.17 , Issue.6 , pp. 851-859
    • Mathis, D.1
  • 32
    • 84857985148 scopus 로고    scopus 로고
    • The cellular and signaling networks linking the immune system and metabolism in disease
    • Osborn O, Olefsky JM. The cellular and signaling networks linking the immune system and metabolism in disease. Nat Med. 2012; 18(3): 363-374.
    • (2012) Nat Med. , vol.18 , Issue.3 , pp. 363-374
    • Osborn, O.1    Olefsky, J.M.2
  • 33
    • 58149347227 scopus 로고    scopus 로고
    • Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes
    • Lumeng CN, DelProposto JB, Westcott DJ, Saltiel AR. Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes. Diabetes. 2008; 57(12): 3239-3246.
    • (2008) Diabetes. , vol.57 , Issue.12 , pp. 3239-3246
    • Lumeng, C.N.1    DelProposto, J.B.2    Westcott, D.J.3    Saltiel, A.R.4
  • 34
    • 33846026712 scopus 로고    scopus 로고
    • Obesity induces a phenotypic switch in adipose tissue macrophage polarization
    • Lumeng CN, Bodzin JL, Saltiel AR. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest. 2007; 117(1): 175-184.
    • (2007) J Clin Invest. , vol.117 , Issue.1 , pp. 175-184
    • Lumeng, C.N.1    Bodzin, J.L.2    Saltiel, A.R.3
  • 35
    • 84863223829 scopus 로고    scopus 로고
    • CCR5 plays a critical role in obesity-induced adipose tissue inflammation and insulin resistance by regulating both macrophage recruitment and M1/M2 status
    • Kitade H, Sawamoto K, Nagashimada M, et al. CCR5 plays a critical role in obesity-induced adipose tissue inflammation and insulin resistance by regulating both macrophage recruitment and M1/M2 status. Diabetes. 2012; 61(7): 1680-1690.
    • (2012) Diabetes. , vol.61 , Issue.7 , pp. 1680-1690
    • Kitade, H.1    Sawamoto, K.2    Nagashimada, M.3
  • 36
    • 79952437112 scopus 로고    scopus 로고
    • Differential lipid partitioning between adipocytes and tissue macrophages modulates macrophage lipotoxicity and M2/M1 polarization in obese mice
    • Prieur X, Mok CY, Velagapudi VR, et al. Differential lipid partitioning between adipocytes and tissue macrophages modulates macrophage lipotoxicity and M2/M1 polarization in obese mice. Diabetes. 2011; 60(3): 797-809.
    • (2011) Diabetes. , vol.60 , Issue.3 , pp. 797-809
    • Prieur, X.1    Mok, C.Y.2    Velagapudi, V.R.3
  • 37
    • 20044387026 scopus 로고    scopus 로고
    • IKK-beta links inflammation to obesity-induced insulin resistance
    • Arkan MC, Hevener AL, Greten FR, et al. IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med. 2005; 11(2): 191-198.
    • (2005) Nat Med. , vol.11 , Issue.2 , pp. 191-198
    • Arkan, M.C.1    Hevener, A.L.2    Greten, F.R.3
  • 38
    • 0036894360 scopus 로고    scopus 로고
    • Interleukin-6 induces cellular insulin resistance in hepatocytes
    • Senn JJ, Klover PJ, Nowak IA, Mooney RA. Interleukin-6 induces cellular insulin resistance in hepatocytes. Diabetes. 2002; 51(12): 3391-3399.
    • (2002) Diabetes. , vol.51 , Issue.12 , pp. 3391-3399
    • Senn, J.J.1    Klover, P.J.2    Nowak, I.A.3    Mooney, R.A.4
  • 39
    • 69949187947 scopus 로고    scopus 로고
    • Chronic TNFalpha and cAMP pre-treatment of human adipocytes alter HSL, ATGL and perilipin to regulate basal and stimulated lipolysis
    • Bézaire V, Mairal A, Anesia R, Lefort C, Langin D. Chronic TNFalpha and cAMP pre-treatment of human adipocytes alter HSL, ATGL and perilipin to regulate basal and stimulated lipolysis. FEBS Lett. 2009; 583(18): 3045-3049.
    • (2009) FEBS Lett. , vol.583 , Issue.18 , pp. 3045-3049
    • Bézaire, V.1    Mairal, A.2    Anesia, R.3    Lefort, C.4    Langin, D.5
  • 40
    • 78751524862 scopus 로고    scopus 로고
    • Regulation of fat specific protein 27 by isoproterenol and TNF-αto control lipolysis in murine adipocytes
    • Ranjit S, Boutet E, Gandhi P, et al. Regulation of fat specific protein 27 by isoproterenol and TNF-αto control lipolysis in murine adipocytes. J Lipid Res. 2011; 52(2): 221-236.
    • (2011) J Lipid Res. , vol.52 , Issue.2 , pp. 221-236
    • Ranjit, S.1    Boutet, E.2    Gandhi, P.3
  • 41
    • 84858630049 scopus 로고    scopus 로고
    • A role for the NLRP3 inflammasome in metabolic diseases-did Warburg miss inflammation?
    • Wen H, Ting JP, O'Neill LA. A role for the NLRP3 inflammasome in metabolic diseases-did Warburg miss inflammation? Nat Immunol. 2012; 13(4): 352-357.
    • (2012) Nat Immunol. , vol.13 , Issue.4 , pp. 352-357
    • Wen, H.1    Ting, J.P.2    O'Neill, L.A.3
  • 42
    • 0036671894 scopus 로고    scopus 로고
    • The inflammasome: A molecular platform triggering activation of inflammatory caspases and processing of proIL-beta
    • Martinon F, Burns K, Tschopp J. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell. 2002; 10(2): 417-426.
    • (2002) Mol Cell. , vol.10 , Issue.2 , pp. 417-426
    • Martinon, F.1    Burns, K.2    Tschopp, J.3
  • 43
    • 79955038882 scopus 로고    scopus 로고
    • Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling
    • Wen H, Gris D, Lei Y, et al. Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling. Nat Immunol. 2011; 12(5): 408-415.
    • (2011) Nat Immunol. , vol.12 , Issue.5 , pp. 408-415
    • Wen, H.1    Gris, D.2    Lei, Y.3
  • 44
    • 79751512463 scopus 로고    scopus 로고
    • The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
    • Vandanmagsar B, Youm YH, Ravussin A, et al. The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nat Med. 2011; 17(2): 179-188.
    • (2011) Nat Med. , vol.17 , Issue.2 , pp. 179-188
    • Vandanmagsar, B.1    Youm, Y.H.2    Ravussin, A.3
  • 45
    • 84872018875 scopus 로고    scopus 로고
    • Upregulated NLRP3 inflammasome activation in patients with type 2 diabetes
    • Lee HM, Kim JJ, Kim HJ, Shong M, Ku BJ, Jo EK. Upregulated NLRP3 inflammasome activation in patients with type 2 diabetes. Diabetes. 2013; 62(1): 194-204.
    • (2013) Diabetes. , vol.62 , Issue.1 , pp. 194-204
    • Lee, H.M.1    Kim, J.J.2    Kim, H.J.3    Shong, M.4    Ku, B.J.5    Jo, E.K.6
  • 46
    • 80053087484 scopus 로고    scopus 로고
    • Inflammasome is a central player in the induction of obesity and insulin resistance
    • Stienstra R, van Diepen JA, Tack CJ, et al. Inflammasome is a central player in the induction of obesity and insulin resistance. Proc Natl Acad Sci U S A. 2011; 108(37): 15324-15329.
    • (2011) Proc Natl Acad Sci U S A. , vol.108 , Issue.37 , pp. 15324-15329
    • Stienstra, R.1    van Diepen, J.A.2    Tack, C.J.3
  • 47
    • 77952313777 scopus 로고    scopus 로고
    • Differentiation of effector CD4 T cell populations (*)
    • Zhu J, Yamane H, Paul WE. Differentiation of effector CD4 T cell populations (*). Annu Rev Immunol. 2010; 28: 445-489.
    • (2010) Annu Rev Immunol. , vol.28 , pp. 445-489
    • Zhu, J.1    Yamane, H.2    Paul, W.E.3
  • 48
    • 68349150756 scopus 로고    scopus 로고
    • CD8+effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity
    • Nishimura S, Manabe I, Nagasaki M, et al. CD8+effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat Med. 2009; 15(8): 914-920.
    • (2009) Nat Med. , vol.15 , Issue.8 , pp. 914-920
    • Nishimura, S.1    Manabe, I.2    Nagasaki, M.3
  • 49
    • 84874249393 scopus 로고    scopus 로고
    • The immune system's involvement in obesity-driven type 2 diabetes
    • Shu CJ, Benoist C, Mathis D. The immune system's involvement in obesity-driven type 2 diabetes. Semin Immunol. 2012; 24(6): 436-442.
    • (2012) Semin Immunol. , vol.24 , Issue.6 , pp. 436-442
    • Shu, C.J.1    Benoist, C.2    Mathis, D.3
  • 50
    • 68349148211 scopus 로고    scopus 로고
    • Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters
    • Feuerer M, Herrero L, Cipolletta D, et al. Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat Med. 2009; 15(8): 930-939.
    • (2009) Nat Med. , vol.15 , Issue.8 , pp. 930-939
    • Feuerer, M.1    Herrero, L.2    Cipolletta, D.3
  • 51
    • 33847073149 scopus 로고    scopus 로고
    • Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity
    • Lumeng CN, Deyoung SM, Bodzin JL, Saltiel AR. Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity. Diabetes. 2007; 56(1): 16-23.
    • (2007) Diabetes. , vol.56 , Issue.1 , pp. 16-23
    • Lumeng, C.N.1    Deyoung, S.M.2    Bodzin, J.L.3    Saltiel, A.R.4
  • 52
    • 68349137821 scopus 로고    scopus 로고
    • Normalization of obesity-associated insulin resistance through immunotherapy
    • Winer S, Chan Y, Paltser G, et al. Normalization of obesity-associated insulin resistance through immunotherapy. Nat Med. 2009; 15(8): 921-929.
    • (2009) Nat Med. , vol.15 , Issue.8 , pp. 921-929
    • Winer, S.1    Chan, Y.2    Paltser, G.3
  • 53
    • 84862986986 scopus 로고    scopus 로고
    • PPAR-γis a major driver of the accumulation and phenotype of adipose tissue Treg cells
    • Cipolletta D, Feuerer M, Li A, et al. PPAR-γis a major driver of the accumulation and phenotype of adipose tissue Treg cells. Nature. 2012; 486(7404): 549-553.
    • (2012) Nature. , vol.486 , Issue.7404 , pp. 549-553
    • Cipolletta, D.1    Feuerer, M.2    Li, A.3
  • 54
    • 85027938385 scopus 로고    scopus 로고
    • B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies
    • Winer DA, Winer S, Shen L, et al. B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies. Nat Med. 2011; 17(5): 610-617.
    • (2011) Nat Med. , vol.17 , Issue.5 , pp. 610-617
    • Winer, D.A.1    Winer, S.2    Shen, L.3
  • 55
    • 54049086276 scopus 로고    scopus 로고
    • Interferon-gamma, a Th1 cytokine, regulates fat inflammation: A role for adaptive immunity in obesity
    • Rocha VZ, Folco EJ, Sukhova G, et al. Interferon-gamma, a Th1 cytokine, regulates fat inflammation: a role for adaptive immunity in obesity. Circ Res. 2008; 103(5): 467-476.
    • (2008) Circ Res. , vol.103 , Issue.5 , pp. 467-476
    • Rocha, V.Z.1    Folco, E.J.2    Sukhova, G.3
  • 56
    • 70450277113 scopus 로고    scopus 로고
    • Interferon gamma attenuates insulin signaling, lipid storage, and differentiation in human adipocytes via activation of the JAK/STAT pathway
    • McGillicuddy FC, Chiquoine EH, Hinkle CC, et al. Interferon gamma attenuates insulin signaling, lipid storage, and differentiation in human adipocytes via activation of the JAK/STAT pathway. J Biol Chem. 2009; 284(46): 31936-31944.
    • (2009) J Biol Chem. , vol.284 , Issue.46 , pp. 31936-31944
    • McGillicuddy, F.C.1    Chiquoine, E.H.2    Hinkle, C.C.3
  • 57
    • 84864286000 scopus 로고    scopus 로고
    • Systemic inflammation and insulin sensitivity in obese IFN-γ knockout mice
    • O'Rourke RW, White AE, Metcalf MD, et al. Systemic inflammation and insulin sensitivity in obese IFN-γ knockout mice. Metabolism. 2012; 61(8): 1152-1161.
    • (2012) Metabolism. , vol.61 , Issue.8 , pp. 1152-1161
    • O'Rourke, R.W.1    White, A.E.2    Metcalf, M.D.3
  • 58
    • 80053148046 scopus 로고    scopus 로고
    • Deficiency in interferon-gamma results in reduced body weight and better glucose tolerance in mice
    • Wong N, Fam BC, Cempako GR, et al. Deficiency in interferon-gamma results in reduced body weight and better glucose tolerance in mice. Endocrinology. 2011; 152(10): 3690-3699.
    • (2011) Endocrinology. , vol.152 , Issue.10 , pp. 3690-3699
    • Wong, N.1    Fam, B.C.2    Cempako, G.R.3
  • 59
  • 61
    • 27744571314 scopus 로고    scopus 로고
    • T-bet is required for optimal proinflammatory CD4+T-cell trafficking
    • Lord GM, Rao RM, Choe H, et al. T-bet is required for optimal proinflammatory CD4+T-cell trafficking. Blood. 2005; 106(10): 3432-3439.
    • (2005) Blood. , vol.106 , Issue.10 , pp. 3432-3439
    • Lord, G.M.1    Rao, R.M.2    Choe, H.3
  • 62
    • 12344269852 scopus 로고    scopus 로고
    • T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3
    • Hwang ES, Szabo SJ, Schwartzberg PL, Glimcher LH. T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3. Science. 2005; 307(5708): 430-433.
    • (2005) Science. , vol.307 , Issue.5708 , pp. 430-433
    • Hwang, E.S.1    Szabo, S.J.2    Schwartzberg, P.L.3    Glimcher, L.H.4
  • 63
    • 78650306567 scopus 로고    scopus 로고
    • T-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγt
    • Lazarevic V, Chen X, Shim JH, et al. T-bet represses T(H)17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγt. Nat Immunol. 2011; 12(1): 96-104.
    • (2011) Nat Immunol. , vol.12 , Issue.1 , pp. 96-104
    • Lazarevic, V.1    Chen, X.2    Shim, J.H.3
  • 65
    • 84886790466 scopus 로고    scopus 로고
    • T-bet: A bridge between innate and adaptive immunity
    • Lazarevic V, Glimcher LH, Lord GM. T-bet: a bridge between innate and adaptive immunity. Nat Rev Immunol. 2013; 13(11): 777-789.
    • (2013) Nat Rev Immunol. , vol.13 , Issue.11 , pp. 777-789
    • Lazarevic, V.1    Glimcher, L.H.2    Lord, G.M.3
  • 66
    • 8544234990 scopus 로고    scopus 로고
    • Recent developments in the transcriptional regulation of cytolytic effector cells
    • Glimcher LH, Townsend MJ, Sullivan BM, Lord GM. Recent developments in the transcriptional regulation of cytolytic effector cells. Nat Rev Immunol. 2004; 4(11): 900-911.
    • (2004) Nat Rev Immunol. , vol.4 , Issue.11 , pp. 900-911
    • Glimcher, L.H.1    Townsend, M.J.2    Sullivan, B.M.3    Lord, G.M.4
  • 68
    • 0037117557 scopus 로고    scopus 로고
    • T-bet regulates IgG class switching and pathogenic autoantibody production
    • Peng SL, Szabo SJ, Glimcher LH. T-bet regulates IgG class switching and pathogenic autoantibody production. Proc Natl Acad Sci U S A. 2002; 99(8): 5545-5550.
    • (2002) Proc Natl Acad Sci U S A. , vol.99 , Issue.8 , pp. 5545-5550
    • Peng, S.L.1    Szabo, S.J.2    Glimcher, L.H.3
  • 69
    • 84882759383 scopus 로고    scopus 로고
    • T-box transcription factor T-bet, a key player in a unique type of B-cell activation essential for effective viral clearance
    • Rubtsova K, Rubtsov AV, van Dyk LF, Kappler JW, Marrack P. T-box transcription factor T-bet, a key player in a unique type of B-cell activation essential for effective viral clearance. Proc Natl Acad Sci U S A. 2013; 110(34): E3216-E3224.
    • (2013) Proc Natl Acad Sci U S A. , vol.110 , Issue.34
    • Rubtsova, K.1    Rubtsov, A.V.2    van Dyk, L.F.3    Kappler, J.W.4    Marrack, P.5
  • 70
    • 0037934497 scopus 로고    scopus 로고
    • T-bet is required for optimal production of IFN-gamma and antigen-specific T cell activation by dendritic cells
    • Lugo-Villarino G, Maldonado-Lopez R, Possemato R, Penaranda C, Glimcher LH. T-bet is required for optimal production of IFN-gamma and antigen-specific T cell activation by dendritic cells. Proc Natl Acad Sci U S A. 2003; 100(13): 7749-7754.
    • (2003) Proc Natl Acad Sci U S A. , vol.100 , Issue.13 , pp. 7749-7754
    • Lugo-Villarino, G.1    Maldonado-Lopez, R.2    Possemato, R.3    Penaranda, C.4    Glimcher, L.H.5
  • 71
    • 24944452197 scopus 로고    scopus 로고
    • The adjuvant activity of CpG DNA requires T-bet expression in dendritic cells
    • Lugo-Villarino G, Ito S, Klinman DM, Glimcher LH. The adjuvant activity of CpG DNA requires T-bet expression in dendritic cells. Proc Natl Acad Sci U S A. 2005; 102(37): 13248-13253.
    • (2005) Proc Natl Acad Sci U S A. , vol.102 , Issue.37 , pp. 13248-13253
    • Lugo-Villarino, G.1    Ito, S.2    Klinman, D.M.3    Glimcher, L.H.4
  • 72
    • 1842785209 scopus 로고    scopus 로고
    • T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells
    • Townsend MJ, Weinmann AS, Matsuda JL, et al. T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells. Immunity. 2004; 20(4): 477-494.
    • (2004) Immunity. , vol.20 , Issue.4 , pp. 477-494
    • Townsend, M.J.1    Weinmann, A.S.2    Matsuda, J.L.3
  • 73
    • 50949108980 scopus 로고    scopus 로고
    • T-bet plays a key role in NK-mediated control of melanoma metastatic disease
    • Werneck MB, Lugo-Villarino G, Hwang ES, Cantor H, Glimcher LH. T-bet plays a key role in NK-mediated control of melanoma metastatic disease. J Immunol. 2008; 180(12): 8004-8010.
    • (2008) J Immunol. , vol.180 , Issue.12 , pp. 8004-8010
    • Werneck, M.B.1    Lugo-Villarino, G.2    Hwang, E.S.3    Cantor, H.4    Glimcher, L.H.5
  • 74
    • 0037059509 scopus 로고    scopus 로고
    • Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet
    • Finotto S, Neurath MF, Glickman JN, et al. Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet. Science. 2002; 295(5553): 336-338.
    • (2002) Science. , vol.295 , Issue.5553 , pp. 336-338
    • Finotto, S.1    Neurath, M.F.2    Glickman, J.N.3
  • 75
    • 0037059462 scopus 로고    scopus 로고
    • Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells
    • Szabo SJ, Sullivan BM, Stemmann C, Satoskar AR, Sleckman BP, Glimcher LH. Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells. Science. 2002; 295(5553): 338-342.
    • (2002) Science. , vol.295 , Issue.5553 , pp. 338-342
    • Szabo, S.J.1    Sullivan, B.M.2    Stemmann, C.3    Satoskar, A.R.4    Sleckman, B.P.5    Glimcher, L.H.6
  • 76
    • 84875883411 scopus 로고    scopus 로고
    • Improved insulin sensitivity despite increased visceral adiposity in mice deficient for the immune cell transcription factor T-bet
    • Stolarczyk E, Vong CT, Perucha E, et al. Improved insulin sensitivity despite increased visceral adiposity in mice deficient for the immune cell transcription factor T-bet. Cell Metab. 2013; 17(4): 520-533.
    • (2013) Cell Metab. , vol.17 , Issue.4 , pp. 520-533
    • Stolarczyk, E.1    Vong, C.T.2    Perucha, E.3
  • 77
    • 27744461314 scopus 로고    scopus 로고
    • IL-2 production in developing Th1 cells is regulated by heterodimerization of RelA and T-bet and requires T-bet serine residue 508
    • Hwang ES, Hong JH, Glimcher LH. IL-2 production in developing Th1 cells is regulated by heterodimerization of RelA and T-bet and requires T-bet serine residue 508. J Exp Med. 2005; 202(9): 1289-1300.
    • (2005) J Exp Med. , vol.202 , Issue.9 , pp. 1289-1300
    • Hwang, E.S.1    Hong, J.H.2    Glimcher, L.H.3
  • 78
    • 33845901507 scopus 로고    scopus 로고
    • Microbial ecology: Human gut microbes associated with obesity
    • Ley RE, Turnbaugh PJ, Klein S, Gordon JI. Microbial ecology: human gut microbes associated with obesity. Nature. 2006; 444(7122): 1022-1023.
    • (2006) Nature. , vol.444 , Issue.7122 , pp. 1022-1023
    • Ley, R.E.1    Turnbaugh, P.J.2    Klein, S.3    Gordon, J.I.4
  • 79
    • 84878709716 scopus 로고    scopus 로고
    • Gut metagenome in European women with normal, impaired and diabetic glucose control
    • Karlsson FH, Tremaroli V, Nookaew I, et al. Gut metagenome in European women with normal, impaired and diabetic glucose control. Nature. 2013; 498(7452): 99-103.
    • (2013) Nature. , vol.498 , Issue.7452 , pp. 99-103
    • Karlsson, F.H.1    Tremaroli, V.2    Nookaew, I.3
  • 80
    • 84883181684 scopus 로고    scopus 로고
    • Human gut microbiota changes reveal the progression of glucose intolerance
    • Zhang X, Shen D, Fang Z, et al. Human gut microbiota changes reveal the progression of glucose intolerance. PLoS One. 2013; 8(8): e71108.
    • (2013) PLoS One. , vol.8 , Issue.8
    • Zhang, X.1    Shen, D.2    Fang, Z.3
  • 81
    • 8144226856 scopus 로고    scopus 로고
    • The gut microbiota as an environmental factor that regulates fat storage
    • Bäckhed F, Ding H, Wang T, et al. The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci U S A. 2004; 101(44): 15718-15723.
    • (2004) Proc Natl Acad Sci U S A. , vol.101 , Issue.44 , pp. 15718-15723
    • Bäckhed, F.1    Ding, H.2    Wang, T.3
  • 84
    • 33845874101 scopus 로고    scopus 로고
    • An obesity-associated gut microbiome with increased capacity for energy harvest
    • Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature. 2006; 444(7122): 1027-1031.
    • (2006) Nature. , vol.444 , Issue.7122 , pp. 1027-1031
    • Turnbaugh, P.J.1    Ley, R.E.2    Mahowald, M.A.3    Magrini, V.4    Mardis, E.R.5    Gordon, J.I.6
  • 85
    • 0037029649 scopus 로고    scopus 로고
    • The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease
    • Neurath MF, Weigmann B, Finotto S, et al. The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease. J Exp Med. 2002; 195(9): 1129-1143.
    • (2002) J Exp Med. , vol.195 , Issue.9 , pp. 1129-1143
    • Neurath, M.F.1    Weigmann, B.2    Finotto, S.3
  • 86
    • 34848889673 scopus 로고    scopus 로고
    • Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system
    • Garrett WS, Lord GM, Punit S, et al. Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system. Cell. 2007; 131(1): 33-45.
    • (2007) Cell. , vol.131 , Issue.1 , pp. 33-45
    • Garrett, W.S.1    Lord, G.M.2    Punit, S.3
  • 87
    • 84867856710 scopus 로고    scopus 로고
    • The transcription factor T-bet regulates intestinal inflammation mediated by interleukin-7 receptor+ innate lymphoid cells
    • Powell N, Walker AW, Stolarczyk E, et al. The transcription factor T-bet regulates intestinal inflammation mediated by interleukin-7 receptor+ innate lymphoid cells. Immunity. 2012; 37(4): 674-684.
    • (2012) Immunity. , vol.37 , Issue.4 , pp. 674-684
    • Powell, N.1    Walker, A.W.2    Stolarczyk, E.3
  • 88
    • 84875280888 scopus 로고    scopus 로고
    • Class II major histocompatibility complex plays an essential role in obesity-induced adipose inflammation
    • Deng T, Lyon CJ, Minze LJ, et al. Class II major histocompatibility complex plays an essential role in obesity-induced adipose inflammation. Cell Metab. 2013; 17(3): 411-422.
    • (2013) Cell Metab. , vol.17 , Issue.3 , pp. 411-422
    • Deng, T.1    Lyon, C.J.2    Minze, L.J.3
  • 89
    • 78649468820 scopus 로고    scopus 로고
    • The genetics of type 2 diabetes: What have we learned from GWAS?
    • Billings LK, Florez JC. The genetics of type 2 diabetes: what have we learned from GWAS? Ann N Y Acad Sci. 2010; 1212: 59-77.
    • (2010) Ann N Y Acad Sci. , vol.1212 , pp. 59-77
    • Billings, L.K.1    Florez, J.C.2
  • 90
    • 67349199566 scopus 로고    scopus 로고
    • Type 1 Diabetes Genetics Consortium. Genome-wide association study and metaanalysis find that over 40 loci affect risk of type 1 diabetes
    • Barrett JC, Clayton DG, Concannon P, et al; Type 1 Diabetes Genetics Consortium. Genome-wide association study and metaanalysis find that over 40 loci affect risk of type 1 diabetes. Nat Genet. 2009; 41(6): 703-707.
    • (2009) Nat Genet. , vol.41 , Issue.6 , pp. 703-707
    • Barrett, J.C.1    Clayton, D.G.2    Concannon, P.3
  • 91
    • 84879260045 scopus 로고    scopus 로고
    • Type 2 diabetes genetics: Beyond GWAS
    • Sanghera DK, Blackett PR. Type 2 diabetes genetics: beyond GWAS. J Diabetes Metab. 2012; 3(198): 6948.
    • (2012) J Diabetes Metab. , vol.3 , Issue.198 , pp. 6948
    • Sanghera, D.K.1    Blackett, P.R.2
  • 92
    • 0033857387 scopus 로고    scopus 로고
    • Treatment of insulin resistance with peroxisome proliferator-activated receptor γagonists
    • Olefsky JM. Treatment of insulin resistance with peroxisome proliferator-activated receptor γagonists. J Clin Invest. 2000; 106(4): 467-472.
    • (2000) J Clin Invest. , vol.106 , Issue.4 , pp. 467-472
    • Olefsky, J.M.1
  • 93
    • 82755182907 scopus 로고    scopus 로고
    • Tissular T(regs): A unique population of adipose-tissue-resident Foxp3+CD4+T cells that impacts organismal metabolism
    • Cipolletta D, Kolodin D, Benoist C, Mathis D. Tissular T(regs): a unique population of adipose-tissue-resident Foxp3+CD4+T cells that impacts organismal metabolism. Semin Immunol. 2011; 23(6): 431-437.
    • (2011) Semin Immunol. , vol.23 , Issue.6 , pp. 431-437
    • Cipolletta, D.1    Kolodin, D.2    Benoist, C.3    Mathis, D.4


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