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Volumn 8, Issue 8, 2013, Pages

Mitochondrial Transcription Factor A, an Endogenous Danger Signal, Promotes TNFα Release via RAGE- and TLR9-Responsive Plasmacytoid Dendritic Cells

Author keywords

[No Author keywords available]

Indexed keywords

ADVANCED GLYCATION END PRODUCT RECEPTOR; ENDOTHELIN CONVERTING ENZYME; FLT3 LIGAND; HEPARIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOCHONDRIAL DNA; MITOCHONDRIAL TRANSCRIPTION FACTOR A; MITOCHONDRIAL TRANSCRIPTION FACTOR A BOX 1; MITOCHONDRIAL TRANSCRIPTION FACTOR A BOX 2; PHOSPHATIDYLINOSITOL 3 KINASE; RECOMBINANT PROTEIN; TOLL LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 84881506336     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0072354     Document Type: Article
Times cited : (72)

References (52)
  • 1
    • 77950275298 scopus 로고    scopus 로고
    • Circulating mitochondrial DAMPs cause inflammatory responses to injury
    • 10.1038/nature08780
    • Zhang Q, Raoof M, Chen Y, Sumi Y, Sursal T, et al. (2010) Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature 464: 104-107. doi:10.1038/nature08780. PubMed: 20203610.
    • (2010) Nature , vol.464 , pp. 104-107
    • Zhang, Q.1    Raoof, M.2    Chen, Y.3    Sumi, Y.4    Sursal, T.5
  • 2
    • 84862841848 scopus 로고    scopus 로고
    • Mitochondrial transcription factor A serves as a danger signal by augmenting plasmacytoid dendritic cell responses to DNA
    • 10.4049/jimmunol.1101375
    • Julian MW, Shao G, Bao S, Knoell DL, Papenfuss TL, et al. (2012) Mitochondrial transcription factor A serves as a danger signal by augmenting plasmacytoid dendritic cell responses to DNA. J Immunol 189: 433-443. doi:10.4049/jimmunol.1101375. PubMed: 22675199.
    • (2012) J Immunol , vol.189 , pp. 433-443
    • Julian, M.W.1    Shao, G.2    Bao, S.3    Knoell, D.L.4    Papenfuss, T.L.5
  • 3
    • 66449102219 scopus 로고    scopus 로고
    • Monocyte activation by necrotic cells is promoted by mitochondrial proteins and formyl peptide receptors
    • 10.1097/CCM.0b013e3181a001ae
    • Crouser ED, Shao G, Julian MW, Macre JE, Shadel GS, et al. (2009) Monocyte activation by necrotic cells is promoted by mitochondrial proteins and formyl peptide receptors. Crit Care Med 37: 2000-2009. doi:10.1097/CCM.0b013e3181a001ae. PubMed: 19384205.
    • (2009) Crit Care Med , vol.37 , pp. 2000-2009
    • Crouser, E.D.1    Shao, G.2    Julian, M.W.3    Macre, J.E.4    Shadel, G.S.5
  • 4
    • 84870206960 scopus 로고    scopus 로고
    • Mitochondria: master regulators of danger signaling
    • 10.1038/nrm3479
    • Galluzzi L, Kepp O, Kroemer G, (2012) Mitochondria: master regulators of danger signaling. Nat Rev Mol Cell Biol 13: 780-788. doi:10.1038/nrm3479. PubMed: 23175281.
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 780-788
    • Galluzzi, L.1    Kepp, O.2    Kroemer, G.3
  • 5
    • 77957745555 scopus 로고    scopus 로고
    • Type I interferon: friend or foe?
    • 10.1084/jem.20101664
    • Trinchieri G, (2010) Type I interferon: friend or foe? J Exp Med 207: 2053-2063. doi:10.1084/jem.20101664. PubMed: 20837696.
    • (2010) J Exp Med , vol.207 , pp. 2053-2063
    • Trinchieri, G.1
  • 6
    • 17144404177 scopus 로고    scopus 로고
    • IRF-7 is the master regulator of type-I interferon-dependent immune responses
    • 10.1038/nature03464
    • Honda K, Yanai H, Negishi H, Asagiri M, Sato M, et al. (2005) IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature 434: 772-777. doi:10.1038/nature03464. PubMed: 15800576.
    • (2005) Nature , vol.434 , pp. 772-777
    • Honda, K.1    Yanai, H.2    Negishi, H.3    Asagiri, M.4    Sato, M.5
  • 7
    • 51349099789 scopus 로고    scopus 로고
    • Antigen-presentation properties of plasmacytoid dendritic cells
    • 10.1016/j.immuni.2008.09.002
    • Villadangos JA, Young L, (2008) Antigen-presentation properties of plasmacytoid dendritic cells. Immunity 29: 352-361. doi:10.1016/j.immuni.2008.09.002. PubMed: 18799143.
    • (2008) Immunity , vol.29 , pp. 352-361
    • Villadangos, J.A.1    Young, L.2
  • 8
    • 10644262982 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells: linking innate and adaptive immunity
    • 10.1128/JVI.79.1.17-27.2005
    • McKenna K, Beignon AS, Bhardwaj N, (2005) Plasmacytoid dendritic cells: linking innate and adaptive immunity. J Virol 79: 17-27. doi:10.1128/JVI.79.1.17-27.2005. PubMed: 15596797.
    • (2005) J Virol , vol.79 , pp. 17-27
    • McKenna, K.1    Beignon, A.S.2    Bhardwaj, N.3
  • 9
    • 0037062934 scopus 로고    scopus 로고
    • Release of chromatin protein HMGB1 by necrotic cells triggers inflammation
    • 10.1038/nature00858
    • Scaffidi P, Misteli T, Bianchi ME, (2002) Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 418: 191-195. doi:10.1038/nature00858. PubMed: 12110890.
    • (2002) Nature , vol.418 , pp. 191-195
    • Scaffidi, P.1    Misteli, T.2    Bianchi, M.E.3
  • 10
    • 26944453605 scopus 로고    scopus 로고
    • Submitochondrial localization of the mitochondrial isoforms of folylpolyglutamate synthetase in CCRF-CEM human T-lymphoblastic leukemia cells
    • 10.1016/j.bbamcr.2005.08.004
    • Nair JR, McGuire JJ, (2005) Submitochondrial localization of the mitochondrial isoforms of folylpolyglutamate synthetase in CCRF-CEM human T-lymphoblastic leukemia cells. Biochim Biophys Acta 1746: 38-44. doi:10.1016/j.bbamcr.2005.08.004. PubMed: 16169100.
    • (2005) Biochim Biophys Acta , vol.1746 , pp. 38-44
    • Nair, J.R.1    McGuire, J.J.2
  • 11
    • 0034047619 scopus 로고    scopus 로고
    • Differences in dendritic cells stimulated in vivo by tumors engineered to secrete granulocyte-macrophage colony-stimulating factor or Flt3-ligand
    • 10866317
    • Mach N, Gillessen S, Wilson SB, Sheehan C, Mihm M, et al. (2000) Differences in dendritic cells stimulated in vivo by tumors engineered to secrete granulocyte-macrophage colony-stimulating factor or Flt3-ligand. Cancer Res 60: 3239-3246. PubMed: 10866317.
    • (2000) Cancer Res , vol.60 , pp. 3239-3246
    • Mach, N.1    Gillessen, S.2    Wilson, S.B.3    Sheehan, C.4    Mihm, M.5
  • 12
    • 37249081101 scopus 로고    scopus 로고
    • Disease-modifying capability of murine Flt3-ligand DCs in experimental autoimmune encephalomyelitis
    • 10.1189/jlb.0406257
    • Papenfuss TL, Kithcart AP, Powell ND, McClain MA, Gienapp IE, et al. (2007) Disease-modifying capability of murine Flt3-ligand DCs in experimental autoimmune encephalomyelitis. J Leukoc Biol 82: 1510-1518. doi:10.1189/jlb.0406257. PubMed: 17855499.
    • (2007) J Leukoc Biol , vol.82 , pp. 1510-1518
    • Papenfuss, T.L.1    Kithcart, A.P.2    Powell, N.D.3    McClain, M.A.4    Gienapp, I.E.5
  • 13
    • 78649825344 scopus 로고    scopus 로고
    • Compartment-specific control of signaling from a DNA-sensing immune receptor
    • 21119105
    • Engel A, Barton GM, (2010) Compartment-specific control of signaling from a DNA-sensing immune receptor. Sci Signal 150: e45. PubMed: 21119105.
    • (2010) Sci Signal , vol.150
    • Engel, A.1    Barton, G.M.2
  • 14
    • 0037102393 scopus 로고    scopus 로고
    • Receptor for advanced glycation end products-binding COOH-terminal motif of amphoterin inhibits invasive migration and metastasis
    • 12183440
    • Huttunen HJ, Fages C, Kuja-Panula J, Ridley AJ, Rauvala H, (2002) Receptor for advanced glycation end products-binding COOH-terminal motif of amphoterin inhibits invasive migration and metastasis. Cancer Res 62: 4805-4811. PubMed: 12183440.
    • (2002) Cancer Res , vol.62 , pp. 4805-4811
    • Huttunen, H.J.1    Fages, C.2    Kuja-Panula, J.3    Ridley, A.J.4    Rauvala, H.5
  • 15
    • 77953788926 scopus 로고    scopus 로고
    • Mitochondrial peptides are potent immune activators that activate human neutrophils via FPR-1
    • 10.1097/TA.0b013e3181dcd28d
    • Raoof M, Zhang Q, Itagaki K, Hauser CJ, (2010) Mitochondrial peptides are potent immune activators that activate human neutrophils via FPR-1. J Trauma 68: 1328-1332. doi:10.1097/TA.0b013e3181dcd28d. PubMed: 20539176.
    • (2010) J Trauma , vol.68 , pp. 1328-1332
    • Raoof, M.1    Zhang, Q.2    Itagaki, K.3    Hauser, C.J.4
  • 16
    • 23844446792 scopus 로고    scopus 로고
    • Human mitochondria-derived N-formylated peptides are novel agonists equally active on FPR and FPRL1, while Listeria monocytogenes-derived peptides preferentially activate FPR
    • 10.1002/eji.200526338
    • Rabiet MJ, Huet E, Boulay F, (2005) Human mitochondria-derived N-formylated peptides are novel agonists equally active on FPR and FPRL1, while Listeria monocytogenes-derived peptides preferentially activate FPR. Eur J Immunol 35: 2486-2495. doi:10.1002/eji.200526338. PubMed: 16025565.
    • (2005) Eur J Immunol , vol.35 , pp. 2486-2495
    • Rabiet, M.J.1    Huet, E.2    Boulay, F.3
  • 17
    • 82355181520 scopus 로고    scopus 로고
    • Heparin sulfate is essential for high mobility group protein 1 (HMGB1) signaling by the receptor for advanced glycation end products (RAGE)
    • 10.1074/jbc.M111.299685
    • Xu D, Young J, Song D, Esko JD, (2011) Heparin sulfate is essential for high mobility group protein 1 (HMGB1) signaling by the receptor for advanced glycation end products (RAGE). J Biol Chem 286: 41736-41744. doi:10.1074/jbc.M111.299685. PubMed: 21990362.
    • (2011) J Biol Chem , vol.286 , pp. 41736-41744
    • Xu, D.1    Young, J.2    Song, D.3    Esko, J.D.4
  • 18
    • 39549116503 scopus 로고    scopus 로고
    • PI3K is critical for the nuclear translocation of IRF-7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activation
    • 10.1084/jem.20070763
    • Guiducci C, Ghirelli C, Marloie-Provost MA, Matray T, Coffman RL, et al. (2008) PI3K is critical for the nuclear translocation of IRF-7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activation. J Exp Med 205: 315-322. doi:10.1084/jem.20070763. PubMed: 18227218.
    • (2008) J Exp Med , vol.205 , pp. 315-322
    • Guiducci, C.1    Ghirelli, C.2    Marloie-Provost, M.A.3    Matray, T.4    Coffman, R.L.5
  • 19
    • 56349114913 scopus 로고    scopus 로고
    • Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9
    • 10.1038/ni.1669
    • Park B, Brinkmann MM, Spooner E, Lee CC, Kim YM, et al. (2008) Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9. Nat Immunol 9: 1407-1401. doi:10.1038/ni.1669. PubMed: 18931679.
    • (2008) Nat Immunol , vol.9 , pp. 1401-1407
    • Park, B.1    Brinkmann, M.M.2    Spooner, E.3    Lee, C.C.4    Kim, Y.M.5
  • 20
    • 84872717154 scopus 로고    scopus 로고
    • Toll-like receptor 9 processing: The key event in Toll-like receptor 9 activation?
    • 23183093
    • Bauer S, (2003) Toll-like receptor 9 processing: The key event in Toll-like receptor 9 activation? Immunol Lett 149: 85-87. PubMed: 23183093.
    • (2003) Immunol Lett , vol.149 , pp. 85-87
    • Bauer, S.1
  • 21
    • 79955046267 scopus 로고    scopus 로고
    • Mechanism of endosomal TLR inhibition by antimalarial drugs and imidazoquinolones
    • 10.4049/jimmunol.1000702
    • Kuznik A, Bencina M, Svajger U, Jeras M, Rozman B, et al. (2011) Mechanism of endosomal TLR inhibition by antimalarial drugs and imidazoquinolones. J Immunol 186: 4794-4804. doi:10.4049/jimmunol.1000702. PubMed: 21398612.
    • (2011) J Immunol , vol.186 , pp. 4794-4804
    • Kuznik, A.1    Bencina, M.2    Svajger, U.3    Jeras, M.4    Rozman, B.5
  • 22
    • 0027764386 scopus 로고
    • Endosome acidification and receptor trafficking: bafilomycin A1 slows receptor externalization by a mechanism involving the receptor's internalization motif
    • 8167408
    • Johnson LS, Dunn KW, Pytowski B, McGraw TE, (1993) Endosome acidification and receptor trafficking: bafilomycin A1 slows receptor externalization by a mechanism involving the receptor's internalization motif. Mol Biol Cell 4: 1251-1266. PubMed: 8167408.
    • (1993) Mol Biol Cell , vol.4 , pp. 1251-1266
    • Johnson, L.S.1    Dunn, K.W.2    Pytowski, B.3    McGraw, T.E.4
  • 24
    • 80054991446 scopus 로고    scopus 로고
    • Endothelin-converting enzyme-1 regulates trafficking and signaling of neurokinin 1 receptor in endosomes of myenteric neurons
    • 21878523
    • Pelayo JC, Poole DP, Steinhoff M, Cottrell GS, Bunnett NW, (2011) Endothelin-converting enzyme-1 regulates trafficking and signaling of neurokinin 1 receptor in endosomes of myenteric neurons. J Physiol 589: 5213-5230. PubMed: 21878523.
    • (2011) J Physiol , vol.589 , pp. 5213-5230
    • Pelayo, J.C.1    Poole, D.P.2    Steinhoff, M.3    Cottrell, G.S.4    Bunnett, N.W.5
  • 25
    • 38949087160 scopus 로고    scopus 로고
    • Burn-induced immunosuppression: attenuated T cell signaling independent of IFN-γ- and nitric oxide-mediated pathways
    • 18024716
    • Duan X, Yarmush D, Leeder A, Yarmush ML, Mitchell RN, (2008) Burn-induced immunosuppression: attenuated T cell signaling independent of IFN-γ- and nitric oxide-mediated pathways. J Leukoc Biol 83: 305-313. PubMed: 18024716.
    • (2008) J Leukoc Biol , vol.83 , pp. 305-313
    • Duan, X.1    Yarmush, D.2    Leeder, A.3    Yarmush, M.L.4    Mitchell, R.N.5
  • 26
    • 33845633996 scopus 로고    scopus 로고
    • Involvement of IL-10 in exhaustion of myeloid dendritic cells and rescue by CD40 stimulation
    • 17034426
    • Kajino K, Nakamura I, Bamba H, Sawai T, Ogasawara K, (2007) Involvement of IL-10 in exhaustion of myeloid dendritic cells and rescue by CD40 stimulation. Immunology 120: 28-37. PubMed: 17034426.
    • (2007) Immunology , vol.120 , pp. 28-37
    • Kajino, K.1    Nakamura, I.2    Bamba, H.3    Sawai, T.4    Ogasawara, K.5
  • 27
    • 79953268311 scopus 로고    scopus 로고
    • Type I IFN and TNFα cross-regulation in immune-mediated inflammatory disease: basic concepts and clinical relevance
    • 10.1186/ar3205
    • Cantaert T, Baeten D, Tak PP, van Baarsen LGM, (2010) Type I IFN and TNFα cross-regulation in immune-mediated inflammatory disease: basic concepts and clinical relevance. Arthritis Res Ther 12: 219. doi:10.1186/ar3205. PubMed: 21062511.
    • (2010) Arthritis Res Ther , vol.12 , pp. 219
    • Cantaert, T.1    Baeten, D.2    Tak, P.P.3    van Baarsen, L.G.M.4
  • 28
    • 84861467922 scopus 로고    scopus 로고
    • Mitochondrial transcription factor A is a proinflammatory mediator in hemorrhagic shock
    • 22469910
    • Chaung WW, Wu R, Ji W, Wang P, (2012) Mitochondrial transcription factor A is a proinflammatory mediator in hemorrhagic shock. Int J Mol Med 30: 199-203. PubMed: 22469910.
    • (2012) Int J Mol Med , vol.30 , pp. 199-203
    • Chaung, W.W.1    Wu, R.2    Ji, W.3    Wang, P.4
  • 29
    • 79957597757 scopus 로고    scopus 로고
    • Mitochondria in innate immune responses
    • 10.1038/nri2975
    • West AP, Shadel GS, Ghosh S, (2011) Mitochondria in innate immune responses. Nat Rev Immunol 11: 389-402. doi:10.1038/nri2975. PubMed: 21597473.
    • (2011) Nat Rev Immunol , vol.11 , pp. 389-402
    • West, A.P.1    Shadel, G.S.2    Ghosh, S.3
  • 30
    • 0033813705 scopus 로고    scopus 로고
    • Heparin-binding proteins HB-GAM (pleiotrophin) and amphoterin in the regulation of cell motility
    • 10.1016/S0945-053X(00)00084-6
    • Rauvala H, Huttunen HJ, Fages C, Kaksonen M, Kinnunen T, et al. (2000) Heparin-binding proteins HB-GAM (pleiotrophin) and amphoterin in the regulation of cell motility. Matrix Biol 19: 377-387. doi:10.1016/S0945-053X(00)00084-6. PubMed: 10980414.
    • (2000) Matrix Biol , vol.19 , pp. 377-387
    • Rauvala, H.1    Huttunen, H.J.2    Fages, C.3    Kaksonen, M.4    Kinnunen, T.5
  • 31
    • 34247236200 scopus 로고    scopus 로고
    • Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE
    • 10.1038/nrg2148
    • Tian J, Avalos AM, Mao SY, Chen B, Senthil K, et al. (2007) Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE. Nat Immunol 8: 487-496. doi:10.1038/nrg2148. PubMed: 17417641.
    • (2007) Nat Immunol , vol.8 , pp. 487-496
    • Tian, J.1    Avalos, A.M.2    Mao, S.Y.3    Chen, B.4    Senthil, K.5
  • 32
    • 0025829045 scopus 로고
    • Similarity of human mitochondrial transcription factor 1 to high mobility group proteins
    • 10.1126/science.2035027
    • Parisi MA, Clayton DA, (1991) Similarity of human mitochondrial transcription factor 1 to high mobility group proteins. Science 252: 965-969. doi:10.1126/science.2035027. PubMed: 2035027.
    • (1991) Science , vol.252 , pp. 965-969
    • Parisi, M.A.1    Clayton, D.A.2
  • 33
    • 33847656213 scopus 로고    scopus 로고
    • Mitochondrial transcription factor A (TFAM): roles in maintenance of mtDNA and cellular functions
    • 10.1016/j.mito.2006.11.017
    • Kang D, Kim SH, Hamasaki N, (2007) Mitochondrial transcription factor A (TFAM): roles in maintenance of mtDNA and cellular functions. Mitochondrion 7: 39-44. doi:10.1016/j.mito.2006.11.017. PubMed: 17280879.
    • (2007) Mitochondrion , vol.7 , pp. 39-44
    • Kang, D.1    Kim, S.H.2    Hamasaki, N.3
  • 34
    • 79953066407 scopus 로고    scopus 로고
    • HMGB1 is a therapeutic target for sterile inflammation and infection
    • 10.1146/annurev-immunol-030409-101323
    • Andersson U, Tracey KJ, (2011) HMGB1 is a therapeutic target for sterile inflammation and infection. Annu Rev Immunol 29: 139-162. doi:10.1146/annurev-immunol-030409-101323. PubMed: 21219181.
    • (2011) Annu Rev Immunol , vol.29 , pp. 139-162
    • Andersson, U.1    Tracey, K.J.2
  • 35
    • 77955403878 scopus 로고    scopus 로고
    • A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release
    • 10.1073/pnas.1003893107
    • Yang H, Hreggvidsdottir HS, Palmblad K, Wang H, Ochani M, et al. (2010) A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release. Proc Natl Acad Sci U S A 107: 11942-11947. doi:10.1073/pnas.1003893107. PubMed: 20547845.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 11942-11947
    • Yang, H.1    Hreggvidsdottir, H.S.2    Palmblad, K.3    Wang, H.4    Ochani, M.5
  • 36
    • 73349095758 scopus 로고    scopus 로고
    • Biophysical characterizations of human mitochondrial transcription factor A and its binding to tumor suppressor p53
    • 10.1093/nar/gkp750
    • Wong TS, Rajagopalan S, Freund SM, Rutherford TJ, Andreeva A, et al. (2009) Biophysical characterizations of human mitochondrial transcription factor A and its binding to tumor suppressor p53. Nucleic Acids Res 37: 6765-6783. doi:10.1093/nar/gkp750. PubMed: 19755502.
    • (2009) Nucleic Acids Res , vol.37 , pp. 6765-6783
    • Wong, T.S.1    Rajagopalan, S.2    Freund, S.M.3    Rutherford, T.J.4    Andreeva, A.5
  • 37
    • 84863129261 scopus 로고    scopus 로고
    • DNA binding to proteolytically activated TLR9 is sequence-independent and enhanced by DNA curvature
    • 10.1038/emboj.2011.441
    • Li Y, Berke IC, Modis Y, (2011) DNA binding to proteolytically activated TLR9 is sequence-independent and enhanced by DNA curvature. EMBO J 31: 919-931. doi:10.1038/emboj.2011.441. PubMed: 22258621.
    • (2011) EMBO J , vol.31 , pp. 919-931
    • Li, Y.1    Berke, I.C.2    Modis, Y.3
  • 38
    • 76649117721 scopus 로고    scopus 로고
    • Conventional DCs reduce liver ischemia/reperfusion injury in mice via IL-10 secretion
    • 10.1172/JCI40008
    • Bamboat ZM, Ocuin LM, Balachandran VP, Obaid H, Plitas G, et al. (2010) Conventional DCs reduce liver ischemia/reperfusion injury in mice via IL-10 secretion. J Clin Invest 120: 559-569. doi:10.1172/JCI40008. PubMed: 20093775.
    • (2010) J Clin Invest , vol.120 , pp. 559-569
    • Bamboat, Z.M.1    Ocuin, L.M.2    Balachandran, V.P.3    Obaid, H.4    Plitas, G.5
  • 39
    • 57349191215 scopus 로고    scopus 로고
    • The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor
    • 10.1038/nature07405
    • Ewald SE, Lee BL, Lau L, Wickliffe KE, Shi GP, et al. (2008) The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor. Nature 456: 658-662. doi:10.1038/nature07405. PubMed: 18820679.
    • (2008) Nature , vol.456 , pp. 658-662
    • Ewald, S.E.1    Lee, B.L.2    Lau, L.3    Wickliffe, K.E.4    Shi, G.P.5
  • 40
    • 0033771729 scopus 로고    scopus 로고
    • Pharmacological characterization of a novel sulfonylureid-pyrazole derivative, SM-19712, a potent nonpeptidic inhibitor of endothelin converting enzyme
    • 10.1254/jjp.84.7
    • Umekawa K, Hasegawa H, Tsutsumi Y, Sato K, Matsumura Y, et al. (2000) Pharmacological characterization of a novel sulfonylureid-pyrazole derivative, SM-19712, a potent nonpeptidic inhibitor of endothelin converting enzyme. Jpn J Pharmacol 84: 7-15. doi:10.1254/jjp.84.7. PubMed: 11043447.
    • (2000) Jpn J Pharmacol , vol.84 , pp. 7-15
    • Umekawa, K.1    Hasegawa, H.2    Tsutsumi, Y.3    Sato, K.4    Matsumura, Y.5
  • 41
    • 0033771712 scopus 로고    scopus 로고
    • Protective effect of SM-19712, a novel and potent endothelin converting enzyme inhibitor, on ischemic acute renal failure in rats
    • 10.1254/jjp.84.16
    • Matsumura Y, Kuro T, Kobayashi Y, Umekawa K, Ohashi N, et al. (2000) Protective effect of SM-19712, a novel and potent endothelin converting enzyme inhibitor, on ischemic acute renal failure in rats. Jpn J Pharmacol 84: 16-24. doi:10.1254/jjp.84.16. PubMed: 11043448.
    • (2000) Jpn J Pharmacol , vol.84 , pp. 16-24
    • Matsumura, Y.1    Kuro, T.2    Kobayashi, Y.3    Umekawa, K.4    Ohashi, N.5
  • 42
    • 77949940198 scopus 로고    scopus 로고
    • Intracellular Toll-like receptors
    • 10.1016/j.immuni.2010.03.012
    • Blasius AL, Beutler B, (2010) Intracellular Toll-like receptors. Immunity 32: 305-315. doi:10.1016/j.immuni.2010.03.012. PubMed: 20346772.
    • (2010) Immunity , vol.32 , pp. 305-315
    • Blasius, A.L.1    Beutler, B.2
  • 43
    • 68149132205 scopus 로고    scopus 로고
    • Late endosome/lysosome-localized Rab7b suppresses TLR9-initiated proinflammatory cytokine and type I IFN production in macrophages
    • 10.4049/jimmunol.0900249
    • Yao M, Liu X, Li D, Chen T, Cai Z, et al. (2009) Late endosome/lysosome-localized Rab7b suppresses TLR9-initiated proinflammatory cytokine and type I IFN production in macrophages. J Immunol 183: 1751-1758. doi:10.4049/jimmunol.0900249. PubMed: 19587007.
    • (2009) J Immunol , vol.183 , pp. 1751-1758
    • Yao, M.1    Liu, X.2    Li, D.3    Chen, T.4    Cai, Z.5
  • 44
    • 84856278890 scopus 로고    scopus 로고
    • Genome wide association identifies PPFIA1 as a candidate gene for acute lung injury risk following major trauma
    • 10.1371/journal.pone.0028268
    • Christie JD, Wurfel MM, Feng R, O'Keefe GE, Bradfield J, et al. (2012) Genome wide association identifies PPFIA1 as a candidate gene for acute lung injury risk following major trauma. PLOS ONE 7: e28268. doi:10.1371/journal.pone.0028268. PubMed: 22295056.
    • (2012) PLOS ONE , vol.7
    • Christie, J.D.1    Wurfel, M.M.2    Feng, R.3    O'Keefe, G.E.4    Bradfield, J.5
  • 45
    • 36549039493 scopus 로고    scopus 로고
    • The systemic inflammatory response induced by trauma is reflected by multiple phenotypes of blood neutrophils
    • 10.1016/j.injury.2007.09.016
    • Pillay J, Hietbrink F, Koenderman L, Leenen LP, (2007) The systemic inflammatory response induced by trauma is reflected by multiple phenotypes of blood neutrophils. Injury 38: 1365-1372. doi:10.1016/j.injury.2007.09.016. PubMed: 18061190.
    • (2007) Injury , vol.38 , pp. 1365-1372
    • Pillay, J.1    Hietbrink, F.2    Koenderman, L.3    Leenen, L.P.4
  • 46
    • 67650508418 scopus 로고    scopus 로고
    • A genomic score prognostic of outcome in trauma patients
    • 19593405
    • Warren HS, Elson CM, Hayden DL, Schoenfeld DA, Cobb JP, et al. (2009) A genomic score prognostic of outcome in trauma patients. Mol Med 15: 220-227. PubMed: 19593405.
    • (2009) Mol Med , vol.15 , pp. 220-227
    • Warren, H.S.1    Elson, C.M.2    Hayden, D.L.3    Schoenfeld, D.A.4    Cobb, J.P.5
  • 47
    • 33847045478 scopus 로고    scopus 로고
    • Postburn monocytes are the major producers of TNF-alpha in the heterogeneous splenic macrophage population
    • 10.1097/01.shk.0000239753.75088.5e
    • Noel G, Guo X, Wang Q, Schwemberger S, Byrum D, et al. (2007) Postburn monocytes are the major producers of TNF-alpha in the heterogeneous splenic macrophage population. Shock 27: 312-319. doi:10.1097/01.shk.0000239753.75088.5e. PubMed: 17304113.
    • (2007) Shock , vol.27 , pp. 312-319
    • Noel, G.1    Guo, X.2    Wang, Q.3    Schwemberger, S.4    Byrum, D.5
  • 48
    • 78650058880 scopus 로고    scopus 로고
    • A role for spleen monocytes in post-ischemic brain inflammation and injury
    • 10.1186/1742-2094-7-92
    • Bao Y, Kim E, Bhosle S, Mehta H, Cho S, (2010) A role for spleen monocytes in post-ischemic brain inflammation and injury. J Neuroinflammation 7: 92. doi:10.1186/1742-2094-7-92. PubMed: 21159187.
    • (2010) J Neuroinflammation , vol.7 , pp. 92
    • Bao, Y.1    Kim, E.2    Bhosle, S.3    Mehta, H.4    Cho, S.5
  • 49
    • 33745830175 scopus 로고    scopus 로고
    • Splenectomy inactivates the cholinergic anti-inflammatory pathway during lethal endotoxemia and polymicrobial sepsis
    • 10.1084/jem.20052362
    • Huston JM, Ochani M, Rosas-Ballina M, Liao H, Ochani K, et al. (2006) Splenectomy inactivates the cholinergic anti-inflammatory pathway during lethal endotoxemia and polymicrobial sepsis. J Exp Med 203: 1623-1628. doi:10.1084/jem.20052362. PubMed: 16785311.
    • (2006) J Exp Med , vol.203 , pp. 1623-1628
    • Huston, J.M.1    Ochani, M.2    Rosas-Ballina, M.3    Liao, H.4    Ochani, K.5
  • 50
    • 33845413623 scopus 로고    scopus 로고
    • Human monocyte-derived dendritic cells express TLR9 and react directly to the CpG-A oligonucleotide D19
    • 10.1189/jlb.0106011
    • Hoene V, Peiser M, Wanner R, (2006) Human monocyte-derived dendritic cells express TLR9 and react directly to the CpG-A oligonucleotide D19. J Leukoc Biol 80: 1328-1336. doi:10.1189/jlb.0106011. PubMed: 17000899.
    • (2006) J Leukoc Biol , vol.80 , pp. 1328-1336
    • Hoene, V.1    Peiser, M.2    Wanner, R.3
  • 51
    • 77953772222 scopus 로고    scopus 로고
    • Low anticoagulant heparin targets multiple sites of inflammation, suppresses heparin-induced thrombocytopenia, and inhibits interaction of RAGE with its ligands
    • 10.1152/ajpheart.01105.2009
    • Rao NV, Argyle B, Xu X, Reynolds PR, Walenga JM, et al. (2010) Low anticoagulant heparin targets multiple sites of inflammation, suppresses heparin-induced thrombocytopenia, and inhibits interaction of RAGE with its ligands. Am J Physiol Cell Physiol 299: C97-C110. doi:10.1152/ajpheart.01105.2009. PubMed: 20375277.
    • (2010) Am J Physiol Cell Physiol , vol.299
    • Rao, N.V.1    Argyle, B.2    Xu, X.3    Reynolds, P.R.4    Walenga, J.M.5
  • 52
    • 34247894050 scopus 로고    scopus 로고
    • Influence of hypersulfated and low molecular weight heparins on ischemia/reperfusion: injury and allograft rejection in rat kidneys
    • 10.1111/j.1432-2277.2007.00471.x
    • Gottmann U, Mueller-Falcke A, Schnuelle P, Birck R, Nickeleit V, et al. (2007) Influence of hypersulfated and low molecular weight heparins on ischemia/reperfusion: injury and allograft rejection in rat kidneys. Transpl Int 20: 542-549. doi:10.1111/j.1432-2277.2007.00471.x. PubMed: 17355246.
    • (2007) Transpl Int , vol.20 , pp. 542-549
    • Gottmann, U.1    Mueller-Falcke, A.2    Schnuelle, P.3    Birck, R.4    Nickeleit, V.5


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