Incidence, organ dysfunction and mortality in severe sepsis: A Spanish multicentre study

Critical Care

Volumn 12, Issue 6, 2008, Pages

  Blanco, Jesús ^a,b   Muriel Bombín, Arturo ^a   Sagredo, Víctor ^c   Taboada, Francisco ^d   Gandía, Francisco ^e   Tamayo, Luís ^f   Collado, Javier ^f   García Labattut, Ángel ^g   Carriedo, Demetrio ^h   Valledor, Manuel ⁱ   De Frutos, Martín ^j   López, María Jesús ^k   Caballero, Ana ^l   Guerra, José ^m   Álvarez, Braulio ⁿ   Mayo, Agustín ^o   Villar, Jesús ^b,p,q  

^a HOSPITAL UNIVERSITARIO RÍO HORTEGA   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c HOSPITAL UNIVERSITARIO DE SALAMANCA   (Spain)

^d HOSPITAL UNIVERSITARIO CENTRAL DE ASTURIAS   (Spain)

^e HOSPITAL CLÍNICO UNIVERSITARIO DE VALLADOLID   (Spain)

^f HOSPITAL RÍO CARRIÓN   (Spain)

^g Hospital General del Insalud Soria   (Spain)

^h Complejo Asistencial Universitario de León   (Spain)

ⁱ Hospital de San Agustín   (Spain)

^j HOSPITAL UNIVERSITARIO DE BURGOS   (Spain)

^k HOSPITAL GENERAL DE SEGOVIA   (Spain)

^l HOSPITAL VIRGEN DE LA CONCHA   (Spain)

^m HOSPITAL DE CABUEÑES   (Spain)

ⁿ HOSPITAL EL BIERZO   (Spain)

^o UNIVERSITY OF VALLADOLID   (Spain)

^p HOSPITAL UNIVERSITARIO DE GRAN CANARIA DR NEGRÍN   (Spain)

^q ST MICHAEL'S HOSPITAL   (Canada)

more..

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN C;

ADULT; AGED; APACHE; ARTICLE; BACTERIUM ISOLATION; CLINICAL TRIAL; COMORBIDITY; DEATH; FEMALE; HEART FAILURE; HUMAN; INCIDENCE; INTENSIVE CARE UNIT; KIDNEY FAILURE; LIVER FAILURE; MAJOR CLINICAL STUDY; MALE; MORTALITY; MULTICENTER STUDY; MULTIPLE ORGAN FAILURE; PATIENT CARE; PNEUMONIA; PREVALENCE; PRIORITY JOURNAL; RESPIRATORY FAILURE; RISK FACTOR; SEPSIS; SEPTIC SHOCK; SPAIN; COHORT ANALYSIS; COMMUNITY HOSPITAL; HOSPITALIZATION; MIDDLE AGED; OBSERVATION; PATHOPHYSIOLOGY; PROSPECTIVE STUDY;

AGED; AGED, 80 AND OVER; COHORT STUDIES; FEMALE; HOSPITAL MORTALITY; HOSPITALS, COMMUNITY; HUMANS; INTENSIVE CARE UNITS; MALE; MIDDLE AGED; MULTIPLE ORGAN FAILURE; OBSERVATION; PROSPECTIVE STUDIES; RISK FACTORS; SEPSIS; SEVERITY OF ILLNESS INDEX; SPAIN;

EID: 58849147094     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc7157     Document Type: Article

References (32)

1. Martin GS Mannino DM Eaton S Moss M The epidemiology of sepsis in the United States from 1979 through 2000 N Engl J Med 2003, 348:1546-1554. 10.1056/NEJMoa022139 12700374
2. Bone RC Balk RA Cerra FB Dellinger RP Fein AM Knaus WA Schein RM Sibbald WJ Definition for sepsis and organ failure and guidelines for use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine Chest 1992, 101:1644-1655. 10.1378/chest.101.6.1644 1303622
3. Brun-Buisson C The epidemiology of the systemic inflammatory response Intensive Care Med 2000, 26(Suppl 1):S64-S74. 10786961 10.1007/ s001340051121
4. Barriere SL Lowry SF An overview of mortality risk prediction in sepsis Crit Care Med 1995, 23:376-393. 10.1097/00003246-199502000-00026 7867363
5. Brun-Buisson C Doyon F Carlet J Dellamonica P Gouin F Lepoutre A Mercier JC Offenstadt G Régnier B Incidence, risk factors, and outcome of severe sepsis and septic shock in adults. A multicenter prospective study in intensive care units. French ICU Group for Severe Sepsis JAMA 1995, 274:968-974. 10.1001/jama.274.12.968 7674528
6. Rangel-Frausto MS Pittet D Costigan M Hwang T Davis CS Wenzel RP The natural history of the systemic inflammatory response syndrome (SIRS): A prospective study JAMA 1995, 273:117-123. 10.1001/jama.273.2.117 7799491
7. Sands KE Bates DW Lanken PN Graman PS Hibberd PL Kahn KL Parsonnet J Panzer R Orav EJ Snydman DR Black E Schwartz JS Moore R Johnson BL Jr Platt R Academic Medical Center Consortium Sepsis Project Working Group Epidemiology of sepsis syndrome in 8 academic medical centers JAMA 1997, 278:234-240. 10.1001/jama.278.3.234 9218672
8. Salvo I de Cian W Musicco M Langer M Piadena R Wolfler A Montani C Magni E The Italian sepsis study: Preliminary results on the incidence and evolution of SIRS, sepsis, severe sepsis and septic shock Intensive Care Med 1995, 21(Suppl 2):S244-S249. 8636531 10.1007/BF01740762
9. Angus DC Linde-Zwirble WT Lidicker J Clermont G Carcillo J Pinsky MR Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care Crit Care Med 2001, 29:1303-1310. 10.1097/00003246-200107000-00002 11445675
10. Esteban A Frutos-Vivar F Ferguson ND Peñuelas O Lorente JA Gordo F Honrubia T Algora A Bustos A García G Díaz-Regañón IR de Luna RR Sepsis incidence and outcome: Contrasting the intensive care unit with the hospital ward Crit Care Med 2007, 35:1284-1289. 10.1097/01.CCM.0000260960.94300.DE 17414725
11. Padkin A Goldfrad C Brady AR Young D Black N Rowan K Epidemiology of severe sepsis occurring in the first 24 hrs in intensive care units in England, Wales, and Northern Ireland Crit Care Med 2003, 31:2332-2338. 10.1097/01.CCM.0000085141.75513.2B 14501964
12. Annane D Aegerter P Jars-Guincestre MC Guidet B CUB-Réa Network Current epidemiology of septic shock: The CUB-Réa Network Am J Respir Crit Care Med 2003, 168:165-172. 10.1164/rccm.2201087 12851245
13. Finfer S Bellomo R Lipman J French C Dobb G Myburgh J Adult-population incidence of severe sepsis in Australian and New Zealand intensive care units Intensive Care Med 2004, 30:589-596. 14963646 10.1007/ s00134-004-2157-0
14. Brun-Buisson C Meshaka P Pinton P Vallet B EPISEPSIS Study Group EPISEPSIS: A reappraisal of the epidemiology and outcome of severe sepsis in French intensive care units Intensive Care Med 2004, 30:580-588. 14997295 10.1007/s00134-003-2121-4
15. Alberti C Brun-Buisson C Burchardi H Martin C Goodman S Artigas A Sicignano A Palazzo M Moreno R Boulmé R Lepage E Le Gall R Epidemiology of sepsis and infection in ICU patients from an international multicentre cohort study Intensive Care Med 2002, 28:108-121. 11907653 10.1007/s00134-001-1143-z
16. Bernard GR Vincent JL Laterre PF LaRosa SP Dhainaut JF Lopez-Rodriguez A Steingrub JS Garber GE Helterbrand JD Ely EW Fisher CJ Jr Recombinant human protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group Efficacy and safety of recombinant human activated protein C for severe sepsis N Engl J Med 2001, 344:699-709. 10.1056/ NEJM200103083441001 11236773
17. Angus DC Wax RS Epidemiology of sepsis: An update Crit Care Med 2001, 29:S109-S116. 11445744 10.1097/00003246-200107001-00035
18. Dellinger RP Carlet JM Masur H Gerlach H Calandra T Cohen J Gea-Banacloche J Keh D Marshall JC Parker MM Ramsay G Zimmerman JL Vincent JL Levy MM Surviving Sepsis Campaign Guidelines for management of severe sepsis and septic shock Intensive Care Med 2004, 30:536-555. 10.1007/s00134-004-2398-y 14997291
19. McCabe WR Jackson GG Gram negative bateremia: Etiology and ecology Arch Intern Med 1962, 110:847-852.
20. Knaus WA Draper EA Wagner DP Zimmerman JE APACHE II: A severity of disease classification system Crit Care Med 1985, 13:818-829. 10.1097/ 00003246-198510000-00009 3928249
21. Le Gall JR Klar J Lemeshow S Saulnier F Alberti C Artigas A Teres D The Logistic Organ Dysfunction system. A new way to assess organ dysfunction in the intensive care unit. ICU Scoring Group JAMA 1996, 276:802-810. 10.1001/jama.276.10.802 8769590
22. Vincent JL Moreno R Takala J Willatts S De Mendonça A Bruining H Reinhart CK Suter PM Thijs LG The SOFA (Sepsis Related Organ Failure Assessment) score to describe organ/dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine Intensive Care Med 1996, 22:707-710. 8844239 10.1007/BF01709751
23. Garner JS Jarvis WR Emori TG Horan TC Hughes JM CDC definitions for nosocomial infections Am J Infect Control 1988, 16:128-140. 10.1016/ 0196-6553(88)90053-3 2841893
24. Instituto Nacional de Estadística (INE) Censo de Población y Viviendas 2001. http://www.ine.es/jaxi/menu.do?type=pcaxis&path= %2Ft20%2Fe242&file=inebase&L=
25. Ferrer R Artigas A Levy MM Blanco J González-Díaz G Garnacho-Montero J Ibáñez J Palencia E Quintana M de la Torre-Prados MV Edusepsis Study Group Improvement in process of care and outcome after a multicenter severe sepsis educational program in Spain JAMA 2008, 299:2294-2303. 10.1001/jama.299.19.2294 18492971
26. Engel C Brunkhorst FM Bone HG Brunkhorst R Gerlach H Grond S Gruendling M Huhle G Jaschinski U John S Mayer K Oppert M Olthoff D Quintel M Ragaller M Rossaint R Stuber F Weiler N Welte T Bogatsch H Hartog C Loeffler M Reinhart K Epidemiology of sepsis in Germany: Results from a national prospective multicenter study Intensive Care Med 2007, 33:606-618. 10.1007/s00134-006-0517-7 17323051
27. Vincent JL Sakr Y Sprung CL Ranieri VM Reinhart K Gerlach H Moreno R Carlet J Le Gall JR Payen D Sepsis Occurrence in Acutely Ill Patients Investigators Sepsis in European intensive care units: Results of the SOAP Study Crit Care Med 2006, 34:344-353. 10.1097/ 01.CCM.0000194725.48928.3A 16424713
28. Alberti C Brun-Buisson C Chevret S Antonelli M Goodman SV Martin C Moreno R Ochagavia AR Palazzo M Werdan K Le Gall JR European Sepsis Study Group Systemic inflammatory response and progresion to severe sepsis in critically ill infected patients Am J Respir Crit Care Med 2005, 171:461-468. 10.1164/rccm.200403-324OC 15531752
29. Moreno R Vincent JL Matos R Mendonça A Cantraine F Thijs L Takala J Sprung C Antonelli M Bruining H Willatts S The use of maximum SOFA score to quantify organ dysfunction/failure in intensive care. Results of a prospective, multicentre study Intensive Care Med 1999, 25:686-696. 10.1007/s001340050931 10470572
30. Ferreira FL Bota DP Bross A Mélot C Vincent JL Serial evaluation of the SOFA score to predict outcome in critically ill patients JAMA 2001, 286:1754-1758. 10.1001/jama.286.14.1754 11594901
31. Danai PA Sinha S Moss M Haber MJ Martin GS Seasonal variation in the epidemiology of sepsis Crit Care Med 2007, 35:410-415. 10.1097/ 01.CCM.0000253405.17038.43 17167351
32. Annane D Sébille V Charpentier C Bollaert PE François B Korach JM Capellier G Cohen Y Azoulay E Troché G Chaumet-Riffaut P Bellissant E Effect of treatment with low doses of hydrocortidsone and fludrocortisone on mortality in patients with septic shock JAMA 2002, 288:862-871. 10.1001/jama.288.7.862 12186604