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Volumn 269, Issue 1, 2016, Pages 212-227

Negative regulation of TLR signaling in myeloid cells-implications for autoimmune diseases

Author keywords

Autoimmune disease; Dendritic cells; Macrophages; Signal transduction; Toll like receptors

Indexed keywords

DEUBIQUITINASE; INTERLEUKIN 6; PHOSPHATIDYLINOSITOL 3 KINASE; TOLL LIKE RECEPTOR; CARRIER PROTEIN; DNA BINDING PROTEIN; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 22; NUCLEAR PROTEIN; ODF2L PROTEIN, HUMAN; PTPN22 PROTEIN, HUMAN; SIGNAL PEPTIDE; TNFAIP3 PROTEIN, HUMAN; TUMOR NECROSIS FACTOR ALPHA INDUCED PROTEIN 3;

EID: 84950138795     PISSN: 01052896     EISSN: 1600065X     Source Type: Journal    
DOI: 10.1111/imr.12381     Document Type: Article
Times cited : (97)

References (115)
  • 1
    • 0032509295 scopus 로고    scopus 로고
    • Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene
    • Poltorak A, et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 1998;282:2085-2088.
    • (1998) Science , vol.282 , pp. 2085-2088
    • Poltorak, A.1
  • 2
    • 79951670558 scopus 로고    scopus 로고
    • Nucleic acid sensing Toll-like receptors in autoimmunity
    • Ewald SE, Barton GM. Nucleic acid sensing Toll-like receptors in autoimmunity. Curr Opin Immunol 2011;23:3-9.
    • (2011) Curr Opin Immunol , vol.23 , pp. 3-9
    • Ewald, S.E.1    Barton, G.M.2
  • 3
    • 80052184362 scopus 로고    scopus 로고
    • Recognition of nucleic acids by pattern-recognition receptors and its relevance in autoimmunity
    • Kawasaki T, Kawai T, Akira S. Recognition of nucleic acids by pattern-recognition receptors and its relevance in autoimmunity. Immunol Rev 2011;243:61-73.
    • (2011) Immunol Rev , vol.243 , pp. 61-73
    • Kawasaki, T.1    Kawai, T.2    Akira, S.3
  • 5
    • 77951260924 scopus 로고    scopus 로고
    • The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
    • Kawai T, Akira S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol 2010;11:373-384.
    • (2010) Nat Immunol , vol.11 , pp. 373-384
    • Kawai, T.1    Akira, S.2
  • 7
    • 84936891410 scopus 로고    scopus 로고
    • Heterogeneity of autoimmune diseases: pathophysiologic insights from genetics and implications for new therapies
    • Cho JH, Feldman M. Heterogeneity of autoimmune diseases: pathophysiologic insights from genetics and implications for new therapies. Nat Med 2015;21:730-738.
    • (2015) Nat Med , vol.21 , pp. 730-738
    • Cho, J.H.1    Feldman, M.2
  • 8
    • 84874660169 scopus 로고    scopus 로고
    • The problem of choice: current biologic agents and future prospects in RA
    • Choy EH, Kavanaugh AF, Jones SA. The problem of choice: current biologic agents and future prospects in RA. Nat Rev Rheumatol 2013;9:154-163.
    • (2013) Nat Rev Rheumatol , vol.9 , pp. 154-163
    • Choy, E.H.1    Kavanaugh, A.F.2    Jones, S.A.3
  • 9
    • 84864874057 scopus 로고    scopus 로고
    • Type I IFN system in the development and manifestations of SLE
    • Elkon KB, Wiedeman A. Type I IFN system in the development and manifestations of SLE. Curr Opin Rheumatol 2012;24:499-505.
    • (2012) Curr Opin Rheumatol , vol.24 , pp. 499-505
    • Elkon, K.B.1    Wiedeman, A.2
  • 10
    • 44849085476 scopus 로고    scopus 로고
    • The innate immune system in SLE: type I interferons and dendritic cells
    • Ronnblom L, Pascual V. The innate immune system in SLE: type I interferons and dendritic cells. Lupus 2008;17:394-399.
    • (2008) Lupus , vol.17 , pp. 394-399
    • Ronnblom, L.1    Pascual, V.2
  • 11
    • 84904898296 scopus 로고    scopus 로고
    • Type I interferon blockade in systemic lupus erythematosus: where do we stand?
    • Lauwerys BR, Ducreux J, Houssiau FA. Type I interferon blockade in systemic lupus erythematosus: where do we stand? Rheumatology (Oxford) 2014;53:1369-1376.
    • (2014) Rheumatology (Oxford) , vol.53 , pp. 1369-1376
    • Lauwerys, B.R.1    Ducreux, J.2    Houssiau, F.A.3
  • 12
    • 84899131835 scopus 로고    scopus 로고
    • The cGAS-cGAMP-STING pathway of cytosolic DNA sensing and signaling
    • Cai X, Chiu Y-H, Chen ZJ. The cGAS-cGAMP-STING pathway of cytosolic DNA sensing and signaling. Mol Cell 2014;54:289-296.
    • (2014) Mol Cell , vol.54 , pp. 289-296
    • Cai, X.1    Chiu, Y.-H.2    Chen, Z.J.3
  • 13
    • 34247891509 scopus 로고    scopus 로고
    • Immunologically active autoantigens: the role of toll-like receptors in the development of chronic inflammatory disease
    • Marshak-Rothstein A, Rifkin IR. Immunologically active autoantigens: the role of toll-like receptors in the development of chronic inflammatory disease. Annu Rev Immunol 2007;25:419-441.
    • (2007) Annu Rev Immunol , vol.25 , pp. 419-441
    • Marshak-Rothstein, A.1    Rifkin, I.R.2
  • 14
    • 84943524718 scopus 로고    scopus 로고
    • Nucleic acid-sensing receptors: rheostats of autoimmunity and autoinflammation
    • Sharma S, Fitzgerald KA, Cancro MP, Marshak-Rothstein A. Nucleic acid-sensing receptors: rheostats of autoimmunity and autoinflammation. J Immunol 2015;195:3507-3512.
    • (2015) J Immunol , vol.195 , pp. 3507-3512
    • Sharma, S.1    Fitzgerald, K.A.2    Cancro, M.P.3    Marshak-Rothstein, A.4
  • 15
    • 36048962438 scopus 로고    scopus 로고
    • Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation
    • Deane JA, et al. Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation. Immunity 2007;27:801-810.
    • (2007) Immunity , vol.27 , pp. 801-810
    • Deane, J.A.1
  • 17
    • 77957673544 scopus 로고    scopus 로고
    • Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus
    • Shen N, et al. Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus. Proc Natl Acad Sci USA 2010;107:15838-15843.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 15838-15843
    • Shen, N.1
  • 18
    • 84874782774 scopus 로고    scopus 로고
    • MicroRNA-3148 modulates allelic expression of toll-like receptor 7 variant associated with systemic lupus erythematosus
    • Deng Y, et al. MicroRNA-3148 modulates allelic expression of toll-like receptor 7 variant associated with systemic lupus erythematosus. PLoS Genet 2013;9:e1003336.
    • (2013) PLoS Genet , vol.9 , pp. e1003336
    • Deng, Y.1
  • 19
    • 84892976361 scopus 로고    scopus 로고
    • Genetic variations in Toll-like receptors (TLRs 3/7/8) are associated with systemic lupus erythematosus in a Taiwanese population
    • Wang C-M, et al. Genetic variations in Toll-like receptors (TLRs 3/7/8) are associated with systemic lupus erythematosus in a Taiwanese population. Sci Rep 2014;4:3792.
    • (2014) Sci Rep , vol.4 , pp. 3792
    • Wang, C.-M.1
  • 20
    • 79952461669 scopus 로고    scopus 로고
    • TLR7 single-nucleotide polymorphisms in the 3′ untranslated region and intron 2 independently contribute to systemic lupus erythematosus in Japanese women: a case-control association study
    • Kawasaki A, et al. TLR7 single-nucleotide polymorphisms in the 3′ untranslated region and intron 2 independently contribute to systemic lupus erythematosus in Japanese women: a case-control association study. Arthritis Res Ther 2011;13:R41.
    • (2011) Arthritis Res Ther , vol.13 , pp. R41
    • Kawasaki, A.1
  • 21
    • 84906935272 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms in genes encoding toll-like receptors 7, 8 and 9 in Danish patients with systemic lupus erythematosus
    • Enevold C, et al. Single nucleotide polymorphisms in genes encoding toll-like receptors 7, 8 and 9 in Danish patients with systemic lupus erythematosus. Mol Biol Rep 2014;41:5755-5763.
    • (2014) Mol Biol Rep , vol.41 , pp. 5755-5763
    • Enevold, C.1
  • 22
    • 37549066665 scopus 로고    scopus 로고
    • Treatment of lupus-prone mice with a dual inhibitor of TLR7 and TLR9 leads to reduction of autoantibody production and amelioration of disease symptoms
    • Barrat FJ, Meeker T, Chan JH, Guiducci C, Coffman RL. Treatment of lupus-prone mice with a dual inhibitor of TLR7 and TLR9 leads to reduction of autoantibody production and amelioration of disease symptoms. Eur J Immunol 2007;37:3582-3586.
    • (2007) Eur J Immunol , vol.37 , pp. 3582-3586
    • Barrat, F.J.1    Meeker, T.2    Chan, J.H.3    Guiducci, C.4    Coffman, R.L.5
  • 23
    • 78650315462 scopus 로고    scopus 로고
    • Autoimmune skin inflammation is dependent on plasmacytoid dendritic cell activation by nucleic acids via TLR7 and TLR9
    • Guiducci C, et al. Autoimmune skin inflammation is dependent on plasmacytoid dendritic cell activation by nucleic acids via TLR7 and TLR9. J Exp Med 2010;207:2931-2942.
    • (2010) J Exp Med , vol.207 , pp. 2931-2942
    • Guiducci, C.1
  • 24
    • 84855163540 scopus 로고    scopus 로고
    • Intrinsic danger: activation of Toll-like receptors in rheumatoid arthritis
    • Goh FG, Midwood KS. Intrinsic danger: activation of Toll-like receptors in rheumatoid arthritis. Rheumatology (Oxford) 2012;51:7-23.
    • (2012) Rheumatology (Oxford) , vol.51 , pp. 7-23
    • Goh, F.G.1    Midwood, K.S.2
  • 25
    • 81755161555 scopus 로고    scopus 로고
    • Toll-like receptors in rheumatic diseases: are we paying a high price for our defense against bugs?
    • Santegoets KCM, van Bon L, van den Berg WB, Wenink MH, Radstake TRDJ. Toll-like receptors in rheumatic diseases: are we paying a high price for our defense against bugs?. FEBS Lett 2011;585:3660-3666.
    • (2011) FEBS Lett , vol.585 , pp. 3660-3666
    • Santegoets, K.C.M.1    van Bon, L.2    van den Berg, W.B.3    Wenink, M.H.4    Radstake, T.R.D.J.5
  • 26
    • 79955589106 scopus 로고    scopus 로고
    • Trapped in a vicious loop: Toll-like receptors sustain the spontaneous cytokine production by rheumatoid synovium
    • Abdollahi-Roodsaz S, van de Loo FAJ, van den Berg WB. Trapped in a vicious loop: Toll-like receptors sustain the spontaneous cytokine production by rheumatoid synovium. Arthritis Res Ther 2011;13:105.
    • (2011) Arthritis Res Ther , vol.13 , pp. 105
    • Abdollahi-Roodsaz, S.1    van de Loo, F.A.J.2    van den Berg, W.B.3
  • 27
    • 38149048556 scopus 로고    scopus 로고
    • Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis
    • Abdollahi-Roodsaz S, et al. Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis. J Clin Invest 2008;118:205-216.
    • (2008) J Clin Invest , vol.118 , pp. 205-216
    • Abdollahi-Roodsaz, S.1
  • 29
    • 34848840994 scopus 로고    scopus 로고
    • Inhibition of Toll-like receptor 4 breaks the inflammatory loop in autoimmune destructive arthritis
    • Abdollahi-Roodsaz S, et al. Inhibition of Toll-like receptor 4 breaks the inflammatory loop in autoimmune destructive arthritis. Arthritis Rheum 2007;56:2957-2967.
    • (2007) Arthritis Rheum , vol.56 , pp. 2957-2967
    • Abdollahi-Roodsaz, S.1
  • 30
    • 20644450804 scopus 로고    scopus 로고
    • Negative regulation of toll-like receptor-mediated immune responses
    • Liew FY, Xu D, Brint EK, O'Neill LAJ. Negative regulation of toll-like receptor-mediated immune responses. Nat Rev Immunol 2005;5:446-458.
    • (2005) Nat Rev Immunol , vol.5 , pp. 446-458
    • Liew, F.Y.1    Xu, D.2    Brint, E.K.3    O'Neill, L.A.J.4
  • 31
    • 84865298775 scopus 로고    scopus 로고
    • Dissecting negative regulation of Toll-like receptor signaling
    • Kondo T, Kawai T, Akira S. Dissecting negative regulation of Toll-like receptor signaling. Trends Immunol 2012;33:449-458.
    • (2012) Trends Immunol , vol.33 , pp. 449-458
    • Kondo, T.1    Kawai, T.2    Akira, S.3
  • 32
    • 84867898782 scopus 로고    scopus 로고
    • A20: linking a complex regulator of ubiquitylation to immunity and human disease
    • Ma A, Malynn BA. A20: linking a complex regulator of ubiquitylation to immunity and human disease. Nat Rev Immunol 2012;12:774-785.
    • (2012) Nat Rev Immunol , vol.12 , pp. 774-785
    • Ma, A.1    Malynn, B.A.2
  • 34
    • 50449103533 scopus 로고    scopus 로고
    • Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus
    • Musone SL, et al. Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus. Nat Genet 2008;40:1062-1064.
    • (2008) Nat Genet , vol.40 , pp. 1062-1064
    • Musone, S.L.1
  • 35
    • 79952192654 scopus 로고    scopus 로고
    • Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus
    • Adrianto I, et al. Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus. Nat Genet 2011;43:253-258.
    • (2011) Nat Genet , vol.43 , pp. 253-258
    • Adrianto, I.1
  • 36
    • 84904068775 scopus 로고    scopus 로고
    • The deubiquitinase A20 in immunopathology of autoimmune diseases
    • Majumdar I, Paul J. The deubiquitinase A20 in immunopathology of autoimmune diseases. Autoimmunity 2014;47:307-319.
    • (2014) Autoimmunity , vol.47 , pp. 307-319
    • Majumdar, I.1    Paul, J.2
  • 37
    • 0034730713 scopus 로고    scopus 로고
    • Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice
    • Lee EG, et al. Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice. Science 2000;289:2350-2354.
    • (2000) Science , vol.289 , pp. 2350-2354
    • Lee, E.G.1
  • 38
    • 80052195163 scopus 로고    scopus 로고
    • A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis
    • Matmati M, et al. A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis. Nat Genet 2011;43:908-912.
    • (2011) Nat Genet , vol.43 , pp. 908-912
    • Matmati, M.1
  • 39
    • 81255160601 scopus 로고    scopus 로고
    • Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis
    • Hammer GE, et al. Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis. Nat Immunol 2011;12:1184-1193.
    • (2011) Nat Immunol , vol.12 , pp. 1184-1193
    • Hammer, G.E.1
  • 40
    • 79960467121 scopus 로고    scopus 로고
    • The ubiquitin-editing protein A20 prevents dendritic cell activation, recognition of apoptotic cells, and systemic autoimmunity
    • Kool M, et al. The ubiquitin-editing protein A20 prevents dendritic cell activation, recognition of apoptotic cells, and systemic autoimmunity. Immunity 2011;35:82-96.
    • (2011) Immunity , vol.35 , pp. 82-96
    • Kool, M.1
  • 41
    • 84921748195 scopus 로고    scopus 로고
    • PTPN22: the archetypal non-HLA autoimmunity gene
    • Stanford SM, Bottini N. PTPN22: the archetypal non-HLA autoimmunity gene. Nat Rev Rheumatol 2014;10:602-611.
    • (2014) Nat Rev Rheumatol , vol.10 , pp. 602-611
    • Stanford, S.M.1    Bottini, N.2
  • 42
    • 81755179431 scopus 로고    scopus 로고
    • Why is PTPN22 a good candidate susceptibility gene for autoimmune disease?
    • Burn GL, Svensson L, Sanchez-Blanco C, Saini M, Cope AP. Why is PTPN22 a good candidate susceptibility gene for autoimmune disease? FEBS Lett 2011;585:3689-3698.
    • (2011) FEBS Lett , vol.585 , pp. 3689-3698
    • Burn, G.L.1    Svensson, L.2    Sanchez-Blanco, C.3    Saini, M.4    Cope, A.P.5
  • 43
    • 33745652977 scopus 로고    scopus 로고
    • Genetic influence of PTPN22 R620W polymorphism in tuberculosis
    • Gomez LM, Anaya J-M, Martin J. Genetic influence of PTPN22 R620W polymorphism in tuberculosis. Hum Immunol 2005;66:1242-1247.
    • (2005) Hum Immunol , vol.66 , pp. 1242-1247
    • Gomez, L.M.1    Anaya, J.-M.2    Martin, J.3
  • 44
    • 84876330108 scopus 로고    scopus 로고
    • Association between the PTPN22 1858C/T gene polymorphism and tuberculosis resistance
    • Boechat AL, Ogusku MM, Sadahiro A, dos Santos MC. Association between the PTPN22 1858C/T gene polymorphism and tuberculosis resistance. Infect Genet Evol 2013;16:310-313.
    • (2013) Infect Genet Evol , vol.16 , pp. 310-313
    • Boechat, A.L.1    Ogusku, M.M.2    Sadahiro, A.3    dos Santos, M.C.4
  • 45
    • 68249090600 scopus 로고    scopus 로고
    • Association of PTPN22 gene functional variants with development of pulmonary tuberculosis in Moroccan population
    • Lamsyah H, et al. Association of PTPN22 gene functional variants with development of pulmonary tuberculosis in Moroccan population. Tissue Antigens 2009;74:228-232.
    • (2009) Tissue Antigens , vol.74 , pp. 228-232
    • Lamsyah, H.1
  • 46
    • 49149095185 scopus 로고    scopus 로고
    • The PTPN22 R620W polymorphism is associated with severe bacterial infections after human leukocyte antigen geno-identical haematopoietic stem-cell transplantations
    • Azarian M, et al. The PTPN22 R620W polymorphism is associated with severe bacterial infections after human leukocyte antigen geno-identical haematopoietic stem-cell transplantations. Transplantation 2008;85:1859-1862.
    • (2008) Transplantation , vol.85 , pp. 1859-1862
    • Azarian, M.1
  • 47
    • 84930485479 scopus 로고    scopus 로고
    • R620W functional polymorphism of protein tyrosine phosphatase non-receptor type 22 is not associated with pulmonary tuberculosis in Zahedan, southeast Iran
    • Kouhpayeh H-R, et al. R620W functional polymorphism of protein tyrosine phosphatase non-receptor type 22 is not associated with pulmonary tuberculosis in Zahedan, southeast Iran. Genet Mol Res 2012;11:1075-1081.
    • (2012) Genet Mol Res , vol.11 , pp. 1075-1081
    • Kouhpayeh, H.-R.1
  • 48
    • 58449111291 scopus 로고    scopus 로고
    • PTPN22 C1858T polymorphism and human brucellosis
    • Bravo MJ, et al. PTPN22 C1858T polymorphism and human brucellosis. Scand J Infect Dis 2009;41:109-112.
    • (2009) Scand J Infect Dis , vol.41 , pp. 109-112
    • Bravo, M.J.1
  • 50
    • 58149229588 scopus 로고    scopus 로고
    • PTPN22 C1858T polymorphism and the outcome of hepatitis C virus infection
    • Montes-Cano MA, et al. PTPN22 C1858T polymorphism and the outcome of hepatitis C virus infection. Viral Immunol 2008;21:491-494.
    • (2008) Viral Immunol , vol.21 , pp. 491-494
    • Montes-Cano, M.A.1
  • 51
    • 84925858831 scopus 로고    scopus 로고
    • The role of PTPN22 risk variant in the development of autoimmunity: finding common ground between mouse and human
    • Rawlings DJ, Dai X, Buckner JH. The role of PTPN22 risk variant in the development of autoimmunity: finding common ground between mouse and human. J Immunol 2015;194:2977-2984.
    • (2015) J Immunol , vol.194 , pp. 2977-2984
    • Rawlings, D.J.1    Dai, X.2    Buckner, J.H.3
  • 52
    • 84897106158 scopus 로고    scopus 로고
    • Tyrosine phosphatase PTPN22: multifunctional regulator of immune signaling, development, and disease
    • Bottini N, Peterson EJ. Tyrosine phosphatase PTPN22: multifunctional regulator of immune signaling, development, and disease. Annu Rev Immunol 2014;32:83-119.
    • (2014) Annu Rev Immunol , vol.32 , pp. 83-119
    • Bottini, N.1    Peterson, E.J.2
  • 53
    • 0942279640 scopus 로고    scopus 로고
    • PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells
    • Hasegawa K, Martin F, Huang G, Tumas D, Diehl L, Chan AC. PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells. Science 2004;303:685-689.
    • (2004) Science , vol.303 , pp. 685-689
    • Hasegawa, K.1    Martin, F.2    Huang, G.3    Tumas, D.4    Diehl, L.5    Chan, A.C.6
  • 54
    • 84863518421 scopus 로고    scopus 로고
    • Overexpression of the autoimmunity-associated phosphatase PTPN22 promotes survival of antigen-stimulated CLL cells by selectively activating AKT
    • Negro R, et al. Overexpression of the autoimmunity-associated phosphatase PTPN22 promotes survival of antigen-stimulated CLL cells by selectively activating AKT. Blood 2012;119:6278-6287.
    • (2012) Blood , vol.119 , pp. 6278-6287
    • Negro, R.1
  • 55
    • 84877115482 scopus 로고    scopus 로고
    • A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models
    • Dai X, et al. A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models. J Clin Invest 2013;123:2024-2036.
    • (2013) J Clin Invest , vol.123 , pp. 2024-2036
    • Dai, X.1
  • 56
    • 80052239824 scopus 로고    scopus 로고
    • The autoimmune disease-associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness
    • Zhang J, et al. The autoimmune disease-associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness. Nat Genet 2011;43:902-907.
    • (2011) Nat Genet , vol.43 , pp. 902-907
    • Zhang, J.1
  • 57
    • 64249119896 scopus 로고    scopus 로고
    • PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background
    • Zikherman J, Hermiston M, Steiner D, Hasegawa K, Chan A, Weiss A. PTPN22 deficiency cooperates with the CD45 E613R allele to break tolerance on a non-autoimmune background. J Immunol 2009;182:4093-4106.
    • (2009) J Immunol , vol.182 , pp. 4093-4106
    • Zikherman, J.1    Hermiston, M.2    Steiner, D.3    Hasegawa, K.4    Chan, A.5    Weiss, A.6
  • 58
    • 65449176044 scopus 로고    scopus 로고
    • Cutting edge: the PTPN22 allelic variant associated with autoimmunity impairs B cell signaling
    • Arechiga AF, et al. Cutting edge: the PTPN22 allelic variant associated with autoimmunity impairs B cell signaling. J Immunol 2009;182:3343-3347.
    • (2009) J Immunol , vol.182 , pp. 3343-3347
    • Arechiga, A.F.1
  • 60
    • 77956627113 scopus 로고    scopus 로고
    • Comprehensive expression profiles of genes for protein tyrosine phosphatases in immune cells
    • Arimura Y, Yagi J. Comprehensive expression profiles of genes for protein tyrosine phosphatases in immune cells. Sci Signal 2010;3:rs1.
    • (2010) Sci Signal , vol.3 , pp. rs1
    • Arimura, Y.1    Yagi, J.2
  • 61
    • 84880733694 scopus 로고    scopus 로고
    • The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity
    • Wang Y, et al. The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity. Immunity 2013;39:111-122.
    • (2013) Immunity , vol.39 , pp. 111-122
    • Wang, Y.1
  • 62
    • 84940108777 scopus 로고    scopus 로고
    • PTPN22 variant R620W is associated with reduced Toll-like receptor 7-induced type I interferon in systemic lupus erythematosus
    • Wang Y, et al. PTPN22 variant R620W is associated with reduced Toll-like receptor 7-induced type I interferon in systemic lupus erythematosus. Arthritis Rheumatol 2015;67:2403-2414.
    • (2015) Arthritis Rheumatol , vol.67 , pp. 2403-2414
    • Wang, Y.1
  • 63
    • 20644443886 scopus 로고    scopus 로고
    • Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12
    • Hamerman JA, Tchao NK, Lowell CA, Lanier LL. Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12. Nat Immunol 2005;6:579-586.
    • (2005) Nat Immunol , vol.6 , pp. 579-586
    • Hamerman, J.A.1    Tchao, N.K.2    Lowell, C.A.3    Lanier, L.L.4
  • 64
    • 33746875981 scopus 로고    scopus 로고
    • Cutting edge: inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12
    • Hamerman JA, Jarjoura JR, Humphrey MB, Nakamura MC, Seaman WE, Lanier LL. Cutting edge: inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12. J Immunol 2006;177:2051-2055.
    • (2006) J Immunol , vol.177 , pp. 2051-2055
    • Hamerman, J.A.1    Jarjoura, J.R.2    Humphrey, M.B.3    Nakamura, M.C.4    Seaman, W.E.5    Lanier, L.L.6
  • 65
    • 84855221945 scopus 로고    scopus 로고
    • TREM-2, triggering receptor expressed on myeloid cell-2, negatively regulates TLR responses in dendritic cells
    • Ito H, Hamerman JA. TREM-2, triggering receptor expressed on myeloid cell-2, negatively regulates TLR responses in dendritic cells. Eur J Immunol 2012;42:176-185.
    • (2012) Eur J Immunol , vol.42 , pp. 176-185
    • Ito, H.1    Hamerman, J.A.2
  • 66
    • 84932107529 scopus 로고    scopus 로고
    • The Tec kinase-regulated phosphoproteome reveals a mechanism for the regulation of inhibitory signals in murine macrophages
    • Tampella G, et al. The Tec kinase-regulated phosphoproteome reveals a mechanism for the regulation of inhibitory signals in murine macrophages. J Immunol 2015;195:246-256.
    • (2015) J Immunol , vol.195 , pp. 246-256
    • Tampella, G.1
  • 67
    • 38049160121 scopus 로고    scopus 로고
    • Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases
    • Yu X, et al. Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases. Proc Natl Acad Sci USA 2007;104:19767-19772.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 19767-19772
    • Yu, X.1
  • 68
    • 79952797194 scopus 로고    scopus 로고
    • Discovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cells
    • Stanford SM, et al. Discovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cells. J Med Chem 2011;54:1640-1654.
    • (2011) J Med Chem , vol.54 , pp. 1640-1654
    • Stanford, S.M.1
  • 69
    • 34547868501 scopus 로고    scopus 로고
    • A common human TLR1 polymorphism regulates the innate immune response to lipopeptides
    • Hawn TR, et al. A common human TLR1 polymorphism regulates the innate immune response to lipopeptides. Eur J Immunol 2007;37:2280-2289.
    • (2007) Eur J Immunol , vol.37 , pp. 2280-2289
    • Hawn, T.R.1
  • 70
    • 84862794148 scopus 로고    scopus 로고
    • Akt2 inhibits the activation of NFAT in lymphocytes by modulating calcium release from intracellular stores
    • Martin VA, et al. Akt2 inhibits the activation of NFAT in lymphocytes by modulating calcium release from intracellular stores. Cell Signal 2012;24:1064-1073.
    • (2012) Cell Signal , vol.24 , pp. 1064-1073
    • Martin, V.A.1
  • 71
    • 84876463917 scopus 로고    scopus 로고
    • Loss of protein tyrosine phosphatase nonreceptor type 22 regulates interferon-γ-induced signaling in human monocytes
    • e10.
    • Spalinger MR, et al. Loss of protein tyrosine phosphatase nonreceptor type 22 regulates interferon-γ-induced signaling in human monocytes. Gastroenterology 2013;144:978-988 e10.
    • (2013) Gastroenterology , vol.144 , pp. 978-988
    • Spalinger, M.R.1
  • 72
    • 84883394259 scopus 로고    scopus 로고
    • PTPN22 modulates macrophage polarization and susceptibility to dextran sulfate sodium-induced colitis
    • Chang H-H, et al. PTPN22 modulates macrophage polarization and susceptibility to dextran sulfate sodium-induced colitis. J Immunol 2013;191:2134-2143.
    • (2013) J Immunol , vol.191 , pp. 2134-2143
    • Chang, H.-H.1
  • 73
    • 84940367331 scopus 로고    scopus 로고
    • The autoimmune-associated genetic variant PTPN22 R620W enhances neutrophil activation and function in patients with rheumatoid arthritis and healthy individuals
    • Bayley R, et al. The autoimmune-associated genetic variant PTPN22 R620W enhances neutrophil activation and function in patients with rheumatoid arthritis and healthy individuals. Ann Rheum Dis 2015;74:1588-1595.
    • (2015) Ann Rheum Dis , vol.74 , pp. 1588-1595
    • Bayley, R.1
  • 74
    • 84940121364 scopus 로고    scopus 로고
    • The W620 polymorphism in PTPN22 disrupts its interaction with peptidylarginine deiminase type 4 and enhances citrullination and NETosis
    • Chang H-H, Dwivedi N, Nicholas AP, Ho I-C. The W620 polymorphism in PTPN22 disrupts its interaction with peptidylarginine deiminase type 4 and enhances citrullination and NETosis. Arthritis Rheumatol 2015;67:2323-2334.
    • (2015) Arthritis Rheumatol , vol.67 , pp. 2323-2334
    • Chang, H.-H.1    Dwivedi, N.2    Nicholas, A.P.3    Ho, I.-C.4
  • 75
    • 33746257209 scopus 로고    scopus 로고
    • The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
    • Engelman JA, Luo J, Cantley LC. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet 2006;7:606-619.
    • (2006) Nat Rev Genet , vol.7 , pp. 606-619
    • Engelman, J.A.1    Luo, J.2    Cantley, L.C.3
  • 76
    • 0037205048 scopus 로고    scopus 로고
    • The phosphoinositide 3-kinase pathway
    • Cantley LC. The phosphoinositide 3-kinase pathway. Science 2002;296:1655-1657.
    • (2002) Science , vol.296 , pp. 1655-1657
    • Cantley, L.C.1
  • 77
    • 0037199972 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells
    • Guha M, Mackman N. The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells. J Biol Chem 2002;277:32124-32132.
    • (2002) J Biol Chem , vol.277 , pp. 32124-32132
    • Guha, M.1    Mackman, N.2
  • 78
    • 0038446051 scopus 로고    scopus 로고
    • Role of the phosphatidylinositol 3 kinase-Akt pathway in the regulation of IL-10 and IL-12 by Porphyromonas gingivalis lipopolysaccharide
    • Martin M, Schifferle RE, Cuesta N, Vogel SN, Katz J, Michalek SM. Role of the phosphatidylinositol 3 kinase-Akt pathway in the regulation of IL-10 and IL-12 by Porphyromonas gingivalis lipopolysaccharide. J Immunol 2003;171:717-725.
    • (2003) J Immunol , vol.171 , pp. 717-725
    • Martin, M.1    Schifferle, R.E.2    Cuesta, N.3    Vogel, S.N.4    Katz, J.5    Michalek, S.M.6
  • 79
    • 0037031924 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase activity negatively regulates stability of cyclooxygenase 2 mRNA
    • Monick MM, et al. Phosphatidylinositol 3-kinase activity negatively regulates stability of cyclooxygenase 2 mRNA. J Biol Chem 2002;277:32992-33000.
    • (2002) J Biol Chem , vol.277 , pp. 32992-33000
    • Monick, M.M.1
  • 80
    • 0036707521 scopus 로고    scopus 로고
    • PI3K-mediated negative feedback regulation of IL-12 production in DCs
    • Fukao T, et al. PI3K-mediated negative feedback regulation of IL-12 production in DCs. Nat Immunol 2002;3:875-881.
    • (2002) Nat Immunol , vol.3 , pp. 875-881
    • Fukao, T.1
  • 81
    • 77956627302 scopus 로고    scopus 로고
    • Phosphoinositide-dependent kinase 1 provides negative feedback inhibition to Toll-like receptor-mediated NF-kappaB activation in macrophages
    • Chaurasia B, Mauer J, Koch L, Goldau J, Kock A-S, Brüning JC. Phosphoinositide-dependent kinase 1 provides negative feedback inhibition to Toll-like receptor-mediated NF-kappaB activation in macrophages. Mol Cell Biol 2010;30:4354-4366.
    • (2010) Mol Cell Biol , vol.30 , pp. 4354-4366
    • Chaurasia, B.1    Mauer, J.2    Koch, L.3    Goldau, J.4    Kock, A.-S.5    Brüning, J.C.6
  • 82
    • 68649091506 scopus 로고    scopus 로고
    • The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs
    • Androulidaki A, et al. The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs. Immunity 2009;31:220-231.
    • (2009) Immunity , vol.31 , pp. 220-231
    • Androulidaki, A.1
  • 83
    • 84862187485 scopus 로고    scopus 로고
    • Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization
    • Arranz A, et al. Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization. Proc Natl Acad Sci USA 2012;109:9517-9522.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 9517-9522
    • Arranz, A.1
  • 84
    • 1842424697 scopus 로고    scopus 로고
    • The inositol 3-phosphatase PTEN negatively regulates Fc gamma receptor signaling, but supports Toll-like receptor 4 signaling in murine peritoneal macrophages
    • Cao X, et al. The inositol 3-phosphatase PTEN negatively regulates Fc gamma receptor signaling, but supports Toll-like receptor 4 signaling in murine peritoneal macrophages. J Immunol 2004;172:4851-4857.
    • (2004) J Immunol , vol.172 , pp. 4851-4857
    • Cao, X.1
  • 85
    • 44849113635 scopus 로고    scopus 로고
    • Genetic analysis of the role of the PI3K-Akt pathway in lipopolysaccharide-induced cytokine and tissue factor gene expression in monocytes/macrophages
    • Luyendyk JP, Schabbauer GA, Tencati M, Holscher T, Pawlinski R, Mackman N. Genetic analysis of the role of the PI3K-Akt pathway in lipopolysaccharide-induced cytokine and tissue factor gene expression in monocytes/macrophages. J Immunol 2008;180:4218-4226.
    • (2008) J Immunol , vol.180 , pp. 4218-4226
    • Luyendyk, J.P.1    Schabbauer, G.A.2    Tencati, M.3    Holscher, T.4    Pawlinski, R.5    Mackman, N.6
  • 86
    • 47049086825 scopus 로고    scopus 로고
    • Effective clearance of intracellular Leishmania major in vivo requires Pten in macrophages
    • Kuroda S, et al. Effective clearance of intracellular Leishmania major in vivo requires Pten in macrophages. Eur J Immunol 2008;38:1331-1340.
    • (2008) Eur J Immunol , vol.38 , pp. 1331-1340
    • Kuroda, S.1
  • 87
    • 79954577277 scopus 로고    scopus 로고
    • TLR-signaling networks: an integration of adaptor molecules, kinases, and cross-talk
    • Brown J, Wang H, Hajishengallis GN, Martin M. TLR-signaling networks: an integration of adaptor molecules, kinases, and cross-talk. J Dent Res 2011;90:417-427.
    • (2011) J Dent Res , vol.90 , pp. 417-427
    • Brown, J.1    Wang, H.2    Hajishengallis, G.N.3    Martin, M.4
  • 88
    • 50949130076 scopus 로고    scopus 로고
    • Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced interleukin-12 production in dendritic cells
    • Ohtani M, et al. Mammalian target of rapamycin and glycogen synthase kinase 3 differentially regulate lipopolysaccharide-induced interleukin-12 production in dendritic cells. Blood 2008;112:635-643.
    • (2008) Blood , vol.112 , pp. 635-643
    • Ohtani, M.1
  • 89
    • 78650266432 scopus 로고    scopus 로고
    • FoxO1 regulates Tlr4 inflammatory pathway signalling in macrophages
    • Fan W, et al. FoxO1 regulates Tlr4 inflammatory pathway signalling in macrophages. EMBO J 2010;29:4223-4236.
    • (2010) EMBO J , vol.29 , pp. 4223-4236
    • Fan, W.1
  • 90
    • 84455161606 scopus 로고    scopus 로고
    • Mammalian target of rapamycin complex 2 (mTORC2) negatively regulates Toll-like receptor 4-mediated inflammatory response via FoxO1
    • Brown J, Wang H, Suttles J, Graves DT, Martin M. Mammalian target of rapamycin complex 2 (mTORC2) negatively regulates Toll-like receptor 4-mediated inflammatory response via FoxO1. J Biol Chem 2011;286:44295-44305.
    • (2011) J Biol Chem , vol.286 , pp. 44295-44305
    • Brown, J.1    Wang, H.2    Suttles, J.3    Graves, D.T.4    Martin, M.5
  • 91
    • 70350539525 scopus 로고    scopus 로고
    • FoxO1 links insulin resistance to proinflammatory cytokine IL-1beta production in macrophages
    • Su D, et al. FoxO1 links insulin resistance to proinflammatory cytokine IL-1beta production in macrophages. Diabetes 2009;58:2624-2633.
    • (2009) Diabetes , vol.58 , pp. 2624-2633
    • Su, D.1
  • 92
    • 54949109311 scopus 로고    scopus 로고
    • The TSC-mTOR signaling pathway regulates the innate inflammatory response
    • Weichhart T, et al. The TSC-mTOR signaling pathway regulates the innate inflammatory response. Immunity 2008;29:565-577.
    • (2008) Immunity , vol.29 , pp. 565-577
    • Weichhart, T.1
  • 93
    • 23944486750 scopus 로고    scopus 로고
    • Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3
    • Martin M, Rehani K, Jope RS, Michalek SM. Toll-like receptor-mediated cytokine production is differentially regulated by glycogen synthase kinase 3. Nat Immunol 2005;6:777-784.
    • (2005) Nat Immunol , vol.6 , pp. 777-784
    • Martin, M.1    Rehani, K.2    Jope, R.S.3    Michalek, S.M.4
  • 94
    • 84872899284 scopus 로고    scopus 로고
    • FOXOs: signalling integrators for homeostasis maintenance
    • Eijkelenboom A, Burgering BMT. FOXOs: signalling integrators for homeostasis maintenance. Nat Rev Mol Cell Biol 2013;14:83-97.
    • (2013) Nat Rev Mol Cell Biol , vol.14 , pp. 83-97
    • Eijkelenboom, A.1    Burgering, B.M.T.2
  • 95
    • 0034577944 scopus 로고    scopus 로고
    • Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway
    • Arbibe L, et al. Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway. Nat Immunol 2000;1:533-540.
    • (2000) Nat Immunol , vol.1 , pp. 533-540
    • Arbibe, L.1
  • 96
    • 7544225495 scopus 로고    scopus 로고
    • Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling
    • Sarkar SN, Peters KL, Elco CP, Sakamoto S, Pal S, Sen GC. Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling. Nat Struct Mol Biol 2004;11:1060-1067.
    • (2004) Nat Struct Mol Biol , vol.11 , pp. 1060-1067
    • Sarkar, S.N.1    Peters, K.L.2    Elco, C.P.3    Sakamoto, S.4    Pal, S.5    Sen, G.C.6
  • 97
    • 33745868678 scopus 로고    scopus 로고
    • Role of MyD88 in phosphatidylinositol 3-kinase activation by flagellin/toll-like receptor 5 engagement in colonic epithelial cells
    • Rhee SH, Kim H, Moyer MP, Pothoulakis C. Role of MyD88 in phosphatidylinositol 3-kinase activation by flagellin/toll-like receptor 5 engagement in colonic epithelial cells. J Biol Chem 2006;281:18560-18568.
    • (2006) J Biol Chem , vol.281 , pp. 18560-18568
    • Rhee, S.H.1    Kim, H.2    Moyer, M.P.3    Pothoulakis, C.4
  • 98
    • 67651183597 scopus 로고    scopus 로고
    • Mal connects TLR2 to PI3Kinase activation and phagocyte polarization
    • Santos-Sierra S, et al. Mal connects TLR2 to PI3Kinase activation and phagocyte polarization. EMBO J 2009;28:2018-2027.
    • (2009) EMBO J , vol.28 , pp. 2018-2027
    • Santos-Sierra, S.1
  • 99
    • 67149121074 scopus 로고    scopus 로고
    • TLR4/MyD88/PI3K interactions regulate TLR4 signaling
    • Laird MHW, et al. TLR4/MyD88/PI3K interactions regulate TLR4 signaling. J Leukoc Biol 2009;85:966-977.
    • (2009) J Leukoc Biol , vol.85 , pp. 966-977
    • Laird, M.H.W.1
  • 100
    • 0034507903 scopus 로고    scopus 로고
    • BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation
    • Okada T, Maeda A, Iwamatsu A, Gotoh K, Kurosaki T. BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation. Immunity 2000;13:817-827.
    • (2000) Immunity , vol.13 , pp. 817-827
    • Okada, T.1    Maeda, A.2    Iwamatsu, A.3    Gotoh, K.4    Kurosaki, T.5
  • 101
    • 0041695162 scopus 로고    scopus 로고
    • Contribution of BCAP to maintenance of mature B cells through c-Rel
    • Yamazaki T, Kurosaki T. Contribution of BCAP to maintenance of mature B cells through c-Rel. Nat Immunol 2003;4:780-786.
    • (2003) Nat Immunol , vol.4 , pp. 780-786
    • Yamazaki, T.1    Kurosaki, T.2
  • 103
    • 84855992592 scopus 로고    scopus 로고
    • B-cell adaptor for PI3K (BCAP) negatively regulates Toll-like receptor signaling through activation of PI3K
    • Ni M, MacFarlane AW, Toft M, Lowell CA, Campbell KS, Hamerman JA. B-cell adaptor for PI3K (BCAP) negatively regulates Toll-like receptor signaling through activation of PI3K. Proc Natl Acad Sci USA 2012;109:267-272.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 267-272
    • Ni, M.1    MacFarlane, A.W.2    Toft, M.3    Lowell, C.A.4    Campbell, K.S.5    Hamerman, J.A.6
  • 104
    • 84856008042 scopus 로고    scopus 로고
    • Role for B-cell adapter for PI3K (BCAP) as a signaling adapter linking Toll-like receptors (TLRs) to serine/threonine kinases PI3K/Akt
    • Troutman TD, et al. Role for B-cell adapter for PI3K (BCAP) as a signaling adapter linking Toll-like receptors (TLRs) to serine/threonine kinases PI3K/Akt. Proc Natl Acad Sci USA 2012;109:273-278.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 273-278
    • Troutman, T.D.1
  • 105
    • 77956742502 scopus 로고    scopus 로고
    • Identification of BCAP-(L) as a negative regulator of the TLR signaling-induced production of IL-6 and IL-10 in macrophages by tyrosine phosphoproteomics
    • Matsumura T, et al. Identification of BCAP-(L) as a negative regulator of the TLR signaling-induced production of IL-6 and IL-10 in macrophages by tyrosine phosphoproteomics. Biochem Biophys Res Commun 2010;400:265-270.
    • (2010) Biochem Biophys Res Commun , vol.400 , pp. 265-270
    • Matsumura, T.1
  • 106
    • 84855975404 scopus 로고    scopus 로고
    • Abi-1-bridged tyrosine phosphorylation of VASP by Abelson kinase impairs association of VASP to focal adhesions and regulates leukemic cell adhesion
    • Maruoka M, et al. Abi-1-bridged tyrosine phosphorylation of VASP by Abelson kinase impairs association of VASP to focal adhesions and regulates leukemic cell adhesion. Biochem J 2011;441:889-899.
    • (2011) Biochem J , vol.441 , pp. 889-899
    • Maruoka, M.1
  • 107
    • 84940181646 scopus 로고    scopus 로고
    • Phosphatase and tensin homolog (PTEN) in antigen-presenting cells controls Th17-mediated autoimmune arthritis
    • Blüml S, et al. Phosphatase and tensin homolog (PTEN) in antigen-presenting cells controls Th17-mediated autoimmune arthritis. Arthritis Res Ther 2015;17:230.
    • (2015) Arthritis Res Ther , vol.17 , pp. 230
    • Blüml, S.1
  • 109
    • 84906314487 scopus 로고    scopus 로고
    • PI3K inhibitors as potential therapeutics for autoimmune disease
    • Ball J, Archer S, Ward S. PI3K inhibitors as potential therapeutics for autoimmune disease. Drug Discov Today 2014;19:1195-1199.
    • (2014) Drug Discov Today , vol.19 , pp. 1195-1199
    • Ball, J.1    Archer, S.2    Ward, S.3
  • 110
    • 84893249799 scopus 로고    scopus 로고
    • PI3K and cancer: lessons, challenges and opportunities
    • Fruman DA, Rommel C. PI3K and cancer: lessons, challenges and opportunities. Nat Rev Drug Discov 2014;13:140-156.
    • (2014) Nat Rev Drug Discov , vol.13 , pp. 140-156
    • Fruman, D.A.1    Rommel, C.2
  • 111
    • 15244344110 scopus 로고    scopus 로고
    • Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17
    • Stark MA, Huo Y, Burcin TL, Morris MA, Olson TS, Ley K. Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17. Immunity 2005;22:285-294.
    • (2005) Immunity , vol.22 , pp. 285-294
    • Stark, M.A.1    Huo, Y.2    Burcin, T.L.3    Morris, M.A.4    Olson, T.S.5    Ley, K.6
  • 112
    • 0037047590 scopus 로고    scopus 로고
    • Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice
    • Okkenhaug K, et al. Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice. Science 2002;297:1031-1034.
    • (2002) Science , vol.297 , pp. 1031-1034
    • Okkenhaug, K.1
  • 113
    • 78049476532 scopus 로고    scopus 로고
    • Altered macrophage function contributes to colitis in mice defective in the phosphoinositide-3 kinase subunit p110δ
    • 1653.e1-6.
    • Uno JK, et al. Altered macrophage function contributes to colitis in mice defective in the phosphoinositide-3 kinase subunit p110δ. Gastroenterology 2010;139:1642-1653. 1653.e1-6.
    • (2010) Gastroenterology , vol.139 , pp. 1642-1653
    • Uno, J.K.1
  • 114
    • 84896692766 scopus 로고    scopus 로고
    • Idelalisib and rituximab in relapsed chronic lymphocytic leukemia
    • Furman RR, et al. Idelalisib and rituximab in relapsed chronic lymphocytic leukemia. N Engl J Med 2014;370:997-1007.
    • (2014) N Engl J Med , vol.370 , pp. 997-1007
    • Furman, R.R.1
  • 115
    • 84927673054 scopus 로고    scopus 로고
    • FDA approval: idelalisib monotherapy for the treatment of patients with follicular lymphoma and small lymphocytic lymphoma
    • Miller BW, et al. FDA approval: idelalisib monotherapy for the treatment of patients with follicular lymphoma and small lymphocytic lymphoma. Clin Cancer Res 2015;21:1525-1529.
    • (2015) Clin Cancer Res , vol.21 , pp. 1525-1529
    • Miller, B.W.1


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