Diabetes prevention by immunomodulatory FTY720 treatment in the LEW.1AR1-iddm rat despite immune cell activation

Endocrinology

Volumn 151, Issue 8, 2010, Pages 3555-3565

  Jörns, Anne ^a,b   Rath, Klaus Jan ^a   Terbish, Taivankhuu ^a   Arndt, Tanja ^a   Zu Vilsendorf, Andreas Meyer ^c   Wedekind, Dirk ^d   Hedrich, Hans Jürgen ^d   Lenzen, Sigurd ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b Centre of Anatomy   (Germany)

^c Department of General Visceral and Transplantation Surgery ^*  (Germany)

^d Institute of Laboratory Animal Science   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CD8 ANTIGEN; CYTOKINE; FINGOLIMOD; INTERLEUKIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; NITRIC OXIDE SYNTHASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CELL STRUCTURE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; IMMUNOCOMPETENT CELL; IMMUNOMODULATION; INSULIN DEPENDENT DIABETES MELLITUS; LYMPHOID TISSUE; MALE; METABOLISM; NONHUMAN; PANCREAS ISLET CELL; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; T LYMPHOCYTE;

ANIMALS; ANTIGENS, CD8; CYTOKINES; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; DRUG EVALUATION, PRECLINICAL; FEMALE; GENE EXPRESSION REGULATION; IMMUNE SYSTEM; IMMUNOMODULATION; IMMUNOSUPPRESSIVE AGENTS; LYMPH NODES; LYMPHOCYTE ACTIVATION; MALE; PANCREAS; PROPYLENE GLYCOLS; RATS; SPHINGOSINE;

EID: 77954898611     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2010-0202     Document Type: Article

References (32)

1. Kovarik JM, Schmouder R, Barilla D, Riviere GJ, Wang Y, Hunt T 2004 Multiple-dose FTY720: tolerability, pharmacokinetics, and lymphocyte responses in healthy subjects. J Clin Pharmacol 44:532-537 (Pubitemid 38509722)
2. Brinkmann V 2007 Sphingosine 1-phosphate receptors in health and disease: mechanistic insights from gene deletion studies and reverse pharmacology. Pharmacol Ther 115:84-105
3. Brinkmann V, Pinschewer DD, Feng L, Chen S 2001 FTY720: altered lymphocyte traffic results in allograft protection. Transplantation 72:764-769 (Pubitemid 32879840)
4. Martini S, Peters H, Böhler T, Budde K 2007 Current perspectives on FTY720. Expert Opin Investig Drugs 16:505-518
5. Wang F, Tan W, Guo D, He S 2007 Reduction of CD4 positive T cells and improvement of pathological changes of collagen-induced arthritis by FTY720. Eur J Pharmacol 573:230-240 (Pubitemid 47464222)
6. van der Giet M, Tölle M, Kleuser B 2008 Relevance and potential of sphingosine-1-phosphate in vascular inflammatory disease. Biol Chem 389:1381-1390
7. Zhang Z, Zhang ZY, Fauser U, Schluesener HJ 2008 FTY720 ameliorates experimental autoimmune neuritis by inhibition of lymphocyte and monocyte infiltration into peripheral nerves. Exp Neurol 210:681-690
8. O'Connor P, Comi G, Montalban X, Antel J, Radue EW, de Vera A, Pohlmann H, Kappos L 2009 Oral fingolimod (FTY720) in multiple sclerosis: two-year results of a phase II extension study. Neurology 72:73-79
9. Mehling M, Brinkmann V, Antel J, Bar-Or A, Goebels N, Vedrine C, Kristofic C, Kuhle J, Lindberg RL, Kappos L 2008 FTY720 therapy exerts differential effects on T cell subsets in multiple sclerosis. Neurology 71:1261-1267
10. Maki T, Gottschalk R, Monaco AP 2002 Prevention of autoimmune diabetes by FTY720 in nonobese diabetic mice. Transplantation 74:1684-1686 (Pubitemid 36019318)
11. Yang Z, Chen M, Fialkow LB, Ellett JD, Wu R, Brinkmann V, Nadler JL, Lynch KR 2003 The immune modulator FYT720 prevents autoimmune diabetes in nonobese diabetic mice small star, filled. Clin Immunol 107:30-35 (Pubitemid 36539443)
12. Popovic J, Kover KL, Moore WV 2004 The effect of immunomodulators on prevention of autoimmune diabetes is stage dependent: FTY720 prevents diabetes at three different stages in the diabetes-resistant biobreeding rat. Pediatr Diabetes 5:3-9
13. Maki T, Gottschalk R, Ogawa N, Monaco AP 2005 Prevention and cure of autoimmune diabetes in nonobese diabetic mice by continuous administration of FTY720. Transplantation 79:1051-1055 (Pubitemid 40663996)
14. Jörns A, Günther A, Hedrich HJ, Wedekind D, Tiedge M, Lenzen S 2005 Immune cell infiltration, cytokine expression, and β-cell apoptosis during the development of type 1 diabetes in the spontaneously diabetic LEW.1AR1/Ztm-iddm rat. Diabetes 54:2041-2052
15. Uno S, Imagawa A, Okita K, Sayama K, Moriwaki M, Iwahashi H, Yamagata K, Tamura S, Matsuzawa Y, Hanafusa T, Miyagawa J, Shimomura I 2007 Macrophages and dendritic cells infiltrating islets with or without β-cells produce tumour necrosis factor-α in patients with recent-onset type 1 diabetes. Diabetologia 50:596-601
16. Bell EB, Westermann J 2008 CD4 memory T cells on trial: immunological memory without a memory T cell. Trends Immunol 29:405-411
17. Lenzen S, Tiedge M, Elsner M, Lortz S, Weiss H, Jörns A, Klöppel G, Wedekind D, Prokop CM, Hedrich HJ 2001 The LEW.1AR1/Ztm-iddm rat: a new model of spontaneous insulin-dependent diabetes mellitus. Diabetologia 44:1189-1196
18. Awata T, Guberski DL, Like AA 1995 Genetics of the BB rat: association of autoimmune disorders (diabetes, insulitis, and thyroiditis) with lymphopenia and major histocompatibility complex class II. Endocrinology 136:5731-5735
19. Nicklas W, Baneux P, Boot R, Decelle T, Deeny AA, Fumanelli M, Illgen-Wilcke B 2002 Recommendations for the health monitoring of rodent and rabbit colonies in breeding and experimental units. Lab Anim 36:20-42 (Pubitemid 34073119)
20. Lally FJ, Ratcliff H, Bone AJ 2001 Apoptosis and disease progression in the spontaneously diabetic BB/S rat. Diabetologia 44:320-324 (Pubitemid 32234458)
21. + T-cell transfer is associated with a cytokine shift in the pancreas draining lymph nodes. Diabetologia 52:1381-1390
22. Jörns A, Rath KJ, Bock O, Lenzen S 2006 β-Cell death in hyperglycaemic Psammomys obesus is not cytokine-mediated. Diabetologia 49:2704-2712
23. Hering BJ, Wijkstrom M, Graham ML, Hårdstedt M, Aasheim TC, Jie T, Ansite JD, Nakano M, Cheng J, Li W, Moran K, Christians U, Finnegan C, Mills CD, Sutherland DE, Bansal-Pakala P, Murtaugh MP, Kirchhof N, Schuurman HJ 2006 Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates. Nature Med 12:301-303
24. Truong W, Emamaullee JA, Merani S, Anderson CC, James Shapiro AM 2007 Human islet function is not impaired by the sphingosine-1-phosphate receptor modulator FTY720. Am J Transplant 7:2031-2038 (Pubitemid 47037990)
25. Shapiro AM, Lakey JR, Paty BW, Senior PA, Bigam DL, Ryan EA 2005 Strategic opportunities in clinical islet transplantation. Transplantation 79:1304-1307 (Pubitemid 40734790)
26. Chen MC, Proost P, Gysemans C, Mathieu C, Eizirik DL 2001 Monocyte chemoattractant protein-1 is expressed in pancreatic islets from prediabetic NOD mice and in interleukin-1β-exposed human and rat islet cells. Diabetologia 44:325-332 (Pubitemid 32234459)
27. Arnush M, Scarim AL, Heitmeier MR, Kelly CB, Corbett JA 1998 Potential role of resident islet macrophage activation in the initiation of autoimmune diabetes. J Immunol 160:2684-2691 (Pubitemid 28136719)
28. O'Farrell AM, Liu Y, Moore KW, Mui AL 1998 IL-10 inhibits macrophage activation and proliferation by distinct signaling mechanisms: evidence for Stat3-dependent and -independent pathways. EMBO J 17:1006-1018 (Pubitemid 28077655)
29. MacKinnon AC, Farnworth SL, Hodkinson PS, Henderson NC, Atkinson KM, Leffler H, Nilsson UJ, Haslett C, Forbes SJ, Sethi T 2008 Regulation of alternative macrophage activation by galectin-3. J Immunol 180:2650-2658
30. Kappos L, Gold R, Miller DH, Macmanus DG, Havrdova E, Limmroth V, Polman CH, Schmierer K, Yousry TA, Yang M, Eraksoy M, Meluzinova E, Rektor I, Dawson KT, Sandrock AW, O'Neill GN 2008 Efficacy and safety of oral fumarate in patients with relapsingremitting multiple sclerosis: a multicentre, randomised, doubleblind, placebo-controlled phase IIb study. Lancet 372:1463-1472
31. Liu G, Burns S, Huang G, Boyd K, Proia RL, Flavell RA, Chi H 2009 The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR. Nat Immunol 10:769-777
32. Park EJ, Peixoto A, Imai Y, Goodarzi A, Cheng G, Carman CV, von Andrian UH, Shimaoka M 2010 Distinct roles for LFA-1 affinity regulation during T-cell adhesion, diapedesis, and interstitial migration in lymph nodes. Blood 115:1572-1581