Mammalian target of rapamycin complex 2 (mTORC2) negatively regulates toll-like receptor 4-mediated inflammatory response via FoxO1

Journal of Biological Chemistry

Volumn 286, Issue 52, 2011, Pages 44295-44305

  Brown, Jonathan ^a   Wang, Huizhi ^a,b   Suttles, Jill ^a,d   Graves, Dana T ^c   Martin, Michael ^a,b  

^a University of Louisville School of Medicine   (United States)

^b UNIVERSITY OF LOUISVILLE SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; CELL SIGNALING; CHEMICAL ACTIVATION; MAMMALS; PHOSPHORYLATION;

AKT PHOSPHORYLATION; CYTOKINE EXPRESSION; DOWNSTREAM COMPONENTS; INFLAMMATORY RESPONSE; MAMMALIAN TARGET; MOUSE EMBRYONIC FIBROBLASTS; SIGNALING PATHWAYS; TOLL-LIKE RECEPTORS;

CELLS;

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; PROTEIN KINASE B; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR FKHR; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOPLASM; DENDRITIC CELL; FEMALE; IMMUNE RESPONSE; IMMUNOREGULATION; INFLAMMATION; INNATE IMMUNITY; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING;

EID: 84455161606     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.258053     Document Type: Article

References (39)

1. Cantley, L. C. (2002) Science 296, 1655-1657
2. Alessi, D. R., James, S. R., Downes, C. P., Holmes, A. B., Gaffney, P. R., Reese, C. B., and Cohen, P. (1997) Curr. Biol. 7, 261-269
3. Stephens, L., Anderson, K., Stokoe, D., Erdjument-Bromage, H., Painter, G. F., Holmes, A. B., Gaffney, P. R., Reese, C. B., McCormick, F., Tempst, P., Coadwell, J., and Hawkins, P. T. (1998) Science 279, 710-714
4. Persad, S., Attwell, S., Gray, V., Mawji, N., Deng, J. T., Leung, D., Yan, J., Sanghera, J., Walsh, M. P., and Dedhar, S. (2001) J. Biol. Chem. 276, 27462-27469
5. Feng, J., Park, J., Cron, P., Hess, D., and Hemmings, B. A. (2004) J. Biol. Chem. 279, 41189-41196
6. Kawakami, Y., Nishimoto, H., Kitaura, J., Maeda-Yamamoto, M., Kato, R. M., Littman, D. R., Leitges, M., Rawlings, D. J., and Kawakami, T. (2004) J. Biol. Chem. 279, 47720-47725
7. Hresko, R. C., and Mueckler, M. (2005) J. Biol. Chem. 280, 40406-40416
8. Sarbassov, D. D., Guertin, D. A., Ali, S. M., and Sabatini, D. M. (2005) Science 307, 1098-1101
9. Guertin, D. A., Stevens, D. M., Thoreen, C. C., Burds, A. A., Kalaany, N. Y., Moffat, J., Brown, M., Fitzgerald, K. J., and Sabatini, D. M. (2006) Dev. Cell 11, 859-871
10. Guertin, D. A., and Sabatini, D. M. (2005) Trends Mol. Med. 11, 353-361
11. Peterson, T. R., Laplante, M., Thoreen, C. C., Sancak, Y., Kang, S. A., Kuehl, W. M., Gray, N. S., and Sabatini, D. M. (2009) Cell 137, 873-886
12. Kim, D. H., Sarbassov, D. D., Ali, S. M., King, J. E., Latek, R. R., Erdjument-Bromage, H., Tempst, P., and Sabatini, D. M. (2002) Cell 110, 163-175
13. Hara, K., Maruki, Y., Long, X., Yoshino, K., Oshiro, N., Hidayat, S., Tokunaga, C., Avruch, J., and Yonezawa, K. (2002) Cell 110, 177-189
14. Sabatini, D. M., Erdjument-Bromage, H., Lui, M., Tempst, P., and Snyder, S. H. (1994) Cell 78, 35-43
15. Weichhart, T., Costantino, G., Poglitsch, M., Rosner, M., Zeyda, M., Stuhlmeier, K. M., Kolbe, T., Stulnig, T. M., Hörl, W. H., Hengstschläger, M., Müller, M., and Säemann, M. D. (2008) Immunity 29, 565-577
16. Ohtani, M., Nagai, S., Kondo, S., Mizuno, S., Nakamura, K., Tanabe, M., Takeuchi, T., Matsuda, S., and Koyasu, S. (2008) Blood 112, 635-643
17. Jacinto, E., Loewith, R., Schmidt, A., Lin, S., Rüegg, M. A., Hall, A., and Hall, M. N. (2004) Nat. Cell Biol. 6, 1122-1128
18. Sarbassov, D. D., Ali, S. M., Kim, D. H., Guertin, D. A., Latek, R. R., Erdjument-Bromage, H., Tempst, P., and Sabatini, D. M. (2004) Curr. Biol. 14, 1296-1302
19. Martin, M., Schifferle, R. E., Cuesta, N., Vogel, S. N., Katz, J., and Michalek, S. M. (2003) J. Immunol. 171, 717-725
20. Fukao, T., Tanabe, M., Terauchi, Y., Ota, T., Matsuda, S., Asano, T., Kadowaki, T., Takeuchi, T., and Koyasu, S. (2002) Nat. Immunol. 3, 875- 881
21. Guha, M., and Mackman, N. (2002) J. Biol. Chem. 277, 32124-32132
22. Arbibe, L., Mira, J. P., Teusch, N., Kline, L., Guha, M., Mackman, N., Godowski, P. J., Ulevitch, R. J., and Knaus, U. G. (2000) Nat. Immunol. 1, 533-540
23. Androulidaki, A., Iliopoulos, D., Arranz, A., Doxaki, C., Schworer, S., Zacharioudaki, V., Margioris, A. N., Tsichlis, P. N., and Tsatsanis, C. (2009) Immunity 31, 220-231
24. Turnquist, H. R., Cardinal, J., Macedo, C., Rosborough, B. R., Sumpter, T. L., Geller, D. A., Metes, D., and Thomson, A. W. (2010) Blood 115, 4758-4769
25. Su, D., Coudriet, G. M., Hyun Kim, D., Lu, Y., Perdomo, G., Qu, S., Slusher, S., Tse, H. M., Piganelli, J., Giannoukakis, N., Zhang, J., and Dong, H. H. (2009) Diabetes 58, 2624-2633
26. Tang, E. D., Nuñez, G., Barr, F. G., and Guan, K. L. (1999) J. Biol. Chem. 274, 16741-16746
27. Shiota, C., Woo, J. T., Lindner, J., Shelton, K. D., and Magnuson, M. A. (2006) Dev. Cell 11, 583-589
28. Martin, M., Rehani, K., Jope, R. S., and Michalek, S. M. (2005) Nat. Immunol. 6, 777-784
29. Lee, K., Gudapati, P., Dragovic, S., Spencer, C., Joyce, S., Killeen, N., Magnuson, M. A., and Boothby, M. (2010) Immunity 32, 743-753
30. García-Martínez, J. M., and Alessi, D. R. (2008) Biochem. J. 416, 375-385
31. Van Der Heide, L. P., Hoekman, M. F., and Smidt, M. P. (2004) Biochem. J. 380, 297-309
32. Rena, G., Prescott, A. R., Guo, S., Cohen, P., and Unterman, T. G. (2001) Biochem. J. 354, 605-612
33. Fukao, T., Yamada, T., Tanabe, M., Terauchi, Y., Ota, T., Takayama, T., Asano, T., Takeuchi, T., Kadowaki, T., Hata, J. J., and Koyasu, S. (2002) Nat. Immunol. 3, 295-304
34. Schabbauer, G., Tencati, M., Pedersen, B., Pawlinski, R., and Mackman, N. (2004) Arterioscler. Thromb. Vasc. Biol. 24, 1963-1969
35. Hedrick, S. M. (2009) Nat. Immunol. 10, 1057-1063
36. Behl, Y., Krothapalli, P., Desta, T., Roy, S., and Graves, D. T. (2009) Diabetes 58, 917-925
37. Siqueira, M. F., Li, J., Chehab, L., Desta, T., Chino, T., Krothpali, N., Behl, Y., Alikhani, M., Yang, J., Braasch, C., and Graves, D. T. (2010) Diabetologia 53, 378-388
38. Kortylewski, M., Feld, F., Krüger, K. D., Bahrenberg, G., Roth, R. A., Joost, H. G., Heinrich, P. C., Behrmann, I., and Barthel, A. (2003) J. Biol. Chem. 278, 5242-5249
39. Fan, W., Morinaga, H., Kim, J. J., Bae, E., Spann, N. J., Heinz, S., Glass, C. K., and Olefsky, J. M. (2010) EMBO J. 29, 4223-4236