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Volumn 8, Issue , 2015, Pages 181-188

Streptozotocin-induced type 1 diabetes in rodents as a model for studying mitochondrial mechanisms of diabetic β cell glucotoxicity

Author keywords

Diabetes; Glucotoxicity; Mitochondria; Redox imbalance; Streptozotocin; cell

Indexed keywords

ADENOSINE TRIPHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE;

EID: 84936942895     PISSN: None     EISSN: 11787007     Source Type: Journal    
DOI: 10.2147/DMSO.S82272     Document Type: Review
Times cited : (244)

References (71)
  • 1
    • 43549108142 scopus 로고    scopus 로고
    • Glucolipotoxicity: Fuel excess and beta-cell dysfunction
    • Poitout V, Robertson RP. Glucolipotoxicity: fuel excess and beta-cell dysfunction. Endocr Rev. 2008;29(3):351-366.
    • (2008) Endocr Rev. , vol.29 , Issue.3 , pp. 351-366
    • Poitout, V.1    Robertson, R.P.2
  • 2
    • 0025600472 scopus 로고
    • Hyperglycemia-induced B cell toxicity. The fate of pancreatic islets transplanted into diabetic mice is dependent on their genetic background
    • Korsgren O, Jansson L, Sandler S, Andersson A. Hyperglycemia-induced B cell toxicity. The fate of pancreatic islets transplanted into diabetic mice is dependent on their genetic background. J Clin Invest. 1990;86(6): 2161-2168.
    • (1990) J Clin Invest. , vol.86 , Issue.6 , pp. 2161-2168
    • Korsgren, O.1    Jansson, L.2    Sandler, S.3    Andersson, A.4
  • 3
    • 0036153256 scopus 로고    scopus 로고
    • Minireview: Secondary beta-cell failure in type 2 diabetes - A convergence of glucotoxicity and lipotoxicity
    • Poitout V, Robertson RP. Minireview: secondary beta-cell failure in type 2 diabetes - a convergence of glucotoxicity and lipotoxicity. Endocrinology. 2002;143(2):339-342.
    • (2002) Endocrinology. , vol.143 , Issue.2 , pp. 339-342
    • Poitout, V.1    Robertson, R.P.2
  • 4
    • 0035691617 scopus 로고    scopus 로고
    • The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas
    • Szkudelski T. The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Physiol Res. 2001;50(6):537-546.
    • (2001) Physiol Res. , vol.50 , Issue.6 , pp. 537-546
    • Szkudelski, T.1
  • 5
    • 37549029242 scopus 로고    scopus 로고
    • The mechanisms of alloxan- and streptozotocin-induced diabetes
    • Lenzen S. The mechanisms of alloxan- and streptozotocin-induced diabetes. Diabetologia. 2008;51(2):216-226.
    • (2008) Diabetologia. , vol.51 , Issue.2 , pp. 216-226
    • Lenzen, S.1
  • 6
    • 73649197648 scopus 로고
    • Studies on the diabetogenic action of streptozotocin (NSC-37917)
    • Rakieten N, Rakieten ML, Nadkarni MR. Studies on the diabetogenic action of streptozotocin (NSC-37917). Cancer Chemother Rep. 1963; 29:91-98.
    • (1963) Cancer Chemother Rep. , vol.29 , pp. 91-98
    • Rakieten, N.1    Rakieten, M.L.2    Nadkarni, M.R.3
  • 8
    • 84914164473 scopus 로고    scopus 로고
    • Streptozotocin-nicotinamide-induced rat model of type 2 diabetes (review)
    • Ghasemi A, Khalifi S, Jedi S. Streptozotocin-nicotinamide-induced rat model of type 2 diabetes (review). Acta Physiol Hung. 2014;101(4): 408-420.
    • (2014) Acta Physiol Hung. , vol.101 , Issue.4 , pp. 408-420
    • Ghasemi, A.1    Khalifi, S.2    Jedi, S.3
  • 9
    • 0014606996 scopus 로고
    • Diabetogenic action of streptozotocin: Relationship of dose to metabolic response
    • Junod A, Lambert AE, Stauffacher W, Renold AE. Diabetogenic action of streptozotocin: relationship of dose to metabolic response. J Clin Invest. 1969;48(11):2129-2139.
    • (1969) J Clin Invest. , vol.48 , Issue.11 , pp. 2129-2139
    • Junod, A.1    Lambert, A.E.2    Stauffacher, W.3    Renold, A.E.4
  • 10
    • 33845531355 scopus 로고    scopus 로고
    • Recovery of islet beta-cell function in streptozotocin-induced diabetic mice: An indirect role for the spleen
    • Yin D, Tao J, Lee DD, et al. Recovery of islet beta-cell function in streptozotocin-induced diabetic mice: an indirect role for the spleen. Diabetes. 2006;55(12):3256-3263.
    • (2006) Diabetes. , vol.55 , Issue.12 , pp. 3256-3263
    • Yin, D.1    Tao, J.2    Lee, D.D.3
  • 11
    • 44949237880 scopus 로고    scopus 로고
    • Aminoguanidine prevents the impairment of cardiac pumping mechanics in rats with streptozotocin and nicotinamide-induced type 2 diabetes
    • Wu MS, Liang JT, Lin YD, Wu ET, Tseng YZ, Chang KC. Aminoguanidine prevents the impairment of cardiac pumping mechanics in rats with streptozotocin and nicotinamide-induced type 2 diabetes. Br J Pharmacol. 2008;154(4):758-764.
    • (2008) Br J Pharmacol. , vol.154 , Issue.4 , pp. 758-764
    • Wu, M.S.1    Liang, J.T.2    Lin, Y.D.3    Wu, E.T.4    Tseng, Y.Z.5    Chang, K.C.6
  • 12
    • 84862006013 scopus 로고    scopus 로고
    • Streptozotocin-nicotinamide-induced diabetes in the rat. Characteristics of the experimental model
    • Szkudelski T. Streptozotocin-nicotinamide-induced diabetes in the rat. Characteristics of the experimental model. Exp Biol Med (Maywood). 2012;237(5):481-490.
    • (2012) Exp Biol Med (Maywood). , vol.237 , Issue.5 , pp. 481-490
    • Szkudelski, T.1
  • 13
    • 84904668846 scopus 로고    scopus 로고
    • Modeling type 2 diabetes in rats using high fat diet and streptozotocin
    • Skovso S. Modeling type 2 diabetes in rats using high fat diet and streptozotocin. J Diabetes Investig. 2014;5(4):349-358.
    • (2014) J Diabetes Investig. , vol.5 , Issue.4 , pp. 349-358
    • Skovso, S.1
  • 15
    • 0024348805 scopus 로고
    • The rat models of non-insulin dependent diabetes induced by neonatal streptozotocin
    • Portha B, Blondel O, Serradas P, et al. The rat models of non-insulin dependent diabetes induced by neonatal streptozotocin. Diabete Metab. 1989;15(2):61-75.
    • (1989) Diabete Metab. , vol.15 , Issue.2 , pp. 61-75
    • Portha, B.1    Blondel, O.2    Serradas, P.3
  • 16
    • 23844504364 scopus 로고    scopus 로고
    • Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: A model for type 2 diabetes and pharmacological screening
    • Srinivasan K, Viswanad B, Asrat L, Kaul CL, Ramarao P. Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: a model for type 2 diabetes and pharmacological screening. Pharmacol Res. 2005; 52(4):313-320.
    • (2005) Pharmacol Res. , vol.52 , Issue.4 , pp. 313-320
    • Srinivasan, K.1    Viswanad, B.2    Asrat, L.3    Kaul, C.L.4    Ramarao, P.5
  • 17
    • 84864812822 scopus 로고    scopus 로고
    • GC-MS analysis and screening of antidiabetic, antioxidant and hypolipidemic potential of Cinnamomum tamala oil in streptozotocin induced diabetes mellitus in rats
    • Kumar S, Vasudeva N, Sharma S. GC-MS analysis and screening of antidiabetic, antioxidant and hypolipidemic potential of Cinnamomum tamala oil in streptozotocin induced diabetes mellitus in rats. Cardiovasc Diabetol. 2012;11:95.
    • (2012) Cardiovasc Diabetol. , vol.11 , pp. 95
    • Kumar, S.1    Vasudeva, N.2    Sharma, S.3
  • 19
    • 0018182968 scopus 로고
    • Studies on the tissue-disposition and fate of [14C]streptozotocin with special reference to the pancreatic islets
    • Johansson EB, Tjalve H. Studies on the tissue-disposition and fate of [14C]streptozotocin with special reference to the pancreatic islets. Acta Endocrinol. 1978;89(2):339-351.
    • (1978) Acta Endocrinol. , vol.89 , Issue.2 , pp. 339-351
    • Johansson, E.B.1    Tjalve, H.2
  • 20
    • 25444455671 scopus 로고    scopus 로고
    • Regulation of pancreatic beta-cell mass
    • Bouwens L, Rooman I. Regulation of pancreatic beta-cell mass. Physiol Rev. 2005;85(4):1255-1270.
    • (2005) Physiol Rev. , vol.85 , Issue.4 , pp. 1255-1270
    • Bouwens, L.1    Rooman, I.2
  • 22
    • 84908504693 scopus 로고    scopus 로고
    • Review of the mechanism of cell death resulting from streptozotocin challenge in experimental animals, its practical use and potential risk to humans
    • Eleazu CO, Eleazu KC, Chukwuma S, Essien UN. Review of the mechanism of cell death resulting from streptozotocin challenge in experimental animals, its practical use and potential risk to humans. J Diabetes Metab Disord. 2013;12(1):60.
    • (2013) J Diabetes Metab Disord. , vol.12 , Issue.1 , pp. 60
    • Eleazu, C.O.1    Eleazu, K.C.2    Chukwuma, S.3    Essien, U.N.4
  • 23
    • 34248216953 scopus 로고    scopus 로고
    • Rodent models of streptozotocin-induced diabetic nephropathy
    • Tesch GH, Allen TJ. Rodent models of streptozotocin-induced diabetic nephropathy. Nephrology. 2007;12(3):261-266.
    • (2007) Nephrology. , vol.12 , Issue.3 , pp. 261-266
    • Tesch, G.H.1    Allen, T.J.2
  • 24
    • 0043092399 scopus 로고    scopus 로고
    • The streptozotocin-diabetic rat as a model of the chronic complications of human diabetes
    • Wei M, Ong L, Smith MT, et al. The streptozotocin-diabetic rat as a model of the chronic complications of human diabetes. Heart Lung Circ. 2003;12(1):44-50.
    • (2003) Heart Lung Circ. , vol.12 , Issue.1 , pp. 44-50
    • Wei, M.1    Ong, L.2    Smith, M.T.3
  • 25
    • 84904192156 scopus 로고    scopus 로고
    • Pathogenesis of chronic hyperglycemia: From reductive stress to oxidative stress
    • Yan LJ. Pathogenesis of chronic hyperglycemia: from reductive stress to oxidative stress. J Diabetes Res. 2014;2014:137919.
    • (2014) J Diabetes Res. , vol.2014
    • Yan, L.J.1
  • 26
    • 78649990012 scopus 로고    scopus 로고
    • O-GlcNAc modification, insulin signaling and diabetic complications
    • Issad T, Masson E, Pagesy P. O-GlcNAc modification, insulin signaling and diabetic complications. Diabetes Metab. 2010;36(6 pt 1):423-435.
    • (2010) Diabetes Metab. , vol.36 , Issue.6 , pp. 423-435
    • Issad, T.1    Masson, E.2    Pagesy, P.3
  • 27
    • 33644781862 scopus 로고    scopus 로고
    • Activation of vascular protein kinase C-beta inhibits Akt-dependent endothelial nitric oxide synthase function in obesity-associated insulin resistance
    • Naruse K, Rask-Madsen C, Takahara N, et al. Activation of vascular protein kinase C-beta inhibits Akt-dependent endothelial nitric oxide synthase function in obesity-associated insulin resistance. Diabetes. 2006;55(3):691-698.
    • (2006) Diabetes. , vol.55 , Issue.3 , pp. 691-698
    • Naruse, K.1    Rask-Madsen, C.2    Takahara, N.3
  • 28
    • 0027318772 scopus 로고
    • Hyperglycemic pseudohypoxia and diabetic complications
    • Williamson JR, Chang K, Frangos M, et al. Hyperglycemic pseudohypoxia and diabetic complications. Diabetes. 1993;42(6):801-813.
    • (1993) Diabetes. , vol.42 , Issue.6 , pp. 801-813
    • Williamson, J.R.1    Chang, K.2    Frangos, M.3
  • 29
    • 77950362951 scopus 로고    scopus 로고
    • Hyperglycemia impairs proteasome function by methylglyoxal
    • Queisser MA, Yao D, Geisler S, et al. Hyperglycemia impairs proteasome function by methylglyoxal. Diabetes. 2010;59(3):670-678.
    • (2010) Diabetes. , vol.59 , Issue.3 , pp. 670-678
    • Queisser, M.A.1    Yao, D.2    Geisler, S.3
  • 30
    • 0023259759 scopus 로고
    • Glucose autoxidation and protein modification. The potential role of 'autoxidative glycosylation' in diabetes
    • Wolff SP, Dean RT. Glucose autoxidation and protein modification. The potential role of 'autoxidative glycosylation' in diabetes. Biochem J. 1987;245(1):243-250.
    • (1987) Biochem J. , vol.245 , Issue.1 , pp. 243-250
    • Wolff, S.P.1    Dean, R.T.2
  • 32
    • 5644248079 scopus 로고    scopus 로고
    • Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes
    • Robertson RP. Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes. J Biol Chem. 2004;279(41):42351-42354.
    • (2004) J Biol Chem. , vol.279 , Issue.41 , pp. 42351-42354
    • Robertson, R.P.1
  • 33
    • 0032407381 scopus 로고    scopus 로고
    • Role of mitochondria in metabolism-secretion coupling of insulin release in the pancreatic beta-cell
    • Maechler P, Wollheim CB. Role of mitochondria in metabolism-secretion coupling of insulin release in the pancreatic beta-cell. Biofactors. 1998;8(3-4):255-262.
    • (1998) Biofactors. , vol.8 , Issue.3-4 , pp. 255-262
    • Maechler, P.1    Wollheim, C.B.2
  • 34
    • 70450285188 scopus 로고    scopus 로고
    • Tight coupling between glucose and mitochondrial metabolism in clonal beta-cells is required for robust insulin secretion
    • Malmgren S, Nicholls DG, Taneera J, et al. Tight coupling between glucose and mitochondrial metabolism in clonal beta-cells is required for robust insulin secretion. J Biol Chem. 2009;284(47):32395-32404.
    • (2009) J Biol Chem. , vol.284 , Issue.47 , pp. 32395-32404
    • Malmgren, S.1    Nicholls, D.G.2    Taneera, J.3
  • 35
    • 12044255619 scopus 로고
    • Low lactate dehydrogenase and high mitochondrial glycerol phosphate dehydrogenase in pancreatic beta-cells. Potential role in nutrient sensing
    • Sekine N, Cirulli V, Regazzi R, et al. Low lactate dehydrogenase and high mitochondrial glycerol phosphate dehydrogenase in pancreatic beta-cells. Potential role in nutrient sensing. J Biol Chem. 1994;269(7): 4895-4902.
    • (1994) J Biol Chem. , vol.269 , Issue.7 , pp. 4895-4902
    • Sekine, N.1    Cirulli, V.2    Regazzi, R.3
  • 36
    • 33646779855 scopus 로고    scopus 로고
    • Minireview: Implication of mitochondria in insulin secretion and action
    • Wiederkehr A, Wollheim CB. Minireview: implication of mitochondria in insulin secretion and action. Endocrinology. 2006;147(6): 2643-2649.
    • (2006) Endocrinology. , vol.147 , Issue.6 , pp. 2643-2649
    • Wiederkehr, A.1    Wollheim, C.B.2
  • 37
    • 0030810982 scopus 로고    scopus 로고
    • Metabolic fate of glucose in purified islet cells. Glucose-regulated anaplerosis in beta cells
    • Schuit F, De Vos A, Farfari S, et al. Metabolic fate of glucose in purified islet cells. Glucose-regulated anaplerosis in beta cells. J Biol Chem. 1997;272(30):18572-18579.
    • (1997) J Biol Chem. , vol.272 , Issue.30 , pp. 18572-18579
    • Schuit, F.1    De Vos, A.2    Farfari, S.3
  • 38
    • 84884535368 scopus 로고    scopus 로고
    • Mitochondrial function and insulin secretion
    • Maechler P. Mitochondrial function and insulin secretion. Mol Cell Endocrinol. 2013;379(1-2):12-18.
    • (2013) Mol Cell Endocrinol. , vol.379 , Issue.1-2 , pp. 12-18
    • Maechler, P.1
  • 39
    • 33644872401 scopus 로고    scopus 로고
    • In beta-cells, mitochondria integrate and generate metabolic signals controlling insulin secretion
    • Maechler P, Carobbio S, Rubi B. In beta-cells, mitochondria integrate and generate metabolic signals controlling insulin secretion. Int J Biochem Cell Biol. 2006;38(5-6):696-709.
    • (2006) Int J Biochem Cell Biol. , vol.38 , Issue.5-6 , pp. 696-709
    • Maechler, P.1    Carobbio, S.2    Rubi, B.3
  • 40
    • 84869438651 scopus 로고    scopus 로고
    • Mitochondrial signal transduction in pancreatic beta-cells
    • Maechler P. Mitochondrial signal transduction in pancreatic beta-cells. Best Pract Res Clin Endocrinol Metab. 2012;26(6):739-752.
    • (2012) Best Pract Res Clin Endocrinol Metab. , vol.26 , Issue.6 , pp. 739-752
    • Maechler, P.1
  • 41
    • 84926083664 scopus 로고    scopus 로고
    • Metabolic signaling of insulin secretion by pancreatic beta-cell and its derangement in type 2 diabetes
    • Zou CY, Gong Y, Liang J. Metabolic signaling of insulin secretion by pancreatic beta-cell and its derangement in type 2 diabetes. Eur Rev Med Pharmacol Sci. 2014;18(15):2215-2227.
    • (2014) Eur Rev Med Pharmacol Sci. , vol.18 , Issue.15 , pp. 2215-2227
    • Zou, C.Y.1    Gong, Y.2    Liang, J.3
  • 42
    • 84936963851 scopus 로고    scopus 로고
    • Pulsatile insulin secretion, impaired glucose tolerance and type 2 diabetes
    • In press
    • Satin LS, Butler PC, Ha J, Sherman AS. Pulsatile insulin secretion, impaired glucose tolerance and type 2 diabetes. Mol Aspects Med. In press 2015.
    • (2015) Mol Aspects Med
    • Satin, L.S.1    Butler, P.C.2    Ha, J.3    Sherman, A.S.4
  • 43
    • 84857785686 scopus 로고    scopus 로고
    • Mitochondrial signals drive insulin secretion in the pancreatic beta-cell
    • Wiederkehr A, Wollheim CB. Mitochondrial signals drive insulin secretion in the pancreatic beta-cell. Mol Cell Endocrinol. 2012;353(1-2): 128-137.
    • (2012) Mol Cell Endocrinol. , vol.353 , Issue.1-2 , pp. 128-137
    • Wiederkehr, A.1    Wollheim, C.B.2
  • 44
    • 84867507940 scopus 로고    scopus 로고
    • The molecular mechanisms of pancreatic beta-cell glucotoxicity: Recent findings and future research directions
    • Bensellam M, Laybutt DR, Jonas JC. The molecular mechanisms of pancreatic beta-cell glucotoxicity: recent findings and future research directions. Mol Cell Endocrinol. 2012;364(1-2):1-27.
    • (2012) Mol Cell Endocrinol. , vol.364 , Issue.1-2 , pp. 1-27
    • Bensellam, M.1    Laybutt, D.R.2    Jonas, J.C.3
  • 45
    • 84878533789 scopus 로고    scopus 로고
    • The NAD ratio redox paradox: Why does too much reductive power cause oxidative stress?
    • Teodoro JS, Rolo AP, Palmeira CM. The NAD ratio redox paradox: why does too much reductive power cause oxidative stress? Toxicol Mech Methods. 2013;23(5):297-302.
    • (2013) Toxicol Mech Methods. , vol.23 , Issue.5 , pp. 297-302
    • Teodoro, J.S.1    Rolo, A.P.2    Palmeira, C.M.3
  • 46
    • 84936963852 scopus 로고    scopus 로고
    • Roles of pyruvate, NADH, and mitochondrial complex I in redox balance and imbalance in β cell function and dysfunction
    • Luo X, Li R, Yan L-J. Roles of pyruvate, NADH, and mitochondrial complex I in redox balance and imbalance in β cell function and dysfunction. J Diabetes Res. 2015.
    • (2015) J Diabetes Res.
    • Luo, X.1    Li, R.2    Yan, L.-J.3
  • 48
    • 0022654311 scopus 로고
    • Comparative interactions of streptozotocin and chlorozotocin with DNA of an insulin-secreting cell line (RINr)
    • Mossman BT, Ireland CM, Filipak M, LeDoux S, Wilson GL. Comparative interactions of streptozotocin and chlorozotocin with DNA of an insulin-secreting cell line (RINr). Diabetologia. 1986;29(3):186-191.
    • (1986) Diabetologia. , vol.29 , Issue.3 , pp. 186-191
    • Mossman, B.T.1    Ireland, C.M.2    Filipak, M.3    LeDoux, S.4    Wilson, G.L.5
  • 49
    • 0025757259 scopus 로고
    • Repair of alkali-labile sites within the mitochondrial DNA of RINr 38 cells after exposure to the nitrosourea streptozotocin
    • Pettepher CC, LeDoux SP, Bohr VA, Wilson GL. Repair of alkali-labile sites within the mitochondrial DNA of RINr 38 cells after exposure to the nitrosourea streptozotocin. J Biol Chem. 1991;266(5):3113-3117.
    • (1991) J Biol Chem. , vol.266 , Issue.5 , pp. 3113-3117
    • Pettepher, C.C.1    LeDoux, S.P.2    Bohr, V.A.3    Wilson, G.L.4
  • 50
    • 0014886814 scopus 로고
    • Drugs producing diabetes through damage of the insulin secreting cells
    • Rerup CC. Drugs producing diabetes through damage of the insulin secreting cells. Pharmacol Rev. 1970;22(4):485-518.
    • (1970) Pharmacol Rev. , vol.22 , Issue.4 , pp. 485-518
    • Rerup, C.C.1
  • 51
    • 0033935559 scopus 로고    scopus 로고
    • K(ATP) channel openers protect rat islets against the toxic effect of streptozotocin
    • Kullin M, Li Z, Hansen JB, Bjork E, Sandler S, Karlsson FA. K(ATP) channel openers protect rat islets against the toxic effect of streptozotocin. Diabetes. 2000;49(7):1131-1136.
    • (2000) Diabetes. , vol.49 , Issue.7 , pp. 1131-1136
    • Kullin, M.1    Li, Z.2    Hansen, J.B.3    Bjork, E.4    Sandler, S.5    Karlsson, F.A.6
  • 52
    • 0037131008 scopus 로고    scopus 로고
    • Rescue of beta-cell exhaustion by diazoxide after the development of diabetes mellitus in rats with streptozotocin-induced diabetes
    • Matsuda M, Kawasaki F, Mikami Y, et al. Rescue of beta-cell exhaustion by diazoxide after the development of diabetes mellitus in rats with streptozotocin-induced diabetes. Eur J Pharmacol. 2002;453(1): 141-148.
    • (2002) Eur J Pharmacol. , vol.453 , Issue.1 , pp. 141-148
    • Matsuda, M.1    Kawasaki, F.2    Mikami, Y.3
  • 53
    • 77649309901 scopus 로고    scopus 로고
    • Glycemic control promotes pancreatic beta-cell regeneration in streptozotocin-induced diabetic mice
    • Grossman EJ, Lee DD, Tao J, et al. Glycemic control promotes pancreatic beta-cell regeneration in streptozotocin-induced diabetic mice. PLoS One. 2010;5(1):e8749.
    • (2010) PLoS One. , vol.5 , Issue.1
    • Grossman, E.J.1    Lee, D.D.2    Tao, J.3
  • 54
    • 0001824765 scopus 로고    scopus 로고
    • Streptozotocin-induced diabetes: Induction, mechanism(s), and dose dependency
    • McNeill JH, editor. Boca Raton: CRC Press
    • Rodrigues B, Poucheret P, Battell ML, Mcneill JH. Streptozotocin-induced diabetes: Induction, mechanism(s), and dose dependency. In: McNeill JH, editor. Experimental Models of Diabetes. Boca Raton: CRC Press; 1999:3-18.
    • (1999) Experimental Models of Diabetes. , pp. 3-18
    • Rodrigues, B.1    Poucheret, P.2    Battell, M.L.3    McNeill, J.H.4
  • 55
    • 84926429654 scopus 로고    scopus 로고
    • Gamma-oryzanol protects pancreatic beta-cells against endoplasmic reticulum stress in male mice
    • Kozuka C, Sunagawa S, Ueda R, et al. Gamma-oryzanol protects pancreatic beta-cells against endoplasmic reticulum stress in male mice. Endocrinology. 2015;156(4):1242-1250.
    • (2015) Endocrinology. , vol.156 , Issue.4 , pp. 1242-1250
    • Kozuka, C.1    Sunagawa, S.2    Ueda, R.3
  • 56
    • 77953381883 scopus 로고    scopus 로고
    • Effects of atorvastatin on the regeneration of pancreatic {beta}-cells after streptozotocin treatment in the neonatal rodent
    • Marchand KC, Arany EJ, Hill DJ. Effects of atorvastatin on the regeneration of pancreatic {beta}-cells after streptozotocin treatment in the neonatal rodent. Am J Physiol Endocrinol Metab. 2010;299(1): E92-E100.
    • (2010) Am J Physiol Endocrinol Metab. , vol.299 , Issue.1 , pp. E92-E100
    • Marchand, K.C.1    Arany, E.J.2    Hill, D.J.3
  • 57
    • 0017343325 scopus 로고
    • DNA synthesis in pancreatic islet and acinar cells in rats with streptozotocin-induced diabetes
    • Hamming NA, Reynolds WA. DNA synthesis in pancreatic islet and acinar cells in rats with streptozotocin-induced diabetes. Horm Metab Res. 1977;9(2):114-116.
    • (1977) Horm Metab Res. , vol.9 , Issue.2 , pp. 114-116
    • Hamming, N.A.1    Reynolds, W.A.2
  • 58
    • 84880335696 scopus 로고    scopus 로고
    • Grape seed proanthocyanidins ameliorate pancreatic beta-cell dysfunction and death in low-dose streptozotocin- and high-carbohydrate/high-fat diet-induced diabetic rats partially by regulating endoplasmic reticulum stress
    • Ding Y, Zhang Z, Dai X, et al. Grape seed proanthocyanidins ameliorate pancreatic beta-cell dysfunction and death in low-dose streptozotocin- and high-carbohydrate/high-fat diet-induced diabetic rats partially by regulating endoplasmic reticulum stress. Nutr Metab. 2013;10:51.
    • (2013) Nutr Metab. , vol.10 , pp. 51
    • Ding, Y.1    Zhang, Z.2    Dai, X.3
  • 59
    • 84855494579 scopus 로고    scopus 로고
    • Effect of curcumin in the amelioration of pancreatic islets in streptozotocin-induced diabetic mice
    • Chanpoo M, Petchpiboonthai H, Panyarachun B, Anupunpisit V. Effect of curcumin in the amelioration of pancreatic islets in streptozotocin-induced diabetic mice. J Med Assoc Thai. 2010;93(Suppl 6): S152-S159.
    • (2010) J Med Assoc Thai. , vol.93 , pp. S152-S159
    • Chanpoo, M.1    Petchpiboonthai, H.2    Panyarachun, B.3    Anupunpisit, V.4
  • 60
    • 84863243411 scopus 로고    scopus 로고
    • Resveratrol prevents streptozotocin-induced diabetes by inhibiting the apoptosis of pancreatic beta-cell and the cleavage of poly (ADP-ribose) polymerase
    • Ku CR, Lee HJ, Kim SK, Lee EY, Lee MK, Lee EJ. Resveratrol prevents streptozotocin-induced diabetes by inhibiting the apoptosis of pancreatic beta-cell and the cleavage of poly (ADP-ribose) polymerase. Endocr J. 2012;59(2):103-109.
    • (2012) Endocr J. , vol.59 , Issue.2 , pp. 103-109
    • Ku, C.R.1    Lee, H.J.2    Kim, S.K.3    Lee, E.Y.4    Lee, M.K.5    Lee, E.J.6
  • 61
    • 84873088642 scopus 로고    scopus 로고
    • Modulatory effects of Pycnogenol in a rat model of insulin-dependent diabetes mellitus: Biochemical, histological, and immunohistochemical evidences
    • Parveen K, Ishrat T, Malik S, Kausar MA, Siddiqui WA. Modulatory effects of Pycnogenol in a rat model of insulin-dependent diabetes mellitus: biochemical, histological, and immunohistochemical evidences. Protoplasma. 2013;250(1):347-360.
    • (2013) Protoplasma. , vol.250 , Issue.1 , pp. 347-360
    • Parveen, K.1    Ishrat, T.2    Malik, S.3    Kausar, M.A.4    Siddiqui, W.A.5
  • 62
    • 84936941529 scopus 로고    scopus 로고
    • Phytochemical and antioxidant activity of polyherbal hydroethanolic extract in streptozotocin induced β cell destruction in rats
    • Kannadhasan R, Ashwini Anjana AJ. Phytochemical and antioxidant activity of polyherbal hydroethanolic extract in streptozotocin induced β cell destruction in rats. Int J Pharm Sci Drug Res. 2012;4(1): 25-30.
    • (2012) Int J Pharm Sci Drug Res. , vol.4 , Issue.1 , pp. 25-30
    • Kannadhasan, R.1    Ashwini Anjana, A.J.2
  • 63
    • 77956232225 scopus 로고    scopus 로고
    • Antioxidant protection of Malaysian tualang honey in pancreas of normal and streptozotocin-induced diabetic rats
    • Erejuwa OO, Sulaiman SA, Wahab MS, Sirajudeen KN, Salleh MS, Gurtu S. Antioxidant protection of Malaysian tualang honey in pancreas of normal and streptozotocin-induced diabetic rats. Ann Endocrinol. 2010;71(4):291-296.
    • (2010) Ann Endocrinol. , vol.71 , Issue.4 , pp. 291-296
    • Erejuwa, O.O.1    Sulaiman, S.A.2    Wahab, M.S.3    Sirajudeen, K.N.4    Salleh, M.S.5    Gurtu, S.6
  • 64
    • 84903792466 scopus 로고    scopus 로고
    • Anti-hyperglycemic activity of rutin in streptozotocin-induced diabetic rats: An effect mediated through cytokines, antioxidants and lipid biomarkers
    • Niture NT, Ansari AA, Naik SR. Anti-hyperglycemic activity of rutin in streptozotocin-induced diabetic rats: an effect mediated through cytokines, antioxidants and lipid biomarkers. Indian J Exp Biol. 2014;52(7): 720-727.
    • (2014) Indian J Exp Biol. , vol.52 , Issue.7 , pp. 720-727
    • Niture, N.T.1    Ansari, A.A.2    Naik, S.R.3
  • 65
    • 12344270191 scopus 로고    scopus 로고
    • High glucose potentiates cytokine- and streptozotocin-induced apoptosis of rat islet cells: Effect on apoptosis-related genes
    • Mellado-Gil JM, Aguilar-Diosdado M. High glucose potentiates cytokine- and streptozotocin-induced apoptosis of rat islet cells: effect on apoptosis-related genes. J Endocrinol. 2004;183(1):155-162.
    • (2004) J Endocrinol. , vol.183 , Issue.1 , pp. 155-162
    • Mellado-Gil, J.M.1    Aguilar-Diosdado, M.2
  • 66
    • 80055003184 scopus 로고    scopus 로고
    • IL-27 inhibits hyperglycemia and pancreatic islet inflammation induced by streptozotocin in mice
    • Fujimoto H, Hirase T, Miyazaki Y, et al. IL-27 inhibits hyperglycemia and pancreatic islet inflammation induced by streptozotocin in mice. Am J Pathol. 2011;179(5):2327-2336.
    • (2011) Am J Pathol. , vol.179 , Issue.5 , pp. 2327-2336
    • Fujimoto, H.1    Hirase, T.2    Miyazaki, Y.3
  • 67
    • 0030064460 scopus 로고    scopus 로고
    • Beta-cell apoptosis is responsible for the development of IDDM in the multiple low-dose streptozotocin model
    • O'Brien BA, Harmon BV, Cameron DP, Allan DJ. Beta-cell apoptosis is responsible for the development of IDDM in the multiple low-dose streptozotocin model. J Pathol. 1996;178(2):176-181.
    • (1996) J Pathol. , vol.178 , Issue.2 , pp. 176-181
    • O'Brien, B.A.1    Harmon, B.V.2    Cameron, D.P.3    Allan, D.J.4
  • 68
    • 65549131015 scopus 로고    scopus 로고
    • The characterization of high-fat diet and multiple low-dose streptozotocin induced type 2 diabetes rat model
    • Zhang M, Lv XY, Li J, Xu ZG, Chen L. The characterization of high-fat diet and multiple low-dose streptozotocin induced type 2 diabetes rat model. Exp Diabetes Res. 2008;2008:704045.
    • (2008) Exp Diabetes Res. , vol.2008
    • Zhang, M.1    Lv, X.Y.2    Li, J.3    Xu, Z.G.4    Chen, L.5
  • 69
    • 34250024843 scopus 로고    scopus 로고
    • Neonatal streptozotocin-induced diabetes mellitus: A model of insulin resistance associated with loss of adipose mass
    • Takada J, Machado MA, Peres SB, et al. Neonatal streptozotocin-induced diabetes mellitus: a model of insulin resistance associated with loss of adipose mass. Metabolism. 2007;56(7):977-984.
    • (2007) Metabolism. , vol.56 , Issue.7 , pp. 977-984
    • Takada, J.1    McHado, M.A.2    Peres, S.B.3
  • 70
    • 70449808042 scopus 로고    scopus 로고
    • Beta-cell function and mass in type 2 diabetes
    • Larsen MO. Beta-cell function and mass in type 2 diabetes. Dan Med Bull. 2009;56(3):153-164.
    • (2009) Dan Med Bull. , vol.56 , Issue.3 , pp. 153-164
    • Larsen, M.O.1
  • 71
    • 80054695683 scopus 로고    scopus 로고
    • Single dose streptozotocin-induced diabetes: Considerations for study design in islet transplantation models
    • Deeds MC, Anderson JM, Armstrong AS, et al. Single dose streptozotocin-induced diabetes: considerations for study design in islet transplantation models. Lab Anim. 2011;45(3):131-140.
    • (2011) Lab Anim. , vol.45 , Issue.3 , pp. 131-140
    • Deeds, M.C.1    Anderson, J.M.2    Armstrong, A.S.3


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