The autoimmune-associated genetic variant PTPN22 R620W enhances neutrophil activation and function in patients with rheumatoid arthritis and healthy individuals

Annals of the Rheumatic Diseases

Volumn 74, Issue 8, 2015, Pages 1588-1595

  Bayley, Rachel ^a   Kite, Kerry A ^a   McGettrick, Helen M ^a   Smith, Jacqueline P ^b   Kitas, George D ^b   Buckley, Christopher D ^a   Young, Stephen P ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b RUSSELLS HALL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; CALCIUM ION; DISEASE MODIFYING ANTIRHEUMATIC DRUG; METHOTREXATE; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 22; NONSTEROID ANTIINFLAMMATORY AGENT; REACTIVE OXYGEN METABOLITE; STEROID; TRYPTOPHAN; TUMOR NECROSIS FACTOR ALPHA; PTPN22 PROTEIN, HUMAN;

ADULT; ARTICLE; AUTOIMMUNITY; CALCIUM SIGNALING; CALCIUM TRANSPORT; CELL ADHESION; COHORT ANALYSIS; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENETIC VARIABILITY; GENOTYPE; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; HUMAN CELL; LEUKOCYTE ACTIVATION; MAJOR CLINICAL STUDY; MALE; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; PRIORITY JOURNAL; PTPN22 GENE; RHEUMATOID ARTHRITIS; CELL MOTION; GENETIC VARIATION; GENETICS; IMMUNOLOGY; METABOLISM; MIDDLE AGED; PHYSIOLOGY; SIGNAL TRANSDUCTION; YOUNG ADULT;

ADULT; ARTHRITIS, RHEUMATOID; CELL ADHESION; CELL MOVEMENT; FEMALE; GENETIC VARIATION; GENOTYPE; HUMANS; MALE; MIDDLE AGED; NEUTROPHILS; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 22; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; YOUNG ADULT;

EID: 84940367331     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/annrheumdis-2013-204796     Document Type: Article

References (45)

1. Eyre S, Bowes J, Diogo D, et al. High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. Nat Genet 2012;44:1336-40.
2. Burn GL, Svensson L, Sanchez-Blanco C, et al. Why is PTPN22 a good candidate susceptibility gene for autoimmune disease FEBS Lett 2011;585:3689-98.
3. Vang T, Congia M, Macis MD, et al. Autoimmune-Associated lymphoid tyrosine phosphatase is a gain-of-function variant. Nat Genet 2005;37:1317-19.
4. Aarnisalo J, Treszl A, Svec P, et al. Reduced CD4+T cell activation in children with type diabetes carrying the PTPN22/Lyp 620Trp variant. J Autoimmun 2008;31:13-21.
5. Rieck M, Arechiga A, Onengut-Gumuscu S, et al. Genetic variation in PTPN22 corresponds to altered function of T and B lymphocytes. J Immunol 2007;179:4704-10.
6. Dai X, James RG, Habib T, et al. A disease-Associated PTPN22 variant promotes systemic autoimmunity in murine models. J Clin Invest 2013;123:2024-36.
7. Habib T, Funk A, Rieck M, et al. Altered B cell homeostasis is associated with type I diabetes and carriers of the PTPN22 Allelic variant. J Immunol 2012;188:487-96.
8. Maine CJ, Hamilton-Williams EE, Cheung J, et al. PTPN22 Alters the development of regulatory T cells in the Thymus. J Immunol 2012;188:5267-75.
9. Brownlie RJ, Miosge LA, Vassilakos D, et al. Lack of the Phosphatase PTPN22 increases Adhesion of murine regulatory T cells to improve their immunosuppressive function. Sci Signal 2012;5:ra87.
10. Hermiston ML, Zikherman J, Zhu JW. CD45, CD148, and Lyp/Pep: critical phosphatases regulating Src family kinase signaling networks in immune cells. Immunol Rev 2009;228:288-311.
11. Chien W, Tidow N, Williamson EA, et al. Characterization of a myeloid tyrosine phosphatase, Lyp, and its role in the Bcr-Abl signal transduction pathway. J Biol Chem 2003;278:27413-20.
12. Lloyds D, Davies EV, Williams BD, et al. Tyrosine phosphorylation in neutrophils from synovial fluid of patients with rheumatoid arthritis. Br J Rheumatol 1996;35:846-52.
13. Wright HL, Moots RJ, Bucknall RC, et al. Neutrophil function in inflammation and inflammatory diseases. Rheumatology 2010;49:1618-31.
14. Davies EV, Williams BD, Whiston RJ, et al. Altered Ca2+ signalling in human neutrophils from inflammatory sites. Ann Rheum Dis 1994;53:446-9.
15. Weissmann G, Korchak H. Rheumatoid arthritis. The role of neutrophil activation. Inflammation 1984;8(Suppl):S3-14.
16. Wipke BT, Allen PM. Essential role of neutrophils in the initiation and progression of a murine model of rheumatoid arthritis. J Immunol 2001;167:1601-8.
17. Lunec J, Blake DR, McCleary SJ, et al. Self-perpetuating mechanisms of immunoglobulin G aggregation in rheumatoid inflammation. J Clin Invest 1985;76:2084-90.
18. Wade CR, Jackson PG, Highton J, et al. Lipid peroxidation and malondialdehyde in the synovial fluid and plasma of patients with rheumatoid arthritis. Clin Chim Acta 1987;164:245-50.
19. Panoulas VF, Douglas KM, Smith JP, et al. Polymorphisms of the endothelin-1 gene associate with hypertension in patients with rheumatoid arthritis. Endothelium 2008;15:203-12.
20. Toms TE, Panoulas VF, Smith JP, et al. Rheumatoid arthritis susceptibility genes associate with lipid levels in patients with rheumatoid arthritis. Ann Rheum Dis 2011;70:1025-32.
21. McGettrick HM, Hunter K, Moss PA, et al. Direct observations of the kinetics of migrating T cells suggest active retention by endothelial cells with continual bidirectional migration. J Leukocyte Biol 2009;85:98-107.
22. McGettrick HM, Butler LM, Nash GB. Analysis of leukocyte migration through monolayers of cultured endothelial cells. Methods Mol Biol 2007;370:37-54.
23. Andersson T, Dahlgren C, Pozzan T, et al. Characterization of fMet-Leu-Phe receptor-mediated Ca2+ influx across the plasma membrane of human neutrophils. Mol Pharmacol 1986;30:437-43.
24. Brown-Galatola CH, Hall ND. Impaired suppressor cell activity due to surface sulphydryl oxidation in rheumatoid arthritis. Br J Rheumatol 1992;31:599-603.
25. Okada Y, Wu D, Trynka G, et al. Genetics of rheumatoid arthritis contributes to biology and drug discovery. Nature 2014;506:376-81; advance online publication.
26. Moriarty SE, Shah JH, Lynn M, et al. Oxidation of glutathione and cysteine in human plasma associated with smoking. Free Radic Biol Med 2003;35:1582-8.
27. Bayley R, Yang P, Buckley CD, et al. Measuring the specific activity of the protein tyrosine phosphatase Lyp. J Immunol Methods 2013;388:33-9.
28. Rider DA, Sinclair AJ, Young SP. Oxidative inactivation of CD45 protein tyrosine phosphatase may contribute to T lymphocyte dysfunction in the elderly. Mech Ageing Dev 2003;124:191-8.
29. Liu L, Wang YX, Zhou J, et al. Rapid non-genomic inhibitory effects of glucocorticoids on human neutrophil degranulation. Inflammation Res 2005;54:37-41.
30. Neal TM, Vissers MCM, Winterbourn CC. Inhibition by nonsteroidal antiinflammatory drugs of superoxide production and granule enzyme-release by Polymorphonuclear leukocytes stimulated with immune-complexes or Formyl-Methionyl-Leucyl-Phenylalanine. Biochem Pharmacol 1987;36:2511-17.
31. Laurindo IMM, Mello SBV, Cossermelli W. Influence of low-Doses of Methotrexate on Superoxide Anion Production by Polymorphonuclear Leukocytes from Patients with Rheumatoid-Arthritis. J Rheumatol 1995;22:633-8.
32. Hoffmeyer F, Witte K, Gebhardt U, et al. The low affinity Fc gamma RIIa and Fc gamma RIIIb on polymorphonuclear neutrophils are differentially regulated by CD45 phosphatase. J Immunol 1995;155:4016-23.
33. Zhu JW, Doan K, Park J, et al. Receptor-like tyrosine phosphatases CD45 and CD148 have distinct functions in chemoattractant-mediated neutrophil migration and response to S. aureus. Immunity 2011;35:757-69.
34. Reumaux D, Hordijk PL, Duthilleul P, et al. Priming by tumor necrosis factor-Alpha of human neutrophil NADPH-oxidase activity induced by anti-proteinase-3 or anti-myeloperoxidase antibodies. J Leukocyte Biol 2006;80:1424-33.
35. Sheppard FR, Kelher MR, Moore EE, et al. Structural organization of the neutrophil NADPH oxidase: phosphorylation and translocation during priming and activation. J Leukocyte Biol 2005;78:1025-42.
36. El Benna J, Hayem G, Dang PM, et al. NADPH oxidase priming and p47phox phosphorylation in neutrophils from synovial fluid of patients with rheumatoid arthritis and spondylarthropathy. Inflammation 2002;26:273-8.
37. Dang PM, Dewas C, Gaudry M, et al. Priming of human neutrophil respiratory burst by granulocyte/macrophage colony-stimulating factor (GM-CSF) involves partial phosphorylation of p47( phox). J Biol Chem 1999;274:20704-8.
38. Babior BM. NADPH oxidase: an update. Blood 1999;93:1464-76.
39. Chowdhury AK, Watkins T, Parinandi NL, et al. Src-mediated tyrosine phosphorylation of p47phox in hyperoxia-induced activation of NADPH oxidase and generation of reactive oxygen species in lung endothelial cells. J Biol Chem 2005;280:20700-11.
40. Moores SL, Selfors LM, Fredericks J, et al. Vav family proteins couple to diverse cell surface receptors. Mol Cell Biol 2000;20:6364-73.
41. Wu J, Katrekar A, Honigberg LA, et al. Identification of substrates of human protein-tyrosine phosphatase PTPN22. J Biol Chem 2006;281: 11002-10.
42. Gakidis MA, Cullere X, Olson T, et al. Vav GEFs are required for beta2 integrin-dependent functions of neutrophils. J Cell Biol 2004;166:273-82.
43. Jakus Z, Simon E, Frommhold D, et al. Critical role of phospholipase Cgamma2 in integrin and Fc receptor-mediated neutrophil functions and the effector phase of autoimmune arthritis. J Exp Med 2009;206:577-93.
44. Yang L, Froio RM, Sciuto TE, et al. ICAM-1 regulates neutrophil adhesion and transcellular migration of TNF-Alpha-Activated vascular endothelium under flow. Blood 2005;106:584-92.
45. Ley K, Laudanna C, Cybulsky MI, et al. Getting to the site of inflammation: the leukocyte adhesion cascade updated. Nature Reviews Immunology 2007;7:678-89.