TLR2 ligands attenuate cardiac dysfunction in polymicrobial sepsis via a phosphoinositide 3-kinase-dependent mechanism

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 298, Issue 3, 2010, Pages

  Ha, Tuanzhu ^a   Lu, Chen ^a,c   Liu, Li ^c   Hua, Fang ^d   Hu, Yulong ^a   Kelley, Jim ^a   Singh, Krishna ^b   Kao, Race L ^a   Kalbfleisch, John ^b   Williams, David L ^a   Gao, Xiang ^e   Li, Chuanfu ^a  

^a East Tennessee State University   (United States)

^b EAST TENNESSEE STATE UNIVERSITY   (United States)

^c NANJING MEDICAL UNIVERSITY   (China)

^d EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e NANJING UNIVERSITY   (China)

Author keywords

Akt, cardiac function; Pam3CSK4; Toll like receptor 2

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3BETA; LIPOPEPTIDE; PAM3CSK4 PEPTIDE; PEPTIDOGLYCAN; PHOSPHATIDYLINOSITOL 3 KINASE; TOLL LIKE RECEPTOR 2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; C57BL 6 MOUSE; CATHETER; CECUM; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG EFFECT; ENZYME INHIBITION; ENZYME MECHANISM; HEART DISEASE; HEART EJECTION FRACTION; HEART FUNCTION; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE; HEART OUTPUT; HEART STROKE VOLUME; LIGATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PUNCTURE; SEPSIS; SHAM PROCEDURE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CARDIAC OUTPUT; DISEASE MODELS, ANIMAL; GLYCOGEN SYNTHASE KINASE 3; HEART; HEART DISEASES; LIGANDS; LIPOPEPTIDES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PEPTIDOGLYCAN; PROTO-ONCOGENE PROTEINS C-AKT; SEPSIS; SIGNAL TRANSDUCTION; STROKE VOLUME; TOLL-LIKE RECEPTOR 2;

EID: 77749242763     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.01109.2009     Document Type: Article

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