RAGE and modulation of ischemic injury in the diabetic myocardium

Diabetes

Volumn 57, Issue 7, 2008, Pages 1941-1951

  Bucciarelli, Loredana G ^a   Ananthakrishnan, Radha ^b   Hwang, Yuying C ^b   Kaneko, Michiyo ^b   Song, Fei ^b   Sell, David R ^b   Strauch, Christopher ^b   Monnier, Vincent M ^b   Yan, Shi Fang ^b   Schmidt, Ann Marie ^b   Ramasamy, Ravichandran ^b  

^a HUMANITAS CLINICAL AND RESEARCH CENTER   (Italy)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

6 N CARBOXYMETHYLLYSINE; ADENOSINE TRIPHOSPHATE; ADVANCED GLYCATION END PRODUCT RECEPTOR; CASPASE 3; CYTOCHROME C; LACTATE DEHYDROGENASE; LIGAND; PENTOSIDINE; ADVANCED GLYCOSYLATION END PRODUCT RECEPTOR; ADVANCED GLYCOSYLATION END-PRODUCT RECEPTOR; IMMUNOGLOBULIN RECEPTOR; INSULIN;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARDIOVASCULAR RISK; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; ENDOTHELIUM CELL; GLYCATION; HEART MUSCLE ISCHEMIA; INSULIN DEPENDENT DIABETES MELLITUS; ISOLATED HEART; MALE; MONONUCLEAR PHAGOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; REPERFUSION INJURY; SIGNAL TRANSDUCTION; STREPTOZOCIN DIABETES; TRANSGENIC MOUSE; ANIMAL; BAGG ALBINO MOUSE; BIOBREEDING RAT; C57BL MOUSE; DIABETIC ANGIOPATHY; EXPERIMENTAL DIABETES MELLITUS; GENETICS; HEART LEFT VENTRICLE FUNCTION; METABOLISM; MOUSE MUTANT;

ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC ANGIOPATHIES; INSULIN; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MYOCARDIAL ISCHEMIA; RATS; RATS, INBRED BB; RECEPTORS, IMMUNOLOGIC; VENTRICULAR DYSFUNCTION, LEFT;

EID: 48249134831     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db07-0326     Document Type: Article

References (49)

1. Jaffe AS, Spadaro JJ, Schetman R, Roberts R, Geltman EM, Sobel BE: Increased congestive heart failure after myocardial infarction of moderate extent in patients with diabetes mellitus. Am, Heart J 108:31-37, 1984
2. Lehto S, Pyorala K, Miettinen H, Ronnemaa T, Palomaki P, Tuomilehto J, Laakso M: Myocardial infarct size and mortality in patients with non- insulin dependent diabetes mellitus. J Intern Med 236:291-297, 1994
3. Shedaheh A, Regan TJ: Cardiac consequences in diabetes mellitus. Clin Cardiol 18:301-305, 1995
4. Levine B, Kalman J, Mayer L, Fillit HM, Packer M: Elevated circulating levels of tumor necrosis factor in severe chronic heart failure. N Engl J Med 323:236-241, 1990
5. Yokoyama T, Vaca L, Rossen RD, Durante W, Hazarika P, Mann DL: Cellular basis for the negative inotropic effects of tumor necrosis factor- alpha in the adult mammalian heart. J Clin Invest 92:2303-2312, 1993
6. Kubota T, McTiernan CF, Frye CS, Slawson SE, Lemster BH, Koretsky AP, Demetris AJ, Feldman AM: Dilated cardiomyopathy in transgenic mice with cardiac-specific overexpression of tumor necrosis factor-alpha. Circ Res 81:627-635, 1997
7. Bradham WS, Bozkurt B, Gunasinghe H, Mann D, Spinale FG: Tumor necrosis factor-alpha and myocardial remodeling in progression of heart failure: a current prospective. Cardiovasc Res 53:822-830, 2002
8. Aikawa R, Nitta-Komatsubara Y, Kudoh S, Takano H, Nagai T, Yazaki Y, Nagai R, Komuro I: Reactive oxygen species induce cardiomyocyte apoptosis partly through TNF-alpha. Cytokine 18:179-183, 2002
9. Brownlee M: Glycation products and the pathogenesis of diabetic complications. Diabetes Care 15:1835-1843, 1992
10. Schmidt AM, Vianna M, Gerlach M, Brett J, Ryan J, Kao J, Esposito C, Hegarty H, Hurley W, Clauss M, et al.: Isolation and characterization of binding proteins for advanced glycosylation endproducts from lung tissue which are present on the endothelial cell surface. J Biol Chem 267:14987-14997, 1992
11. Kislinger T, Fu C, Huber B, Qu W, Taguchi A, Du Yan S, Hofmann M, Yan SF, Pischetsrieder M, Stern D, Schmidt AM: N(epsilon)-(carboxymethyl) lysine modifications of proteins are ligands for RAGE that activate cell signalling pathways and modulate gene expression. J Biol Chem 274: 31740-31749, 1999
12. Hofmann MA, Drury S, Fu C, Qu W, Taguchi A, Lu Y, Avila C, Kambham N, Bierhaus A, Nawroth P, et al.: RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides. Cell 97:889-901, 1999
13. Taguchi A, Blood DC, del Toro G, Canet A, Lee DC, Qu W, Tanji N, Lu Y, Lalla E, Fu C, Hofmann MA, Kislinger T, Ingram M, Lu A, Tanaka H, Hori O, Ogawa S, Stern DM, Schmidt AM: Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases. Nature 405:354 -360, 2000
14. Crisa L, Mordes JP, Rossini AA: Autoimmune diabetes mellitus in the BB rat. Diabete Metab Rev 8:9-37, 1992
15. Malhotra A, Mordes JP, McDermott L, Schaible TF: Abnormal cardiac biochemistry in spontaneously diabetic Bio-Breeding/Worcester rat. Am J Physiol 249:H1051-H1055, 1985
16. Park L, Raman KG, Lee KJ, Yan L, Ferran LJ, Chow WS, Stern D, Schmidt AM: Suppression of accelerated diabetic atherosclerosis by soluble receptor for AGE (sRAGE). Nat Med 4:1025-1031, 1998
17. Wendt TM, Tanji N, Guo J, Kislinger TR, Qu W, Lu Y, Bucciarelli LG, Rong LL, Moser B, Markowitz GS, Stein G, Bierhaus A, Liliensiek B, Arnold B, Nawroth PP, Stern DM, D'Agati VD, Schmidt AM: RAGE drives the development of glomerulosclerosis and implicates podocyte activation in the pathogenesis of diabetic nephropathy. Am J Pathol 162:1123-1137, 2003
18. Sakaguchi T, Yan SF, Yan SD, Rong LL, Sousa M, Belov D, Andrassy M, Marso SP, Duda S, Arnold B, Liliensiek B, Nawroth PP, Stern DM, Schmidt AM, Naka Y: Arterial restenosis: central role of RAGE-dependent neointimal expansion. J Clin Invest 111:959-972, 2003
19. Constien R, Forde A, Liliensiek B, Grone HJ, Nawroth P, Hammerling G, Arnold B: Characterization of a novel EGFP reporter mouse to monitor Cre recombination as demonstrated by a Tie2 Cre mouse line. Genesis 30:36-44, 2001
20. Harja E, Bu DX, Hudson BI, Chang JS, Shen X, Hallam K, Kalea AZ, Lu Y, Rosario RH, Oruganti S, Nikolla Z, Belov D, Lalla E, Ramasamy R, Yan SF, Schmidt AM: Vascular and inflammatory stresses mediate atherosclerosis via RAGE in apo E deficient mice. J Clin Invest 118:183-194, 2008
21. Wu H, Moulton K, Horval A, Parik S, Glass CK: Combinatorial interactions between AP-1 and ets domain proteins contribute to the developmental regulation of the macrophage scavenger gene. Mol Cell Biol 14:2129-2139, 1994
22. Rong LL, Yan SF, Wendt T, Hans D, Pachydaki S, Bucciarelli LG, Adebayo A, Qu W, Lu Y, Kostov K, Lalla E, Yan SD, Gooch C, Szabolcs M, Trojaborg W, Hays AP, Schmidt AM: RAGE modulates peripheral nerve regeneration via recruitment of both inflammatory and axonal outgrowth pathways. FASEB J 18:1818-1825, 2004
23. Ramasamy R, Hwang YC, Whang J, Bergmann SR: Protection of ischemic hearts by high glucose is mediated by the glucose transporter, GLUT-4. Am J Physiol 281:H290-H297, 2001
24. Hwang YC, Sato S, Tsai JY, Bakr S, Yan SD, Oates PJ, Ramasamy R: Aldose reductase activation is a key component of myocardial response to ischemia. FASEB J 16:243-245, 2002
25. Sell DR, Strauch CM, Shen W, Monnier VM: 2-Aminoadipic acid is a marker of protein carbonyl oxidation in the aging human skin: effects of diabetes, renal failure and sepsis. Biochem J 404:269-277, 2007
26. Sell DR, Kleinman NR, Monnier VM: Longitudinal determination of skin collagen glycation and glycoxidation rates predicts early death in C57BL/ 6NNIA mice. FASEB J 14:145-156, 2000
27. Schleicher ED, Wagner E, Nerlich AG: Increased accumulation of the glycoxidation product N(epsilon)-(carboxymethyl)lysine in human tissues in diabetes and aging. J Clin Invest 99:457-468, 1997
28. Horie K, Miyata T, Maeda K, Miyata S, Sugiyama S, Sakai H, van Ypersele de Strihou C, Monnier VM, Witztum JL, Kurokawa K: Immunohistochem- ical colocalization of glycoxidation products and lipid peroxidation products in diabetic renal glomerular lesions: implications for glycoxidative stress in the pathogenesis of diabetic nephropathy. J Clin Invest 100:2995-3004, 1997
29. Li J, Schmidt AM: Characterization and functional analysis of the promoter of RAGE, the receptor for advanced glycation endproducts. J Biol Chem 272:16498-16506, 1997
30. Cosentino F, Hishikawa K, Katusic ZS, Luscher TF: High glucose increased nitric oxide synthase expression and superoxide anion generation in human aortic endothelial cells. Circ 96:25-28, 1997
31. Ceriello A, Quagliaro L, D'Amico M, Di Filippo C, Marfella R, Nappo F, Berrino L, Rossi F, Giugliano D: Acute hyperglycemia induces nitrotyrosine formation and apoptosis in perfused heart from rat. Diabetes 51:1076-1082, 2002
32. Zou MH, Shi C, Cohen RA: Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite. J Clin Invest 109:817-826, 2002
33. Nagai R, Unno Y, Hayashi MC, Masuda S, Hayase F, Kinae N, Horichi S: Peroxynitrite induces formation of N(epsilon)-(carboxymethyl) lysine by the cleavage of Amadori product and generation of glucosone and glyoxal from glucose: novel pathways for protein modification by peroxynitrite. Diabetes 51:2833-2839, 2002
34. Wang D, Yang XP, Liu YH, Carretero OA, LaPointe MC: Reduction of myocardial infarct size by inhibition of inducible nitric oxide synthase. Am J Hypertens 12:174-182, 1999
35. Wildhirt SM, Weismueller S, Schulze C, Conrad N, Kornberg A, Reichart B: Inducible nitric oxide synthase activation after ischemia/reperfusion contributes to myocardial dysfunction and extent of infarct size in rabbits: evidence for a late phase of nitric oxide-mediated reperfusion injury. Cardiovasc Res 43:698-711, 1999
36. Feng Q, Lu X, Jones DL, Shen J, Arnold, JM: Increased inducible nitric oxide synthase expression contributes to myocardial dysfunction and higher mortality after myocardial infarction in mice. Circulation 104:700-704, 2001
37. Sam F, Sawyer DB, Xie Z, Chang DL, Ngoy S, Brenner DA, Siwik DA, Singh K, Apstein CS, Colucci WS: Mice lacking inducible nitric oxide synthase have improved left ventricular contractile function and reduced apoptotic cell death late after myocardial infarction. Circ Res 89:351-356, 2001
38. Marfella R, DiFilippo C, Esposito K, Nappo F, Piegari E, Cuzzocrea S, Berrino L, Rossi F, Giugliano D, D'Amico M: Absence of inducible nitric oxide synthase reduces myocardial damage during ischemia reperfusion in streptozotocin-induced hyperglycemic mice. Diabetes 53:454-462, 2004
39. Dimmeler S, Lottspeich F, Brune B: Nitric oxide causes ADP-ribosylation and inhibition of glyceraldehyde-3-phosphate dehydrogenase. J Biol Chem 267:16771-16774, 1992
40. Molina y Vedia L, McDonald B, Reep B, Brune B, Di Silvio M, Billiar TR, Lapetina EG: Nitric oxide-induced S-nitrosylation of glyceraldehyde-3- phosphate dehydrogenase inhibits enzymatic activity and increases endogenous ADP-ribosylation. J Biol Chem 267:24929-24932, 1992
41. Ramasamy R, Hwang YC, Liu Y, Son NH, Szabolcs MJ, Cannon PJ: Metabolic and functional protection by selective inhibition of NOS-2 during ischemia-reperfusion in isolated perfused hearts. Circ 109:1668-1673, 2004
42. Smith JM, Paulson DJ, Romano FD: Inhibition of nitric oxide synthase by L-NAME improves ventricular performance in streptozotocin-diabetic rats. J Mol Cell Cardiol 29:2393-2402, 1997
43. Tsoporis JN, Marks A, Kahn HJ, Butany JW, Liu PP, O'Hanlon D, Parker TG: Inhibition of norepinephrine-induced cardiac hypertrophy in s100beta transgenic mice. J Clin Invest 102:1609-1616, 1998
44. Tsoporis JN, Marks A, Haddad A, Dawood F, Liu PP, Parker TG: S100B expression modulates left ventricular remodeling after myocardial infarction in mice. Circulation 111:598-606, 2005
45. Bucciarelli LG, Kaneko M, Ananthakrishnan R, Harja E, Lee LK, Hwang YC, Lerner S, Bakr S, Li Q, Lu Y, Song F, Qu W, Gomez T, Zou YS, Yan SF, Schmidt AM, Ramasamy R: Receptor for advanced-glycation end products: key modulator of myocardial ischemic injury. Circulation 113:1226-1234, 2006
46. Aleshin A, Ananthakrishanan R, Li Q, Rosario R, Lu Y, Qu W, Song F, Bakr S, Szabolcs MJ, D'agati VD, Yan SF, Liu R, Homma S, Schmidt AM, Ramasamy R: RAGE modulates myocardial injury consequent to LAD infarction via impact on JNK and STAT signaling in a murine model. Am J Physiol Heart Circ Physiol 294:H1823-H1832, 2008.
47. Thirunaukkarasu M, Penumathsa SV, Koneru S, Juhasz B, Zhan L, Otani H, Bagchi D, Otani H, Bagchi D, Das DK, Maulik N: Resveratrol alleviates cardiac dysfunction in streptozotocin-induced diabetes: role of nitric oxide, thioredoxin, and heme oxygenase. Free Radic Biol Med 43:720-729, 2007
48. Yue TL, Bao W, Gu JL, Cui J, Tao L, Ma XL, Ohlstein EH, Jucker BM: Rosiglitazone treatment in Zucker diabetic fatty rats is associated with ameliorated cardiac insulin resistance and protection from ischemia/ reperfusion-induced myocardial injury. Diabetes 54:554-562, 2005 49. Zhao ZQ, Morris CD, Budde JM, Wang NP, Muraki S, Sun HY, Guyton RA: Inhibition of myocardial apoptosis reduces infarct size and improves regional contractile dysfunction during reperfusion. Cardiovasc Res 59: 132-142, 2003
49. Fan GC, Ren X, Qian J, Yuan Q, Nicolaou P, Wang Y, Jones WK, Chu G, Kranias EG: Novel cardioprotective role of a small heat-shock protein, Hsp20, against ischemia/reperfusion injury. Circulation 111:1792-1799, 2005