Toll-like receptor 9 promotes cardiac inflammation and heart failure during polymicrobial sepsis

Mediators of Inflammation

Volumn 2013, Issue , 2013, Pages

  Lohner, Ralph ^a   Schwederski, Markus ^b   Narath, Carolin ^b   Klein, Johanna ^b   Duerr, Georg D ^b   Torno, Alexandra ^a   Knuefermann, Pascal ^b   Hoeft, Andreas ^b   Baumgarten, Georg ^b   Meyer, Rainer ^a   Boehm, Olaf ^b  

^a UNIVERSITY OF BONN   (Germany)

^b UNIVERSITY HOSPITAL BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; MESSENGER RNA; TOLL LIKE RECEPTOR 9; TLR9 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL LOAD; BACTERIAL SURVIVAL; BACTERIUM CULTURE; CARDIOVASCULAR PARAMETERS; CARDITIS; COLON ASCENDEN STENT PERITONITIS; CONTROLLED STUDY; ENDSYSTOLIC PRESSURE; GENE EXPRESSION; HEART FAILURE; HEART FUNCTION; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; HEART OUTPUT; HEART STROKE VOLUME; HEAT; HISTOLOGY; IMMUNOREGULATION; IN VIVO STUDY; INNATE IMMUNITY; MACROPHAGE MIGRATION; MORTALITY; MOUSE; NONHUMAN; PERITONEAL CAVITY; PERITONITIS; POLYMICROBIAL SEPSIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; SARCOMERE LENGTH; SEPSIS; SIGNAL TRANSDUCTION; WILD TYPE; ANIMAL; C57BL MOUSE; COMPLICATION; GENE EXPRESSION REGULATION; HEART; HEMODYNAMICS; INFLAMMATION; MACROPHAGE; METABOLISM; MICROBIOLOGY; MIXED INFECTION; PATHOLOGY; PATHOPHYSIOLOGY; SARCOMERE; TIME;

ANIMALS; COINFECTION; CYTOKINES; GENE EXPRESSION REGULATION; HEART; HEART FAILURE; HEMODYNAMICS; IMMUNITY, INNATE; INFLAMMATION; MACROPHAGES; MICE; MICE, INBRED C57BL; PERITONITIS; SARCOMERES; SEPSIS; SIGNAL TRANSDUCTION; TIME FACTORS; TOLL-LIKE RECEPTOR 9;

EID: 84880835106     PISSN: 09629351     EISSN: 14661861     Source Type: Journal    
DOI: 10.1155/2013/261049     Document Type: Article

References (33)

1. Martin G. S., Mannino D. M., Eaton S., Moss M., The epidemiology of sepsis in the United States from 1979 through 2000. The New England Journal of Medicine 2003 348 16 1546 1554 2-s2.0-0037451929 10.1056/NEJMoa022139 (Pubitemid 36437931)
2. Vincent J. L., Taccone F., Schmit X., Classification, incidence, and outcomes of sepsis and multiple organ failure. Contributions to Nephrology 2007 156 64 74 2-s2.0-34247621990 10.1159/0000102071
3. Zanotti-Cavazzonia S. L., Hollenberg S. M., Cardiac dysfunction in severe sepsis and septic shock. Current Opinion in Critical Care 2009 15 5 392 397 2-s2.0-70350123038 10.1097/MCC.0b013e3283307a4e
4. Tsujimoto H., Ono S., Efron P. A., Scumpia P. O., Moldawer L. L., Mochizuki H., Role of toll-like receptors in the development of sepsis. Shock 2008 29 3 315 321 2-s2.0-39449112833 10.1097/SHK.0b013e318157ee55 (Pubitemid 351271701)
5. Salomão R., Martins P. S., Brunialti M. K. C., Fernandes M. D. L., Martos L. S. W., Mendes M. E., Gomes N. E., Rigato O., TLR signaling pathway in patients with sepsis. Shock 2008 30 1 73 77 2-s2.0-54049102007 10.1097/SHK.0b013e318181af2a
6. Knuefermann P., Nemoto S., Baumgarten G., Misra A., Sivasubramanian N., Carabello B. A., Vallejo J. G., Cardiac inflammation and innate immunity in septic shock: is there a role for toll-like receptors? Chest 2002 121 4 1329 1336 2-s2.0-0036204061 10.1378/chest.121.4.1329 (Pubitemid 34280460)
7. Knuefermann P., Schwederski M., Velten M., Krings P., Ehrentraut H., Rüdiger M., Boehm O., Fink K., Dreiner U., Grohé C., Hoeft A., Baumgarten G., Koch A., Zacharowski K., Meyer R., Bacterial DNA induces myocardial inflammation and reduces cardiomyocyte contractility: role of toll-like receptor 9. Cardiovascular Research 2008 78 1 26 35 2-s2.0-41149145130 10.1093/cvr/cvn011 (Pubitemid 351430962)
8. Baumgarten G., Knuefermann P., Schuhmacher G., Vervölgyi V., von Rappard J., Dreiner U., Fink K., Djoufack C., Hoeft A., Grohé C., Knowlton A. A., Meyer R., Toll-like receptor 4, nitric oxide, and myocardial depression in endotoxemia. Shock 2006 25 1 43 49 2-s2.0-33646347668 10.1097/01.shk.0000196498.57306.a6
9. Nicoletti G., Nicolosi D., Rossolini G. M., Stefani S., Intra-abdominal infections: etiology, epidemiology, microbiological diagnosis and antibiotic resistance. Journal of Chemotherapy 2009 21 1 5 11 2-s2.0-70350489407
10. Maier S., Traeger T., Entleutner M., Westerholt A., Kleist B., Hüser N., Holzmann B., Stier A., Pfeffer K., Heidecke C., Cecal ligation and puncture versus colon ascendens stent peritonitis: two distinct animal models for polymicrobial sepsis. Shock 2004 21 6 505 511 2-s2.0-16644385124
11. Dewald O., Frangogiannis N. G., Zoerlein M., Duerr G. D., Klemm C., Knuefermann P., Taffet G., Michael L. H., Crapo J. D., Welz A., Entman M. L., Development of murine ischemic cardiomyopathy is associated with a transient inflammatory reaction and depends on reactive oxygen species. Proceedings of the National Academy of Sciences of the United States of America 2003 100 5 2700 2705 2-s2.0-0037418276 10.1073/pnas.0438035100 (Pubitemid 36297562)
12. Tiemann K., Weyer D., Djoufack P. C., Ghanem A., Lewalter T., Dreiner U., Meyer R., Groht C., Fink K. B., Increasing myocardial contraction and blood pressure in C57BL/6 mice during early postnatal development. The American Journal of Physiology 2003 284 2 H464 H474 2-s2.0-0037307478 (Pubitemid 36142872)
13. Boehm O., Markowski P., van der Giet M., Gielen V., Kokalova A., Brill C., Hoeft A., Baumgarten G., Meyer R., Knuefermann P., In vivo TLR9 inhibition attenuates CpG-induced myocardial dysfunction. Mediators of Inflammation 2013 2013 9 217297 10.1155/2013/217297
14. Ehrentraut S. F., Dorr A., Ehrentraut H., Lohner R., Lee S. H., Hoeft A., Baumgarten G., Knuefermann P., Boehm O., Meyer R., Vascular dysfunction following polymicrobial sepsis: role of pattern recognition receptors. PloS ONE 2012 7 9 e44531
15. Dejager L., Pinheiro I., Dejonckheere E., Libert C., Cecal ligation and puncture: the gold standard model for polymicrobial sepsis? Trends in Microbiology 2011 19 4 198 208 2-s2.0-79953292076 10.1016/j.tim.2011.01.001
16. Plitas G., Burt B. M., Nguyen H. M., Bamboat Z. M., DeMatteo R. P., Toll-like receptor 9 inhibition reduces mortality in polymicrobial sepsis. Journal of Experimental Medicine 2008 205 6 1277 1283 2-s2.0-45149129895 10.1084/jem.20080162 (Pubitemid 351831485)
17. Williams D. L., Ha T., Li C., Kalbfleisch J. H., Ferguson D. A. Jr., Early activation of hepatic NF B and NF-IL6 in polymicrobial sepsis correlates with bacteremia, cytokine expression, and mortality. Annals of Surgery 1999 230 1 95 104 2-s2.0-0033504127 10.1097/00000658-199907000-00014 (Pubitemid 30190370)
18. Gao M., Ha T., Zhang X., Wang X., Liu L., Kalbfleisch J., Singh K., Williams D., Li C., The toll-like receptor 9 ligand, CpG oligodeoxynucleotide, attenuates cardiac dysfunction in polymicrobial sepsis, involving activation of both phosphoinositide 3 kinase/Akt and extracellular-signal-related kinase signaling. The Journal of Infectious Diseases 2013 207 9 1471 1479 10.1093/infdis/jit036
19. Ha T., Lu C., Liu L., Hua F., Hu Y., Kelley J., Singh K., Kao R. L., Kalbfleisch J., Williams D. L., Gao X., Li C., TLR2 ligands attenuate cardiac dysfunction in polymicrobial sepsis via a phosphoinositide 3-kinase-dependent mechanism. The American Journal of Physiology 2010 298 3 H984 H991 2-s2.0-77749242763 10.1152/ajpheart.01109.2009
20. Grandel U., Fink L., Blum A., Heep M., Buerke M., Kraemer H. J., Mayer K., Bohle R. M., Seeger W., Grimminger F., Sibelius U., Endotoxin-induced myocardial tumor necrosis factor- α synthesis depresses contractility of isolated rat hearts: evidence for a role of sphingosine and cyclooxygenase-2- derived thromboxane production. Circulation 2000 102 22 2758 2764 2-s2.0-0034727713
21. Balija T. M., Lowry S. F., Lipopolysaccharide and sepsis-associated myocardial dysfunction. Current Opinion in Infectious Diseases 2011 24 3 248 253 2-s2.0-79955488142 10.1097/QCO.0b013e32834536ce
22. Jones S. P., Trocha S. D., Lefer D. J., Cardioprotective actions of endogenous IL-10 are independent of iNOS. The American Journal of Physiology 2001 281 1 H48 H52 2-s2.0-0034803142
23. Serra A. J., Santos M. H. H., Bocalini D. S., Antônio E. L., Levy R. F., Santos A. A., Higuchi M. L., Silva J. A., Magalhães F. C., Baraúna V. G., Krieger J. E., Tucci P. J. F., Exercise training inhibits inflammatory cytokines and more than prevents myocardial dysfunction in rats with sustained β -adrenergic hyperactivity. Journal of Physiology 2010 588 13 2431 2442 2-s2.0-77954509173 10.1113/jphysiol.2010.187310
24. Dhingra S., Sharma A. K., Arora R. C., Slezak J., Singal P. K., IL-10 attenuates TNF- α -induced NF B pathway activation and cardiomyocyte apoptosis. Cardiovascular Research 2009 82 1 59 66 2-s2.0-62349108668 10.1093/cvr/cvp040
25. Kaur K., Dhingra S., Slezak J., Sharma A. K., Bajaj A., Singal P. K., Biology of TNF α and IL-10, and their imbalance in heart failure. Heart Failure Reviews 2009 14 2 113 123 2-s2.0-63449104627 10.1007/s10741-008-9104-z
26. Williams D. L., Ha T., Li C., Kalbfleisch J. H., Schweitzer J., Vogt W., Browder I. W., Modulation of tissue toll-like receptor 2 and 4 during the early phases of polymicrobial sepsis correlates with mortality. Critical Care Medicine 2003 31 6 1808 1818 2-s2.0-0038047587 10.1097/01.CCM.0000069343.27691.F3 (Pubitemid 36714241)
27. Knuefermann P., Nemoto S., Misra A., Nozaki N., Defreitas G., Goyert S. M., Carabello B. A., Mann D. L., Vallejo J. G., CD14-deficient mice are protected against lipopolysaccharide-induced cardiac inflammation and left ventricular dysfunction. Circulation 2002 106 20 2608 2615 2-s2.0-0037069420 10.1161/01.CIR.0000038110.69369.4C (Pubitemid 35340698)
28. Baumann C. L., Aspalter I. M., Sharif O., Pichlmair A., Blüml S., Grebien F., Bruckner M., Pasierbek P., Aumayr K., Planyavsky M., Bennett K. L., Colinge J., Knapp S., Superti-Furga G., CD14 is a coreceptor of toll-like receptors 7 and 9. Journal of Experimental Medicine 2010 207 12 2689 2701 2-s2.0-78649434143 10.1084/jem.20101111
29. Ford J. W., McVicar D. W., TREM and TREM-like receptors in inflammation and disease. Current Opinion in Immunology 2009 21 1 38 46 2-s2.0-64049095240 10.1016/j.coi.2009.01.009
30. Massion P. B., Balligand J. L., Modulation of cardiac contraction, relaxation and rate by the endothelial nitric oxide synthase (eNOS): lessons from genetically modified mice. Journal of Physiology 2003 546 1 63 75 2-s2.0-0037232585 10.1113/jphysiol.2002.025973 (Pubitemid 36104972)
31. Rastaldo R., Pagliaro P., Cappello S., Penna C., Mancardi D., Westerhof N., Losano G., Nitric oxide and cardiac function. Life Sciences 2007 81 10 779 793 2-s2.0-34548247143 10.1016/j.lfs.2007.07.019 (Pubitemid 47332516)
32. Ehrentraut S., Frede S., Stapel H., Mengden T., Grohé C., Fandrey J., Meyer R., Baumgarten G., Antagonism of lipopolysaccharide-induced blood pressure attenuation and vascular contractility. Arteriosclerosis, Thrombosis, and Vascular Biology 2007 27 10 2170 2176 2-s2.0-35148836026 10.1161/ATVBAHA.107.146100 (Pubitemid 350287246)
33. Wang Y., Liu H., McKenzie G., Witting P. K., Stasch J., Hahn M., Changsirivathanathamrong D., Wu B. J., Ball H. J., Thomas S. R., Kapoor V., Celermajer D. S., Mellor A. L., Keaney J. F. Jr., Hunt N. H., Stocker R., Kynurenine is an endothelium-derived relaxing factor produced during inflammation. Nature Medicine 2010 16 3 279 285 2-s2.0-77949261548 10.1038/nm.2092