-
1
-
-
0032509295
-
Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene
-
Poltorak A, et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 1998;282:2085-2088.
-
(1998)
Science
, vol.282
, pp. 2085-2088
-
-
Poltorak, A.1
-
2
-
-
79951670558
-
Nucleic acid sensing Toll-like receptors in autoimmunity
-
Ewald SE, Barton GM. Nucleic acid sensing Toll-like receptors in autoimmunity. Curr Opin Immunol 2011;23:3-9.
-
(2011)
Curr Opin Immunol
, vol.23
, pp. 3-9
-
-
Ewald, S.E.1
Barton, G.M.2
-
3
-
-
80052184362
-
Recognition of nucleic acids by pattern-recognition receptors and its relevance in autoimmunity
-
Kawasaki T, Kawai T, Akira S. Recognition of nucleic acids by pattern-recognition receptors and its relevance in autoimmunity. Immunol Rev 2011;243:61-73.
-
(2011)
Immunol Rev
, vol.243
, pp. 61-73
-
-
Kawasaki, T.1
Kawai, T.2
Akira, S.3
-
5
-
-
77951260924
-
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
-
Kawai T, Akira S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol 2010;11:373-384.
-
(2010)
Nat Immunol
, vol.11
, pp. 373-384
-
-
Kawai, T.1
Akira, S.2
-
7
-
-
84936891410
-
Heterogeneity of autoimmune diseases: pathophysiologic insights from genetics and implications for new therapies
-
Cho JH, Feldman M. Heterogeneity of autoimmune diseases: pathophysiologic insights from genetics and implications for new therapies. Nat Med 2015;21:730-738.
-
(2015)
Nat Med
, vol.21
, pp. 730-738
-
-
Cho, J.H.1
Feldman, M.2
-
8
-
-
84874660169
-
The problem of choice: current biologic agents and future prospects in RA
-
Choy EH, Kavanaugh AF, Jones SA. The problem of choice: current biologic agents and future prospects in RA. Nat Rev Rheumatol 2013;9:154-163.
-
(2013)
Nat Rev Rheumatol
, vol.9
, pp. 154-163
-
-
Choy, E.H.1
Kavanaugh, A.F.2
Jones, S.A.3
-
9
-
-
84864874057
-
Type I IFN system in the development and manifestations of SLE
-
Elkon KB, Wiedeman A. Type I IFN system in the development and manifestations of SLE. Curr Opin Rheumatol 2012;24:499-505.
-
(2012)
Curr Opin Rheumatol
, vol.24
, pp. 499-505
-
-
Elkon, K.B.1
Wiedeman, A.2
-
10
-
-
44849085476
-
The innate immune system in SLE: type I interferons and dendritic cells
-
Ronnblom L, Pascual V. The innate immune system in SLE: type I interferons and dendritic cells. Lupus 2008;17:394-399.
-
(2008)
Lupus
, vol.17
, pp. 394-399
-
-
Ronnblom, L.1
Pascual, V.2
-
11
-
-
84904898296
-
Type I interferon blockade in systemic lupus erythematosus: where do we stand?
-
Lauwerys BR, Ducreux J, Houssiau FA. Type I interferon blockade in systemic lupus erythematosus: where do we stand? Rheumatology (Oxford) 2014;53:1369-1376.
-
(2014)
Rheumatology (Oxford)
, vol.53
, pp. 1369-1376
-
-
Lauwerys, B.R.1
Ducreux, J.2
Houssiau, F.A.3
-
12
-
-
84899131835
-
The cGAS-cGAMP-STING pathway of cytosolic DNA sensing and signaling
-
Cai X, Chiu Y-H, Chen ZJ. The cGAS-cGAMP-STING pathway of cytosolic DNA sensing and signaling. Mol Cell 2014;54:289-296.
-
(2014)
Mol Cell
, vol.54
, pp. 289-296
-
-
Cai, X.1
Chiu, Y.-H.2
Chen, Z.J.3
-
13
-
-
34247891509
-
Immunologically active autoantigens: the role of toll-like receptors in the development of chronic inflammatory disease
-
Marshak-Rothstein A, Rifkin IR. Immunologically active autoantigens: the role of toll-like receptors in the development of chronic inflammatory disease. Annu Rev Immunol 2007;25:419-441.
-
(2007)
Annu Rev Immunol
, vol.25
, pp. 419-441
-
-
Marshak-Rothstein, A.1
Rifkin, I.R.2
-
14
-
-
84943524718
-
Nucleic acid-sensing receptors: rheostats of autoimmunity and autoinflammation
-
Sharma S, Fitzgerald KA, Cancro MP, Marshak-Rothstein A. Nucleic acid-sensing receptors: rheostats of autoimmunity and autoinflammation. J Immunol 2015;195:3507-3512.
-
(2015)
J Immunol
, vol.195
, pp. 3507-3512
-
-
Sharma, S.1
Fitzgerald, K.A.2
Cancro, M.P.3
Marshak-Rothstein, A.4
-
15
-
-
36048962438
-
Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation
-
Deane JA, et al. Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation. Immunity 2007;27:801-810.
-
(2007)
Immunity
, vol.27
, pp. 801-810
-
-
Deane, J.A.1
-
16
-
-
33745168605
-
Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication
-
Pisitkun P, Deane JA, Difilippantonio MJ, Tarasenko T, Satterthwaite AB, Bolland S. Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication. Science 2006;312:1669-1672.
-
(2006)
Science
, vol.312
, pp. 1669-1672
-
-
Pisitkun, P.1
Deane, J.A.2
Difilippantonio, M.J.3
Tarasenko, T.4
Satterthwaite, A.B.5
Bolland, S.6
-
17
-
-
77957673544
-
Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus
-
Shen N, et al. Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus. Proc Natl Acad Sci USA 2010;107:15838-15843.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 15838-15843
-
-
Shen, N.1
-
18
-
-
84874782774
-
MicroRNA-3148 modulates allelic expression of toll-like receptor 7 variant associated with systemic lupus erythematosus
-
Deng Y, et al. MicroRNA-3148 modulates allelic expression of toll-like receptor 7 variant associated with systemic lupus erythematosus. PLoS Genet 2013;9:e1003336.
-
(2013)
PLoS Genet
, vol.9
, pp. e1003336
-
-
Deng, Y.1
-
19
-
-
84892976361
-
Genetic variations in Toll-like receptors (TLRs 3/7/8) are associated with systemic lupus erythematosus in a Taiwanese population
-
Wang C-M, et al. Genetic variations in Toll-like receptors (TLRs 3/7/8) are associated with systemic lupus erythematosus in a Taiwanese population. Sci Rep 2014;4:3792.
-
(2014)
Sci Rep
, vol.4
, pp. 3792
-
-
Wang, C.-M.1
-
20
-
-
79952461669
-
TLR7 single-nucleotide polymorphisms in the 3′ untranslated region and intron 2 independently contribute to systemic lupus erythematosus in Japanese women: a case-control association study
-
Kawasaki A, et al. TLR7 single-nucleotide polymorphisms in the 3′ untranslated region and intron 2 independently contribute to systemic lupus erythematosus in Japanese women: a case-control association study. Arthritis Res Ther 2011;13:R41.
-
(2011)
Arthritis Res Ther
, vol.13
, pp. R41
-
-
Kawasaki, A.1
-
21
-
-
84906935272
-
Single nucleotide polymorphisms in genes encoding toll-like receptors 7, 8 and 9 in Danish patients with systemic lupus erythematosus
-
Enevold C, et al. Single nucleotide polymorphisms in genes encoding toll-like receptors 7, 8 and 9 in Danish patients with systemic lupus erythematosus. Mol Biol Rep 2014;41:5755-5763.
-
(2014)
Mol Biol Rep
, vol.41
, pp. 5755-5763
-
-
Enevold, C.1
-
22
-
-
37549066665
-
Treatment of lupus-prone mice with a dual inhibitor of TLR7 and TLR9 leads to reduction of autoantibody production and amelioration of disease symptoms
-
Barrat FJ, Meeker T, Chan JH, Guiducci C, Coffman RL. Treatment of lupus-prone mice with a dual inhibitor of TLR7 and TLR9 leads to reduction of autoantibody production and amelioration of disease symptoms. Eur J Immunol 2007;37:3582-3586.
-
(2007)
Eur J Immunol
, vol.37
, pp. 3582-3586
-
-
Barrat, F.J.1
Meeker, T.2
Chan, J.H.3
Guiducci, C.4
Coffman, R.L.5
-
23
-
-
78650315462
-
Autoimmune skin inflammation is dependent on plasmacytoid dendritic cell activation by nucleic acids via TLR7 and TLR9
-
Guiducci C, et al. Autoimmune skin inflammation is dependent on plasmacytoid dendritic cell activation by nucleic acids via TLR7 and TLR9. J Exp Med 2010;207:2931-2942.
-
(2010)
J Exp Med
, vol.207
, pp. 2931-2942
-
-
Guiducci, C.1
-
24
-
-
84855163540
-
Intrinsic danger: activation of Toll-like receptors in rheumatoid arthritis
-
Goh FG, Midwood KS. Intrinsic danger: activation of Toll-like receptors in rheumatoid arthritis. Rheumatology (Oxford) 2012;51:7-23.
-
(2012)
Rheumatology (Oxford)
, vol.51
, pp. 7-23
-
-
Goh, F.G.1
Midwood, K.S.2
-
25
-
-
81755161555
-
Toll-like receptors in rheumatic diseases: are we paying a high price for our defense against bugs?
-
Santegoets KCM, van Bon L, van den Berg WB, Wenink MH, Radstake TRDJ. Toll-like receptors in rheumatic diseases: are we paying a high price for our defense against bugs?. FEBS Lett 2011;585:3660-3666.
-
(2011)
FEBS Lett
, vol.585
, pp. 3660-3666
-
-
Santegoets, K.C.M.1
van Bon, L.2
van den Berg, W.B.3
Wenink, M.H.4
Radstake, T.R.D.J.5
-
26
-
-
79955589106
-
Trapped in a vicious loop: Toll-like receptors sustain the spontaneous cytokine production by rheumatoid synovium
-
Abdollahi-Roodsaz S, van de Loo FAJ, van den Berg WB. Trapped in a vicious loop: Toll-like receptors sustain the spontaneous cytokine production by rheumatoid synovium. Arthritis Res Ther 2011;13:105.
-
(2011)
Arthritis Res Ther
, vol.13
, pp. 105
-
-
Abdollahi-Roodsaz, S.1
van de Loo, F.A.J.2
van den Berg, W.B.3
-
27
-
-
38149048556
-
Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis
-
Abdollahi-Roodsaz S, et al. Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis. J Clin Invest 2008;118:205-216.
-
(2008)
J Clin Invest
, vol.118
, pp. 205-216
-
-
Abdollahi-Roodsaz, S.1
-
28
-
-
73649088291
-
Local interleukin-1-driven joint pathology is dependent on toll-like receptor 4 activation
-
Abdollahi-Roodsaz S, Joosten LAB, Koenders MI, van den Brand BT, van de Loo FAJ, van den Berg WB. Local interleukin-1-driven joint pathology is dependent on toll-like receptor 4 activation. Am J Pathol 2009;175:2004-2013.
-
(2009)
Am J Pathol
, vol.175
, pp. 2004-2013
-
-
Abdollahi-Roodsaz, S.1
Joosten, L.A.B.2
Koenders, M.I.3
van den Brand, B.T.4
van de Loo, F.A.J.5
van den Berg, W.B.6
-
29
-
-
34848840994
-
Inhibition of Toll-like receptor 4 breaks the inflammatory loop in autoimmune destructive arthritis
-
Abdollahi-Roodsaz S, et al. Inhibition of Toll-like receptor 4 breaks the inflammatory loop in autoimmune destructive arthritis. Arthritis Rheum 2007;56:2957-2967.
-
(2007)
Arthritis Rheum
, vol.56
, pp. 2957-2967
-
-
Abdollahi-Roodsaz, S.1
-
30
-
-
20644450804
-
Negative regulation of toll-like receptor-mediated immune responses
-
Liew FY, Xu D, Brint EK, O'Neill LAJ. Negative regulation of toll-like receptor-mediated immune responses. Nat Rev Immunol 2005;5:446-458.
-
(2005)
Nat Rev Immunol
, vol.5
, pp. 446-458
-
-
Liew, F.Y.1
Xu, D.2
Brint, E.K.3
O'Neill, L.A.J.4
-
31
-
-
84865298775
-
Dissecting negative regulation of Toll-like receptor signaling
-
Kondo T, Kawai T, Akira S. Dissecting negative regulation of Toll-like receptor signaling. Trends Immunol 2012;33:449-458.
-
(2012)
Trends Immunol
, vol.33
, pp. 449-458
-
-
Kondo, T.1
Kawai, T.2
Akira, S.3
-
32
-
-
84867898782
-
A20: linking a complex regulator of ubiquitylation to immunity and human disease
-
Ma A, Malynn BA. A20: linking a complex regulator of ubiquitylation to immunity and human disease. Nat Rev Immunol 2012;12:774-785.
-
(2012)
Nat Rev Immunol
, vol.12
, pp. 774-785
-
-
Ma, A.1
Malynn, B.A.2
-
34
-
-
50449103533
-
Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus
-
Musone SL, et al. Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus. Nat Genet 2008;40:1062-1064.
-
(2008)
Nat Genet
, vol.40
, pp. 1062-1064
-
-
Musone, S.L.1
-
35
-
-
79952192654
-
Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus
-
Adrianto I, et al. Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus. Nat Genet 2011;43:253-258.
-
(2011)
Nat Genet
, vol.43
, pp. 253-258
-
-
Adrianto, I.1
-
36
-
-
84904068775
-
The deubiquitinase A20 in immunopathology of autoimmune diseases
-
Majumdar I, Paul J. The deubiquitinase A20 in immunopathology of autoimmune diseases. Autoimmunity 2014;47:307-319.
-
(2014)
Autoimmunity
, vol.47
, pp. 307-319
-
-
Majumdar, I.1
Paul, J.2
-
37
-
-
0034730713
-
Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice
-
Lee EG, et al. Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice. Science 2000;289:2350-2354.
-
(2000)
Science
, vol.289
, pp. 2350-2354
-
-
Lee, E.G.1
-
38
-
-
80052195163
-
A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis
-
Matmati M, et al. A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis. Nat Genet 2011;43:908-912.
-
(2011)
Nat Genet
, vol.43
, pp. 908-912
-
-
Matmati, M.1
-
39
-
-
81255160601
-
Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis
-
Hammer GE, et al. Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis. Nat Immunol 2011;12:1184-1193.
-
(2011)
Nat Immunol
, vol.12
, pp. 1184-1193
-
-
Hammer, G.E.1
-
40
-
-
79960467121
-
The ubiquitin-editing protein A20 prevents dendritic cell activation, recognition of apoptotic cells, and systemic autoimmunity
-
Kool M, et al. The ubiquitin-editing protein A20 prevents dendritic cell activation, recognition of apoptotic cells, and systemic autoimmunity. Immunity 2011;35:82-96.
-
(2011)
Immunity
, vol.35
, pp. 82-96
-
-
Kool, M.1
-
41
-
-
84921748195
-
PTPN22: the archetypal non-HLA autoimmunity gene
-
Stanford SM, Bottini N. PTPN22: the archetypal non-HLA autoimmunity gene. Nat Rev Rheumatol 2014;10:602-611.
-
(2014)
Nat Rev Rheumatol
, vol.10
, pp. 602-611
-
-
Stanford, S.M.1
Bottini, N.2
-
42
-
-
81755179431
-
Why is PTPN22 a good candidate susceptibility gene for autoimmune disease?
-
Burn GL, Svensson L, Sanchez-Blanco C, Saini M, Cope AP. Why is PTPN22 a good candidate susceptibility gene for autoimmune disease? FEBS Lett 2011;585:3689-3698.
-
(2011)
FEBS Lett
, vol.585
, pp. 3689-3698
-
-
Burn, G.L.1
Svensson, L.2
Sanchez-Blanco, C.3
Saini, M.4
Cope, A.P.5
-
43
-
-
33745652977
-
Genetic influence of PTPN22 R620W polymorphism in tuberculosis
-
Gomez LM, Anaya J-M, Martin J. Genetic influence of PTPN22 R620W polymorphism in tuberculosis. Hum Immunol 2005;66:1242-1247.
-
(2005)
Hum Immunol
, vol.66
, pp. 1242-1247
-
-
Gomez, L.M.1
Anaya, J.-M.2
Martin, J.3
-
44
-
-
84876330108
-
Association between the PTPN22 1858C/T gene polymorphism and tuberculosis resistance
-
Boechat AL, Ogusku MM, Sadahiro A, dos Santos MC. Association between the PTPN22 1858C/T gene polymorphism and tuberculosis resistance. Infect Genet Evol 2013;16:310-313.
-
(2013)
Infect Genet Evol
, vol.16
, pp. 310-313
-
-
Boechat, A.L.1
Ogusku, M.M.2
Sadahiro, A.3
dos Santos, M.C.4
-
45
-
-
68249090600
-
Association of PTPN22 gene functional variants with development of pulmonary tuberculosis in Moroccan population
-
Lamsyah H, et al. Association of PTPN22 gene functional variants with development of pulmonary tuberculosis in Moroccan population. Tissue Antigens 2009;74:228-232.
-
(2009)
Tissue Antigens
, vol.74
, pp. 228-232
-
-
Lamsyah, H.1
-
46
-
-
49149095185
-
The PTPN22 R620W polymorphism is associated with severe bacterial infections after human leukocyte antigen geno-identical haematopoietic stem-cell transplantations
-
Azarian M, et al. The PTPN22 R620W polymorphism is associated with severe bacterial infections after human leukocyte antigen geno-identical haematopoietic stem-cell transplantations. Transplantation 2008;85:1859-1862.
-
(2008)
Transplantation
, vol.85
, pp. 1859-1862
-
-
Azarian, M.1
-
47
-
-
84930485479
-
R620W functional polymorphism of protein tyrosine phosphatase non-receptor type 22 is not associated with pulmonary tuberculosis in Zahedan, southeast Iran
-
Kouhpayeh H-R, et al. R620W functional polymorphism of protein tyrosine phosphatase non-receptor type 22 is not associated with pulmonary tuberculosis in Zahedan, southeast Iran. Genet Mol Res 2012;11:1075-1081.
-
(2012)
Genet Mol Res
, vol.11
, pp. 1075-1081
-
-
Kouhpayeh, H.-R.1
-
48
-
-
58449111291
-
PTPN22 C1858T polymorphism and human brucellosis
-
Bravo MJ, et al. PTPN22 C1858T polymorphism and human brucellosis. Scand J Infect Dis 2009;41:109-112.
-
(2009)
Scand J Infect Dis
, vol.41
, pp. 109-112
-
-
Bravo, M.J.1
-
49
-
-
34247892256
-
Association study of PTPN22 C1858T polymorphism in Trypanosoma cruzi infection
-
Robledo G, González CI, Morillo C, Martin J, González A. Association study of PTPN22 C1858T polymorphism in Trypanosoma cruzi infection. Tissue Antigens 2007;69:261-264.
-
(2007)
Tissue Antigens
, vol.69
, pp. 261-264
-
-
Robledo, G.1
González, C.I.2
Morillo, C.3
Martin, J.4
González, A.5
-
50
-
-
58149229588
-
PTPN22 C1858T polymorphism and the outcome of hepatitis C virus infection
-
Montes-Cano MA, et al. PTPN22 C1858T polymorphism and the outcome of hepatitis C virus infection. Viral Immunol 2008;21:491-494.
-
(2008)
Viral Immunol
, vol.21
, pp. 491-494
-
-
Montes-Cano, M.A.1
-
51
-
-
84925858831
-
The role of PTPN22 risk variant in the development of autoimmunity: finding common ground between mouse and human
-
Rawlings DJ, Dai X, Buckner JH. The role of PTPN22 risk variant in the development of autoimmunity: finding common ground between mouse and human. J Immunol 2015;194:2977-2984.
-
(2015)
J Immunol
, vol.194
, pp. 2977-2984
-
-
Rawlings, D.J.1
Dai, X.2
Buckner, J.H.3
-
52
-
-
84897106158
-
Tyrosine phosphatase PTPN22: multifunctional regulator of immune signaling, development, and disease
-
Bottini N, Peterson EJ. Tyrosine phosphatase PTPN22: multifunctional regulator of immune signaling, development, and disease. Annu Rev Immunol 2014;32:83-119.
-
(2014)
Annu Rev Immunol
, vol.32
, pp. 83-119
-
-
Bottini, N.1
Peterson, E.J.2
-
53
-
-
0942279640
-
PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells
-
Hasegawa K, Martin F, Huang G, Tumas D, Diehl L, Chan AC. PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells. Science 2004;303:685-689.
-
(2004)
Science
, vol.303
, pp. 685-689
-
-
Hasegawa, K.1
Martin, F.2
Huang, G.3
Tumas, D.4
Diehl, L.5
Chan, A.C.6
-
54
-
-
84863518421
-
Overexpression of the autoimmunity-associated phosphatase PTPN22 promotes survival of antigen-stimulated CLL cells by selectively activating AKT
-
Negro R, et al. Overexpression of the autoimmunity-associated phosphatase PTPN22 promotes survival of antigen-stimulated CLL cells by selectively activating AKT. Blood 2012;119:6278-6287.
-
(2012)
Blood
, vol.119
, pp. 6278-6287
-
-
Negro, R.1
-
55
-
-
84877115482
-
A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models
-
Dai X, et al. A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models. J Clin Invest 2013;123:2024-2036.
-
(2013)
J Clin Invest
, vol.123
, pp. 2024-2036
-
-
Dai, X.1
-
56
-
-
80052239824
-
The autoimmune disease-associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness
-
Zhang J, et al. The autoimmune disease-associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness. Nat Genet 2011;43:902-907.
-
(2011)
Nat Genet
, vol.43
, pp. 902-907
-
-
Zhang, J.1
-
57
-
-
64249119896
-
PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background
-
Zikherman J, Hermiston M, Steiner D, Hasegawa K, Chan A, Weiss A. PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background. J Immunol 2009;182:4093-4106.
-
(2009)
J Immunol
, vol.182
, pp. 4093-4106
-
-
Zikherman, J.1
Hermiston, M.2
Steiner, D.3
Hasegawa, K.4
Chan, A.5
Weiss, A.6
-
58
-
-
65449176044
-
Cutting edge: the PTPN22 allelic variant associated with autoimmunity impairs B cell signaling
-
Arechiga AF, et al. Cutting edge: the PTPN22 allelic variant associated with autoimmunity impairs B cell signaling. J Immunol 2009;182:3343-3347.
-
(2009)
J Immunol
, vol.182
, pp. 3343-3347
-
-
Arechiga, A.F.1
-
59
-
-
40349109578
-
Genetic variation in PTPN22 corresponds to altered function of T and B lymphocytes
-
Rieck M, Arechiga A, Onengut-Gumuscu S, Greenbaum C, Concannon P, Buckner JH. Genetic variation in PTPN22 corresponds to altered function of T and B lymphocytes. J Immunol 2007;179:4704-4710.
-
(2007)
J Immunol
, vol.179
, pp. 4704-4710
-
-
Rieck, M.1
Arechiga, A.2
Onengut-Gumuscu, S.3
Greenbaum, C.4
Concannon, P.5
Buckner, J.H.6
-
60
-
-
77956627113
-
Comprehensive expression profiles of genes for protein tyrosine phosphatases in immune cells
-
Arimura Y, Yagi J. Comprehensive expression profiles of genes for protein tyrosine phosphatases in immune cells. Sci Signal 2010;3:rs1.
-
(2010)
Sci Signal
, vol.3
, pp. rs1
-
-
Arimura, Y.1
Yagi, J.2
-
61
-
-
84880733694
-
The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity
-
Wang Y, et al. The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity. Immunity 2013;39:111-122.
-
(2013)
Immunity
, vol.39
, pp. 111-122
-
-
Wang, Y.1
-
62
-
-
84940108777
-
PTPN22 variant R620W is associated with reduced Toll-like receptor 7-induced type I interferon in systemic lupus erythematosus
-
Wang Y, et al. PTPN22 variant R620W is associated with reduced Toll-like receptor 7-induced type I interferon in systemic lupus erythematosus. Arthritis Rheumatol 2015;67:2403-2414.
-
(2015)
Arthritis Rheumatol
, vol.67
, pp. 2403-2414
-
-
Wang, Y.1
-
63
-
-
20644443886
-
Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12
-
Hamerman JA, Tchao NK, Lowell CA, Lanier LL. Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12. Nat Immunol 2005;6:579-586.
-
(2005)
Nat Immunol
, vol.6
, pp. 579-586
-
-
Hamerman, J.A.1
Tchao, N.K.2
Lowell, C.A.3
Lanier, L.L.4
-
64
-
-
33746875981
-
Cutting edge: inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12
-
Hamerman JA, Jarjoura JR, Humphrey MB, Nakamura MC, Seaman WE, Lanier LL. Cutting edge: inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12. J Immunol 2006;177:2051-2055.
-
(2006)
J Immunol
, vol.177
, pp. 2051-2055
-
-
Hamerman, J.A.1
Jarjoura, J.R.2
Humphrey, M.B.3
Nakamura, M.C.4
Seaman, W.E.5
Lanier, L.L.6
-
65
-
-
84855221945
-
TREM-2, triggering receptor expressed on myeloid cell-2, negatively regulates TLR responses in dendritic cells
-
Ito H, Hamerman JA. TREM-2, triggering receptor expressed on myeloid cell-2, negatively regulates TLR responses in dendritic cells. Eur J Immunol 2012;42:176-185.
-
(2012)
Eur J Immunol
, vol.42
, pp. 176-185
-
-
Ito, H.1
Hamerman, J.A.2
-
66
-
-
84932107529
-
The Tec kinase-regulated phosphoproteome reveals a mechanism for the regulation of inhibitory signals in murine macrophages
-
Tampella G, et al. The Tec kinase-regulated phosphoproteome reveals a mechanism for the regulation of inhibitory signals in murine macrophages. J Immunol 2015;195:246-256.
-
(2015)
J Immunol
, vol.195
, pp. 246-256
-
-
Tampella, G.1
-
67
-
-
38049160121
-
Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases
-
Yu X, et al. Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases. Proc Natl Acad Sci USA 2007;104:19767-19772.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 19767-19772
-
-
Yu, X.1
-
68
-
-
79952797194
-
Discovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cells
-
Stanford SM, et al. Discovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cells. J Med Chem 2011;54:1640-1654.
-
(2011)
J Med Chem
, vol.54
, pp. 1640-1654
-
-
Stanford, S.M.1
-
69
-
-
34547868501
-
A common human TLR1 polymorphism regulates the innate immune response to lipopeptides
-
Hawn TR, et al. A common human TLR1 polymorphism regulates the innate immune response to lipopeptides. Eur J Immunol 2007;37:2280-2289.
-
(2007)
Eur J Immunol
, vol.37
, pp. 2280-2289
-
-
Hawn, T.R.1
-
70
-
-
84862794148
-
Akt2 inhibits the activation of NFAT in lymphocytes by modulating calcium release from intracellular stores
-
Martin VA, et al. Akt2 inhibits the activation of NFAT in lymphocytes by modulating calcium release from intracellular stores. Cell Signal 2012;24:1064-1073.
-
(2012)
Cell Signal
, vol.24
, pp. 1064-1073
-
-
Martin, V.A.1
-
71
-
-
84876463917
-
Loss of protein tyrosine phosphatase nonreceptor type 22 regulates interferon-γ-induced signaling in human monocytes
-
e10.
-
Spalinger MR, et al. Loss of protein tyrosine phosphatase nonreceptor type 22 regulates interferon-γ-induced signaling in human monocytes. Gastroenterology 2013;144:978-988 e10.
-
(2013)
Gastroenterology
, vol.144
, pp. 978-988
-
-
Spalinger, M.R.1
-
72
-
-
84883394259
-
PTPN22 modulates macrophage polarization and susceptibility to dextran sulfate sodium-induced colitis
-
Chang H-H, et al. PTPN22 modulates macrophage polarization and susceptibility to dextran sulfate sodium-induced colitis. J Immunol 2013;191:2134-2143.
-
(2013)
J Immunol
, vol.191
, pp. 2134-2143
-
-
Chang, H.-H.1
-
73
-
-
84940367331
-
The autoimmune-associated genetic variant PTPN22 R620W enhances neutrophil activation and function in patients with rheumatoid arthritis and healthy individuals
-
Bayley R, et al. The autoimmune-associated genetic variant PTPN22 R620W enhances neutrophil activation and function in patients with rheumatoid arthritis and healthy individuals. Ann Rheum Dis 2015;74:1588-1595.
-
(2015)
Ann Rheum Dis
, vol.74
, pp. 1588-1595
-
-
Bayley, R.1
-
74
-
-
84940121364
-
The W620 polymorphism in PTPN22 disrupts its interaction with peptidylarginine deiminase type 4 and enhances citrullination and NETosis
-
Chang H-H, Dwivedi N, Nicholas AP, Ho I-C. The W620 polymorphism in PTPN22 disrupts its interaction with peptidylarginine deiminase type 4 and enhances citrullination and NETosis. Arthritis Rheumatol 2015;67:2323-2334.
-
(2015)
Arthritis Rheumatol
, vol.67
, pp. 2323-2334
-
-
Chang, H.-H.1
Dwivedi, N.2
Nicholas, A.P.3
Ho, I.-C.4
-
75
-
-
33746257209
-
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
-
Engelman JA, Luo J, Cantley LC. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet 2006;7:606-619.
-
(2006)
Nat Rev Genet
, vol.7
, pp. 606-619
-
-
Engelman, J.A.1
Luo, J.2
Cantley, L.C.3
-
76
-
-
0037205048
-
The phosphoinositide 3-kinase pathway
-
Cantley LC. The phosphoinositide 3-kinase pathway. Science 2002;296:1655-1657.
-
(2002)
Science
, vol.296
, pp. 1655-1657
-
-
Cantley, L.C.1
-
77
-
-
0037199972
-
The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells
-
Guha M, Mackman N. The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells. J Biol Chem 2002;277:32124-32132.
-
(2002)
J Biol Chem
, vol.277
, pp. 32124-32132
-
-
Guha, M.1
Mackman, N.2
-
78
-
-
0038446051
-
Role of the phosphatidylinositol 3 kinase-Akt pathway in the regulation of IL-10 and IL-12 by Porphyromonas gingivalis lipopolysaccharide
-
Martin M, Schifferle RE, Cuesta N, Vogel SN, Katz J, Michalek SM. Role of the phosphatidylinositol 3 kinase-Akt pathway in the regulation of IL-10 and IL-12 by Porphyromonas gingivalis lipopolysaccharide. J Immunol 2003;171:717-725.
-
(2003)
J Immunol
, vol.171
, pp. 717-725
-
-
Martin, M.1
Schifferle, R.E.2
Cuesta, N.3
Vogel, S.N.4
Katz, J.5
Michalek, S.M.6
-
79
-
-
0037031924
-
Phosphatidylinositol 3-kinase activity negatively regulates stability of cyclooxygenase 2 mRNA
-
Monick MM, et al. Phosphatidylinositol 3-kinase activity negatively regulates stability of cyclooxygenase 2 mRNA. J Biol Chem 2002;277:32992-33000.
-
(2002)
J Biol Chem
, vol.277
, pp. 32992-33000
-
-
Monick, M.M.1
-
80
-
-
0036707521
-
PI3K-mediated negative feedback regulation of IL-12 production in DCs
-
Fukao T, et al. PI3K-mediated negative feedback regulation of IL-12 production in DCs. Nat Immunol 2002;3:875-881.
-
(2002)
Nat Immunol
, vol.3
, pp. 875-881
-
-
Fukao, T.1
-
81
-
-
77956627302
-
Phosphoinositide-dependent kinase 1 provides negative feedback inhibition to Toll-like receptor-mediated NF-kappaB activation in macrophages
-
Chaurasia B, Mauer J, Koch L, Goldau J, Kock A-S, Brüning JC. Phosphoinositide-dependent kinase 1 provides negative feedback inhibition to Toll-like receptor-mediated NF-kappaB activation in macrophages. Mol Cell Biol 2010;30:4354-4366.
-
(2010)
Mol Cell Biol
, vol.30
, pp. 4354-4366
-
-
Chaurasia, B.1
Mauer, J.2
Koch, L.3
Goldau, J.4
Kock, A.-S.5
Brüning, J.C.6
-
82
-
-
68649091506
-
The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs
-
Androulidaki A, et al. The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs. Immunity 2009;31:220-231.
-
(2009)
Immunity
, vol.31
, pp. 220-231
-
-
Androulidaki, A.1
-
83
-
-
84862187485
-
Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization
-
Arranz A, et al. Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization. Proc Natl Acad Sci USA 2012;109:9517-9522.
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. 9517-9522
-
-
Arranz, A.1
-
84
-
-
1842424697
-
The inositol 3-phosphatase PTEN negatively regulates Fc gamma receptor signaling, but supports Toll-like receptor 4 signaling in murine peritoneal macrophages
-
Cao X, et al. The inositol 3-phosphatase PTEN negatively regulates Fc gamma receptor signaling, but supports Toll-like receptor 4 signaling in murine peritoneal macrophages. J Immunol 2004;172:4851-4857.
-
(2004)
J Immunol
, vol.172
, pp. 4851-4857
-
-
Cao, X.1
-
85
-
-
44849113635
-
Genetic analysis of the role of the PI3K-Akt pathway in lipopolysaccharide-induced cytokine and tissue factor gene expression in monocytes/macrophages
-
Luyendyk JP, Schabbauer GA, Tencati M, Holscher T, Pawlinski R, Mackman N. Genetic analysis of the role of the PI3K-Akt pathway in lipopolysaccharide-induced cytokine and tissue factor gene expression in monocytes/macrophages. J Immunol 2008;180:4218-4226.
-
(2008)
J Immunol
, vol.180
, pp. 4218-4226
-
-
Luyendyk, J.P.1
Schabbauer, G.A.2
Tencati, M.3
Holscher, T.4
Pawlinski, R.5
Mackman, N.6
-
86
-
-
47049086825
-
Effective clearance of intracellular Leishmania major in vivo requires Pten in macrophages
-
Kuroda S, et al. Effective clearance of intracellular Leishmania major in vivo requires Pten in macrophages. Eur J Immunol 2008;38:1331-1340.
-
(2008)
Eur J Immunol
, vol.38
, pp. 1331-1340
-
-
Kuroda, S.1
-
87
-
-
79954577277
-
TLR-signaling networks: an integration of adaptor molecules, kinases, and cross-talk
-
Brown J, Wang H, Hajishengallis GN, Martin M. TLR-signaling networks: an integration of adaptor molecules, kinases, and cross-talk. J Dent Res 2011;90:417-427.
-
(2011)
J Dent Res
, vol.90
, pp. 417-427
-
-
Brown, J.1
Wang, H.2
Hajishengallis, G.N.3
Martin, M.4
-
88
-
-
50949130076
-
Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced interleukin-12 production in dendritic cells
-
Ohtani M, et al. Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced interleukin-12 production in dendritic cells. Blood 2008;112:635-643.
-
(2008)
Blood
, vol.112
, pp. 635-643
-
-
Ohtani, M.1
-
89
-
-
78650266432
-
FoxO1 regulates Tlr4 inflammatory pathway signalling in macrophages
-
Fan W, et al. FoxO1 regulates Tlr4 inflammatory pathway signalling in macrophages. EMBO J 2010;29:4223-4236.
-
(2010)
EMBO J
, vol.29
, pp. 4223-4236
-
-
Fan, W.1
-
90
-
-
84455161606
-
Mammalian target of rapamycin complex 2 (mTORC2) negatively regulates Toll-like receptor 4-mediated inflammatory response via FoxO1
-
Brown J, Wang H, Suttles J, Graves DT, Martin M. Mammalian target of rapamycin complex 2 (mTORC2) negatively regulates Toll-like receptor 4-mediated inflammatory response via FoxO1. J Biol Chem 2011;286:44295-44305.
-
(2011)
J Biol Chem
, vol.286
, pp. 44295-44305
-
-
Brown, J.1
Wang, H.2
Suttles, J.3
Graves, D.T.4
Martin, M.5
-
91
-
-
70350539525
-
FoxO1 links insulin resistance to proinflammatory cytokine IL-1beta production in macrophages
-
Su D, et al. FoxO1 links insulin resistance to proinflammatory cytokine IL-1beta production in macrophages. Diabetes 2009;58:2624-2633.
-
(2009)
Diabetes
, vol.58
, pp. 2624-2633
-
-
Su, D.1
-
92
-
-
54949109311
-
The TSC-mTOR signaling pathway regulates the innate inflammatory response
-
Weichhart T, et al. The TSC-mTOR signaling pathway regulates the innate inflammatory response. Immunity 2008;29:565-577.
-
(2008)
Immunity
, vol.29
, pp. 565-577
-
-
Weichhart, T.1
-
93
-
-
23944486750
-
Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3
-
Martin M, Rehani K, Jope RS, Michalek SM. Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3. Nat Immunol 2005;6:777-784.
-
(2005)
Nat Immunol
, vol.6
, pp. 777-784
-
-
Martin, M.1
Rehani, K.2
Jope, R.S.3
Michalek, S.M.4
-
94
-
-
84872899284
-
FOXOs: signalling integrators for homeostasis maintenance
-
Eijkelenboom A, Burgering BMT. FOXOs: signalling integrators for homeostasis maintenance. Nat Rev Mol Cell Biol 2013;14:83-97.
-
(2013)
Nat Rev Mol Cell Biol
, vol.14
, pp. 83-97
-
-
Eijkelenboom, A.1
Burgering, B.M.T.2
-
95
-
-
0034577944
-
Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway
-
Arbibe L, et al. Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway. Nat Immunol 2000;1:533-540.
-
(2000)
Nat Immunol
, vol.1
, pp. 533-540
-
-
Arbibe, L.1
-
96
-
-
7544225495
-
Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling
-
Sarkar SN, Peters KL, Elco CP, Sakamoto S, Pal S, Sen GC. Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling. Nat Struct Mol Biol 2004;11:1060-1067.
-
(2004)
Nat Struct Mol Biol
, vol.11
, pp. 1060-1067
-
-
Sarkar, S.N.1
Peters, K.L.2
Elco, C.P.3
Sakamoto, S.4
Pal, S.5
Sen, G.C.6
-
97
-
-
33745868678
-
Role of MyD88 in phosphatidylinositol 3-kinase activation by flagellin/toll-like receptor 5 engagement in colonic epithelial cells
-
Rhee SH, Kim H, Moyer MP, Pothoulakis C. Role of MyD88 in phosphatidylinositol 3-kinase activation by flagellin/toll-like receptor 5 engagement in colonic epithelial cells. J Biol Chem 2006;281:18560-18568.
-
(2006)
J Biol Chem
, vol.281
, pp. 18560-18568
-
-
Rhee, S.H.1
Kim, H.2
Moyer, M.P.3
Pothoulakis, C.4
-
98
-
-
67651183597
-
Mal connects TLR2 to PI3Kinase activation and phagocyte polarization
-
Santos-Sierra S, et al. Mal connects TLR2 to PI3Kinase activation and phagocyte polarization. EMBO J 2009;28:2018-2027.
-
(2009)
EMBO J
, vol.28
, pp. 2018-2027
-
-
Santos-Sierra, S.1
-
99
-
-
67149121074
-
TLR4/MyD88/PI3K interactions regulate TLR4 signaling
-
Laird MHW, et al. TLR4/MyD88/PI3K interactions regulate TLR4 signaling. J Leukoc Biol 2009;85:966-977.
-
(2009)
J Leukoc Biol
, vol.85
, pp. 966-977
-
-
Laird, M.H.W.1
-
100
-
-
0034507903
-
BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation
-
Okada T, Maeda A, Iwamatsu A, Gotoh K, Kurosaki T. BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation. Immunity 2000;13:817-827.
-
(2000)
Immunity
, vol.13
, pp. 817-827
-
-
Okada, T.1
Maeda, A.2
Iwamatsu, A.3
Gotoh, K.4
Kurosaki, T.5
-
101
-
-
0041695162
-
Contribution of BCAP to maintenance of mature B cells through c-Rel
-
Yamazaki T, Kurosaki T. Contribution of BCAP to maintenance of mature B cells through c-Rel. Nat Immunol 2003;4:780-786.
-
(2003)
Nat Immunol
, vol.4
, pp. 780-786
-
-
Yamazaki, T.1
Kurosaki, T.2
-
102
-
-
47249118882
-
Enhanced NK-cell development and function in BCAP-deficient mice
-
MacFarlane AWT, Yamazaki T, Fang M, Sigal LJ, Kurosaki T, Campbell KS. Enhanced NK-cell development and function in BCAP-deficient mice. Blood 2008;112:131-140.
-
(2008)
Blood
, vol.112
, pp. 131-140
-
-
MacFarlane, A.W.T.1
Yamazaki, T.2
Fang, M.3
Sigal, L.J.4
Kurosaki, T.5
Campbell, K.S.6
-
103
-
-
84855992592
-
B-cell adaptor for PI3K (BCAP) negatively regulates Toll-like receptor signaling through activation of PI3K
-
Ni M, MacFarlane AW, Toft M, Lowell CA, Campbell KS, Hamerman JA. B-cell adaptor for PI3K (BCAP) negatively regulates Toll-like receptor signaling through activation of PI3K. Proc Natl Acad Sci USA 2012;109:267-272.
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. 267-272
-
-
Ni, M.1
MacFarlane, A.W.2
Toft, M.3
Lowell, C.A.4
Campbell, K.S.5
Hamerman, J.A.6
-
104
-
-
84856008042
-
Role for B-cell adapter for PI3K (BCAP) as a signaling adapter linking Toll-like receptors (TLRs) to serine/threonine kinases PI3K/Akt
-
Troutman TD, et al. Role for B-cell adapter for PI3K (BCAP) as a signaling adapter linking Toll-like receptors (TLRs) to serine/threonine kinases PI3K/Akt. Proc Natl Acad Sci USA 2012;109:273-278.
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. 273-278
-
-
Troutman, T.D.1
-
105
-
-
77956742502
-
Identification of BCAP-(L) as a negative regulator of the TLR signaling-induced production of IL-6 and IL-10 in macrophages by tyrosine phosphoproteomics
-
Matsumura T, et al. Identification of BCAP-(L) as a negative regulator of the TLR signaling-induced production of IL-6 and IL-10 in macrophages by tyrosine phosphoproteomics. Biochem Biophys Res Commun 2010;400:265-270.
-
(2010)
Biochem Biophys Res Commun
, vol.400
, pp. 265-270
-
-
Matsumura, T.1
-
106
-
-
84855975404
-
Abi-1-bridged tyrosine phosphorylation of VASP by Abelson kinase impairs association of VASP to focal adhesions and regulates leukemic cell adhesion
-
Maruoka M, et al. Abi-1-bridged tyrosine phosphorylation of VASP by Abelson kinase impairs association of VASP to focal adhesions and regulates leukemic cell adhesion. Biochem J 2011;441:889-899.
-
(2011)
Biochem J
, vol.441
, pp. 889-899
-
-
Maruoka, M.1
-
107
-
-
84940181646
-
Phosphatase and tensin homolog (PTEN) in antigen-presenting cells controls Th17-mediated autoimmune arthritis
-
Blüml S, et al. Phosphatase and tensin homolog (PTEN) in antigen-presenting cells controls Th17-mediated autoimmune arthritis. Arthritis Res Ther 2015;17:230.
-
(2015)
Arthritis Res Ther
, vol.17
, pp. 230
-
-
Blüml, S.1
-
108
-
-
84935890863
-
PI3K inhibitors in inflammation, autoimmunity and cancer
-
Stark A-K, Sriskantharajah S, Hessel EM, Okkenhaug K. PI3K inhibitors in inflammation, autoimmunity and cancer. Curr Opin Pharmacol 2015;23:82-91.
-
(2015)
Curr Opin Pharmacol
, vol.23
, pp. 82-91
-
-
Stark, A.-K.1
Sriskantharajah, S.2
Hessel, E.M.3
Okkenhaug, K.4
-
109
-
-
84906314487
-
PI3K inhibitors as potential therapeutics for autoimmune disease
-
Ball J, Archer S, Ward S. PI3K inhibitors as potential therapeutics for autoimmune disease. Drug Discov Today 2014;19:1195-1199.
-
(2014)
Drug Discov Today
, vol.19
, pp. 1195-1199
-
-
Ball, J.1
Archer, S.2
Ward, S.3
-
110
-
-
84893249799
-
PI3K and cancer: lessons, challenges and opportunities
-
Fruman DA, Rommel C. PI3K and cancer: lessons, challenges and opportunities. Nat Rev Drug Discov 2014;13:140-156.
-
(2014)
Nat Rev Drug Discov
, vol.13
, pp. 140-156
-
-
Fruman, D.A.1
Rommel, C.2
-
111
-
-
15244344110
-
Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17
-
Stark MA, Huo Y, Burcin TL, Morris MA, Olson TS, Ley K. Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17. Immunity 2005;22:285-294.
-
(2005)
Immunity
, vol.22
, pp. 285-294
-
-
Stark, M.A.1
Huo, Y.2
Burcin, T.L.3
Morris, M.A.4
Olson, T.S.5
Ley, K.6
-
112
-
-
0037047590
-
Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice
-
Okkenhaug K, et al. Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice. Science 2002;297:1031-1034.
-
(2002)
Science
, vol.297
, pp. 1031-1034
-
-
Okkenhaug, K.1
-
113
-
-
78049476532
-
Altered macrophage function contributes to colitis in mice defective in the phosphoinositide-3 kinase subunit p110δ
-
1653.e1-6.
-
Uno JK, et al. Altered macrophage function contributes to colitis in mice defective in the phosphoinositide-3 kinase subunit p110δ. Gastroenterology 2010;139:1642-1653. 1653.e1-6.
-
(2010)
Gastroenterology
, vol.139
, pp. 1642-1653
-
-
Uno, J.K.1
-
114
-
-
84896692766
-
Idelalisib and rituximab in relapsed chronic lymphocytic leukemia
-
Furman RR, et al. Idelalisib and rituximab in relapsed chronic lymphocytic leukemia. N Engl J Med 2014;370:997-1007.
-
(2014)
N Engl J Med
, vol.370
, pp. 997-1007
-
-
Furman, R.R.1
-
115
-
-
84927673054
-
FDA approval: idelalisib monotherapy for the treatment of patients with follicular lymphoma and small lymphocytic lymphoma
-
Miller BW, et al. FDA approval: idelalisib monotherapy for the treatment of patients with follicular lymphoma and small lymphocytic lymphoma. Clin Cancer Res 2015;21:1525-1529.
-
(2015)
Clin Cancer Res
, vol.21
, pp. 1525-1529
-
-
Miller, B.W.1
|