Cloning and sequencing of the biosynthetic gene cluster for saquayamycin Z and galtamycin B and the elucidation of the assembly of their saccharide chains

ChemBioChem

Volumn 10, Issue 8, 2009, Pages 1392-1401

  Erb, Annette ^a   Luzhetskyy, Andriy ^a   Hardter, Uwe ^a   Bechthold, Andreas ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Actinomycetes; Gene technology; Glycosyltransferases; Natural products; Polyketides

Indexed keywords

ANTIBIOTIC AGENT; CARBOHYDRATE; GALTAMYCIN B; GLYCOSYLTRANSFERASE; QUINONE DERIVATIVE; SAQUAYAMYCIN Z; UNCLASSIFIED DRUG; ANTHRACYCLINE; CARBOHYDRASE; GALTAMYCIN; GLYCOSIDASE; MUTANT PROTEIN;

ARTICLE; BACTERIAL GROWTH; BACTERIAL STRAIN; BACTERIUM MUTANT; CHEMICAL MODIFICATION; CONTROLLED STUDY; DNA SEQUENCE; DRUG STRUCTURE; DRUG SYNTHESIS; ESCHERICHIA COLI; GENE CLUSTER; GENE EXPRESSION; GENE INACTIVATION; GENE SEQUENCE; GRAM POSITIVE BACTERIUM; MICROMONOSPORA; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMID; PRIORITY JOURNAL; SEQUENCE ANALYSIS; BIOLOGICAL MODEL; CHEMISTRY; GENETICS; GLYCOSYLATION; METABOLISM; MULTIGENE FAMILY;

ACTINOBACTERIA (CLASS); MICROMONOSPORA SP.; POSIBACTERIA;

ANTHRACYCLINES; CLONING, MOLECULAR; GLYCOSIDE HYDROLASES; GLYCOSYLATION; GLYCOSYLTRANSFERASES; MICROMONOSPORA; MODELS, BIOLOGICAL; MULTIGENE FAMILY; MUTANT PROTEINS; SEQUENCE ANALYSIS;

EID: 67651171430     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.200900054     Document Type: Article

References (33)

1. J. S. Thorson, T. Vogt, Carbohydrate-Based Drug Discovery (Ed.: C.-H. Wong), VCH, Weinheim, 2003, pp. 685-711.
2. N. Antal, H.-P. Fiedler, E. Stackebrandt, W. Beil, K. Ströch, A. Zeeck, J. Antibiot. 2005, 58, 95-102.
3. K. Str_soch, A. Zeeck, N. Antal, H.-P. Fiedler, J. Antibiot. 2005, 58, 103-110.
4. A. Luzhetskyy, M. Fedoryshyn, C. Dürr, T. Taguchi, V. Novikov, A. Bechthold, Chem. Biol. 2005, 12, 725-729.
5. O. Gabriel, Adv. Chem. Series 1973, 117, 387-410.
6. X. He, J. S. Thorson, H. W. Liu, Biochemistry 1996, 35, 4721-4731.
7. C. R. Woese, Microbiol. Rev. 1987, 51, 221-271.
8. B. Ostash, Y. Rebets, V. Yuskevich, A. Luzhetskyy, V. Tkachenko, V. Fedorenko, Folia Microbiol. 2003, 48, 484-488.
9. A. Trefzer, S. Pelzer, J. Schimana, S. Stockert, C. Bihlmaier, H.-P. Fiedler, K. Welzel, A. Vente, A. Bechthold, Antimicrob. Agents Chemother. 2002, 46, 1174-1182.
10. I. Alexeev, A. Sultana, P. Mäntsälä, N. Niemi, G. Schneider, Proc. Natl. Acad. Sci. USA 2007, 104, 6170-6175.
11. K. F. Chater, M. Bibb, Biotechnology: Products of Secondary Metabolism, Vol. 7 (Eds.: H. Kleinkauf, H. von Dören), VCH, Weinheim 1997, pp. 57-105.
12. B. Faust, D. Hoffmeister, G. Weitnauer, L. Westrich, S. Haag, P. Schneider, H. Decker, E. Künzel, J. Rohr, A. Bechthold, Microbiology 2000, 146, 147-154.
13. A. Luzhetskyy, T. Taguchi, M. Fedoryshyn, C. Dürr, S. E. Wohlert, V Novikov, A. Bechthold, ChemBioChem 2005, 6, 1406-1410.
14. M. Sezaki, S. Kondo, K. Maeda, H. Umezawa, M. Ono, Tetrahedron 1970, 26, 5171-5190.
15. A. Trefzer, D. Hoffmeister, E. Künzel, S. Stockert, G. Weitnauer, L. Westrich, U. Rix, J. Fuchser, K. U. Bindseil, J. Rohr, A. Bechthold, Chem. Biol. 2000, 7, 133-142.
16. C. Hertweck, A. Luzhetskyy, Y. Rebets, A. Bechthold, Nat. Prod. Rep. 2007, 24, 162-190.
17. S. E. Wohlert, E. Künzel, R. Machinek, C. Méndez, J. A. Salas, J. Rohr, J. Nat. Prod. 1999, 62, 119-121.
18. N. Menéndez, M. Nur-e-Alam, A. F. Braña, J. Rohr, J. A. Salas, C. Méndez, Chem. Biol. 2004, 11, 21-32.
19. T. Henkel, J. Rohr, J. M. Beale, L. Schwenen, J. Antibiot. 1990, 43, 492-503.
20. H. Drautz, H. Zähner, J. Rohr, A. Zeeck, J. Antibiot. 1986, 39, 1657-1669.
21. W. Lu, C. Leimkuhler, M. Oberthür, D. Kahne, C. T. Walsh, Biochemistry 2004, 43, 4548-4558.
22. C. Krauth, M. Fedoryshyn, C. Schleberger, A. Luzhetskyy, A. Bechthold, Chem. Biol. 2009, 16, 28-35.
23. T. Kieser, M. J. Bibb, M. J. Buttner, K. F. Chater, D. A. Hopwood, Practical Streptomyces Genetics, The John Innes Foundation, Norwich, 2000.
24. J. Sambrook, D. W. Russell, Molecular Cloning: A Laboratory Manual, 3rd ed., Cold Spring Harbor Laboratory Press, New York, 2001.
25. A. H. Rosenberg, B. N. Lade, D. S. Chui, S. W. Lin, J. J. Dunn, F. W. Studier, Gene 1987, 56, 125-135.
26. C. Yanisch-Perron, J. Vieira, J. Messing, Gene 1985, 33, 103-119.
27. M. Bierman, R. Logan, K. O'Brien, E. T. Seno, R. N. Rao, B. E. Schoner, Gene 1992, 116, 43-49.
28. D. Hoffmeister, K. Ichinose, A. Bechthold, Chem. Biol. 2001, 8, 557-567.
29. A. Luzhetskyy, L. Zhu, M. Gibson, M. Fedoryshyn, C. Dürr, C. Hofmann, D. Hoffmeister, B. Ostash, C. Mattingly, V. Adams, V. Fedorenko, J. Rohr, A. Bechthold, ChemBioChem 2005, 6, 675-678.
30. M. Redenbach, H. M. Kieser, D. Denapaite, A. Eichner, J. Cullum, H. Kinashi, D. A. Hopwood, Mol. Microbiol. 1996, 21, 77-96.
31. A. Luzhetskyy, H. Weiss, A. Chargé, E. Welle, A. Linnenbrink, A. Vente, A. Bechthold, Appl. Gen. Mol. Biotech. 2007, 75, 1367-1375.
32. S. F. Altschul, T. L. Madden, A. A. Schaffer, J. Zhang, Z. Zhang, W. Miller, D. J. Lipman, Nucleic Acids Res. 1997, 25, 3389-3402.
33. B. Gust, G. L. Challis, K. Fowler, T. Kieser, K. F. Chater, Proc. Natl. Acad. Sci. USA 2003, 100, 1541-1546.