-
1
-
-
0037089332
-
Autoimmunity in human primary immunodeficiency diseases
-
P.D. Arkwright et al. Autoimmunity in human primary immunodeficiency diseases Blood 99 2002 2694 2702
-
(2002)
Blood
, vol.99
, pp. 2694-2702
-
-
Arkwright, P.D.1
-
2
-
-
0033851221
-
Autoimmune diseases: A leading cause of death among young and middle-aged women in the United States
-
S.J. Walsh Autoimmune diseases: a leading cause of death among young and middle-aged women in the United States Am. J. Public Health 90 2000 1463 1465
-
(2000)
Am. J. Public Health
, vol.90
, pp. 1463-1465
-
-
Walsh, S.J.1
-
3
-
-
68049113582
-
Prevalence of and predictive factors for sustained disease-modifying antirheumatic drug-free remission in rheumatoid arthritis: Results from two large early arthritis cohorts
-
D. Van der Woude et al. Prevalence of and predictive factors for sustained disease-modifying antirheumatic drug-free remission in rheumatoid arthritis: results from two large early arthritis cohorts Arthritis Rheum. 60 2009 2262 2271
-
(2009)
Arthritis Rheum.
, vol.60
, pp. 2262-2271
-
-
Van Der Woude, D.1
-
4
-
-
84906318082
-
A cost-effectiveness of biological therapeutic sequences for rheumatoid arthritis in the UK
-
P. Emery et al. A cost-effectiveness of biological therapeutic sequences for rheumatoid arthritis in the UK Value Health 12 2009 A439
-
(2009)
Value Health
, vol.12
, pp. 439
-
-
Emery, P.1
-
5
-
-
77951621262
-
The emerging mechanisms of isoform-specific PI3K signalling
-
B. Vanhaesebroeck et al. The emerging mechanisms of isoform-specific PI3K signalling Nat. Rev. Mol. Cell Biol. 11 2010 329 341
-
(2010)
Nat. Rev. Mol. Cell Biol.
, vol.11
, pp. 329-341
-
-
Vanhaesebroeck, B.1
-
6
-
-
68149164783
-
PI3Kgamma adaptor subunits define coupling to degranulation and cell motility by distinct PtdIns(3,4,5)P3 pools in mast cells
-
T. Bohnacker et al. PI3Kgamma adaptor subunits define coupling to degranulation and cell motility by distinct PtdIns(3,4,5)P3 pools in mast cells Sci. Signal. 2 2009 ra27
-
(2009)
Sci. Signal.
, vol.2
, pp. 27
-
-
Bohnacker, T.1
-
7
-
-
79958696667
-
Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3Kγ, a single convergent point promoting tumor inflammation and progression
-
M.C. Schmid et al. Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3Kγ, a single convergent point promoting tumor inflammation and progression Cancer Cell 19 2011 715 727
-
(2011)
Cancer Cell
, vol.19
, pp. 715-727
-
-
Schmid, M.C.1
-
8
-
-
46149106818
-
The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma
-
J. Guillermet-Guibert et al. The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma Proc. Natl. Acad. Sci. U. S. A. 105 2008 8292 8297
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, pp. 8292-8297
-
-
Guillermet-Guibert, J.1
-
9
-
-
84865012034
-
Targeting PI3K isoforms and SHIP in the immune system: New therapeutics for inflammation and leukemia
-
M.D. Blunt, and S.G. Ward Targeting PI3K isoforms and SHIP in the immune system: new therapeutics for inflammation and leukemia Curr. Opin. Pharmacol. 12 2012 444 451
-
(2012)
Curr. Opin. Pharmacol.
, vol.12
, pp. 444-451
-
-
Blunt, M.D.1
Ward, S.G.2
-
10
-
-
84867091296
-
Inhibition of PI3K signaling spurs new therapeutic opportunities in inflammatory/autoimmune diseases and hematological malignancies
-
J.G. Foster et al. Inhibition of PI3K signaling spurs new therapeutic opportunities in inflammatory/autoimmune diseases and hematological malignancies Pharmacol. Rev. 64 2012 1026 1054
-
(2012)
Pharmacol. Rev.
, vol.64
, pp. 1026-1054
-
-
Foster, J.G.1
-
11
-
-
51849111556
-
PI3K pathway alterations in cancer: Variations on a theme
-
T.L. Yuan, and L.C. Cantley PI3K pathway alterations in cancer: variations on a theme Oncogene 27 2008 5497 5510
-
(2008)
Oncogene
, vol.27
, pp. 5497-5510
-
-
Yuan, T.L.1
Cantley, L.C.2
-
12
-
-
0033634827
-
Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine
-
E.H. Walker et al. Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine Mol. Cell 6 2000 909 919
-
(2000)
Mol. Cell
, vol.6
, pp. 909-919
-
-
Walker, E.H.1
-
13
-
-
75349106113
-
The p110delta structure: Mechanisms for selectivity and potency of new PI(3)K inhibitors
-
A. Berndt et al. The p110delta structure: mechanisms for selectivity and potency of new PI(3)K inhibitors Nat. Chem. Biol. 6 2010 117 124
-
(2010)
Nat. Chem. Biol.
, vol.6
, pp. 117-124
-
-
Berndt, A.1
-
14
-
-
78751553221
-
CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability
-
B.J. Lannutti et al. CAL-101, a p110delta selective phosphatidylinositol- 3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability Blood 117 2011 591 594
-
(2011)
Blood
, vol.117
, pp. 591-594
-
-
Lannutti, B.J.1
-
15
-
-
80053345977
-
The phosphoinositide 3-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia
-
J. Hoellenriegel et al. The phosphoinositide 3-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia Blood 118 2011 3603 3612
-
(2011)
Blood
, vol.118
, pp. 3603-3612
-
-
Hoellenriegel, J.1
-
16
-
-
84857875585
-
PI3K signalling in B- and T-lymphocytes: New developments and therapeutic advances
-
D.A. Fruman PI3K signalling in B- and T-lymphocytes: new developments and therapeutic advances Biochem. J. 442 2012 465 481
-
(2012)
Biochem. J.
, vol.442
, pp. 465-481
-
-
Fruman, D.A.1
-
17
-
-
84861329091
-
A selective inhibitor reveals PI3Kγ dependence of T(H)17 cell differentiation
-
G. Bergamini et al. A selective inhibitor reveals PI3Kγ dependence of T(H)17 cell differentiation Nat. Chem. Biol. 8 2012 576 582
-
(2012)
Nat. Chem. Biol.
, vol.8
, pp. 576-582
-
-
Bergamini, G.1
-
18
-
-
0038011833
-
Evolving concepts of rheumatoid arthritis
-
G.S. Firestein Evolving concepts of rheumatoid arthritis Nature 423 2003 356 361
-
(2003)
Nature
, vol.423
, pp. 356-361
-
-
Firestein, G.S.1
-
19
-
-
24744435115
-
Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis
-
M. Camps et al. Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis Nat. Med. 11 2005 936 943
-
(2005)
Nat. Med.
, vol.11
, pp. 936-943
-
-
Camps, M.1
-
20
-
-
72749096045
-
PI3Kgamma regulates cartilage damage in chronic inflammatory arthritis
-
S. Hayer et al. PI3Kgamma regulates cartilage damage in chronic inflammatory arthritis FASEB J. 23 2009 4288 4298
-
(2009)
FASEB J.
, vol.23
, pp. 4288-4298
-
-
Hayer, S.1
-
21
-
-
84860114297
-
PI3 kinase δ is a key regulator of synoviocyte function in rheumatoid arthritis
-
B. Bartok et al. PI3 kinase δ is a key regulator of synoviocyte function in rheumatoid arthritis Am. J. Pathol. 180 2012 1906 1916
-
(2012)
Am. J. Pathol.
, vol.180
, pp. 1906-1916
-
-
Bartok, B.1
-
22
-
-
77952246649
-
Inhibitory effects of ZSTK474, a novel phosphoinositide 3-kinase inhibitor, on osteoclasts and collagen-induced arthritis in mice
-
S. Toyama Inhibitory effects of ZSTK474, a novel phosphoinositide 3-kinase inhibitor, on osteoclasts and collagen-induced arthritis in mice Arthritis Res. Ther. 12 2010 R92
-
(2010)
Arthritis Res. Ther.
, vol.12
, pp. 92
-
-
Toyama, S.1
-
23
-
-
0032706819
-
Genetic dissection of systemic lupus erythematosus
-
E.K. Wakeland et al. Genetic dissection of systemic lupus erythematosus Curr. Opin. Immunol. 11 1999 701 707
-
(1999)
Curr. Opin. Immunol.
, vol.11
, pp. 701-707
-
-
Wakeland, E.K.1
-
24
-
-
24744449495
-
PI3Kgamma inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus
-
D.F. Barber et al. PI3Kgamma inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus Nat. Med. 11 2005 933 935
-
(2005)
Nat. Med.
, vol.11
, pp. 933-935
-
-
Barber, D.F.1
-
25
-
-
79551471312
-
The PI3K/Akt/mTOR pathway is activated in murine lupus nephritis and downregulated by rapamycin
-
K. Stylianou et al. The PI3K/Akt/mTOR pathway is activated in murine lupus nephritis and downregulated by rapamycin Nephrol. Dial. Transplant. 26 2011 498 508
-
(2011)
Nephrol. Dial. Transplant.
, vol.26
, pp. 498-508
-
-
Stylianou, K.1
-
26
-
-
84861192191
-
Attenuation of phosphoinositide 3-kinase δ signaling restrains autoimmune disease
-
M.J. Maxwell et al. Attenuation of phosphoinositide 3-kinase δ signaling restrains autoimmune disease J. Autoimmun. 38 2012 381 391
-
(2012)
J. Autoimmun.
, vol.38
, pp. 381-391
-
-
Maxwell, M.J.1
-
27
-
-
80052667108
-
Enhanced phosphoinositide 3-kinase δ activity is a frequent event in systemic lupus erythematosus that confers resistance to activation-induced T cell death
-
A. Suárez-Fueyo et al. Enhanced phosphoinositide 3-kinase δ activity is a frequent event in systemic lupus erythematosus that confers resistance to activation-induced T cell death J. Immunol. 187 2011 2376 2385
-
(2011)
J. Immunol.
, vol.187
, pp. 2376-2385
-
-
Suárez-Fueyo, A.1
-
28
-
-
33846458998
-
IL-25 regulates Th17 function in autoimmune inflammation
-
M.A. Kleinschek et al. IL-25 regulates Th17 function in autoimmune inflammation J. Exp. Med. 204 2007 161 170
-
(2007)
J. Exp. Med.
, vol.204
, pp. 161-170
-
-
Kleinschek, M.A.1
-
29
-
-
77952279397
-
Absence of PI3Kgamma leads to increased leukocyte apoptosis and diminished severity of experimental autoimmune encephalomyelitis
-
D.H. Rodrigues et al. Absence of PI3Kgamma leads to increased leukocyte apoptosis and diminished severity of experimental autoimmune encephalomyelitis J. Neuroimmunol. 222 2010 90 94
-
(2010)
J. Neuroimmunol.
, vol.222
, pp. 90-94
-
-
Rodrigues, D.H.1
-
30
-
-
79954603523
-
PI3Kδ drives the pathogenesis of experimental autoimmune encephalomyelitis by inhibiting effector T cell apoptosis and promoting Th17 differentiation
-
S. Haylock-Jacobs et al. PI3Kδ drives the pathogenesis of experimental autoimmune encephalomyelitis by inhibiting effector T cell apoptosis and promoting Th17 differentiation J. Autoimmun. 36 2011 278 287
-
(2011)
J. Autoimmun.
, vol.36
, pp. 278-287
-
-
Haylock-Jacobs, S.1
-
31
-
-
84872170692
-
Selective pharmacological inhibition of phosphoinositide 3-kinase p110delta opposes the progression of autoimmune diabetes in non-obese diabetic (NOD) mice
-
C.A. Durand et al. Selective pharmacological inhibition of phosphoinositide 3-kinase p110delta opposes the progression of autoimmune diabetes in non-obese diabetic (NOD) mice Autoimmunity 46 2013 62 73
-
(2013)
Autoimmunity
, vol.46
, pp. 62-73
-
-
Durand, C.A.1
-
32
-
-
84861905980
-
The novel therapeutic effect of phosphoinositide 3-kinase-y inhibitor AS605240 in autoimmune diabetes
-
J. Azzi et al. The novel therapeutic effect of phosphoinositide 3-kinase-y inhibitor AS605240 in autoimmune diabetes Diabetes 61 2012 1509 1518
-
(2012)
Diabetes
, vol.61
, pp. 1509-1518
-
-
Azzi, J.1
-
33
-
-
0029826977
-
B lymphocytes are essential for the initiation of T cell-mediated autoimmune diabetes: Analysis of a new "speed congenic" stock of NOD, Ig mu null mice
-
D.V. Serreze et al. B lymphocytes are essential for the initiation of T cell-mediated autoimmune diabetes: analysis of a new "speed congenic" stock of NOD, Ig mu null mice J. Exp. Med. 184 1996 2049 2053
-
(1996)
J. Exp. Med.
, vol.184
, pp. 2049-2053
-
-
Serreze, D.V.1
-
34
-
-
80054804471
-
IKBKE activates Akt independent of phosphatidylinositol 3-kinase/PDK1/mTORC2 and PH domain to sustain malignant transformation
-
J.P. Guo et al. IKBKE activates Akt independent of phosphatidylinositol 3-kinase/PDK1/mTORC2 and PH domain to sustain malignant transformation J. Biol. Chem. 286 2011 37389 37398
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 37389-37398
-
-
Guo, J.P.1
-
35
-
-
80053070033
-
PI3K-targeted therapy can be evaded by gene amplification along the MYC-eukaryotic translation initiation factor 4E(e11 = 4E) axis
-
N. Ilic et al. PI3K-targeted therapy can be evaded by gene amplification along the MYC-eukaryotic translation initiation factor 4E(e11 = 4E) axis Proc. Natl. Acad. Sci. U. S. A. 108 2011 E699 E708
-
(2011)
Proc. Natl. Acad. Sci. U. S. A.
, vol.108
-
-
Ilic, N.1
|