메뉴 건너뛰기




Volumn 9, Issue 3, 2013, Pages 154-163

The problem of choice: Current biologic agents and future prospects in RA

Author keywords

[No Author keywords available]

Indexed keywords

ABATACEPT; ADALIMUMAB; BELIMUMAB; BIOLOGICAL MARKER; BIOLOGICAL PRODUCT; BRODALUMAB; CERTOLIZUMAB PEGOL; CLAZAKIZUMAB; DISEASE MODIFYING ANTIRHEUMATIC DRUG; EPRATUZUMAB; ETANERCEPT; FOSTAMATINIB; GOLIMUMAB; INFLIXIMAB; IXEKIZUMAB; METHOTREXATE; OCRELIZUMAB; OFATUMUMAB; OLOKIZUMAB; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; RITUXIMAB; SARILUMAB; SECUKINUMAB; SIRUKUMAB; TOCILIZUMAB; TOFACITINIB; TUMOR NECROSIS FACTOR INHIBITOR; UNINDEXED DRUG; USTEKINUMAB; VELTUZUMAB;

EID: 84874660169     PISSN: 17594790     EISSN: 17594804     Source Type: Journal    
DOI: 10.1038/nrrheum.2013.8     Document Type: Review
Times cited : (133)

References (91)
  • 1
    • 84859832981 scopus 로고    scopus 로고
    • 2012 update of the 2008 American College of Rheumatology recommendations for the use of disease-modifying antirheumatic drugs and biologic agents in the treatment of rheumatoid arthritis
    • Singh, J. A. et al. 2012 update of the 2008 American College of Rheumatology recommendations for the use of disease-modifying antirheumatic drugs and biologic agents in the treatment of rheumatoid arthritis. Arthritis Care Res. 64, 625-639 (2012).
    • (2012) Arthritis Care Res , vol.64 , pp. 625-639
    • Singh, J.A.1
  • 2
    • 77953696525 scopus 로고    scopus 로고
    • EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs
    • Smolen, J. S. et al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs. Ann. Rheum. Dis. 69, 964-975 (2010).
    • (2010) Ann. Rheum. Dis , vol.69 , pp. 964-975
    • Smolen, J.S.1
  • 3
    • 78650834275 scopus 로고    scopus 로고
    • Biologics for rheumatoid arthritis: An overview of Cochrane reviews
    • Singh, J. A. et al. Biologics for rheumatoid arthritis: an overview of Cochrane reviews. Sao Paulo Med. J. 128, 309-310 (2010).
    • (2010) Sao Paulo Med. J , vol.128 , pp. 309-310
    • Singh, J.A.1
  • 4
    • 67650379733 scopus 로고    scopus 로고
    • Golimumab in patients with active rheumatoid arthritis after treatment with tumour necrosis factor alpha inhibitors (GO-AFTER study): A multicentre, randomised, double-blind, placebo-controlled, phase III trial
    • Smolen, J. S. et al. Golimumab in patients with active rheumatoid arthritis after treatment with tumour necrosis factor alpha inhibitors (GO-AFTER study): a multicentre, randomised, double-blind, placebo-controlled, phase III trial. Lancet 374, 210-221 (2009).
    • (2009) Lancet , vol.374 , pp. 210-221
    • Smolen, J.S.1
  • 5
    • 33746961890 scopus 로고    scopus 로고
    • Rituximab for rheumatoid arthritis refractory to anti-tumor necrosis factor therapy: Results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial evaluating primary efficacy and safety at twenty-four weeks
    • Cohen, S. B. et al. Rituximab for rheumatoid arthritis refractory to anti-tumor necrosis factor therapy: Results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial evaluating primary efficacy and safety at twenty-four weeks. Arthritis Rheum. 54, 2793-2806 (2006).
    • (2006) Arthritis Rheum , vol.54 , pp. 2793-2806
    • Cohen, S.B.1
  • 6
    • 24944498854 scopus 로고    scopus 로고
    • Abatacept for rheumatoid arthritis refractory to tumor necrosis factor α inhibition
    • Genovese, M. C. et al. Abatacept for rheumatoid arthritis refractory to tumor necrosis factor α inhibition. N. Engl. J. Med. 353, 1114-1123 (2005).
    • (2005) N. Engl. J. Med , vol.353 , pp. 1114-1123
    • Genovese, M.C.1
  • 7
    • 52149099504 scopus 로고    scopus 로고
    • IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: Results from a 24-week multicentre randomised placebo-controlled trial
    • Emery, P. et al. IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: results from a 24-week multicentre randomised placebo-controlled trial. Ann. Rheum. Dis. 67, 1516-1523 (2008).
    • (2008) Ann. Rheum. Dis , vol.67 , pp. 1516-1523
    • Emery, P.1
  • 8
    • 0347236888 scopus 로고    scopus 로고
    • Progression of radiologic damage in patients with rheumatoid arthritis in clinical remission
    • Molenaar, E. T. et al. Progression of radiologic damage in patients with rheumatoid arthritis in clinical remission. Arthritis Rheum. 50, 36-42 (2004).
    • (2004) Arthritis Rheum , vol.50 , pp. 36-42
    • Molenaar, E.T.1
  • 9
    • 0348109372 scopus 로고    scopus 로고
    • Adalimumab a fully human anti tumor necrosis factor-α monoclonal antibody and concomitant standard antirheumatic therapy for the treatment of rheumatoid arthritis: Results of STAR Safety Trial of Adalimumab in Rheumatoid Arthritis
    • Furst, D. E. et al. Adalimumab, a fully human anti tumor necrosis factor-α monoclonal antibody, and concomitant standard antirheumatic therapy for the treatment of rheumatoid arthritis: results of STAR (Safety Trial of Adalimumab in Rheumatoid Arthritis). J. Rheumatol. 30, 2563-71 (2003).
    • (2003) J. Rheumatol , vol.30 , pp. 2563-2571
    • Furst, D.E.1
  • 11
    • 84873736397 scopus 로고    scopus 로고
    • Effect of baseline rheumatoid factor and anti-citrullinated peptide antibody serotype on rituximab clinical response: A meta-Analysis
    • Isaacs, J. D. et al. Effect of baseline rheumatoid factor and anti-citrullinated peptide antibody serotype on rituximab clinical response: a meta-Analysis. Ann. Rheum. Dis. http://dx.doi.org/10.1136/annrheumdis-2011- 201117
    • Ann. Rheum. Dis
    • Isaacs, J.D.1
  • 12
    • 80755172249 scopus 로고    scopus 로고
    • Synovial tissue heterogeneity and peripheral blood biomarkers
    • Bugatti, S. A. et al. Synovial tissue heterogeneity and peripheral blood biomarkers. Curr. Rheumatol. Rep. 13, 440-448 (2011).
    • (2011) Curr. Rheumatol. Rep , vol.13 , pp. 440-448
    • Bugatti, S.A.1
  • 13
    • 80052307481 scopus 로고    scopus 로고
    • Synovial tissue analysis for the discovery of diagnostic and prognostic biomarkers in patients with early arthritis
    • de Hair, M. J. et al. Synovial tissue analysis for the discovery of diagnostic and prognostic biomarkers in patients with early arthritis. J. Rheumatol. 38, 2068-2072 (2011).
    • (2011) J. Rheumatol , vol.38 , pp. 2068-2072
    • De Hair, M.J.1
  • 14
    • 79951508967 scopus 로고    scopus 로고
    • Evaluating antirheumatic treatments using synovial biopsy: A recommendation for standardization to be used in clinical trials
    • van de Sande, M. G. et al. Evaluating antirheumatic treatments using synovial biopsy: a recommendation for standardization to be used in clinical trials. Ann. Rheum. Dis. 70, 423-427 (2011).
    • (2011) Ann. Rheum. Dis , vol.70 , pp. 423-427
    • Van De Sande, M.G.1
  • 15
    • 78149492075 scopus 로고    scopus 로고
    • State-of-The-Art: Rheumatoid arthritis
    • McInnes, I. B. &. O'Dell, J. R. State-of-the-Art: rheumatoid arthritis. Ann. Rheum. Dis. 69, 1898-1906 (2010).
    • (2010) Ann. Rheum. Dis , vol.69 , pp. 1898-1906
    • McInnes, I.B.1    O'Dell, J.R.2
  • 16
    • 79951521421 scopus 로고    scopus 로고
    • Progress and promise of genome-wide association studies for human complex trait genetics
    • Stranger, B. E., Stahl, E. A. & Raj, T. Progress and promise of genome-wide association studies for human complex trait genetics. Genetics 187, 367-383 (2011).
    • (2011) Genetics , vol.187 , pp. 367-383
    • Stranger, B.E.1    Stahl, E.A.2    Raj, T.3
  • 18
    • 77952888454 scopus 로고    scopus 로고
    • Genome-wide association study meta-Analysis identifies seven new rheumatoid arthritis risk loci
    • Stahl, E. A. et al. Genome-wide association study meta-Analysis identifies seven new rheumatoid arthritis risk loci. Nat. Gen. 42, 508-514 (2010).
    • (2010) Nat. Gen , vol.42 , pp. 508-514
    • Stahl, E.A.1
  • 19
    • 80455160171 scopus 로고    scopus 로고
    • Safety of biologic therapy in rheumatoid arthritis
    • Woodrick, R. S. & Ruderman, E. M. Safety of biologic therapy in rheumatoid arthritis. Nat. Rev. Rheumatol. 7, 639-652 (2011).
    • (2011) Nat. Rev. Rheumatol , vol.7 , pp. 639-652
    • Woodrick, R.S.1    Ruderman, E.M.2
  • 20
    • 0035932519 scopus 로고    scopus 로고
    • Cytokine pathways and joint inflammation in rheumatoid arthritis
    • Choy, E. H. & Panayi, G. S. Cytokine pathways and joint inflammation in rheumatoid arthritis. N. Engl. J. Med. 344, 907-916 (2001).
    • (2001) N. Engl. J. Med , vol.344 , pp. 907-916
    • Choy, E.H.1    Panayi, G.S.2
  • 21
    • 34249720998 scopus 로고    scopus 로고
    • Cytokines in the pathogenesis of rheumatoid arthritis
    • McInnes, I. B. & Schett, G. Cytokines in the pathogenesis of rheumatoid arthritis. Nat. Rev. Immunol. 7, 429-442 (2007).
    • (2007) Nat. Rev. Immunol , vol.7 , pp. 429-442
    • McInnes, I.B.1    Schett, G.2
  • 22
    • 77955096184 scopus 로고    scopus 로고
    • Therapeutic targets in rheumatoid arthritis: The interleukin-6 receptor
    • Dayer, J. M. & Choy, E. Therapeutic targets in rheumatoid arthritis: the interleukin-6 receptor. Rheumatology 49, 15-24 (2010).
    • (2010) Rheumatology , vol.49 , pp. 15-24
    • Dayer, J.M.1    Choy, E.2
  • 23
    • 30544445602 scopus 로고    scopus 로고
    • Cytokines sing the blues: Inflammation and the pathogenesis of depression
    • Raison, C. L., Capuron, L. & Miller, A. H. Cytokines sing the blues: inflammation and the pathogenesis of depression. Trends Immunol. 27, 24-31 (2006).
    • (2006) Trends Immunol , vol.27 , pp. 24-31
    • Raison, C.L.1    Capuron, L.2    Miller, A.H.3
  • 24
    • 0025922243 scopus 로고
    • Interleukin-1 immune activation pathways, and different mechanisms in osteoarthritis and rheumatoid arthritis
    • Kirkham, B. Interleukin-1, immune activation pathways, and different mechanisms in osteoarthritis and rheumatoid arthritis. Ann. Rheum. Dis. 50, 395-400 (1991).
    • (1991) Ann. Rheum. Dis , vol.50 , pp. 395-400
    • Kirkham, B.1
  • 25
    • 0031984275 scopus 로고    scopus 로고
    • Antagonism of the IL-6 cytokine subfamily-A potential strategy for more effective therapy in rheumatoid arthritis
    • Carroll, G., Bell, M., Wang, H., Chapman, H. & Mills, J. Antagonism of the IL-6 cytokine subfamily-A potential strategy for more effective therapy in rheumatoid arthritis. Inflamm. Res. 47, 1-7 (1998).
    • (1998) Inflamm. Res , vol.47 , pp. 1-7
    • Carroll, G.1    Bell, M.2    Wang, H.3    Chapman, H.4    Mills, J.5
  • 26
    • 77956994318 scopus 로고    scopus 로고
    • Mechanisms of inflammation in gout
    • Busso, N. & So, A. Mechanisms of inflammation in gout. Arthritis Res. Ther. 12, 206 (2010).
    • (2010) Arthritis Res. Ther , vol.12 , pp. 206
    • Busso, N.1    So, A.2
  • 27
    • 84855833408 scopus 로고    scopus 로고
    • Systematic review and meta-Analysis of the efficacy and safety of existing TNF blocking agents in treatment of rheumatoid arthritis
    • Aaltonen, K. J. et al. Systematic review and meta-Analysis of the efficacy and safety of existing TNF blocking agents in treatment of rheumatoid arthritis. PLoS ONE 7, e30275 (2012).
    • (2012) PLoS ONE , vol.7
    • Aaltonen, K.J.1
  • 28
    • 78650907772 scopus 로고    scopus 로고
    • Tocilizumab for rheumatoid arthritis: A Cochrane systematic review
    • Singh, J. A., Beg, S. & Lopez-Olivo, M. A. Tocilizumab for rheumatoid arthritis: a Cochrane systematic review. J. Rheumatol. 38, 10-20 (2011).
    • (2011) J. Rheumatol , vol.38 , pp. 10-20
    • Singh, J.A.1    Beg, S.2    Lopez-Olivo, M.A.3
  • 29
    • 0026602739 scopus 로고
    • TNF α-A pivotal role in rheumatoid arthritis? Br
    • Brennan, F. M., Maini, R. N. & Feldmann, M. TNF α-A pivotal role in rheumatoid arthritis? Br. J. Rheumatol. 31, 293-298 (1992).
    • (1992) J. Rheumatol , vol.31 , pp. 293-298
    • Brennan, F.M.1    Maini, R.N.2    Feldmann, M.3
  • 30
    • 40749152243 scopus 로고    scopus 로고
    • Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis: A randomised, double-blind, placebo-controlled, withdrawal phase III trial
    • Yokota, S. et al. Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled, withdrawal phase III trial. Lancet. 371, 998-1006 (2008).
    • (2008) Lancet , vol.371 , pp. 998-1006
    • Yokota, S.1
  • 31
    • 80053602333 scopus 로고    scopus 로고
    • The regulation of TNF signalling: What a tangled web we weave
    • Silke, J. The regulation of TNF signalling: what a tangled web we weave. Curr. Opin. Immunol. 23, 620-626 (2011).
    • (2011) Curr. Opin. Immunol , vol.23 , pp. 620-626
    • Silke, J.1
  • 32
    • 1542297244 scopus 로고    scopus 로고
    • IL-6 signal transduction and its physiological roles: The signal orchestration model
    • Kamimura, D., Ishihara, K. & Hirano, T. IL-6 signal transduction and its physiological roles: the signal orchestration model. Rev. Physiol. Biochem. Pharmacol. 149, 1-38 (2003).
    • (2003) Rev. Physiol. Biochem. Pharmacol , vol.149 , pp. 1-38
    • Kamimura, D.1    Ishihara, K.2    Hirano, T.3
  • 33
    • 59849091830 scopus 로고    scopus 로고
    • Therapeutic targeting of IL-6 trans signaling counteracts STAT3 control of experimental inflammatory arthritis
    • Nowell, M. A. et al. Therapeutic targeting of IL-6 trans signaling counteracts STAT3 control of experimental inflammatory arthritis. J. Immunol. 182, 613-622 (2009).
    • (2009) J. Immunol , vol.182 , pp. 613-622
    • Nowell, M.A.1
  • 34
    • 2642588293 scopus 로고    scopus 로고
    • Local activation of STAT-1 and STAT-3 in the inflamed synovium during zymosan-induced arthritis: Exacerbation of joint inflammation in STAT-1 gene-knockout mice
    • de Hooge, A. S. et al. Local activation of STAT-1 and STAT-3 in the inflamed synovium during zymosan-induced arthritis: exacerbation of joint inflammation in STAT-1 gene-knockout mice. Arthritis Rheum. 50, 2014-2023 (2004).
    • (2004) Arthritis Rheum , vol.50 , pp. 2014-2023
    • De Hooge, A.S.1
  • 35
    • 84856641109 scopus 로고    scopus 로고
    • NF-κB the first quarter-century remarkable progress and outstanding questions
    • Hayden, M. S. & Ghosh, S. NF-κB, the first quarter-century: remarkable progress and outstanding questions. Genes Dev. 26, 203-234 (2012).
    • (2012) Genes Dev , vol.26 , pp. 203-234
    • Hayden, M.S.1    Ghosh, S.2
  • 36
    • 78651481470 scopus 로고    scopus 로고
    • The functions of signal transducers and activators of transcriptions 1 and 3 as cytokine-inducible proteins
    • Cheon, H., Yang, J. & Stark, G. R. The functions of signal transducers and activators of transcriptions 1 and 3 as cytokine-inducible proteins. J. Interferon Cytokine Res. 31, 33-40 (2011).
    • (2011) J. Interferon Cytokine Res , vol.31 , pp. 33-40
    • Cheon, H.1    Yang, J.2    Stark, G.R.3
  • 37
    • 80052358980 scopus 로고    scopus 로고
    • Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling
    • Jones, S. A., Scheller, J. & Rose-John, S. Therapeutic strategies for the clinical blockade of IL-6/gp130 signaling. J. Clin. Invest. 121, 3375-3383 (2011).
    • (2011) J. Clin. Invest , vol.121 , pp. 3375-3383
    • Jones, S.A.1    Scheller, J.2    Rose-John, S.3
  • 38
    • 84874416884 scopus 로고    scopus 로고
    • Results from a 2-part, proof-of-concept, dose-ranging, randomized, double-blind, placebo-controlled, phase 2 study of sirukumab, a human anti-interleukin-6 monoclonal antibody, in active rheumatoid arthritis patients despite methotrexate therapy
    • Hsu, B., Sheng, S., Smolen, J. & Weinblatt, M. Results from a 2-part, proof-of-concept, dose-ranging, randomized, double-blind, placebo-controlled, phase 2 study of sirukumab, a human anti-interleukin-6 monoclonal antibody, in active rheumatoid arthritis patients despite methotrexate therapy. Arthritis Rheum. 63 (Suppl.), S1034 (2011).
    • (2011) Arthritis Rheum , vol.63 , Issue.SUPPL.
    • Hsu, B.1    Sheng, S.2    Smolen, J.3    Weinblatt, M.4
  • 39
    • 84857748790 scopus 로고    scopus 로고
    • Safety and pharmacokinetics of CDP6038, an anti-IL-6 monoclonal antibody, administered by subcutaneous injection and intravenous infusion to healthy male volunteers: A phase 1 study
    • Hickling, M. et al. Safety and pharmacokinetics of CDP6038, an anti-IL-6 monoclonal antibody, administered by subcutaneous injection and intravenous infusion to healthy male volunteers: a phase 1 study. Ann. Rheum. Dis. 70 (Suppl. 3), 471 (2011).
    • (2011) Ann. Rheum. Dis , vol.70 , Issue.SUPPL. 3 , pp. 471
    • Hickling, M.1
  • 40
    • 84862783578 scopus 로고    scopus 로고
    • A phase II, double-blind, randomised, placebo-controlled study of BMS945429 (ALD518) in patients with rheumatoid arthritis with an inadequate response to methotrexate
    • Mease, P. et al. A phase II, double-blind, randomised, placebo-controlled study of BMS945429 (ALD518) in patients with rheumatoid arthritis with an inadequate response to methotrexate. Ann. Rheum. Dis. 71, 1183-1189 (2012).
    • (2012) Ann. Rheum. Dis , vol.71 , pp. 1183-1189
    • Mease, P.1
  • 41
    • 78651411682 scopus 로고    scopus 로고
    • Safety and effects on markers of inflammation of subcutaneously administered regn88/sar153191 (regn88), an interleukin-6 receptor inhibitor, in patients with rheumatoid arthritis: Findings from phase 1 studies
    • Radin, A. et al. Safety and effects on markers of inflammation of subcutaneously administered regn88/sar153191 (regn88), an interleukin-6 receptor inhibitor, in patients with rheumatoid arthritis: findings from phase 1 studies. Ann. Rheum. Dis. 69 (Suppl. 3), 99 (2010).
    • (2010) Ann. Rheum. Dis , vol.69 , Issue.SUPPL. 3 , pp. 99
    • Radin, A.1
  • 42
    • 78149474747 scopus 로고    scopus 로고
    • Although IL-6 trans-signaling is sufficient to drive local immune responses, classical IL-6 signaling is obligate for the induction of T cell-mediated autoimmunity
    • Lissilaa, R. et al. Although IL-6 trans-signaling is sufficient to drive local immune responses, classical IL-6 signaling is obligate for the induction of T cell-mediated autoimmunity. J. Immunol. 185, 5512-5521 (2010).
    • (2010) J. Immunol , vol.185 , pp. 5512-5521
    • Lissilaa, R.1
  • 43
    • 33646469222 scopus 로고    scopus 로고
    • Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis
    • Richards, P. J. et al. Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis. Arthritis Rheum. 54, 1662-1672 (2006).
    • (2006) Arthritis Rheum , vol.54 , pp. 1662-1672
    • Richards, P.J.1
  • 44
    • 77958072084 scopus 로고    scopus 로고
    • Effects of AIN457, a fully human antibody to interleukin-17A, on psoriasis, rheumatoid arthritis, and uveitis
    • Hueber, W. et al. Effects of AIN457, a fully human antibody to interleukin-17A, on psoriasis, rheumatoid arthritis, and uveitis. Sci. Transl. Med. 2, 52-72 (2010).
    • (2010) Sci. Transl. Med , vol.2 , pp. 52-72
    • Hueber, W.1
  • 45
    • 84859017988 scopus 로고    scopus 로고
    • Brodalumab, an anti-interleukin-17-receptor antibody for psoriasis
    • Papp, K. A. et al. Brodalumab, an anti-interleukin-17-receptor antibody for psoriasis. N. Engl. J. Med. 366, 1181-1189 (2012).
    • (2012) N. Engl. J. Med , vol.366 , pp. 1181-1189
    • Papp, K.A.1
  • 46
    • 77951605086 scopus 로고    scopus 로고
    • Anti-p40 antibodies ustekinumab and briakinumab: Blockade of interleukin-12 and interleukin-23 in the treatment of psoriasis
    • Gandhi, M. et al. Anti-p40 antibodies ustekinumab and briakinumab: blockade of interleukin-12 and interleukin-23 in the treatment of psoriasis. Semin. Cutan. Med. Surg. 29, 48-52 (2010).
    • (2010) Semin. Cutan. Med. Surg , vol.29 , pp. 48-52
    • Gandhi, M.1
  • 47
    • 21844444831 scopus 로고    scopus 로고
    • New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions
    • Hunter, C. A. New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions. Nat. Rev. Immunol. 5, 521-531 (2005).
    • (2005) Nat. Rev. Immunol , vol.5 , pp. 521-531
    • Hunter, C.A.1
  • 48
    • 77954948735 scopus 로고    scopus 로고
    • Effector T cell plasticity: Flexibility in the face of changing circumstances
    • Murphy, K. M. & Stockinger, B. Effector T cell plasticity: flexibility in the face of changing circumstances. Nat Immunol. 11, 674-680 (2010).
    • (2010) Nat Immunol , vol.11 , pp. 674-680
    • Murphy, K.M.1    Stockinger, B.2
  • 49
    • 77953238901 scopus 로고    scopus 로고
    • Epigenetic instability of cytokine and transcription factor gene loci underlies plasticity of the T helper 17 cell lineage
    • Mukasa, A. et al. Epigenetic instability of cytokine and transcription factor gene loci underlies plasticity of the T helper 17 cell lineage. Immunity 32, 616-627 (2010).
    • (2010) Immunity , vol.32 , pp. 616-627
    • Mukasa, A.1
  • 50
    • 58149214356 scopus 로고    scopus 로고
    • Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells
    • Wei, G. et al. Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells. Immunity 30, 155-167 (2009).
    • (2009) Immunity , vol.30 , pp. 155-167
    • Wei, G.1
  • 51
    • 58149251898 scopus 로고    scopus 로고
    • Late developmental plasticity in the T helper 17 lineage
    • Lee, K. Y. et al. Late developmental plasticity in the T helper 17 lineage. Immunity 30, 92-107 (2009).
    • (2009) Immunity , vol.30 , pp. 92-107
    • Lee, K.Y.1
  • 52
    • 74549176150 scopus 로고    scopus 로고
    • CD4+ T cell plasticity-TH2 cells join the crowd
    • Zhu, J. & Paul, W. E. CD4+ T cell plasticity-TH2 cells join the crowd. Immunity 32, 11-13 (2010).
    • (2010) Immunity , vol.32 , pp. 11-13
    • Zhu, J.1    Paul, W.E.2
  • 53
    • 65549115862 scopus 로고    scopus 로고
    • Plasticity of CD4+ T cell lineage differentiation
    • Zhou, L. et al. Plasticity of CD4+ T cell lineage differentiation. Immunity 30, 646-655 (2009).
    • (2009) Immunity , vol.30 , pp. 646-655
    • Zhou, L.1
  • 54
    • 77949653393 scopus 로고    scopus 로고
    • Interleukin-23 is critical for full-blown expression of a non-Autoimmune destructive arthritis and regulates interleukin-17A and RORγt in γδ
    • Cornelissen, F. et al. Interleukin-23 is critical for full-blown expression of a non-Autoimmune destructive arthritis and regulates interleukin-17A and RORγt in γδ T cells. Arthritis Res. Ther. 11, R194 (2009).
    • (2009) T Cells. Arthritis Res. Ther , vol.11
    • Cornelissen, F.1
  • 55
    • 16544389341 scopus 로고    scopus 로고
    • The biology of CD20 and its potential as a target for mAb therapy
    • Cragg, M. S., Walshe, C. A., Ivanov, A. O. & Glennie, M. J. The biology of CD20 and its potential as a target for mAb therapy. Curr. Dir. Autoimmun. 8, 140-174 (2005).
    • (2005) Curr. Dir. Autoimmun , vol.8 , pp. 140-174
    • Cragg, M.S.1    Walshe, C.A.2    Ivanov, A.O.3    Glennie, M.J.4
  • 56
    • 16544374958 scopus 로고    scopus 로고
    • B lymphocyte depletion in rheumatoid arthritis: Targeting of CD20
    • Edwards, J. C., Leandro, M. J. & Cambridge, G. B lymphocyte depletion in rheumatoid arthritis: targeting of CD20. Curr. Dir. Autoimmun. 8, 175-192 (2005).
    • (2005) Curr. Dir. Autoimmun , vol.8 , pp. 175-192
    • Edwards, J.C.1    Leandro, M.J.2    Cambridge, G.3
  • 57
    • 33947102642 scopus 로고    scopus 로고
    • Early effects of rituximab on the synovial cell infiltrate in patients with rheumatoid arthritis
    • Vos, K. et al. Early effects of rituximab on the synovial cell infiltrate in patients with rheumatoid arthritis. Arthritis Rheum. 56, 772-778 (2007).
    • (2007) Arthritis Rheum , vol.56 , pp. 772-778
    • Vos, K.1
  • 58
    • 37149010203 scopus 로고    scopus 로고
    • Immunohistochemical analysis as a means to predict responsiveness to rituximab treatment
    • Teng, Y. K. et al. Immunohistochemical analysis as a means to predict responsiveness to rituximab treatment. Arthritis Rheum. 56, 3909-3918 (2007).
    • (2007) Arthritis Rheum , vol.56 , pp. 3909-3918
    • Teng, Y.K.1
  • 59
    • 77951714619 scopus 로고    scopus 로고
    • Management of nonresponse to rituximab in rheumatoid arthritis: Predictors and outcome of re-treatment
    • Vital, E. M. et al. Management of nonresponse to rituximab in rheumatoid arthritis: predictors and outcome of re-treatment. Arthritis Rheum. 62, 1273-1279 (2010).
    • (2010) Arthritis Rheum , vol.62 , pp. 1273-1279
    • Vital, E.M.1
  • 60
    • 76849086881 scopus 로고    scopus 로고
    • Targeting B cells in immune-mediated inflammatory disease: A comprehensive review of mechanisms of action and identification of biomarkers
    • Dorner, T., Kinnman, N. & Tak, P. P. Targeting B cells in immune-mediated inflammatory disease: a comprehensive review of mechanisms of action and identification of biomarkers. Pharmacol. Ther. 125, 464-475 (2010).
    • (2010) Pharmacol. Ther , vol.125 , pp. 464-475
    • Dorner, T.1    Kinnman, N.2    Tak, P.P.3
  • 61
    • 67650345281 scopus 로고    scopus 로고
    • Ocrelizumab: A step forward in the evolution of B-cell therapy
    • Kausar, F. et al. Ocrelizumab: a step forward in the evolution of B-cell therapy. Exp. Opin. Biol. Ther. 9, 889-895 (2009).
    • (2009) Exp. Opin. Biol. Ther , vol.9 , pp. 889-895
    • Kausar, F.1
  • 62
    • 77951829072 scopus 로고    scopus 로고
    • Veltuzumab (humanized anti-CD20 monoclonal antibody): Characterization, current clinical results, and future prospects
    • Goldenberg, D. M., Morschhauser, F. & Wegener, W. A. Veltuzumab (humanized anti-CD20 monoclonal antibody): characterization, current clinical results, and future prospects. Leuk. Lymphoma. 51, 747-755 (2010).
    • (2010) Leuk. Lymphoma , vol.51 , pp. 747-755
    • Goldenberg, D.M.1    Morschhauser, F.2    Wegener, W.A.3
  • 63
    • 84860390375 scopus 로고    scopus 로고
    • Ofatumumab, a fully human anti-CD20 monoclonal antibody, in biological-naive, rheumatoid arthritis patients with an inadequate response to methotrexate: A randomised, double-blind, placebo-controlled clinical trial
    • Taylor, P. C. et al. Ofatumumab, a fully human anti-CD20 monoclonal antibody, in biological-naive, rheumatoid arthritis patients with an inadequate response to methotrexate: a randomised, double-blind, placebo-controlled clinical trial. Ann. Rheum. Dis. 70, 2119-2125 (2011).
    • (2011) Ann. Rheum. Dis , vol.70 , pp. 2119-2125
    • Taylor, P.C.1
  • 64
    • 36448931656 scopus 로고    scopus 로고
    • Targeting CD22 as a strategy for treating systemic autoimmune diseases
    • Dorner, T. & Goldenberg, D. M. Targeting CD22 as a strategy for treating systemic autoimmune diseases. Ther. Clin. Risk Manage. 3, 953-959 (2007).
    • (2007) Ther. Clin. Risk Manage , vol.3 , pp. 953-959
    • Dorner, T.1    Goldenberg, D.M.2
  • 65
    • 38149114077 scopus 로고    scopus 로고
    • Atacicept in patients with rheumatoid arthritis: Results of a multicenter, phase Ib, double-blind, placebo-controlled, dose-escalating, single-And repeated-dose study
    • Tak, P. P. et al. Atacicept in patients with rheumatoid arthritis: results of a multicenter, phase Ib, double-blind, placebo-controlled, dose-escalating, single-And repeated-dose study. Arthritis Rheum. 58, 61-72 (2008).
    • (2008) Arthritis Rheum , vol.58 , pp. 61-72
    • Tak, P.P.1
  • 66
    • 38149065192 scopus 로고    scopus 로고
    • Updates from B cell trials: Efficacy
    • Cohen, S. B. Updates from B cell trials: efficacy. J. Rheumatol. 77 (Suppl.), 12-17 (2006).
    • (2006) J. Rheumatol , vol.77 , Issue.SUPPL. , pp. 12-17
    • Cohen, S.B.1
  • 67
    • 79959856423 scopus 로고    scopus 로고
    • Atacicept in patients with rheumatoid arthritis and an inadequate response to methotrexate: Results of a phase II, randomized, placebo-controlled trial
    • van Vollenhoven, R. F., Kinnman, N., Vincent, E., Wax, S. & Bathon, J. Atacicept in patients with rheumatoid arthritis and an inadequate response to methotrexate: results of a phase II, randomized, placebo-controlled trial. Arthritis Rheum. 63, 1782-1792 (2011).
    • (2011) Arthritis Rheum , vol.63 , pp. 1782-1792
    • Van Vollenhoven, R.F.1    Kinnman, N.2    Vincent, E.3    Wax, S.4    Bathon, J.5
  • 68
    • 79959832697 scopus 로고    scopus 로고
    • Atacicept in patients with rheumatoid arthritis and an inadequate response to tumor necrosis factor antagonist therapy: Results of a phase II, randomized, placebo-controlled, dose-finding trial
    • Genovese, M. C., Kinnman, N., de La Bourdonnaye, G., Pena Rossi, C. & Tak, P. P. Atacicept in patients with rheumatoid arthritis and an inadequate response to tumor necrosis factor antagonist therapy: results of a phase II, randomized, placebo-controlled, dose-finding trial. Arthritis Rheum. 63, 1793-1803 (2011).
    • (2011) Arthritis Rheum , vol.63 , pp. 1793-1803
    • Genovese, M.C.1    Kinnman, N.2    De La Bourdonnaye, G.3    Pena Rossi, C.4    Tak, P.P.5
  • 69
    • 53749087566 scopus 로고    scopus 로고
    • Immunology: Regulating suppression
    • Shevach, E. M. Immunology: regulating suppression. Science 322, 202-203 (2008).
    • (2008) Science , vol.322 , pp. 202-203
    • Shevach, E.M.1
  • 70
    • 0027427549 scopus 로고
    • T cell co-stimulation and in vivo tolerance
    • Lenschow, D. J. & Bluestone, J. A. T cell co-stimulation and in vivo tolerance. Curr. Opin. Immunol. 5, 747-752 (1993).
    • (1993) Curr. Opin. Immunol , vol.5 , pp. 747-752
    • Lenschow, D.J.1    Bluestone, J.A.2
  • 71
    • 67549119579 scopus 로고    scopus 로고
    • Mode of action of abatacept in rheumatoid arthritis patients having failed tumour necrosis factor blockade: A histological, gene expression and dynamic magnetic resonance imaging pilot study
    • Buch, M. H. et al. Mode of action of abatacept in rheumatoid arthritis patients having failed tumour necrosis factor blockade: a histological, gene expression and dynamic magnetic resonance imaging pilot study. Ann. Rheum. Dis. 68, 1220-1227 (2009).
    • (2009) Ann. Rheum. Dis , vol.68 , pp. 1220-1227
    • Buch, M.H.1
  • 72
    • 75349112514 scopus 로고    scopus 로고
    • CTLA4-Ig modifies dendritic cells from mice with collagen-induced arthritis to increase the CD4+CD25+Foxp3+ regulatory T cell population
    • Ko, H. J. et al. CTLA4-Ig modifies dendritic cells from mice with collagen-induced arthritis to increase the CD4+CD25+Foxp3+ regulatory T cell population. J. Autoimmun. 34, 111-120 (2010).
    • (2010) J. Autoimmun , vol.34 , pp. 111-120
    • Ko, H.J.1
  • 73
    • 67651159215 scopus 로고    scopus 로고
    • Selective modulation of T-cell co-stimulation: A novel mode of action for the treatment of rheumatoid arthritis
    • Choy, E. H. Selective modulation of T-cell co-stimulation: a novel mode of action for the treatment of rheumatoid arthritis. Clin. Exp. Rheumatol. 27, 510-518 (2009).
    • (2009) Clin. Exp. Rheumatol , vol.27 , pp. 510-518
    • Choy, E.H.1
  • 74
    • 33750343810 scopus 로고    scopus 로고
    • CTLA-4IG suppresses reactive oxygen species by preventing synovial adherent cell-induced inactivation of Rap1, a Ras family GTPASE mediator of oxidative stress in rheumatoid arthritis T cells
    • Remans, P. H. et al. CTLA-4IG suppresses reactive oxygen species by preventing synovial adherent cell-induced inactivation of Rap1, a Ras family GTPASE mediator of oxidative stress in rheumatoid arthritis T cells. Arthritis Rheum. 54, 3135-3143 (2006).
    • (2006) Arthritis Rheum , vol.54 , pp. 3135-3143
    • Remans, P.H.1
  • 75
    • 80555126845 scopus 로고    scopus 로고
    • CTLA-4-Ig therapy diminishes the frequency but enhances the function of TREG cells in patients with rheumatoid arthritis
    • Alvarez-Quiroga, C. et al. CTLA-4-Ig therapy diminishes the frequency but enhances the function of TREG cells in patients with rheumatoid arthritis. J. Clin. Immunol. 31, 588-595 (2011).
    • (2011) J. Clin. Immunol , vol.31 , pp. 588-595
    • Alvarez-Quiroga, C.1
  • 76
    • 77956410939 scopus 로고    scopus 로고
    • Abatacept limits breach of self-tolerance in a murine model of arthritis via effects on the generation of T follicular helper cells
    • Platt, A. M. et al. Abatacept limits breach of self-tolerance in a murine model of arthritis via effects on the generation of T follicular helper cells. J. Immunol. 185, 1558-1567 (2010).
    • (2010) J. Immunol , vol.185 , pp. 1558-1567
    • Platt, A.M.1
  • 77
    • 0036796835 scopus 로고    scopus 로고
    • Repeat-cycle study of high-dose intravenous 4162W94 anti-CD4 humanized monoclonal antibody in rheumatoid arthritis. A randomized placebo-controlled trial
    • Choy, E. H. et al. Repeat-cycle study of high-dose intravenous 4162W94 anti-CD4 humanized monoclonal antibody in rheumatoid arthritis. A randomized placebo-controlled trial. Rheumatology (Oxford) 41, 1142-1148 (2002).
    • (2002) Rheumatology (Oxford) , vol.41 , pp. 1142-1148
    • Choy, E.H.1
  • 78
    • 0031862925 scopus 로고    scopus 로고
    • Clinical and immunologic effects of a PRIMATIZED anti-CD4 monoclonal antibody in active rheumatoid arthritis: Results of a phase I, single dose, dose escalating trial
    • Yocum, D. E. et al. Clinical and immunologic effects of a PRIMATIZED anti-CD4 monoclonal antibody in active rheumatoid arthritis: results of a phase I, single dose, dose escalating trial. J. Rheumatol. 25, 1257-1262 (1998).
    • (1998) J. Rheumatol , vol.25 , pp. 1257-1262
    • Yocum, D.E.1
  • 79
    • 53049090681 scopus 로고    scopus 로고
    • Therapeutic T-cell manipulation in rheumatoid arthritis: Past, present and future
    • Isaacs, J. D. Therapeutic T-cell manipulation in rheumatoid arthritis: past, present and future. Rheumatology 47, 1461-1468 (2008).
    • (2008) Rheumatology , vol.47 , pp. 1461-1468
    • Isaacs, J.D.1
  • 80
    • 18144428686 scopus 로고    scopus 로고
    • New strategies for immunosuppression: Interfering with cytokines by targeting the Jak/Stat pathway
    • O'Shea, J. J., Park, H., Pesu, M., Borie, D. & Changelian, P. New strategies for immunosuppression: interfering with cytokines by targeting the Jak/Stat pathway. Curr. Opin. Rheumatol. 17, 305-311 (2005).
    • (2005) Curr. Opin. Rheumatol , vol.17 , pp. 305-311
    • O'Shea, J.J.1    Park, H.2    Pesu, M.3    Borie, D.4    Changelian, P.5
  • 81
    • 61849086101 scopus 로고    scopus 로고
    • Janus kinases in immune cell signaling
    • Ghoreschi, K., Laurence, A. & O'Shea, J. J. Janus kinases in immune cell signaling. Immunol. Rev. 228, 273-287 (2009).
    • (2009) Immunol. Rev , vol.228 , pp. 273-287
    • Ghoreschi, K.1    Laurence, A.2    O'Shea, J.J.3
  • 82
    • 67549133157 scopus 로고    scopus 로고
    • Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut
    • Jiang, H. et al. Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut. Cell 137, 1343-1355 (2009).
    • (2009) Cell , vol.137 , pp. 1343-1355
    • Jiang, H.1
  • 83
    • 84859265385 scopus 로고    scopus 로고
    • Novel small-molecular therapeutics for rheumatoid arthritis
    • Fleischmann, R. Novel small-molecular therapeutics for rheumatoid arthritis. Curr. Opin. Rheumatol. 24, 335-341 (2012).
    • (2012) Curr. Opin. Rheumatol , vol.24 , pp. 335-341
    • Fleischmann, R.1
  • 84
    • 41549107522 scopus 로고    scopus 로고
    • Cytokine signaling modules in inflammatory responses
    • O'Shea, J. J. & Murray, P. J. Cytokine signaling modules in inflammatory responses. Immunity. 28, 477-487 (2008).
    • (2008) Immunity , vol.28 , pp. 477-487
    • O'Shea, J.J.1    Murray, P.J.2
  • 85
    • 84873707288 scopus 로고    scopus 로고
    • Tofacitinib (CP-690, 550) in combination with methotrexate in patients with active rheumatoid arthritis with an inadequate response to tumour necrosis factor inhibitors: A randomised phase 3 trial
    • Burmester, G. R. et al. Tofacitinib (CP-690,550) in combination with methotrexate in patients with active rheumatoid arthritis with an inadequate response to tumour necrosis factor inhibitors: a randomised phase 3 trial. Lancet http://dx.doi.org/10.1016/S0140-6736(12)61424-X.
    • Lancet
    • Burmester, G.R.1
  • 86
    • 84856628204 scopus 로고    scopus 로고
    • Low dose CP-690 550 (tofacitinib), a pan-JAK inhibitor, accelerates the onset of experimental autoimmune encephalomyelitis by potentiating TH17 differentiation
    • Yoshida, H. et al. Low dose CP-690, 550 (tofacitinib), a pan-JAK inhibitor, accelerates the onset of experimental autoimmune encephalomyelitis by potentiating TH17 differentiation. Biochem. Biophys. Res. Commun. 418, 234-240 (2012).
    • (2012) Biochem. Biophys. Res. Commun , vol.418 , pp. 234-240
    • Yoshida, H.1
  • 87
    • 28244470734 scopus 로고    scopus 로고
    • Remission in rheumatoid arthritis: Wishful thinking or clinical reality? Semin
    • Sesin, C. A. & Bingham, C. O. 3rd. Remission in rheumatoid arthritis: wishful thinking or clinical reality? Semin. Arthritis Rheum. 35, 185-196 (2005).
    • (2005) Arthritis Rheum , vol.35 , pp. 185-196
    • Sesin, C.A.1    Bingham III, C.O.2
  • 88
    • 77955293575 scopus 로고    scopus 로고
    • Predictors for remission in rheumatoid arthritis patients: A systematic review
    • Katchamart, W. Predictors for remission in rheumatoid arthritis patients: a systematic review. Arthritis Care Res. 62, 1128-1143 (2010).
    • (2010) Arthritis Care Res , vol.62 , pp. 1128-1143
    • Katchamart, W.1
  • 89
    • 2342551979 scopus 로고    scopus 로고
    • Combination therapy with etanercept and anakinra in the treatment of patients with rheumatoid arthritis who have been treated unsuccessfully with methotrexate
    • Genovese, M. C. et al. Combination therapy with etanercept and anakinra in the treatment of patients with rheumatoid arthritis who have been treated unsuccessfully with methotrexate. Arthritis Rheum. 50, 1412-1419 (2004).
    • (2004) Arthritis Rheum , vol.50 , pp. 1412-1419
    • Genovese, M.C.1
  • 90
    • 33846853779 scopus 로고    scopus 로고
    • Selective costimulation modulation using abatacept in patients with active rheumatoid arthritis while receiving etanercept: A randomised clinical trial
    • Weinblatt, M. et al. Selective costimulation modulation using abatacept in patients with active rheumatoid arthritis while receiving etanercept: a randomised clinical trial. Ann. Rheum. Dis. 66, 228-234 (2007).
    • (2007) Ann. Rheum. Dis , vol.66 , pp. 228-234
    • Weinblatt, M.1
  • 91
    • 84869051805 scopus 로고    scopus 로고
    • Long term amelioration of established collagen-induced arthritis achieved with short term therapy combining anti-CD3 and anti-TNF treatments
    • Dépis, F. et al. Long term amelioration of established collagen-induced arthritis achieved with short term therapy combining anti-CD3 and anti-TNF treatments. Arthritis Rheum. 64, 3189-3198 (2012).
    • (2012) Arthritis Rheum , vol.64 , pp. 3189-3198
    • Dépis, F.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.