-
1
-
-
84858308226
-
Natural products as sources of new drugs over the 30 years from 1981 to 2010
-
Newman, D.J. and Cragg, G.M. (2012) Natural products as sources of new drugs over the 30 years from 1981 to 2010. J. Nat. Prod., 75, 311-335.
-
(2012)
J. Nat. Prod.
, vol.75
, pp. 311-335
-
-
Newman, D.J.1
Cragg, G.M.2
-
2
-
-
11144311139
-
Lessons from natural molecules
-
Clardy, J. and Walsh, C. (2004) Lessons from natural molecules. Nature, 432, 829-837.
-
(2004)
Nature
, vol.432
, pp. 829-837
-
-
Clardy, J.1
Walsh, C.2
-
3
-
-
14944383798
-
The evolving role of natural products in drug discovery
-
Koehn, F.E. and Carter, G.T. (2005) The evolving role of natural products in drug discovery. Nat. Rev. Drug Discovery, 4, 206-220.
-
(2005)
Nat. Rev. Drug Discovery
, vol.4
, pp. 206-220
-
-
Koehn, F.E.1
Carter, G.T.2
-
4
-
-
70350722394
-
Genomic basis for natural product biosynthetic diversity in the actinomycetes
-
Nett, M., Ikeda, H. and Moore, B.S. (2009) Genomic basis for natural product biosynthetic diversity in the actinomycetes. Nat. Prod. Rep., 26, 1362-1384.
-
(2009)
Nat. Prod. Rep.
, vol.26
, pp. 1362-1384
-
-
Nett, M.1
Ikeda, H.2
Moore, B.S.3
-
5
-
-
84883615133
-
Comparative genomics of actinomycetes with a focus on natural product biosynthetic genes
-
Doroghazi, J.R. and Metcalf, W.W. (2013) Comparative genomics of actinomycetes with a focus on natural product biosynthetic genes. BMC Genomics, 14, 611.
-
(2013)
BMC Genomics
, vol.14
, pp. 611
-
-
Doroghazi, J.R.1
Metcalf, W.W.2
-
6
-
-
77649305354
-
Natural products version 2.0: Connecting genes to molecules
-
Walsh, C.T. and Fischbach, M.A. (2010) Natural products version 2.0: connecting genes to molecules. J. Am. Chem. Soc., 132, 2469-2493.
-
(2010)
J. Am. Chem. Soc.
, vol.132
, pp. 2469-2493
-
-
Walsh, C.T.1
Fischbach, M.A.2
-
7
-
-
3442896886
-
NRPS-PKS: A knowledge-based resource for analysis of NRPS/PKS megasynthases
-
Ansari, M.Z., Yadav, G., Gokhale, R.S. and Mohanty, D. (2004) NRPS-PKS: a knowledge-based resource for analysis of NRPS/PKS megasynthases. Nucleic Acids Res., 32, W405-W413.
-
(2004)
Nucleic Acids Res.
, vol.32
, pp. W405-W413
-
-
Ansari, M.Z.1
Yadav, G.2
Gokhale, R.S.3
Mohanty, D.4
-
8
-
-
34247279292
-
Comprehensive analysis of distinctive polyketide and nonribosomal peptide structural motifs encoded in microbial genomes
-
Minowa, Y., Araki, M. and Kanehisa, M. (2007) Comprehensive analysis of distinctive polyketide and nonribosomal peptide structural motifs encoded in microbial genomes. J. Mol. Biol., 368, 1500-1517.
-
(2007)
J. Mol. Biol.
, vol.368
, pp. 1500-1517
-
-
Minowa, Y.1
Araki, M.2
Kanehisa, M.3
-
9
-
-
64249084052
-
Chapter 8. Methods for in silico prediction of microbial polyketide and nonribosomal peptide biosynthetic pathways from DNA sequence data
-
Bachmann, B.O. and Ravel, J. (2009) Chapter 8. Methods for in silico prediction of microbial polyketide and nonribosomal peptide biosynthetic pathways from DNA sequence data. Methods Enzymol., 458, 181-217.
-
(2009)
Methods Enzymol.
, vol.458
, pp. 181-217
-
-
Bachmann, B.O.1
Ravel, J.2
-
10
-
-
79959936207
-
NRPSpredictor2-A web server for predicting NRPS adenylation domain specificity
-
Rottig, M., Medema, M.H., Blin, K., Weber, T., Rausch, C. and Kohlbacher, O. (2011) NRPSpredictor2-a web server for predicting NRPS adenylation domain specificity. Nucleic Acids Res., 39, W362-W367.
-
(2011)
Nucleic Acids Res.
, vol.39
, pp. W362-W367
-
-
Rottig, M.1
Medema, M.H.2
Blin, K.3
Weber, T.4
Rausch, C.5
Kohlbacher, O.6
-
11
-
-
84856587901
-
NRPSsp: Non-ribosomal peptide synthase substrate predictor
-
Prieto, C., Garcia-Estrada, C., Lorenzana, D. and Martin, J.F. (2012) NRPSsp: non-ribosomal peptide synthase substrate predictor. Bioinformatics, 28, 426-427.
-
(2012)
Bioinformatics
, vol.28
, pp. 426-427
-
-
Prieto, C.1
Garcia-Estrada, C.2
Lorenzana, D.3
Martin, J.F.4
-
12
-
-
84876340080
-
Classification of the adenylation and acyl-transferase activity of NRPS and PKS systems using ensembles of substrate specific hidden markov models
-
Khayatt, B.I., Overmars, L., Siezen, R.J. and Francke, C. (2013) Classification of the adenylation and acyl-transferase activity of NRPS and PKS systems using ensembles of substrate specific hidden Markov models. PLoS One, 8, e62136.
-
(2013)
PLoS One
, vol.8
, pp. e62136
-
-
Khayatt, B.I.1
Overmars, L.2
Siezen, R.J.3
Francke, C.4
-
13
-
-
84893481062
-
Predicting substrate specificity of adenylation domains of nonribosomal peptide synthetases and other protein properties by latent semantic indexing
-
Baranasic, D., Zucko, J., Diminic, J., Gacesa, R., Long, P.F., Cullum, J., Hranueli, D. and Starcevic, A. (2014) Predicting substrate specificity of adenylation domains of nonribosomal peptide synthetases and other protein properties by latent semantic indexing. J. Ind. Microbiol. Biotechnol., 41, 461-467.
-
(2014)
J. Ind. Microbiol. Biotechnol.
, vol.41
, pp. 461-467
-
-
Baranasic, D.1
Zucko, J.2
Diminic, J.3
Gacesa, R.4
Long, P.F.5
Cullum, J.6
Hranueli, D.7
Starcevic, A.8
-
14
-
-
57149112966
-
Clust scan: An integrated program package for the semi-automatic annotation of modular biosynthetic gene clusters and in silico prediction of novel chemical structures
-
Starcevic, A., Zucko, J., Simunkovic, J., Long, P.F., Cullum, J. and Hranueli, D. (2008) Clust Scan: an integrated program package for the semi-automatic annotation of modular biosynthetic gene clusters and in silico prediction of novel chemical structures. Nucleic Acids Res., 36, 6882-6892.
-
(2008)
Nucleic Acids Res.
, vol.36
, pp. 6882-6892
-
-
Starcevic, A.1
Zucko, J.2
Simunkovic, J.3
Long, P.F.4
Cullum, J.5
Hranueli, D.6
-
15
-
-
67650898253
-
Automated genome mining for natural products
-
Li, M.H., Ung, P.M., Zajkowski, J., Garneau-Tsodikova, S. and Sherman, D.H. (2009) Automated genome mining for natural products. BMC Bioinformatics, 10, 185.
-
(2009)
BMC Bioinformatics
, vol.10
, pp. 185
-
-
Li, M.H.1
Ung, P.M.2
Zajkowski, J.3
Garneau-Tsodikova, S.4
Sherman, D.H.5
-
16
-
-
84979859096
-
Anti SMASH 3.0-A comprehensive resource for the genome mining of biosynthetic gene clusters
-
Weber, T., Blin, K., Duddela, S., Krug, D., Kim, H.U., Bruccoleri, R., Lee, S.Y., Fischbach, M.A., Muller, R., Wohlleben, W. et al. (2015) anti SMASH 3.0-a comprehensive resource for the genome mining of biosynthetic gene clusters. Nucleic Acids Res., 43, W237-W243.
-
(2015)
Nucleic Acids Res.
, vol.43
, pp. W237-W243
-
-
Weber, T.1
Blin, K.2
Duddela, S.3
Krug, D.4
Kim, H.U.5
Bruccoleri, R.6
Lee, S.Y.7
Fischbach, M.A.8
Muller, R.9
Wohlleben, W.10
-
17
-
-
84904554933
-
Insights into secondary metabolism from a global analysis of prokaryotic biosynthetic gene clusters
-
Cimermancic, P., Medema, M.H., Claesen, J., Kurita, K., Wieland Brown, L.C., Mavrommatis, K., Pati, A., Godfrey, P.A., Koehrsen, M., Clardy, J. et al. (2014) Insights into secondary metabolism from a global analysis of prokaryotic biosynthetic gene clusters. Cell, 158, 412-421.
-
(2014)
Cell
, vol.158
, pp. 412-421
-
-
Cimermancic, P.1
Medema, M.H.2
Claesen, J.3
Kurita, K.4
Wieland Brown, L.C.5
Mavrommatis, K.6
Pati, A.7
Godfrey, P.A.8
Koehrsen, M.9
Clardy, J.10
-
18
-
-
0036007875
-
Biosynthesis and attachment of novel bacterial polyketide synthase starter units
-
Moore, B.S. and Hertweck, C. (2002) Biosynthesis and attachment of novel bacterial polyketide synthase starter units. Nat. Prod. Rep., 19, 70-99.
-
(2002)
Nat. Prod. Rep.
, vol.19
, pp. 70-99
-
-
Moore, B.S.1
Hertweck, C.2
-
19
-
-
57549105096
-
Natural-product sugar biosynthesis and enzymatic glycodiversification
-
Thibodeaux, C.J., Melancon, C.E. 3rd and Liu, H.W. (2008) Natural-product sugar biosynthesis and enzymatic glycodiversification. Angew. Chem. Int. Ed., 47, 9814-9859.
-
(2008)
Angew. Chem. Int. Ed.
, vol.47
, pp. 9814-9859
-
-
Thibodeaux, C.J.1
Melancon, C.E.2
Liu, H.W.3
-
20
-
-
0025183708
-
Basic local alignment search tool
-
Altschul, S.F., Gish, W., Miller, W., Myers, E.W. and Lipman, D.J. (1990) Basic local alignment search tool. J. Mol. Biol., 215, 403-410.
-
(1990)
J. Mol. Biol.
, vol.215
, pp. 403-410
-
-
Altschul, S.F.1
Gish, W.2
Miller, W.3
Myers, E.W.4
Lipman, D.J.5
-
21
-
-
80055082271
-
Accelerated profile HMM searches
-
Eddy, S.R. (2011) Accelerated Profile HMM Searches. PLoS Comput. Biol., 7, e1002195.
-
(2011)
PLoS Comput. Biol.
, vol.7
, pp. e1002195
-
-
Eddy, S.R.1
-
22
-
-
0037361967
-
The chemistry development kit (CDK): An open-source Java library for chemo- and bioinformatics
-
Steinbeck, C., Han, Y., Kuhn, S., Horlacher, O., Luttmann, E. and Willighagen, E. (2003) The Chemistry Development Kit (CDK): an open-source Java library for Chemo- and Bioinformatics. J. Chem. Inf. Comput. Sci., 43, 493-500.
-
(2003)
J. Chem. Inf. Comput. Sci.
, vol.43
, pp. 493-500
-
-
Steinbeck, C.1
Han, Y.2
Kuhn, S.3
Horlacher, O.4
Luttmann, E.5
Willighagen, E.6
-
23
-
-
84870472070
-
Bio Java: An open-source framework for bioinformatics in 2012
-
Prlic, A., Yates, A., Bliven, S.E., Rose, P.W., Jacobsen, J., Troshin, P.V., Chapman, M., Gao, J., Koh, C.H., Foisy, S. et al. (2012) Bio Java: an open-source framework for bioinformatics in 2012. Bioinformatics, 28, 2693-2695.
-
(2012)
Bioinformatics
, vol.28
, pp. 2693-2695
-
-
Prlic, A.1
Yates, A.2
Bliven, S.E.3
Rose, P.W.4
Jacobsen, J.5
Troshin, P.V.6
Chapman, M.7
Gao, J.8
Koh, C.H.9
Foisy, S.10
-
24
-
-
3042666256
-
MUSCLE: Multiple sequence alignment with high accuracy and high throughput
-
Edgar, R.C. (2004) MUSCLE: multiple sequence alignment with high accuracy and high throughput. Nucleic Acids Res., 32, 1792-1797.
-
(2004)
Nucleic Acids Res.
, vol.32
, pp. 1792-1797
-
-
Edgar, R.C.1
-
25
-
-
67650757433
-
Trim al: A tool for automated alignment trimming in large-scale phylogenetic analyses
-
Capella-Gutierrez, S., Silla-Martinez, J.M. and Gabaldon, T. (2009) trim Al: a tool for automated alignment trimming in large-scale phylogenetic analyses. Bioinformatics, 25, 1972-1973.
-
(2009)
Bioinformatics
, vol.25
, pp. 1972-1973
-
-
Capella-Gutierrez, S.1
Silla-Martinez, J.M.2
Gabaldon, T.3
-
26
-
-
79960976768
-
UniProt knowledgebase: A hub of integrated protein data
-
bar009
-
Magrane, M. and Consortium U. (2011) UniProt Knowledgebase: a hub of integrated protein data. Database, bar009.
-
(2011)
Database
-
-
Magrane, M.1
Consortium, U.2
-
27
-
-
79959931985
-
HMMER web server: Interactive sequence similarity searching
-
Finn, R.D., Clements, J. and Eddy, S.R. (2011) HMMER web server: interactive sequence similarity searching. Nucleic Acids Res., 39, W29-W37.
-
(2011)
Nucleic Acids Res.
, vol.39
, pp. W29-W37
-
-
Finn, R.D.1
Clements, J.2
Eddy, S.R.3
-
28
-
-
33750403801
-
RAxML-VI-HPC: Maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models
-
Stamatakis, A. (2006) RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models. Bioinformatics, 22, 2688-2690.
-
(2006)
Bioinformatics
, vol.22
, pp. 2688-2690
-
-
Stamatakis, A.1
-
29
-
-
79954529507
-
ProtTest 3: Fast selection of best-fit models of protein evolution
-
Darriba, D., Taboada, G.L., Doallo, R. and Posada, D. (2011) ProtTest 3: fast selection of best-fit models of protein evolution. Bioinformatics, 27, 1164-1165.
-
(2011)
Bioinformatics
, vol.27
, pp. 1164-1165
-
-
Darriba, D.1
Taboada, G.L.2
Doallo, R.3
Posada, D.4
-
30
-
-
84891782659
-
Pfam: The protein families database
-
Finn, R.D., Bateman, A., Clements, J., Coggill, P., Eberhardt, R.Y., Eddy, S.R., Heger, A., Hetherington, K., Holm, L., Mistry, J. et al. (2014) Pfam: the protein families database. Nucleic Acids Res., 42, D222-D230.
-
(2014)
Nucleic Acids Res.
, vol.42
, pp. D222-D230
-
-
Finn, R.D.1
Bateman, A.2
Clements, J.3
Coggill, P.4
Eberhardt, R.Y.5
Eddy, S.R.6
Heger, A.7
Hetherington, K.8
Holm, L.9
Mistry, J.10
-
31
-
-
84862221167
-
SMART 7: Recent updates to the protein domain annotation resource
-
Letunic, I., Doerks, T. and Bork, P. (2012) SMART 7: recent updates to the protein domain annotation resource. Nucleic Acids Res., 40, D302-D305.
-
(2012)
Nucleic Acids Res.
, vol.40
, pp. D302-D305
-
-
Letunic, I.1
Doerks, T.2
Bork, P.3
-
32
-
-
58149287683
-
In silico analysis of methyltransferase domains involved in biosynthesis of secondary metabolites
-
Ansari, M.Z., Sharma, J., Gokhale, R.S. and Mohanty, D. (2008) In silico analysis of methyltransferase domains involved in biosynthesis of secondary metabolites. BMC Bioinformatics, 9, 454.
-
(2008)
BMC Bioinformatics
, vol.9
, pp. 454
-
-
Ansari, M.Z.1
Sharma, J.2
Gokhale, R.S.3
Mohanty, D.4
-
33
-
-
77954937832
-
Classification, prediction, and verification of the regioselectivity of fungal polyketide synthase product template domains
-
Li, Y., Xu, W. and Tang, Y. (2010) Classification, prediction, and verification of the regioselectivity of fungal polyketide synthase product template domains. J. Biol. Chem., 285, 22764-22773.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 22764-22773
-
-
Li, Y.1
Xu, W.2
Tang, Y.3
-
34
-
-
38549095277
-
Starter unit specificity directs genome mining of polyketide synthase pathways in fungi
-
Crawford, J.M., Vagstad, A.L., Erlich, K.C. and Townsend, C.A. (2008) Starter unit specificity directs genome mining of polyketide synthase pathways in fungi. Bioorg. Chem., 36, 16-22.
-
(2008)
Bioorg. Chem.
, vol.36
, pp. 16-22
-
-
Crawford, J.M.1
Vagstad, A.L.2
Erlich, K.C.3
Townsend, C.A.4
-
35
-
-
34548139023
-
The cytochrome P450 engineering database: A navigation and prediction tool for the cytochrome P450 protein family
-
Fischer, M., Knoll, M., Sirim, D., Wagner, F., Funke, S. and Pleiss, J. (2007) The Cytochrome P450 Engineering Database: a navigation and prediction tool for the cytochrome P450 protein family. Bioinformatics, 23, 2015-2017.
-
(2007)
Bioinformatics
, vol.23
, pp. 2015-2017
-
-
Fischer, M.1
Knoll, M.2
Sirim, D.3
Wagner, F.4
Funke, S.5
Pleiss, J.6
-
36
-
-
84859078407
-
The natural product domain seeker NaPDoS: A phylogeny based bioinformatic tool to classify secondary metabolite gene diversity
-
Ziemert, N., Podell, S., Penn, K., Badger, J.H., Allen, E. and Jensen, P.R. (2012) The natural product domain seeker NaPDoS: a phylogeny based bioinformatic tool to classify secondary metabolite gene diversity. PLoS One, 7, e34064.
-
(2012)
PLoS One
, vol.7
, pp. e34064
-
-
Ziemert, N.1
Podell, S.2
Penn, K.3
Badger, J.H.4
Allen, E.5
Jensen, P.R.6
-
37
-
-
84921632491
-
Improved annotation of antibiotic resistance determinants reveals microbial resistomes cluster by ecology
-
Gibson, M.K., Forsberg, K.J. and Dantas, G. (2015) Improved annotation of antibiotic resistance determinants reveals microbial resistomes cluster by ecology. ISME J., 9, 207-216.
-
(2015)
ISME J.
, vol.9
, pp. 207-216
-
-
Gibson, M.K.1
Forsberg, K.J.2
Dantas, G.3
-
38
-
-
34250710858
-
Phylogenetic analysis of condensation domains in NRPS sheds light on their functional evolution
-
Rausch, C., Hoof, I., Weber, T., Wohlleben, W. and Huson, D.H. (2007) Phylogenetic analysis of condensation domains in NRPS sheds light on their functional evolution. BMC Evol. Biol., 7, 78.
-
(2007)
BMC Evol. Biol.
, vol.7
, pp. 78
-
-
Rausch, C.1
Hoof, I.2
Weber, T.3
Wohlleben, W.4
Huson, D.H.5
-
39
-
-
38949203821
-
Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection
-
Nguyen, T., Ishida, K., Jenke-Kodama, H., Dittmann, E., Gurgui, C., Hochmuth, T., Taudien, S., Platzer, M., Hertweck, C. and Piel, J. (2008) Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection. Nat. Biotechnol., 26, 225-233.
-
(2008)
Nat. Biotechnol.
, vol.26
, pp. 225-233
-
-
Nguyen, T.1
Ishida, K.2
Jenke-Kodama, H.3
Dittmann, E.4
Gurgui, C.5
Hochmuth, T.6
Taudien, S.7
Platzer, M.8
Hertweck, C.9
Piel, J.10
-
40
-
-
25144520542
-
The biosynthetic genes for disorazoles, potent cytotoxic compounds that disrupt microtubule formation
-
Carvalho, R., Reid, R., Viswanathan, N., Gramajo, H. and Julien, B. (2005) The biosynthetic genes for disorazoles, potent cytotoxic compounds that disrupt microtubule formation. Gene, 359, 91-98.
-
(2005)
Gene
, vol.359
, pp. 91-98
-
-
Carvalho, R.1
Reid, R.2
Viswanathan, N.3
Gramajo, H.4
Julien, B.5
-
41
-
-
33744775994
-
Structural and functional characterization of three polyketide synthase gene clusters in bacillus amyloliquefaciens FZB 42
-
Chen, X.H., Vater, J., Piel, J., Franke, P., Scholz, R., Schneider, K., Koumoutsi, A., Hitzeroth, G., Grammel, N., Strittmatter, A.W. et al. (2006) Structural and functional characterization of three polyketide synthase gene clusters in Bacillus amyloliquefaciens FZB 42. J Bacteriol., 188, 4024-4036.
-
(2006)
J Bacteriol.
, vol.188
, pp. 4024-4036
-
-
Chen, X.H.1
Vater, J.2
Piel, J.3
Franke, P.4
Scholz, R.5
Schneider, K.6
Koumoutsi, A.7
Hitzeroth, G.8
Grammel, N.9
Strittmatter, A.W.10
-
42
-
-
36048989307
-
Biosynthesis of the antibiotic bacillaene, the product of a giant polyketide synthase complex of the trans-AT family
-
Moldenhauer, J., Chen, X.H., Borriss, R. and Piel, J. (2007) Biosynthesis of the antibiotic bacillaene, the product of a giant polyketide synthase complex of the trans-AT family. Angew. Chem. Int. Ed., 46, 8195-8197.
-
(2007)
Angew. Chem. Int. Ed.
, vol.46
, pp. 8195-8197
-
-
Moldenhauer, J.1
Chen, X.H.2
Borriss, R.3
Piel, J.4
-
43
-
-
0032484013
-
Characterization of the syringomycin synthetase gene cluster. A link between prokaryotic and eukaryotic peptide synthetases
-
Guenzi, E., Galli, G., Grgurina, I., Gross, D.C. and Grandi, G. (1998) Characterization of the syringomycin synthetase gene cluster. A link between prokaryotic and eukaryotic peptide synthetases. J. Biol. Chem., 273, 32857-32863.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 32857-32863
-
-
Guenzi, E.1
Galli, G.2
Grgurina, I.3
Gross, D.C.4
Grandi, G.5
-
44
-
-
0035793081
-
Purification, priming, and catalytic acylation of carrier protein domains in the polyketide synthase and nonribosomal peptidyl synthetase modules of the HMWP1 subunit of yersiniabactin synthetase
-
Suo, Z., Tseng, C.C. and Walsh, C.T. (2001) Purification, priming, and catalytic acylation of carrier protein domains in the polyketide synthase and nonribosomal peptidyl synthetase modules of the HMWP1 subunit of yersiniabactin synthetase. Proc. Natl. Acad. Sci. U.S.A., 98, 99-104.
-
(2001)
Proc. Natl. Acad. Sci. U.S.A.
, vol.98
, pp. 99-104
-
-
Suo, Z.1
Tseng, C.C.2
Walsh, C.T.3
-
45
-
-
79955924618
-
Proteomics-based discovery of koranimine, a cyclic imine natural product
-
Evans, B.S., Ntai, I., Chen, Y., Robinson, S.J. and Kelleher, N.L. (2011) Proteomics-based discovery of koranimine, a cyclic imine natural product. J. Am. Chem. Soc., 133, 7316-7319.
-
(2011)
J. Am. Chem. Soc.
, vol.133
, pp. 7316-7319
-
-
Evans, B.S.1
Ntai, I.2
Chen, Y.3
Robinson, S.J.4
Kelleher, N.L.5
-
46
-
-
1642304143
-
Polyketide and nonribosomal peptide antibiotics: Modularity and versatility
-
Walsh, C.T. (2004) Polyketide and nonribosomal peptide antibiotics: modularity and versatility. Science, 303, 1805-1810.
-
(2004)
Science
, vol.303
, pp. 1805-1810
-
-
Walsh, C.T.1
-
47
-
-
33748588122
-
Nature's inventory of halogenation catalysts: Oxidative strategies predominate
-
Vaillancourt, F.H., Yeh, E., Vosburg, D.A., Garneau-Tsodikova, S. and Walsh, C.T. (2006) Nature's inventory of halogenation catalysts: oxidative strategies predominate. Chem Rev., 106, 3364-3378.
-
(2006)
Chem Rev.
, vol.106
, pp. 3364-3378
-
-
Vaillancourt, F.H.1
Yeh, E.2
Vosburg, D.A.3
Garneau-Tsodikova, S.4
Walsh, C.T.5
-
48
-
-
34548647327
-
The biosynthesis of teicoplanin-type glycopeptide antibiotics: Assignment of p450 mono-oxygenases to side chain cyclizations of glycopeptide a47934
-
Hadatsch, B., Butz, D., Schmiederer, T., Steudle, J., Wohlleben, W., Sussmuth, R. and Stegmann, E. (2007) The biosynthesis of teicoplanin-type glycopeptide antibiotics: assignment of p450 mono-oxygenases to side chain cyclizations of glycopeptide a47934. Chem. Biol., 14, 1078-1089.
-
(2007)
Chem. Biol.
, vol.14
, pp. 1078-1089
-
-
Hadatsch, B.1
Butz, D.2
Schmiederer, T.3
Steudle, J.4
Wohlleben, W.5
Sussmuth, R.6
Stegmann, E.7
-
49
-
-
84915763024
-
An evolutionary model encompassing substrate specificity and reactivity of type I polyketide synthase thioesterases
-
Hari, T.P., Labana, P., Boileau, M. and Boddy, C.N. (2014) An evolutionary model encompassing substrate specificity and reactivity of type I polyketide synthase thioesterases. Chembiochem, 15, 2656-2661.
-
(2014)
Chembiochem
, vol.15
, pp. 2656-2661
-
-
Hari, T.P.1
Labana, P.2
Boileau, M.3
Boddy, C.N.4
-
50
-
-
13144252236
-
Multilocus sequence typing: A portable approach to the identification of clones within populations of pathogenic microorganisms
-
Maiden, M.C., Bygraves, J.A., Feil, E., Morelli, G., Russell, J.E., Urwin, R., Zhang, Q., Zhou, J., Zurth, K., Caugant, D.A. et al. (1998) Multilocus sequence typing: a portable approach to the identification of clones within populations of pathogenic microorganisms. Proc. Natl. Acad. Sci. U.S.A., 95, 3140-3145.
-
(1998)
Proc. Natl. Acad. Sci. U.S.A.
, vol.95
, pp. 3140-3145
-
-
Maiden, M.C.1
Bygraves, J.A.2
Feil, E.3
Morelli, G.4
Russell, J.E.5
Urwin, R.6
Zhang, Q.7
Zhou, J.8
Zurth, K.9
Caugant, D.A.10
-
51
-
-
84949940645
-
Sequencing and in silico analysis of the warp drive genome databank
-
SIMB
-
Udwary, D. (2015) Sequencing and in silico analysis of the Warp Drive Genome Databank. Natural Product Discovery & Development in the Post Genomic Era. SIMB, https://sim.confex.com/sim/np2015/webprogram/Paper28929.html.
-
(2015)
Natural Product Discovery & Development in the Post Genomic Era
-
-
Udwary, D.1
-
52
-
-
5344244908
-
Chemical similarity searching
-
Willett, P., Barnard, J.M. and Downs, G.M. (1998) Chemical similarity searching. J. Chem. Inf. Comput. Sci., 38, 983-996.
-
(1998)
J. Chem. Inf. Comput. Sci.
, vol.38
, pp. 983-996
-
-
Willett, P.1
Barnard, J.M.2
Downs, G.M.3
-
53
-
-
84901022772
-
Chemoinformatics-an introduction for computer scientists
-
Brown, N. (2009) Chemoinformatics-an introduction for computer scientists. ACM Comput. Surv., 41, 1-38
-
(2009)
ACM Comput. Surv.
, vol.41
, pp. 1-38
-
-
Brown, N.1
-
54
-
-
77952772341
-
Extended-connectivity fingerprints
-
Rogers, D. and Hahn, M. (2010) Extended-Connectivity Fingerprints. J. Chem. Inf. Model., 50, 742-754.
-
(2010)
J. Chem. Inf. Model.
, vol.50
, pp. 742-754
-
-
Rogers, D.1
Hahn, M.2
-
55
-
-
33751246188
-
Similarity-based virtual screening using 2D fingerprints
-
Willett, P. (2006) Similarity-based virtual screening using 2D fingerprints. Drug Discov. Today, 11, 1046-1053.
-
(2006)
Drug Discov. Today
, vol.11
, pp. 1046-1053
-
-
Willett, P.1
-
56
-
-
84937709062
-
Chem doodle web components: HTML5 toolkit for chemical graphics, interfaces, and informatics
-
Burger, M.C. (2015) Chem Doodle Web Components: HTML5 toolkit for chemical graphics, interfaces, and informatics. J. Cheminform., 7, 35.
-
(2015)
J. Cheminform.
, vol.7
, pp. 35
-
-
Burger, M.C.1
-
57
-
-
0033179468
-
The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases
-
Stachelhaus, T., Mootz, H.D. and Marahiel, M.A. (1999) The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases. Chem. Biol., 6, 493-505.
-
(1999)
Chem. Biol.
, vol.6
, pp. 493-505
-
-
Stachelhaus, T.1
Mootz, H.D.2
Marahiel, M.A.3
-
58
-
-
0034013269
-
Predictive, structure-based model of amino acid recognition by nonribosomal peptide synthetase adenylation domains
-
Challis, G.L., Ravel, J. and Townsend, C.A. (2000) Predictive, structure-based model of amino acid recognition by nonribosomal peptide synthetase adenylation domains. Chem. Biol., 7, 211-224.
-
(2000)
Chem. Biol.
, vol.7
, pp. 211-224
-
-
Challis, G.L.1
Ravel, J.2
Townsend, C.A.3
-
59
-
-
0030669091
-
The tyrocidine biosynthesis operon of bacillus brevis: Complete nucleotide sequence and biochemical characterization of functional internal adenylation domains
-
Mootz, H.D. and Marahiel, M.A. (1997) The tyrocidine biosynthesis operon of Bacillus brevis: complete nucleotide sequence and biochemical characterization of functional internal adenylation domains. J. Bacteriol., 179, 6843-6850.
-
(1997)
J. Bacteriol.
, vol.179
, pp. 6843-6850
-
-
Mootz, H.D.1
Marahiel, M.A.2
-
60
-
-
0037173032
-
Assembling the glycopeptide antibiotic scaffold: The biosynthesis of A47934 from streptomyces toyocaensis NRRL15009
-
Pootoolal, J., Thomas, M.G., Marshall, C.G., Neu, J.M., Hubbard, B.K., Walsh, C.T. and Wright, G.D. (2002) Assembling the glycopeptide antibiotic scaffold: The biosynthesis of A47934 from Streptomyces toyocaensis NRRL15009. Proc. Natl. Acad. Sci. U.S.A., 99, 8962-8967.
-
(2002)
Proc. Natl. Acad. Sci. U.S.A.
, vol.99
, pp. 8962-8967
-
-
Pootoolal, J.1
Thomas, M.G.2
Marshall, C.G.3
Neu, J.M.4
Hubbard, B.K.5
Walsh, C.T.6
Wright, G.D.7
-
61
-
-
33846312155
-
Characterization of SyrC, an aminoacyltransferase shuttling threonyl and chlorothreonyl residues in the syringomycin biosynthetic assembly line
-
Singh, G.M., Vaillancourt, F.H., Yin, J. and Walsh, C.T. (2007) Characterization of SyrC, an aminoacyltransferase shuttling threonyl and chlorothreonyl residues in the syringomycin biosynthetic assembly line. Chem. Biol., 14, 31-40.
-
(2007)
Chem. Biol.
, vol.14
, pp. 31-40
-
-
Singh, G.M.1
Vaillancourt, F.H.2
Yin, J.3
Walsh, C.T.4
-
62
-
-
84855772300
-
Studies on the biosynthesis of the lipodepsipeptide antibiotic ramoplanin A2
-
Hoertz, A.J., Hamburger, J.B., Gooden, D.M., Bednar, M.M. and McCafferty, D.G. (2012) Studies on the biosynthesis of the lipodepsipeptide antibiotic Ramoplanin A2. Bioorg. Med. Chem., 20, 859-865.
-
(2012)
Bioorg. Med. Chem.
, vol.20
, pp. 859-865
-
-
Hoertz, A.J.1
Hamburger, J.B.2
Gooden, D.M.3
Bednar, M.M.4
McCafferty, D.G.5
-
63
-
-
0037151788
-
The barbamide biosynthetic gene cluster: A novel marine cyanobacterial system of mixed polyketide synthase (PKS)-non-ribosomal peptide synthetase (NRPS) origin involving an unusual trichloroleucyl starter unit
-
Chang, Z., Flatt, P., Gerwick, W.H., Nguyen, V.A., Willis, C.L. and Sherman, D.H. (2002) The barbamide biosynthetic gene cluster: a novel marine cyanobacterial system of mixed polyketide synthase (PKS)-non-ribosomal peptide synthetase (NRPS) origin involving an unusual trichloroleucyl starter unit. Gene, 296, 235-247.
-
(2002)
Gene
, vol.296
, pp. 235-247
-
-
Chang, Z.1
Flatt, P.2
Gerwick, W.H.3
Nguyen, V.A.4
Willis, C.L.5
Sherman, D.H.6
-
64
-
-
0347622758
-
Characterization of CmaA, an adenylation-thiolation didomain enzyme involved in the biosynthesis of coronatine
-
Couch, R., O'Connor, S.E., Seidle, H., Walsh, C.T. and Parry, R. (2004) Characterization of CmaA, an adenylation-thiolation didomain enzyme involved in the biosynthesis of coronatine. J. Bacteriol., 186, 35-42.
-
(2004)
J. Bacteriol.
, vol.186
, pp. 35-42
-
-
Couch, R.1
O'Connor, S.E.2
Seidle, H.3
Walsh, C.T.4
Parry, R.5
-
65
-
-
77958455457
-
Insights into an unusual nonribosomal peptide synthetase biosynthesis: Identification and characterization of the GE81112 biosynthetic gene cluster
-
Binz, T.M., Maffioli, S.I., Sosio, M., Donadio, S. and Muller, R. (2010) Insights into an unusual nonribosomal peptide synthetase biosynthesis: identification and characterization of the GE81112 biosynthetic gene cluster. J. Biol. Chem., 285, 32710-32719.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 32710-32719
-
-
Binz, T.M.1
Maffioli, S.I.2
Sosio, M.3
Donadio, S.4
Muller, R.5
-
66
-
-
32344437742
-
Deciphering the biosynthesis pathway of the antitumor thiocoraline from a marine actinomycete and its expression in two streptomyces species
-
Lombo, F., Velasco, A., Castro, S., de la Calle, F., Brana, A.F., Sanchez-Puelles, J.M., Mendez, C. and Salas, J.A. (2006) Deciphering the biosynthesis pathway of the antitumor thiocoraline from a marine actinomycete and its expression in two streptomyces species. Chembiochem, 7, 366-376.
-
(2006)
Chembiochem
, vol.7
, pp. 366-376
-
-
Lombo, F.1
Velasco, A.2
Castro, S.3
De La-Calle, F.4
Brana, A.F.5
Sanchez-Puelles, J.M.6
Mendez, C.7
Salas, J.A.8
-
67
-
-
33746354671
-
Total biosynthesis of antitumor nonribosomal peptides in Escherichia coli
-
Watanabe, K., Hotta, K., Praseuth, A.P., Koketsu, K., Migita, A., Boddy, C.N., Wang, C.C., Oguri, H. and Oikawa, H. (2006) Total biosynthesis of antitumor nonribosomal peptides in Escherichia coli. Nat. Chem. Biol., 2, 423-428.
-
(2006)
Nat. Chem. Biol.
, vol.2
, pp. 423-428
-
-
Watanabe, K.1
Hotta, K.2
Praseuth, A.P.3
Koketsu, K.4
Migita, A.5
Boddy, C.N.6
Wang, C.C.7
Oguri, H.8
Oikawa, H.9
-
68
-
-
84865335226
-
A stand-alone adenylation domain forms amide bonds in streptothricin biosynthesis
-
Maruyama, C., Toyoda, J., Kato, Y., Izumikawa, M., Takagi, M., Shin-ya, K., Katano, H., Utagawa, T. and Hamano, Y. (2012) A stand-alone adenylation domain forms amide bonds in streptothricin biosynthesis. Nat. Chem. Biol., 8, 791-797.
-
(2012)
Nat. Chem. Biol.
, vol.8
, pp. 791-797
-
-
Maruyama, C.1
Toyoda, J.2
Kato, Y.3
Izumikawa, M.4
Takagi, M.5
Shin-Ya, K.6
Katano, H.7
Utagawa, T.8
Hamano, Y.9
-
69
-
-
0029098323
-
The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin
-
Schwecke, T., Aparicio, J.F., Molnar, I., Konig, A., Khaw, L.E., Haydock, S.F., Oliynyk, M., Caffrey, P., Cortes, J., Lester, J.B. et al. (1995) The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin. Proc. Natl. Acad. Sci. U.S.A., 92, 7839-7843.
-
(1995)
Proc. Natl. Acad. Sci. U.S.A.
, vol.92
, pp. 7839-7843
-
-
Schwecke, T.1
Aparicio, J.F.2
Molnar, I.3
Konig, A.4
Khaw, L.E.5
Haydock, S.F.6
Oliynyk, M.7
Caffrey, P.8
Cortes, J.9
Lester, J.B.10
-
70
-
-
0037126024
-
Crystal structure of DhbE, an archetype for aryl acid activating domains of modular nonribosomal peptide synthetases
-
May, J.J., Kessler, N., Marahiel, M.A. and Stubbs, M.T. (2002) Crystal structure of DhbE, an archetype for aryl acid activating domains of modular nonribosomal peptide synthetases. Proc. Natl. Acad. Sci. U.S.A., 99, 12120-12125.
-
(2002)
Proc. Natl. Acad. Sci. U.S.A.
, vol.99
, pp. 12120-12125
-
-
May, J.J.1
Kessler, N.2
Marahiel, M.A.3
Stubbs, M.T.4
-
71
-
-
84885144746
-
Chemical and biosynthetic evolution of the antimycin-type depsipeptides
-
Vanner, S.A., Li, X., Zvanych, R., Torchia, J., Sang, J., Andrews, D.W. and Magarvey, N.A. (2013) Chemical and biosynthetic evolution of the antimycin-type depsipeptides. Mol. Biosyst., 9, 2712-2719.
-
(2013)
Mol. Biosyst.
, vol.9
, pp. 2712-2719
-
-
Vanner, S.A.1
Li, X.2
Zvanych, R.3
Torchia, J.4
Sang, J.5
Andrews, D.W.6
Magarvey, N.A.7
-
72
-
-
0033835373
-
The biosynthetic gene cluster for the antitumor drug bleomycin from streptomyces verticillus ATCC15003 supporting functional interactions between nonribosomal peptide synthetases and a polyketide synthase
-
Du, L., Sanchez, C., Chen, M., Edwards, D.J. and Shen, B. (2000) The biosynthetic gene cluster for the antitumor drug bleomycin from Streptomyces verticillus ATCC15003 supporting functional interactions between nonribosomal peptide synthetases and a polyketide synthase. Chem. Biol., 7, 623-642.
-
(2000)
Chem. Biol.
, vol.7
, pp. 623-642
-
-
Du, L.1
Sanchez, C.2
Chen, M.3
Edwards, D.J.4
Shen, B.5
-
73
-
-
84883157334
-
N-carbamoylation of 2, 4-diaminobutyrate reroutes the outcome in padanamide biosynthesis
-
Du, Y.L., Dalisay, D.S., Andersen, R.J. and Ryan, K.S. (2013) N-carbamoylation of 2, 4-diaminobutyrate reroutes the outcome in padanamide biosynthesis. Chem. Biol., 20, 1002-1011.
-
(2013)
Chem. Biol.
, vol.20
, pp. 1002-1011
-
-
Du, Y.L.1
Dalisay, D.S.2
Andersen, R.J.3
Ryan, K.S.4
-
74
-
-
34249895594
-
Characterization of a gene cluster responsible for the biosynthesis of anticancer agent FK228 in chromobacterium violaceum No. 968
-
Cheng, Y.Q., Yang, M. and Matter, A.M. (2007) Characterization of a gene cluster responsible for the biosynthesis of anticancer agent FK228 in Chromobacterium violaceum No. 968. Appl. Environ. Microbiol., 73, 3460-3469.
-
(2007)
Appl. Environ. Microbiol.
, vol.73
, pp. 3460-3469
-
-
Cheng, Y.Q.1
Yang, M.2
Matter, A.M.3
-
75
-
-
33845543991
-
The tallysomycin biosynthetic gene cluster from streptoalloteichus hindustanus E465-94 ATCC 31158 unveiling new insights into the biosynthesis of the bleomycin family of antitumor antibiotics
-
Tao, M., Wang, L., Wendt-Pienkowski, E., George, N.P., Galm, U., Zhang, G., Coughlin, J.M. and Shen, B. (2007) The tallysomycin biosynthetic gene cluster from Streptoalloteichus hindustanus E465-94 ATCC 31158 unveiling new insights into the biosynthesis of the bleomycin family of antitumor antibiotics. Mol. Biosyst., 3, 60-74.
-
(2007)
Mol. Biosyst.
, vol.3
, pp. 60-74
-
-
Tao, M.1
Wang, L.2
Wendt-Pienkowski, E.3
George, N.P.4
Galm, U.5
Zhang, G.6
Coughlin, J.M.7
Shen, B.8
-
76
-
-
57449094594
-
The biosynthetic gene cluster of zorbamycin, a member of the bleomycin family of antitumor antibiotics, from streptomyces flavoviridis ATCC 21892
-
Galm, U., Wendt-Pienkowski, E., Wang, L., George, N.P., Oh, T.J., Yi, F., Tao, M., Coughlin, J.M. and Shen, B. (2009) The biosynthetic gene cluster of zorbamycin, a member of the bleomycin family of antitumor antibiotics, from Streptomyces flavoviridis ATCC 21892. Mol. Biosyst., 5, 77-90.
-
(2009)
Mol. Biosyst.
, vol.5
, pp. 77-90
-
-
Galm, U.1
Wendt-Pienkowski, E.2
Wang, L.3
George, N.P.4
Oh, T.J.5
Yi, F.6
Tao, M.7
Coughlin, J.M.8
Shen, B.9
-
77
-
-
84906227555
-
Identification and characterization of the spiruchostatin biosynthetic gene cluster enable yield improvement by overexpressing a transcriptional activator
-
Potharla, V.Y., Wang, C. and Cheng, Y.Q. (2014) Identification and characterization of the spiruchostatin biosynthetic gene cluster enable yield improvement by overexpressing a transcriptional activator. J. Ind. Microbiol. Biotechnol., 41, 1457-1465.
-
(2014)
J. Ind. Microbiol. Biotechnol.
, vol.41
, pp. 1457-1465
-
-
Potharla, V.Y.1
Wang, C.2
Cheng, Y.Q.3
-
78
-
-
84888095812
-
Glycogenomics as a mass spectrometry-guided genome-mining method for microbial glycosylated molecules
-
Kersten, R.D., Ziemert, N., Gonzalez, D.J., Duggan, B.M., Nizet, V., Dorrestein, P.C. and Moore, B.S. (2013) Glycogenomics as a mass spectrometry-guided genome-mining method for microbial glycosylated molecules. Proc. Natl. Acad. Sci. U.S.A., 110, E4407-E4416.
-
(2013)
Proc. Natl. Acad. Sci. U.S.A.
, vol.110
, pp. E4407-E4416
-
-
Kersten, R.D.1
Ziemert, N.2
Gonzalez, D.J.3
Duggan, B.M.4
Nizet, V.5
Dorrestein, P.C.6
Moore, B.S.7
-
79
-
-
33746218306
-
Deciphering indolocarbazole and enediyne aminodideoxypentose biosynthesis through comparative genomics: Insights from the AT2433 biosynthetic locus
-
Gao, Q., Zhang, C., Blanchard, S. and Thorson, J.S. (2006) Deciphering indolocarbazole and enediyne aminodideoxypentose biosynthesis through comparative genomics: insights from the AT2433 biosynthetic locus. Chem. Biol., 13, 733-743.
-
(2006)
Chem. Biol.
, vol.13
, pp. 733-743
-
-
Gao, Q.1
Zhang, C.2
Blanchard, S.3
Thorson, J.S.4
-
80
-
-
0024419124
-
Cloning of genes governing the deoxysugar portion of the erythromycin biosynthesis pathway in saccharopolyspora erythraea (Streptomyces erythreus)
-
Vara, J., Lewandowska-Skarbek, M., Wang, Y.G., Donadio, S. and Hutchinson, C.R. (1989) Cloning of genes governing the deoxysugar portion of the erythromycin biosynthesis pathway in Saccharopolyspora erythraea (Streptomyces erythreus). J. Bacteriol., 171, 5872-5881.
-
(1989)
J. Bacteriol.
, vol.171
, pp. 5872-5881
-
-
Vara, J.1
Lewandowska-Skarbek, M.2
Wang, Y.G.3
Donadio, S.4
Hutchinson, C.R.5
-
81
-
-
5444249226
-
Chalcomycin biosynthesis gene cluster from Streptomyces bikiniensis: Novel features of an unusual ketolide produced through expression of the chm polyketide synthase in streptomyces fradiae
-
Ward, S.L., Hu, Z., Schirmer, A., Reid, R., Revill, W.P., Reeves, C.D., Petrakovsky, O.V., Dong, S.D. and Katz, L. (2004) Chalcomycin biosynthesis gene cluster from Streptomyces bikiniensis: novel features of an unusual ketolide produced through expression of the chm polyketide synthase in Streptomyces fradiae. Antimicrob. Agents Chemother., 48, 4703-4712.
-
(2004)
Antimicrob. Agents Chemother.
, vol.48
, pp. 4703-4712
-
-
Ward, S.L.1
Hu, Z.2
Schirmer, A.3
Reid, R.4
Revill, W.P.5
Reeves, C.D.6
Petrakovsky, O.V.7
Dong, S.D.8
Katz, L.9
-
82
-
-
84942761231
-
An automated genomes-to-natural products platform (GNP) for the discovery of modular natural products
-
Johnston, C.W., Skinnider, M.A., Wyatt, M.A., Li, X., Ranieri, M.R., Yang, L., Zechel, D., Ma, B. and Magarvey, N.A. (2015) An automated Genomes-to-Natural Products platform (GNP) for the discovery of modular natural products. Nat. Commun., 6, 8421.
-
(2015)
Nat. Commun.
, vol.6
, pp. 8421
-
-
Johnston, C.W.1
Skinnider, M.A.2
Wyatt, M.A.3
Li, X.4
Ranieri, M.R.5
Yang, L.6
Zechel, D.7
Ma, B.8
Magarvey, N.A.9
-
83
-
-
1142306159
-
Biosynthetic gene cluster of the glycopeptide antibiotic teicoplanin: Characterization of two glycosyltransferases and the key acyltransferase
-
Li, T.L., Huang, F., Haydock, DSF., Mironenko, T., Leadlay, P.F. and Spencer, J.B. (2004) Biosynthetic gene cluster of the glycopeptide antibiotic teicoplanin: characterization of two glycosyltransferases and the key acyltransferase. Chem. Biol., 11, 107-119.
-
(2004)
Chem. Biol.
, vol.11
, pp. 107-119
-
-
Li, T.L.1
Huang, F.2
Haydock, D.S.F.3
Mironenko, T.4
Leadlay, P.F.5
Spencer, J.B.6
-
84
-
-
33846923183
-
Type II polyketide synthases: Gaining a deeper insight into enzymatic teamwork
-
Hertweck, C., Luzhetskyy, A., Rebets, Y. and Bechthold, A. (2007) Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork. Nat. Prod. Rep., 24, 162-190.
-
(2007)
Nat. Prod. Rep.
, vol.24
, pp. 162-190
-
-
Hertweck, C.1
Luzhetskyy, A.2
Rebets, Y.3
Bechthold, A.4
-
85
-
-
84864566650
-
PKMiner: A database for exploring type II polyketide synthases
-
Kim, J. and Yi, G.S. (2012) PKMiner: a database for exploring type II polyketide synthases. BMC Microbiol., 12, 169.
-
(2012)
BMC Microbiol.
, vol.12
, pp. 169
-
-
Kim, J.1
Yi, G.S.2
-
86
-
-
84926664670
-
Expanding our understanding of sequence-function relationships of type II polyketide biosynthetic gene clusters: Bioinformatics-guided identification of Frankiamicin A from frankia sp. EAN1pec
-
Ogasawara, Y., Yackley, Greenberg, B.J., Rogelj, J.A., Melancon, S. and Melançon, C.E. 3rd. (2015) Expanding our understanding of sequence-function relationships of type II polyketide biosynthetic gene clusters: bioinformatics-guided identification of Frankiamicin A from Frankia sp. EAN1pec. PLoS One, 10, e0121505.
-
(2015)
PLoS One
, vol.10
, pp. e0121505
-
-
Ogasawara, Y.1
Yackley, G.B.J.2
Rogelj, J.A.3
Melancon, S.4
Melançon, C.E.5
-
87
-
-
34948828477
-
A type II polyketide synthase is responsible for anthraquinone biosynthesis in photorhabdus luminescens
-
Brachmann, A.O., Joyce, S.A., Jenke-Kodama, H., Schwar, G., Clarke, D.J. and Bode, H.B. (2007) A type II polyketide synthase is responsible for anthraquinone biosynthesis in Photorhabdus luminescens. Chembiochem, 8, 1721-1728.
-
(2007)
Chembiochem
, vol.8
, pp. 1721-1728
-
-
Brachmann, A.O.1
Joyce, S.A.2
Jenke-Kodama, H.3
Schwar, G.4
Clarke, D.J.5
Bode, H.B.6
-
88
-
-
0036731845
-
Molecular evolution of aromatic polyketides and comparative sequence analysis of polyketide ketosynthase and 16S ribosomal DNA genes from various streptomyces species
-
Metsa-Ketela, M., Halo, L., Munukka, E., Hakala, J., Mantsala, P. and Ylihonko, K. (2002) Molecular evolution of aromatic polyketides and comparative sequence analysis of polyketide ketosynthase and 16S ribosomal DNA genes from various streptomyces species. Appl. Environ. Microbiol., 68, 4472-4479.
-
(2002)
Appl. Environ. Microbiol.
, vol.68
, pp. 4472-4479
-
-
Metsa-Ketela, M.1
Halo, L.2
Munukka, E.3
Hakala, J.4
Mantsala, P.5
Ylihonko, K.6
-
89
-
-
79961225518
-
Functional analysis of environmental DNA-derived type II polyketide synthases reveals structurally diverse secondary metabolites
-
Feng, Z., Kallifidas, D. and Brady, S.F. (2011) Functional analysis of environmental DNA-derived type II polyketide synthases reveals structurally diverse secondary metabolites. Proc. Natl. Acad. Sci. U.S.A., 108, 12629-12634.
-
(2011)
Proc. Natl. Acad. Sci. U.S.A.
, vol.108
, pp. 12629-12634
-
-
Feng, Z.1
Kallifidas, D.2
Brady, S.F.3
-
90
-
-
0037019803
-
Cloning and characterization of a polyketide synthase gene cluster involved in biosynthesis of a proposed angucycline-like polyketide auricin in streptomyces aureofaciens CCM 3239
-
Novakova, R., Bistakova, J., Homerova, D., Rezuchova, B. and Kormanec, J. (2002) Cloning and characterization of a polyketide synthase gene cluster involved in biosynthesis of a proposed angucycline-like polyketide auricin in Streptomyces aureofaciens CCM 3239. Gene, 297, 197-208.
-
(2002)
Gene
, vol.297
, pp. 197-208
-
-
Novakova, R.1
Bistakova, J.2
Homerova, D.3
Rezuchova, B.4
Kormanec, J.5
-
91
-
-
46049113897
-
Orchestration of discoid polyketide cyclization in the resistomycin pathway
-
Fritzsche, K., Ishida, K. and Hertweck, C. (2008) Orchestration of discoid polyketide cyclization in the resistomycin pathway. J. Am. Chem. Soc., 130, 8307-8316.
-
(2008)
J. Am. Chem. Soc.
, vol.130
, pp. 8307-8316
-
-
Fritzsche, K.1
Ishida, K.2
Hertweck, C.3
-
92
-
-
84858965936
-
Unveiling the post-PKS redox tailoring steps in biosynthesis of the type II polyketide antitumor antibiotic xantholipin
-
Zhang, W., Wang, L., Kong, L., Wang, T., Chu, Y., Deng, Z. and You, D. (2012) Unveiling the post-PKS redox tailoring steps in biosynthesis of the type II polyketide antitumor antibiotic xantholipin. Chem. Biol., 19, 422-432.
-
(2012)
Chem. Biol.
, vol.19
, pp. 422-432
-
-
Zhang, W.1
Wang, L.2
Kong, L.3
Wang, T.4
Chu, Y.5
Deng, Z.6
You, D.7
-
93
-
-
34547662949
-
Biosynthesis of pentangular polyphenols: Deductions from the benastatin and griseorhodin pathways
-
Lackner, G., Schenk, A., Xu, Z., Reinhardt, K., Yunt, Z.S., Piel, J. and Hertweck, C. (2007) Biosynthesis of pentangular polyphenols: deductions from the benastatin and griseorhodin pathways. J. Am. Chem. Soc., 129, 9306-9312.
-
(2007)
J. Am. Chem. Soc.
, vol.129
, pp. 9306-9312
-
-
Lackner, G.1
Schenk, A.2
Xu, Z.3
Reinhardt, K.4
Yunt, Z.S.5
Piel, J.6
Hertweck, C.7
-
94
-
-
0038148677
-
Cloning, sequencing and heterologous expression of the medermycin biosynthetic gene cluster of streptomyces sp. AM-7161: Towards comparative analysis of the benzoisochromanequinone gene clusters
-
Ichinose, K., Ozawa, M., Itou, K., Kunieda, K. and Ebizuka, Y. (2003) Cloning, sequencing and heterologous expression of the medermycin biosynthetic gene cluster of Streptomyces sp. AM-7161: towards comparative analysis of the benzoisochromanequinone gene clusters. Microbiology, 149, 1633-1645.
-
(2003)
Microbiology
, vol.149
, pp. 1633-1645
-
-
Ichinose, K.1
Ozawa, M.2
Itou, K.3
Kunieda, K.4
Ebizuka, Y.5
-
95
-
-
35548935214
-
Geminal tandem C-methylation in the discoid resistomycin pathway
-
Ishida, K., Fritzsche, K. and Hertweck, C. (2007) Geminal tandem C-methylation in the discoid resistomycin pathway. J. Am. Chem. Soc., 129, 12648-12649.
-
(2007)
J. Am. Chem. Soc.
, vol.129
, pp. 12648-12649
-
-
Ishida, K.1
Fritzsche, K.2
Hertweck, C.3
-
96
-
-
0037439266
-
The structure of ActVA-Orf6, a novel type of monooxygenase involved in actinorhodin biosynthesis
-
Sciara, G., Kendrew, S.G., Miele, A.E., Marsh, N.G., Federici, L., Malatesta, F., Schimperna, G., Savino, C. and Vallone, B. (2003) The structure of ActVA-Orf6, a novel type of monooxygenase involved in actinorhodin biosynthesis. EMBO J., 22, 205-215.
-
(2003)
EMBO J.
, vol.22
, pp. 205-215
-
-
Sciara, G.1
Kendrew, S.G.2
Miele, A.E.3
Marsh, N.G.4
Federici, L.5
Malatesta, F.6
Schimperna, G.7
Savino, C.8
Vallone, B.9
-
97
-
-
34548707013
-
Artificial reconstruction of two cryptic angucycline antibiotic biosynthetic pathways
-
Palmu, K., Ishida, K., Mantsala, P., Hertweck, C. and Metsa-Ketela, M. (2007) Artificial reconstruction of two cryptic angucycline antibiotic biosynthetic pathways. Chembiochem, 8, 1577-1584.
-
(2007)
Chembiochem
, vol.8
, pp. 1577-1584
-
-
Palmu, K.1
Ishida, K.2
Mantsala, P.3
Hertweck, C.4
Metsa-Ketela, M.5
-
98
-
-
0028953765
-
Measuring diversity: Experimental design of combinatorial libraries for drug discovery
-
Martin, E.J., Blaney, J.M., Siani, M.A., Spellmeyer, D.C., Wong, A.K. and Moos, W.H. (1995) Measuring diversity: experimental design of combinatorial libraries for drug discovery. J. Med. Chem., 38, 1431-1436.
-
(1995)
J. Med. Chem.
, vol.38
, pp. 1431-1436
-
-
Martin, E.J.1
Blaney, J.M.2
Siani, M.A.3
Spellmeyer, D.C.4
Wong, A.K.5
Moos, W.H.6
-
99
-
-
67650299761
-
Quantifying biogenic bias in screening libraries
-
Hert, J., Irwin, J.J., Laggner, C., Keiser, M.J. and Shoichet, B.K. (2009) Quantifying biogenic bias in screening libraries. Nat. Chem. Biol., 5, 479-483.
-
(2009)
Nat. Chem. Biol.
, vol.5
, pp. 479-483
-
-
Hert, J.1
Irwin, J.J.2
Laggner, C.3
Keiser, M.J.4
Shoichet, B.K.5
-
100
-
-
70449634957
-
Predicting new molecular targets for known drugs
-
Keiser, M.J., Setola, V., Irwin, J.J., Laggner, C., Abbas, A.I., Hufeisen, S.J., Jensen, N.H., Kuijer, M.B., Matos, R.C., Tran, T.B. et al. (2009) Predicting new molecular targets for known drugs. Nature, 462, 175-181.
-
(2009)
Nature
, vol.462
, pp. 175-181
-
-
Keiser, M.J.1
Setola, V.2
Irwin, J.J.3
Laggner, C.4
Abbas, A.I.5
Hufeisen, S.J.6
Jensen, N.H.7
Kuijer, M.B.8
Matos, R.C.9
Tran, T.B.10
-
101
-
-
66149149851
-
Structure-based discovery of beta2-adrenergic receptor ligands
-
Kolb, P., Rosenbaum, D.M., Irwin, J.J., Fung, J.J., Kobilka, B.K. and Shoichet, B.K. (2009) Structure-based discovery of beta2-adrenergic receptor ligands. Proc. Natl. Acad. Sci. U.S.A., 106, 6843-6848.
-
(2009)
Proc. Natl. Acad. Sci. U.S.A.
, vol.106
, pp. 6843-6848
-
-
Kolb, P.1
Rosenbaum, D.M.2
Irwin, J.J.3
Fung, J.J.4
Kobilka, B.K.5
Shoichet, B.K.6
-
102
-
-
77954675603
-
Biosynthesis of polyketides by trans-AT polyketide synthases
-
Piel, J. (2010) Biosynthesis of polyketides by trans-AT polyketide synthases. Nat. Prod. Rep., 27, 996-1047.
-
(2010)
Nat. Prod. Rep.
, vol.27
, pp. 996-1047
-
-
Piel, J.1
-
103
-
-
67651171430
-
Cloning and sequencing of the biosynthetic gene cluster for saquayamycin Z and galtamycin B and the elucidation of the assembly of their saccharide chains
-
Erb, A., Luzhetskyy, A., Hardter, U. and Bechthold, A. (2009) Cloning and sequencing of the biosynthetic gene cluster for saquayamycin Z and galtamycin B and the elucidation of the assembly of their saccharide chains. Chembiochem, 10, 1392-1401.
-
(2009)
Chembiochem
, vol.10
, pp. 1392-1401
-
-
Erb, A.1
Luzhetskyy, A.2
Hardter, U.3
Bechthold, A.4
-
104
-
-
84155192367
-
Identification of late-stage glycosylation steps in the biosynthetic pathway of the anthracycline nogalamycin
-
Siitonen, V., Claesson, M., Patrikainen, P., Aromaa, M., Mantsala, P., Schneider, G. and Metsa-Ketela, M. (2012) Identification of late-stage glycosylation steps in the biosynthetic pathway of the anthracycline nogalamycin. Chembiochem, 13, 120-128.
-
(2012)
Chembiochem
, vol.13
, pp. 120-128
-
-
Siitonen, V.1
Claesson, M.2
Patrikainen, P.3
Aromaa, M.4
Mantsala, P.5
Schneider, G.6
Metsa-Ketela, M.7
-
105
-
-
52049109838
-
Natural products in drug discovery
-
Harvey, A.L. (2008) Natural products in drug discovery. Drug Discov. Today, 13, 894-901.
-
(2008)
Drug Discov. Today
, vol.13
, pp. 894-901
-
-
Harvey, A.L.1
-
106
-
-
14744303645
-
Marine actinomycete diversity and natural product discovery
-
Jensen, P.R., Mincer, T.J., Williams, P.G. and Fenical, W. (2005) Marine actinomycete diversity and natural product discovery. Antonie Van Leeuwenhoek, 87, 43-48.
-
(2005)
Antonie van Leeuwenhoek
, vol.87
, pp. 43-48
-
-
Jensen, P.R.1
Mincer, T.J.2
Williams, P.G.3
Fenical, W.4
-
107
-
-
79851507787
-
Genomics-inspired discovery of natural products
-
Winter, J.M., Behnken, S. and Hertweck, C. (2011) Genomics-inspired discovery of natural products. Curr. Opin. Chem. Biol., 15, 22-31.
-
(2011)
Curr. Opin. Chem. Biol.
, vol.15
, pp. 22-31
-
-
Winter, J.M.1
Behnken, S.2
Hertweck, C.3
-
108
-
-
84876566794
-
Cluster Mine360: A database of microbial PKS/NRPS biosynthesis
-
Conway, K.R. and Boddy, C.N. (2013) Cluster Mine360: a database of microbial PKS/NRPS biosynthesis. Nucleic Acids Res., 41, D402-D407.
-
(2013)
Nucleic Acids Res.
, vol.41
, pp. D402-D407
-
-
Conway, K.R.1
Boddy, C.N.2
-
109
-
-
79959920872
-
Anti SMASH: Rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences
-
Medema, M.H., Blin, K., Cimermancic, P., de Jager, V., Zakrzewski, P., Fischbach, M.A., Weber, T., Takano, E. and Breitling, R. (2011) anti SMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences. Nucleic Acids Res., 39, W339-W346.
-
(2011)
Nucleic Acids Res.
, vol.39
, pp. W339-W346
-
-
Medema, M.H.1
Blin, K.2
Cimermancic, P.3
De Jager, V.4
Zakrzewski, P.5
Fischbach, M.A.6
Weber, T.7
Takano, E.8
Breitling, R.9
-
110
-
-
84907584619
-
Pep2Path: Automated mass spectrometry-guided genome mining of peptidic natural products
-
Medema, M.H., Paalvast, Y., Nguyen, D.D., Melnik, A., Dorrestein, P.C., Takano, E. and Breitling, R. (2014) Pep2Path: automated mass spectrometry-guided genome mining of peptidic natural products. PLoS Comput. Biol., 10, e1003822.
-
(2014)
PLoS Comput. Biol.
, vol.10
, pp. e1003822
-
-
Medema, M.H.1
Paalvast, Y.2
Nguyen, D.D.3
Melnik, A.4
Dorrestein, P.C.5
Takano, E.6
Breitling, R.7
-
111
-
-
84906328199
-
Structural investigation of ribosomally synthesized natural products by hypothetical structure enumeration and evaluation using tandem MS
-
Zhang, Q., Ortega, M., Shi, Y., Wang, H., Melby, J.O., Tang, W., Mitchell, D.A. and van der Donk, W.A. (2014) Structural investigation of ribosomally synthesized natural products by hypothetical structure enumeration and evaluation using tandem MS. Proc. Natl. Acad. Sci. U.S.A., 111, 12031-12036.
-
(2014)
Proc. Natl. Acad. Sci. U.S.A.
, vol.111
, pp. 12031-12036
-
-
Zhang, Q.1
Ortega, M.2
Shi, Y.3
Wang, H.4
Melby, J.O.5
Tang, W.6
Mitchell, D.A.7
Van Der-Donk, W.A.8
|