Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion

Diabetologia

Volumn 53, Issue 8, 2010, Pages 1656-1668

  Wijesekara, N ^a   Dai, F F ^a   Hardy, A B ^a   Giglou, P R ^a   Bhattacharjee, A ^a   Koshkin, V ^a   Chimienti, F ^b   Gaisano, H Y ^a   Rutter, G A ^c   Wheeler, M B ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b Mellitech   (France)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Alpha cell; Beta cell; Glucagon; Insulin; Pancreatic islets; SLC30A8; Zinc; ZnT8

Indexed keywords

UNCLASSIFIED DRUG; ZINC TRANSPORT FAMILY MEMBER 8; ZINC TRANSPORTER; CATION TRANSPORT PROTEIN; GLUCOSE; INSULIN; ZINC; ZINC TRANSPORTER ZNT8, MOUSE;

ANIMAL CELL; ARTICLE; CELL STRUCTURE; CONTROLLED STUDY; CRYSTALLIZATION; GENE DELETION; GENE EXPRESSION REGULATION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC RISK; IMMUNOREACTIVITY; IN VITRO STUDY; IN VIVO STUDY; INSULIN RELEASE; INSULIN SYNTHESIS; MALE; MOUSE; NONHUMAN; PANCREAS ISLET ALPHA CELL; PANCREAS ISLET BETA CELL; PHENOTYPE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SIGNAL PROCESSING; TRANSMISSION ELECTRON MICROSCOPY; ANALYSIS OF VARIANCE; ANIMAL; CELL GRANULE; CONFOCAL MICROSCOPY; GENETICS; IMMUNOELECTRON MICROSCOPY; IMMUNOHISTOCHEMISTRY; KNOCKOUT MOUSE; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SECRETION (PROCESS); WESTERN BLOTTING;

ANALYSIS OF VARIANCE; ANIMALS; BLOTTING, WESTERN; CATION TRANSPORT PROTEINS; CYTOPLASMIC GRANULES; GLUCAGON-SECRETING CELLS; GLUCOSE; IMMUNOHISTOCHEMISTRY; INSULIN; INSULIN-SECRETING CELLS; MICE; MICE, KNOCKOUT; MICROSCOPY, CONFOCAL; MICROSCOPY, IMMUNOELECTRON; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; ZINC;

EID: 77955514154     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-010-1733-9     Document Type: Article

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