Loss of protein tyrosine phosphatase nonreceptor type 22 regulates interferon-γ-induced signaling in human monocytes

Gastroenterology

Volumn 144, Issue 5, 2013, Pages

  Spalinger, Marianne R ^a   Lang, Silvia ^a   Weber, Achim ^a   Frei, Pascal ^a   Fried, Michael ^a,b   Rogler, Gerhard ^a,b   Scharl, Michael ^a,b  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

ICAM1; MCP1; SOCS1; Th17

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 17; INTERLEUKIN 2; INTERLEUKIN 6; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; MONOCYTE CHEMOTACTIC PROTEIN 1; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 22; STAT1 PROTEIN; STAT3 PROTEIN;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CROHN DISEASE; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; FEMALE; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; MALE; MONOCYTE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; RNA ANALYSIS; SIGNAL TRANSDUCTION; ULCERATIVE COLITIS;

EID: 84876463917     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2013.01.048     Document Type: Article

References (36)

1. D.Q. Shih, S.R. Targan Insights into IBD pathogenesis Curr Gastroenterol Rep 11 2009 473 480
2. S. Ardizzone, G. Bianchi Porro Biologic therapy for inflammatory bowel disease Drugs 65 2005 2253 2286
3. I.J. Fuss, M. Neurath, M. Boirivant Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5 J Immunol 157 1996 1261 1270
4. L. Flaishon, I. Topilski, D. Shoseyov Cutting edge: anti-inflammatory properties of low levels of IFN-γ J Immunol 168 2002 3707 3711
5. Y. Jin, Y. Lin, L. Lin IL-17/IFN-gamma interactions regulate intestinal inflammation in TNBS-induced acute colitis J Interferon Cytokine Res 32 2012 548 556
6. K. Schroder, P.J. Hertzog, T. Ravasi Interferon-gamma: an overview of signals, mechanisms and functions J Leukoc Biol 75 2004 163 189
7. D.L. Krebs, D.J. Hilton SOCS: physiological suppressors of cytokine signaling J Cell Sci 113 2000 2813 2819
8. A.F. Valledor, E. Sanchez-Tillo, L. Arpa Selective roles of MAPKs during the macrophage response to IFN-gamma J Immunol 180 2008 4523 4529
9. C.N. Bernstein, M. Sargent, W.M. Gallatin Beta2 integrin/ICAM expression in Crohn's disease Clin Immunol Immunopathol 86 1998 147 160
10. E.V. Tsianos, K.H. Katsanos, V.E. Tsianos Role of genetics in the diagnosis and prognosis of Crohn's disease World J Gastroenterol 18 2012 105 118
11. D.C. Palmer, N.P. Restifo Suppressors of cytokine signaling (SOCS) in T cell differentiation, maturation, and function Trends Immunol 30 2009 592 602
12. T. Olsen, R. Rismo, G. Cui TH1 and TH17 interactions in untreated inflamed mucosa of inflammatory bowel disease, and their potential to mediate the inflammation Cytokine 56 2011 633 640
13. T. Korn, E. Bettelli, M. Oukka IL-17 and Th17 Cells Annu Rev Immunol 27 2009 485 517
14. T.W. Behrens Lyp breakdown and autoimmunity Nat Genet 43 2011 821 822
15. L.M. Diaz-Gallo, L. Espino-Paisan, K. Fransen Differential association of two PTPN22 coding variants with Crohn's disease and ulcerative colitis Inflamm Bowel Dis 17 2011 2287 2294
16. T. Mustelin, T. Vang, N. Bottini Protein tyrosine phosphatases and the immune response Nat Rev Immunol 5 2005 43 57
17. K. Hasegawa, F. Martin, G. Huang PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells Science 303 2004 685 689
18. M. Rieck, A. Arechiga, S. Onengut-Gumuscu Genetic variation in PTPN22 corresponds to altered function of T and B lymphocytes J Immunol 179 2007 4704 4710
19. K. Douroudis, A. Shcherbakova, H. Everaus PTPN22 gene regulates natural killer cell proliferation during in vitro expansion Tissue Antigens 76 2010 315 318
20. J. Zhang, N. Zahir, Q. Jiang The autoimmune disease-associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness Nat Genet 43 2011 902 907
21. M. Scharl, P. Hruz, D.F. McCole Protein tyrosine phosphatase non-receptor type 2 regulates IFN-gamma-induced cytokine signaling in THP-1 monocytes Inflamm Bowel Dis 16 2010 2055 2064
22. M. Scharl, D.F. McCole, A. Weber Protein tyrosine phosphatase N2 regulates TNFalpha-induced signalling and cytokine secretion in human intestinal epithelial cells Gut 60 2011 189 197
23. M. Scharl, G. Paul, A. Weber Protection of epithelial barrier function by the Crohn's disease associated gene protein tyrosine phosphatase n2 Gastroenterology 137 2009 2030 2040.e5
24. M.F. Neurath, B. Weigmann, S. Finotto The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease J Exp Med 195 2002 1129 1143
25. S. Madonna, C. Scarponi, O. De Pita Suppressor of cytokine signaling 1 inhibits IFN-gamma inflammatory signaling in human keratinocytes by sustaining ERK1/2 activation FASEB J 22 2008 3287 3297
26. J. Wu, A. Katrekar, L.A. Honigberg Identification of substrates of human protein-tyrosine phosphatase PTPN22 J Biol Chem 281 2006 11002 11010
27. J.R. Schoenborn, Y.X. Tan, C. Zhang Feedback circuits monitor and adjust basal Lck-dependent events in T cell receptor signaling Sci Signal 4 2011 ra59
28. C. van Vliet, P.E. Bukczynska, M.A. Puryer Selective regulation of tumor necrosis factor-induced Erk signaling by Src family kinases and the T cell protein tyrosine phosphatase Nat Immunol 6 2005 253 260
29. K. Ono, J. Han The p38 signal transduction pathway: activation and function Cell Signal 12 2000 1 13
30. Y.R. Mahida, L. Kurlac, A. Gallagher High circulating concentrations of interleukin-6 in active Crohn's disease but not ulcerative colitis Gut 32 1991 1531 1534
31. G. Huang, Y. Wang, P. Vogel Signaling via the kinase p38α programs dendritic cells to drive TH17 differentiation and autoimmune inflammation Nat Immunol 13 2012 152 161
32. J. Strebovsky, P. Walker, R. Lang Suppressor of cytokine signaling 1 (SOCS1) limits NFkappaB signaling by decreasing p65 stability within the cell nucleus FASEB J 25 2011 863 874
33. Y. Ogura, D.K. Bonen, N. Inohara A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease Nature 411 2001 603 606
34. T. Petnicki-Ocwieja, T. Hrncir, Y.J. Liu Nod2 is required for the regulation of commensal microbiota in the intestine Proc Natl Acad Sci U S A 106 2009 15813 15818
35. M.C. Grimm, S.K. Elsbury, P. Pavli Enhanced expression and production of monocyte chemoattractant protein-1 in inflammatory bowel disease mucosa J Leukoc Biol 59 1996 804 812
36. T. Spoettl, M. Hausmann, M. Herlyn Monocyte chemoattractant protein-1 (MCP-1) inhibits the intestinal-like differentiation of monocytes Clin Exp Immunol 145 2006 190 199