Identification and characterization of the spiruchostatin biosynthetic gene cluster enable yield improvement by overexpressing a transcriptional activator

Journal of Industrial Microbiology and Biotechnology

Volumn 41, Issue 9, 2014, Pages 1457-1465

  Potharla, Vishwakanth Y ^a,b   Wang, Cheng ^a,c   Cheng, Yi Qiang ^a,d  

^a UNIVERSITY OF WISCONSIN MILWAUKEE   (United States)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

^c Cedarburg Hauser Pharmaceuticals   (United States)

^d UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

Author keywords

Biosynthesis; Genetic engineering; Pseudomonas sp. Q71576; Spiruchostatins; Yield improvement

Indexed keywords

NATURAL PRODUCT; SPIRUCHOSTATIN A; SPIRUCHOSTATIN B; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; CYCLOPEPTIDE; DEPSIPEPTIDE; TRANSACTIVATOR PROTEIN;

ARTICLE; BIOSYNTHESIS; CHROMOBACTERIUM VIOLACEUM; GENE CLUSTER; GENE OVEREXPRESSION; GENE SEQUENCE; GENOME; MUTATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PSEUDOMONAS; REGULATOR GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; CHROMOBACTERIUM; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOLECULAR GENETICS; MULTIGENE FAMILY;

CHROMOBACTERIUM VIOLACEUM; PSEUDOMONAS SP.;

BACTERIAL PROTEINS; BIOSYNTHETIC PATHWAYS; CHROMOBACTERIUM; DEPSIPEPTIDES; GENE EXPRESSION REGULATION, BACTERIAL; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; PEPTIDES, CYCLIC; PSEUDOMONAS; TRANS-ACTIVATORS;

EID: 84906227555     PISSN: 13675435     EISSN: 14765535     Source Type: Journal    
DOI: 10.1007/s10295-014-1474-8     Document Type: Article

References (28)

1. Chen Y, Gambs C, Abe Y, Wentworth P Jr, Janda KD (2003) Total synthesis of the depsipeptide FR-901375. J Org Chem 68(23):8902-8905. doi:10.1021/ jo034765b (Pubitemid 37409537)
2. Chen Y, Smanski MJ, Shen B (2010) Improvement of secondary metabolite production in Streptomyces by manipulating pathway regulation. Appl Microbiol Biotechnol 86(1):19-25. doi:10.1007/s00253-009-2428-3
3. Cheng Y-Q, Yang M, Matter AM (2007) Characterization of a gene cluster responsible for the biosynthesis of anticancer agent FK228 in Chromobacterium violaceum No. 968. Appl Environ Microbiol 73(11):3460-3469. doi:10.1128/AEM. 01751-06 (Pubitemid 46871433)
4. Cheson BD, Horwitz SM, Weisenburger DD (2011) Peripheral T-cell lymphomas: diagnosis and treatment options. Proceedings from a live roundtable, August 17, 2011, Kauai, Hawaii. Clin Adv Hematol Oncol 9(11 Suppl 26):1-14
5. Choi H, Kim S, Mukhopadhyay P, Cho S, Woo J, Storz G, Ryu SE (2001) Structural basis of the redox switch in the OxyR transcription factor. Cell 105(1):103-113. doi:10.1016/S0092-8674(01)00300-2 (Pubitemid 32323920)
6. Davies ER, Haitchi HM, Thatcher TH, Sime PJ, Kottmann RM, Ganesan A, Packham G, O'Reilly KM, Davies DE (2012) Spiruchostatin A inhibits proliferation and differentiation of fibroblasts from patients with pulmonary fibrosis. Am J Respir Cell Mol Biol 46(5):687-694. doi:10.1165/rcmb.2011-0040OC
7. Droege M, Hill B (2008) The Genome Sequencer FLX System - longer reads, more applications, straight forward bioinformatics and more complete data sets. J Biotechnol 136(1-2):3-10. doi:10.1016/j.jbiotec.2008.03.021
8. Finking R, Solsbacher J, Konz D, Schobert M, Schafer A, Jahn D, Marahiel MA (2002) Characterization of a new type of phosphopantetheinyl transferase for fatty acid and siderophore synthesis in Pseudomonas aeruginosa. J Biol Chem 277(52):50293-50302. doi:10.1074/jbc.M205042200 (Pubitemid 36042177)
9. Hoang T, Karkhoff-Schweizer R, Kutchma AJ, Schweizer HP (1998) A broad-host-range Flp-FRT recombination system for site-specific excision of chromosomally-located DNA sequences: application for isolation of unmarked Pseudomonas aeruginosa mutants. Gene 212(1):77-86 pii: S0378111998001309
10. Kanno S, Maeda N, Tomizawa A, Yomogida S, Katoh T, Ishikawa M (2012) Characterization of cells resistant to the potent histone deacetylase inhibitor spiruchostatin B (SP-B) and effect of overexpressed p21waf1/cip1 on the SP-B resistance or susceptibility of human leukemia cells. Int J Oncol 41(3):862-868. doi:10.3892/ijo.2012.1507
11. Lambalot RH, Gehring AM, Flugel RS, Zuber P, LaCelle M, Marahiel MA, Reid R, Khosla C, Walsh CT (1996) A new enzyme superfamily - the phosphopantetheinyl transferases. Chem Biol 3(11):923-936 pii: S1074-5521(96)90181-7
12. Lynch MD, Gill RT (2006) Broad host range vectors for stable genomic library construction. Biotechnol Bioeng 94(1):151-158. doi:10.1002/bit.20836 (Pubitemid 43723207)
13. Masakuni O, Toshio G, Takashi F, Yasuhiro H, Hirotsugu U (1991) FR901375 substance and production thereof. Japan Patent JP 3141296 (A)
14. Masuoka Y, Nagai A, Shin-ya K, Furihata K, Nagai K, Suzuki K, Hayakawa Y, Seto H (2001) Spiruchostatins A and B, novel gene expression-enhancing substances produced by Pseudomonas sp. Tetrahedron Lett 42:41-44 (Pubitemid 32011701)
15. Potharla VY, Wesener SR, Cheng Y-Q (2011) New insights into the genetic organization of the FK228 biosynthetic gene cluster in Chromobacterium violaceum no. 968. Appl Environ Microbiol 77(4):1508-1511. doi:10.1128/AEM.01512-10
16. Sambrook J, Russell DW (2000) Molecular Cloning: a laboratory manual, 3rd edn. Cold Spring Harbor Laboratory Press, Cold Spring Harbor
17. Shindoh N, Mori M, Terada Y, Oda K, Amino N, Kita A, Taniguchi M, Sohda KY, Nagai K, Sowa Y, Masuoka Y, Orita M, Sasamata M, Matsushime H, Furuichi K, Sakai T (2008) YM753, a novel histone deacetylase inhibitor, exhibits antitumor activity with selective, sustained accumulation of acetylated histones in tumors in the WiDr xenograft model. Int J Oncol 32(3):545-555 (Pubitemid 351330460)
18. Ueda H, Manda T, Matsumoto S, Mukumoto S, Nishigaki F, Kawamura I, Shimomura K (1994) FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. III. Antitumor activities on experimental tumors in mice. J Antibiot (Tokyo) 47(3):315-323 (Pubitemid 24106522)
19. Ueda H, Nakajima H, Hori Y, Fujita T, Nishimura M, Goto T, Okuhara M (1994) FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties, and antitumor activity. J Antibiot (Tokyo) 47(3):301-310 (Pubitemid 24106520)
20. Ueda H, Nakajima H, Hori Y, Goto T, Okuhara M (1994) Action of FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum no. 968, on Ha-ras transformed NIH3T3 cells. Biosci Biotechnol Biochem 58(9):1579-1583 (Pubitemid 2159869)
21. VanderMolen KM, McCulloch W, Pearce CJ, Oberlies NH (2011) Romidepsin (Istodax, NSC 630176, FR901228, FK228, depsipeptide): a natural product recently approved for cutaneous T-cell lymphoma. J Antibiot (Tokyo) 64(8):525-531. doi:10.1038/ja.2011.35
22. Wang C, Cheng Y-Q (2011) Thailandepsin a. Acta Crystallogr Sect E Struct Rep Online 67(Pt 11):o2948-o2949. doi:10.1107/S1600536811041390zl2411
23. Wang C, Flemming CJ, Cheng Y-Q (2012) Discovery and activity profiling of thailandepsins A through F, potent histone deacetylase inhibitors, from E264. Medchemcomm 3(8):976-981. doi:10.1039/C2MD20024D
24. Wang C, Henkes LM, Doughty LB, He M, Wang D, Meyer-Almes FJ, Cheng Y-Q (2011) Thailandepsins: bacterial products with potent histone deacetylase inhibitory activities and broadspectrum antiproliferative activities. J Nat Prod 74(10):2031-2038. doi:10.1021/np200324x
25. Wang C, Wesener SR, Zhang H, Cheng Y-Q (2009) An FAD-dependent pyridine nucleotide-disulfide oxidoreductase is involved in disulfide bond formation in FK228 anticancer depsipeptide. Chem Biol 16(6):585-593. doi:10.1016/j.chembiol. 2009.05.005
26. Wesener SR, Potharla VY, Cheng Y-Q (2011) Reconstitution of the FK228 biosynthetic pathway reveals cross talk between modular polyketide synthases and fatty acid synthase. Appl Environ Microbiol 77(4):1501-1507. doi:10.1128/AEM.01513-10
27. Yamada T, Horinaka M, Shinnoh M, Yoshioka T, Miki T, Sakai T (2013) A novel HDAC inhibitor OBP-801 and a PI3 K inhibitor LY294002 synergistically induce apoptosis via the suppression of survivin and XIAP in renal cell carcinoma. Int J Oncol 43(4):1080-1086. doi:10.3892/ijo.2013.2042
28. Yoshioka T, Yogosawa S, Yamada T, Kitawaki J, Sakai T (2013) Combination of a novel HDAC inhibitor OBP-801/YM753 and a PI3 K inhibitor LY294002 synergistically induces apoptosis in human endometrial carcinoma cells due to increase of Bim with accumulation of ROS. Gynecol Oncol 129(2):425-432. doi:10.1016/j.ygyno.2013.02.008