Contribution of BCAP to maintenance of mature B cells through c-Rel

Nature Immunology

Volumn 4, Issue 8, 2003, Pages 780-786

  Yamazaki, Tetsuo ^a   Kurosaki, Tomohiro ^a,b  

^a KANSAI MEDICAL UNIVERSITY   (Japan)

^b RIKEN   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; B LYMPHOCYTE RECEPTOR; IMMUNOGLOBULIN D; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN M; PHOSPHATIDYLINOSITOL 3 KINASE;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CELL DIVISION; CELL MATURATION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; GENE TARGETING; LYMPHOCYTE COUNT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; RETROVIRUS; SPLEEN CELL;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; B-LYMPHOCYTES; CARRIER PROTEINS; MICE; NF-KAPPA B; PROTO-ONCOGENE PROTEINS C-REL;

EID: 0041695162     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/ni949     Document Type: Article

References (50)

1. Karin, M. & Lin, A. NF-κB at the crossroads of life and death. Nat. Immunol. 3, 221-227 (2002).
2. Barkett, M. & Gilmore, T.D. Control of apoptosis by Rel/NF-κB transcription factors. Oncogene 18, 6910-6924 (1999).
3. Ghosh, S., May, M.J. & Kopp, E.B. NF-κB and Rel proteins: evolutionarily conserved mediators of immune responses. Annu. Rev. Immunol. 16, 225-260 (1998).
4. Ghosh, S. & Karin, M. Missing pieces in the NF-κB puzzle. Cell 109, S81-96 (2002).
5. Li, Q. & Verma, I.M. NF-κB regulation in the immune system. Nat. Rev. Immunol. 2, 725-734 (2002).
6. Baldwin, A.S., Jr. The NF-κB and IκB proteins: new discoveries and insights. Annu. Rev. Immunol. 14, 649-683 (1996).
7. Silverman, N. & Maniatis, T. NF-κB signaling pathways in mammalian and insect innate immunity. Genes Dev. 15, 2321-2342 (2001).
8. Gugasyan, R. et al. Rel/NF-κB transcription factors: key mediators of B-cell activation. Immunol. Rev. 176, 134-140 (2000).
9. Gerondakis, S., Grumont, R., Rourke, I. & Grossmann, M. The regulation and roles of Rel/NF-κB transcription factors during lymphocyte activation. Curr. Opin. Immunol. 10, 353-359 (1998).
10. Gerondakis, S., Grossmann, M., Nakamura, Y., Pohl, T. & Grumont, R. Genetic approaches in mice to understand Rel/NF-κB and IκB function: transgenics and knockouts. Oncogene 18, 6888-6895 (1999).
11. Franzoso, G. et al. Requirement for NF-κB in osteoclast and B-cell development. Genes Dev. 11, 3482-3496 (1997).
12. Grossmann, M. et al. The anti-apoptotic activities of Rel and RelA required during B-cell maturation involve the regulation of Bcl-2 expression. EMBO J. 19, 6351-6360 (2000).
13. Lam, K.P., Kuhn, R. & Rajewsky, K. In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death. Cell 90, 1073-1083 (1997).
14. Torres, R.M., Flaswinkel, H., Reth, M. & Rajewsky, K. Aberrant B cell development and immune response in mice with a compromised BCR complex. Science 272, 1804-1808 (1996).
15. Benschop, R.J. & Cambier, J.C. B cell development: signal transduction by antigen receptors and their surrogates. Curr. Opin. Immunol. 11, 143-151 (1999).
16. Hardy, R.R. & Hayakawa, K. B cell development pathways. Annu. Rev. Immunol. 19, 595-621 (2001).
17. Meffre, E., Casellas, R. & Nussenzweig, M.C. Antibody regulation of B cell development. Nat. Immunol. 1, 379-385 (2000).
18. Cariappa, A. & Pillai, S. Antigen-dependent B-cell development. Curr. Opin. Immunol. 14, 241-249 (2002).
19. Niiro, H. & Clark, E.A. Regulation of B-cell fate by antigen-receptor signals. Nat. Rev. Immunol. 2, 945-956 (2002).
20. Campbell, K.S. Signal transduction from the B cell antigen-receptor. Curr. Opin. Immunol. 11, 256-264 (1999).
21. Leo, A. & Schraven, B. Adapters in lymphocyte signalling. Curr. Opin. Immunol. 13, 307-316 (2001).
22. Kelly, M.E. & Chan, A.C. Regulation of B cell function by linker proteins. Curr. Opin. Immunol. 12, 267-275 (2000).
23. Jordan, M.S., Singer, A.L. & Koretzky, G.A. Adaptors as central mediators of signal transduction in immune cells. Nat. Immunol. 4, 110-116 (2003).
24. Kurosaki, T. Regulation of B-cell signal transduction by adaptor proteins. Nat. Rev. Immunol. 2, 354-363 (2002).
25. Samelson, L.E. Signal transduction mediated by the T cell antigen receptor: the role of adapter proteins. Annu. Rev. Immunol. 20, 371-394 (2002).
26. Yamazaki, T. et al. Essential immunoregulatory role for BCAP in B cell development and function. J. Exp. Med. 195, 535-545 (2002).
27. Rolink, A.G., Andersson, J. & Melchers, F. Characterization of immature B cells by a novel monoclonal antibody, by turnover and by mitogen reactivity. Eur. J. Immunol. 28, 3738-3748 (1998).
28. Sandel, P.C. & Monroe, J.G. Negative selection of immature B cells by receptor editing or deletion is determined by site of antigen encounter. Immunity 10, 289-299 (1999).
29. Allman, D. et al. Resolution of three nonproliferative immature splenic B cell subsets reveals multiple selection points during peripheral B cell maturation. J. Immunol. 167, 6834-6840 (2001).
30. Loder, F. et al. B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals. J. Exp. Med. 190, 75-89 (1999).
31. Su, T.T. & Rawlings, D.J. Transitional B lymphocyte subsets operate as distinct checkpoints in murine splenic B cell development. J. Immunol. 168, 2101-2110 (2002).
32. Pahl, H.L. Activators and target genes of Rel/NF-κB transcription factors. Oncogene 18, 6853-6866 (1999).
33. Grumont, R.J., Richardson, I.B., Gaff, C. & Gerondakis, S. rel/NF-κB nuclear complexes that bind κB sites in the murine c-rel promoter are required for constitutive c-rel transcription in B-cells. Cell Growth Differ. 4, 731-743 (1993).
34. hi splenic B cells are an immature developmental intermediate in the production of long-lived marrow-derived B cells. J. Immunol. 151, 4431-4444 (1993).
35. Liou, H.C., Sha, W.C., Scott, M.L. & Baltimore, D. Sequential induction of NF-κB/Rel family proteins during B-cell terminal differentiation. Mol. Cell. Biol. 14, 5349-5359 (1994).
36. Grumont, R.J. & Gerondakis, S. The subunit composition of NF-κB complexes changes during B-cell development. Cell Growth Differ. 5, 1321-1331 (1994).
37. Miyamoto, S., Schmitt, M.J. & Verma, I.M. Qualitative changes in the subunit composition of κB-binding complexes during murine B-cell differentiation. Proc. Natl. Acad. Sci. USA 91, 5056-5060 (1994).
38. Carrasco, D., Weih, F. & Bravo, R. Developmental expression of the mouse c-rel protooncogene in hematopoietic organs. Development 120, 2991-3004 (1994).
39. Hu, C.J. et al. PU. 1/Spi-B regulation of c-rel is essential for mature B cell survival. Immunity 15, 545-555 (2001).
40. Kontgen, F. et al. Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression. Genes Dev. 9, 1965-1977 (1995).
41. Hsia, C.Y., Cheng, S., Owyang, A.M., Dowdy, S.F. & Liou, H.C. c-Rel regulation of the cell cycle in primary mouse B lymphocytes. Int. Immunol. 14, 905-916 (2002).
42. Owyang, A.M. et al. c-Rel is required for the protection of B cells from antigen receptor-mediated, but not Fas-mediated, apoptosis. J. Immunol. 167, 4948-4956 (2001).
43. Grumont, R.J., Rourke, I.J. & Gerondakis, S. Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis. Genes Dev. 13, 400-411 (1999).
44. Chen, C., Edelstein, L.C. & Gelinas, C. The Rel/NF-κB family directly activates expression of the apoptosis inhibitor Bcl-x(L). Mol. Cell. Biol. 20, 2687-2695 (2000).
45. Grumont, R.J. & Gerondakis, S. The murine c-rel proto-oncogene encodes two mRNAs the expression of which is modulated by lymphoid stimuli. Oncogene Res. 5, 245-254 (1990).
46. Rolink, A.G. & Melchers, F. BAFFled B cells survive and thrive: roles of BAFF in B-cell development. Curr. Opin. Immunol. 14, 266-275 (2002).
47. Mackay, F., Schneider, P., Rennert, P. & Browning, J. BAFF AND APRIL: A tutorial on B cell survival. Annu. Rev. Immunol. 21, 231-264 (2003).
48. Schiemann, B. et al. An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway. Science 293, 2111-2114 (2001).
49. Thompson, J.S. et al. BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF. Science 293, 2108-2111 (2001).
50. Schebesta, M., Pfeffer, P.L. & Busslinger, M. Control of pre-BCR signaling by Pax5-dependent activation of the BLNK gene. Immunity 17, 473-485 (2002).