Expanding our understanding of sequence-function relationships of Type II polyketide biosynthetic gene clusters: Bioinformatics-guided identification of frankiamicin a from Frankia sp. EAN1pec

PLoS ONE

Volumn 10, Issue 4, 2015, Pages

  Ogasawara, Yasushi ^a,c   Yackley, Benjamin J ^a   Greenberg, Jacob A ^a   Rogelj, Snezna ^b   Melançon, Charles E ^a  

^a UNIVERSITY OF NEW MEXICO   (United States)

^b NEW MEXICO INSTITUTE OF MINING AND TECHNOLOGY   (United States)

^c HOKKAIDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

FRANKIAMICIN A; KETOSYNTHASE ALPHA; KETOSYNTHASE BETA; NATURAL PRODUCT; SYNTHETASE; UNCLASSIFIED DRUG; ANTHRAQUINONE DERIVATIVE; BACTERIAL PROTEIN; BIOLOGICAL PRODUCT; POLYKETIDE; POLYKETIDE SYNTHASE;

ARTICLE; BACTERIAL GENOME; BACTERIAL GROWTH; BIOINFORMATICS; CONTROLLED STUDY; DRUG SCREENING; DRUG STRUCTURE; FRANKIA; GENE; GENE CLUSTER; GENE FUNCTION; GENE SEQUENCE; GENE STRUCTURE; GENE SYNTHESIS; GENETIC ASSOCIATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NONHUMAN; PHYLOGENY; POLYKETIDE TYPE II GENE; PROTON NUCLEAR MAGNETIC RESONANCE; AMINO ACID SEQUENCE; BIOLOGY; CHEMISTRY; CONSERVED SEQUENCE; ENZYMOLOGY; GENE EXPRESSION; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; MOLECULAR GENETICS; MULTIGENE FAMILY; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY;

ACTINOBACTERIA; BACTERIA (MICROORGANISMS); FRANKIA; FRANKIA SP.;

AMINO ACID SEQUENCE; ANTHRAQUINONES; BACTERIAL PROTEINS; BIOLOGICAL PRODUCTS; COMPUTATIONAL BIOLOGY; CONSERVED SEQUENCE; FRANKIA; GENE EXPRESSION; GENOME, BACTERIAL; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; POLYKETIDE SYNTHASES; POLYKETIDES; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 84926664670     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0121505     Document Type: Article

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