The biosynthetic genes for disorazoles, potent cytotoxic compounds that disrupt microtubule formation

Gene

Volumn 359, Issue 1-2, 2005, Pages 91-98

  Carvalho, Ruby ^a   Reid, Ralph ^a   Viswanathan, Nina ^a   Gramajo, Hugo ^a   Julien, Bryan ^a  

^a KOSAN BIOSCIENCES INC   (United States)

Author keywords

Anticancer; Myxobacteria; Non ribosomal peptide synthetase; Polyketide; Polyketide synthase

Indexed keywords

ACYLTRANSFERASE; CYTOTOXIC AGENT; DISORAZOLE; POLYKETIDE SYNTHASE; POLYPEPTIDE; POLYPEPTIDE DSZA; POLYPEPTIDE DSZB; POLYPEPTIDE DSZC; POLYPEPTIDE DSZD; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL STRAIN; CELL DISRUPTION; CONTROLLED STUDY; DNA FLANKING REGION; DNA SEQUENCE; DRUG SYNTHESIS; GENE CLUSTER; GENE SYNTHESIS; MICROTUBULE ASSEMBLY; MUTAGENESIS; MYXOCOCCALES; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; TRANSPOSON;

AMINO ACID SEQUENCE; CATALYTIC DOMAIN; DIMERIZATION; DNA, BACTERIAL; GENE ORDER; MICROTUBULES; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; MYXOCOCCALES; OXAZOLES; POLYKETIDE SYNTHASES; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS, DNA; SEQUENCE HOMOLOGY, AMINO ACID; TUBULIN;

MYXOCOCCALES; POLYANGIUM CELLULOSUM;

EID: 25144520542     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.gene.2005.06.003     Document Type: Article

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