Mitochondrial ROS induces cardiac inflammation via a pathway through mtDNA damage in a pneumonia-related sepsis model

PLoS ONE

Volumn 10, Issue 10, 2015, Pages

  Yao, Xiao ^a   Carlson, Deborah ^a   Sun, Yuxiao ^a   Ma, Lisha ^a   Wolf, Steven E ^a   Minei, Joseph P ^a   Zang, Qun S ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8 OXOGUANINE GLYCOSYLASE; ADVANCED GLYCATION END PRODUCT RECEPTOR; ALPHA TOCOPHEROL; CARBAMOYL PHOSPHATE SYNTHASE; CARDIOLIPIN; CYTOCHROME C; DNA (APURINIC OR APYRIMIDINIC SITE) LYASE; DNA DIRECTED DNA POLYMERASE GAMMA; HIGH MOBILITY GROUP B1 PROTEIN; INTERLEUKIN 1BETA CONVERTING ENZYME; MEMBRANE ENZYME; MITOCHONDRIAL DNA; MITOCHONDRIAL TRANSCRIPTION FACTOR A; MYELOID DIFFERENTIATION FACTOR 88; OUTER MEMBRANE PROTEIN; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; TOLL LIKE RECEPTOR 9; TROPONIN; TROPONIN I; UNCLASSIFIED DRUG; URACIL DNA GLYCOSIDASE; ANTIOXIDANT; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOGENESIS; CARDITIS; CELL VIABILITY; CENTRIFUGATION; COLONY FORMING UNIT; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA DAMAGE; DNA REPAIR; ELECTRON MICROSCOPY; GENE AMPLIFICATION; HEART MUSCLE CELL; HEART PROTECTION; IMMUNOPRECIPITATION; MALE; MITOCHONDRIAL RESPIRATION; MORPHOLOGY; NONHUMAN; OXIDATION; OXIDATIVE PHOSPHORYLATION; PNEUMONIA; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN DENATURATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RAT; SEPSIS; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; SPECTROPHOTOMETRY; STREPTOCOCCUS PNEUMONIA; STRUCTURAL HOMOLOGY; UPREGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; CARDIAC MUSCLE; CARDIAC MUSCLE CELL; CELL CULTURE; CYTOLOGY; DISEASE MODEL; DRUG EFFECTS; METABOLISM; MITOCHONDRION; OXIDATIVE STRESS; PATHOGENICITY; PATHOLOGY; SPRAGUE DAWLEY RAT; STREPTOCOCCUS PNEUMONIAE;

ANIMALS; ANTIOXIDANTS; CELLS, CULTURED; DISEASE MODELS, ANIMAL; DNA, MITOCHONDRIAL; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; MALE; MITOCHONDRIA; MYOCARDIUM; MYOCYTES, CARDIAC; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SEPSIS; SIGNAL TRANSDUCTION; STREPTOCOCCUS PNEUMONIAE; SUPEROXIDES; TOLL-LIKE RECEPTOR 9; TROPONIN; VITAMIN E;

EID: 84948672710     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0139416     Document Type: Article

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