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Volumn 37, Issue 1, 2009, Pages 291-304

Molecular biology of inflammation and sepsis: A primer*

Author keywords

Activated protein C; Apoptosis; neutrophils; mitochondrial dysfunction; Inflammasome; Inflammation; Nitric oxide; Peroxynitrite; Reactive oxygen species; Sepsis; Signalosome; Toll like receptors

Indexed keywords

6 [N (2 CHLORO 4 FLUOROPHENYL)SULFAMOYL] 1 CYCLOHEXENE 1 CARBOXYLIC ACID ETHYL ESTER; ACTIVATED PROTEIN C; ATORVASTATIN; AZD 9773; CITRULLINE; DROTRECOGIN; ERITORAN; ERYTHROPOIETIN; GR 270773; HIGH MOBILITY GROUP B1 PROTEIN; NITRIC OXIDE; NONSTEROID ANTIINFLAMMATORY AGENT; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN PROTEIN; PATTERN RECOGNITION RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROLYLLEUCYLGLYCINAMIDE; RECOMBINANT ANTITHROMBIN III; RECOMBINANT HUMAN LACTOFERRIN; RECOMBINANT PLASMA GELSOLIN; RECOMBINANT THROMBOMODULIN; RECOMBINANT TISSUE FACTOR PATHWAY INHIBITOR; RETINOIC ACID INDUCIBLE PROTEIN I; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; ROSUVASTATIN; SIMVASTATIN; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG; VON WILLEBRAND FACTOR CLEAVING PROTEINASE; CYTOKINE;

EID: 59649117667     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e31819267fb     Document Type: Review
Times cited : (330)

References (190)
  • 2
    • 67650379922 scopus 로고    scopus 로고
    • Making a difference in outcome in severe sepsis: The organism, the host response and the treating clinician
    • Cinel I, Dellinger RP: Making a difference in outcome in severe sepsis: The organism, the host response and the treating clinician. Emerg Med Crit Care Rev 2007; 1:1-3
    • (2007) Emerg Med Crit Care Rev , vol.1 , pp. 1-3
    • Cinel, I.1    Dellinger, R.P.2
  • 3
    • 34347397197 scopus 로고    scopus 로고
    • Advances in pathogenesis and management of sepsis
    • Cinel I, Dellinger RP: Advances in pathogenesis and management of sepsis. Curr Opin Infect Dis 2007; 20:345-352
    • (2007) Curr Opin Infect Dis , vol.20 , pp. 345-352
    • Cinel, I.1    Dellinger, R.P.2
  • 4
    • 33748308787 scopus 로고    scopus 로고
    • Toll-like receptors and innate immunity
    • Uematsu S, Akira S: Toll-like receptors and innate immunity. J Mol Med 2007; 84: 712-725
    • (2007) J Mol Med , vol.84 , pp. 712-725
    • Uematsu, S.1    Akira, S.2
  • 5
    • 33745847180 scopus 로고    scopus 로고
    • TLRs, NLRs and RLRs: A trinity of pathogen sensors that co-operate in innate immunity
    • Creagh EM, O'Neill LA: TLRs, NLRs and RLRs: A trinity of pathogen sensors that co-operate in innate immunity. Trends Immunol 2006; 27:352-357
    • (2006) Trends Immunol , vol.27 , pp. 352-357
    • Creagh, E.M.1    O'Neill, L.A.2
  • 7
    • 20644450804 scopus 로고    scopus 로고
    • Negative regulation of toll-like receptor-mediated immune responses
    • Liew FY, Xu D, Brint EK, et al: Negative regulation of toll-like receptor-mediated immune responses. Nat Rev Immunol 2005; 5:446-458
    • (2005) Nat Rev Immunol , vol.5 , pp. 446-458
    • Liew, F.Y.1    Xu, D.2    Brint, E.K.3
  • 8
    • 32944464648 scopus 로고    scopus 로고
    • Pathogen recognition and innate immunity
    • Akira S, Uematsu S, Takeuchi O: Pathogen recognition and innate immunity. Cell 2006; 124:783-801
    • (2006) Cell , vol.124 , pp. 783-801
    • Akira, S.1    Uematsu, S.2    Takeuchi, O.3
  • 9
    • 33845951211 scopus 로고    scopus 로고
    • Bianchi ME: DAMPs PAM. Ps and alarmins: All we need to know about danger. J Leukoc Biol 2007; 81:1-5
    • Bianchi ME: DAMPs PAM. Ps and alarmins: All we need to know about danger. J Leukoc Biol 2007; 81:1-5
  • 10
    • 33750312909 scopus 로고    scopus 로고
    • Emerging paradigm: Toll-like receptor 4-sentinel for the detection of tissue damage
    • Mollen KP, Anand RJ, Tsung A, et al: Emerging paradigm: Toll-like receptor 4-sentinel for the detection of tissue damage. Shock 2006; 26:430-437
    • (2006) Shock , vol.26 , pp. 430-437
    • Mollen, K.P.1    Anand, R.J.2    Tsung, A.3
  • 11
    • 8344222719 scopus 로고    scopus 로고
    • Hemoperfusion with polymyxin B-immobilized fibers reduced the number of CD16+ CD14+ monocytes in patients with septic shock
    • Tsujimoto H, Ono S, Hiraki S, et al: Hemoperfusion with polymyxin B-immobilized fibers reduced the number of CD16+ CD14+ monocytes in patients with septic shock. J Endotoxin Res 2004; 10:229-237
    • (2004) J Endotoxin Res , vol.10 , pp. 229-237
    • Tsujimoto, H.1    Ono, S.2    Hiraki, S.3
  • 12
    • 2142703865 scopus 로고    scopus 로고
    • Differential expression of toll-like receptor (TLR)-2 and TLR-4 on monocytes in human sepsis
    • Armstrong L, Medford AR, Hunter KJ, et al: Differential expression of toll-like receptor (TLR)-2 and TLR-4 on monocytes in human sepsis. Clin Exp Immunol 2004; 136: 312-319
    • (2004) Clin Exp Immunol , vol.136 , pp. 312-319
    • Armstrong, L.1    Medford, A.R.2    Hunter, K.J.3
  • 13
    • 19944429804 scopus 로고    scopus 로고
    • Neutrophil elastase, MIP-2, and TLR-4 expression during human and experimental sepsis
    • Tsujimoto H, Ono S, Majima T, et al: Neutrophil elastase, MIP-2, and TLR-4 expression during human and experimental sepsis. Shock 2005; 23:39-44
    • (2005) Shock , vol.23 , pp. 39-44
    • Tsujimoto, H.1    Ono, S.2    Majima, T.3
  • 14
    • 0038047587 scopus 로고    scopus 로고
    • Modulation of tissue toll-like receptor 2 and 4 during the early phases of polymicrobial sepsis correlates with mortality
    • Williams DL, Ha T, Li C, et al: Modulation of tissue toll-like receptor 2 and 4 during the early phases of polymicrobial sepsis correlates with mortality. Crit Care Med 2003; 31:1808-1818
    • (2003) Crit Care Med , vol.31 , pp. 1808-1818
    • Williams, D.L.1    Ha, T.2    Li, C.3
  • 15
    • 0041344362 scopus 로고    scopus 로고
    • Injury primes the innate immune system for enhanced toll-like receptor reactivity
    • Paterson HM, Murphy TJ, Purcell EJ, et al: Injury primes the innate immune system for enhanced toll-like receptor reactivity. J Immunol 2003; 171:1473-1483
    • (2003) J Immunol , vol.171 , pp. 1473-1483
    • Paterson, H.M.1    Murphy, T.J.2    Purcell, E.J.3
  • 16
    • 39449112833 scopus 로고    scopus 로고
    • Role of toll like receptors in the development of sepsis
    • Tsujimoto H, Ono S, Efron PA, et al: Role of toll like receptors in the development of sepsis. Shock 2008; 29:315-321
    • (2008) Shock , vol.29 , pp. 315-321
    • Tsujimoto, H.1    Ono, S.2    Efron, P.A.3
  • 17
    • 33747191203 scopus 로고    scopus 로고
    • The inflammasome: First line of the immune response to cell stress
    • Ogura Y, Sutterwala FS, Flavell RA: The inflammasome: First line of the immune response to cell stress. Cell 2006; 126: 659-662
    • (2006) Cell , vol.126 , pp. 659-662
    • Ogura, Y.1    Sutterwala, F.S.2    Flavell, R.A.3
  • 18
    • 33747340486 scopus 로고    scopus 로고
    • The inflammasome - A linebacker of innate defense
    • Drenth JP, van der Meer JW: The inflammasome - A linebacker of innate defense. N Engl J Med 2006; 355:730-732
    • (2006) N Engl J Med , vol.355 , pp. 730-732
    • Drenth, J.P.1    van der Meer, J.W.2
  • 19
    • 0031739525 scopus 로고    scopus 로고
    • Interleukin-1β, interleukin-18, and the interleukin-1β converting enzyme
    • Dinarello CA: Interleukin-1β, interleukin-18, and the interleukin-1β converting enzyme. Ann NY Acad Sci 1998; 856:1-11
    • (1998) Ann NY Acad Sci , vol.856 , pp. 1-11
    • Dinarello, C.A.1
  • 20
    • 0036671894 scopus 로고    scopus 로고
    • The inflammasome. A molecular platform triggering activation of inflammatory caspases and processing of proIL-1β
    • Martinon F, Burns K, Tschopp J: The inflammasome. A molecular platform triggering activation of inflammatory caspases and processing of proIL-1β. MolCell 2002; 10: 417-426
    • (2002) MolCell , vol.10 , pp. 417-426
    • Martinon, F.1    Burns, K.2    Tschopp, J.3
  • 21
    • 30844432876 scopus 로고    scopus 로고
    • Cryopyrin and pyrin activate caspase-1, but not NF-kappaB, via ASC oligomerization
    • Yu JW, Wu J, Zhang Z, et al: Cryopyrin and pyrin activate caspase-1, but not NF-kappaB, via ASC oligomerization. Cell Death Differ 2005; 13:236-249
    • (2005) Cell Death Differ , vol.13 , pp. 236-249
    • Yu, J.W.1    Wu, J.2    Zhang, Z.3
  • 22
    • 34548768341 scopus 로고    scopus 로고
    • Pyrin levels in human monocytes and monocyte-derived macrophages regulate IL-1β processing and release
    • Seshadri S, Duncan MD, Hart JM, et al: Pyrin levels in human monocytes and monocyte-derived macrophages regulate IL-1β processing and release. J Immunol 2007; 179:1274-1281
    • (2007) J Immunol , vol.179 , pp. 1274-1281
    • Seshadri, S.1    Duncan, M.D.2    Hart, J.M.3
  • 23
    • 0037312509 scopus 로고    scopus 로고
    • NALPs: A novel protein family involved in inflammation
    • Tschopp J, Martinon F, Burns K: NALPs: A novel protein family involved in inflammation. NatRevMol Cell Biol 2003; 4:95-104
    • (2003) NatRevMol Cell Biol , vol.4 , pp. 95-104
    • Tschopp, J.1    Martinon, F.2    Burns, K.3
  • 24
    • 33645757512 scopus 로고    scopus 로고
    • ASC directs NF-kB activation by regulating receptor interacting protein-2 (RIP2) caspase-1 interactions
    • Sarkar A, Duncan M, Hart J, et al: ASC directs NF-kB activation by regulating receptor interacting protein-2 (RIP2) caspase-1 interactions. J Immunol 2006; 176:4979-4986
    • (2006) J Immunol , vol.176 , pp. 4979-4986
    • Sarkar, A.1    Duncan, M.2    Hart, J.3
  • 25
    • 33845478357 scopus 로고    scopus 로고
    • The inflammatory caspases: Guardians against infections and sepsis
    • Scott AM, Saleh M: The inflammatory caspases: Guardians against infections and sepsis. Cell Death Differ 2007; 14:23-31
    • (2007) Cell Death Differ , vol.14 , pp. 23-31
    • Scott, A.M.1    Saleh, M.2
  • 26
    • 33750580090 scopus 로고    scopus 로고
    • Caspase-1 regulates E. coli sepsis and splenic B cell apoptosis independently of IL-1β and IL-18
    • Sarkar A, Hall MW, Exline M, et al: Caspase-1 regulates E. coli sepsis and splenic B cell apoptosis independently of IL-1β and IL-18. Am J Respir Crit Care Med 2006; 174:1003-1010
    • (2006) Am J Respir Crit Care Med , vol.174 , pp. 1003-1010
    • Sarkar, A.1    Hall, M.W.2    Exline, M.3
  • 27
    • 2342457148 scopus 로고    scopus 로고
    • Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms
    • Saleh M, Vaillancourt JP, Graham RK, et al: Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms. Nature 2004; 429:75-79
    • (2004) Nature , vol.429 , pp. 75-79
    • Saleh, M.1    Vaillancourt, J.P.2    Graham, R.K.3
  • 28
    • 33646175602 scopus 로고    scopus 로고
    • Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice
    • Saleh M, Mathison JC, Wolinski MK, et al: Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice. Nature 2006; 440:1064-1068
    • (2006) Nature , vol.440 , pp. 1064-1068
    • Saleh, M.1    Mathison, J.C.2    Wolinski, M.K.3
  • 29
    • 0036721805 scopus 로고    scopus 로고
    • IL-18 levels and the outcome of innate immune response to lipopolysaccharide: Importance of a positive feedback loop with caspase-1 in IL-18 expression
    • Joshi VD, Kalvakolanu DV, Hasday JD, et al: IL-18 levels and the outcome of innate immune response to lipopolysaccharide: Importance of a positive feedback loop with caspase-1 in IL-18 expression. J Immunol 2002; 169:2536-2544
    • (2002) J Immunol , vol.169 , pp. 2536-2544
    • Joshi, V.D.1    Kalvakolanu, D.V.2    Hasday, J.D.3
  • 30
    • 42949162029 scopus 로고    scopus 로고
    • Inflammasome mRNA expression in human monocytes during early septic shock
    • Fahy RJ, Exline MC, Gavrilin MA, et al: Inflammasome mRNA expression in human monocytes during early septic shock. Am J Resp Crit Care Med 2008; 177:983-988.
    • (2008) Am J Resp Crit Care Med , vol.177 , pp. 983-988
    • Fahy, R.J.1    Exline, M.C.2    Gavrilin, M.A.3
  • 31
    • 33745012076 scopus 로고    scopus 로고
    • Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis
    • Lara-Tejero M, Sutterwala FS, Ogura Y, et al: Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis. J Exp Med 2006; 203:1407-1412
    • (2006) J Exp Med , vol.203 , pp. 1407-1412
    • Lara-Tejero, M.1    Sutterwala, F.S.2    Ogura, Y.3
  • 32
    • 0033618562 scopus 로고    scopus 로고
    • Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors
    • Brightbill HD, Libraty DH, Krutzik SR, et al: Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors. Science 1999; 285:732-736
    • (1999) Science , vol.285 , pp. 732-736
    • Brightbill, H.D.1    Libraty, D.H.2    Krutzik, S.R.3
  • 33
    • 0033839992 scopus 로고    scopus 로고
    • Exoenzyme S from Pseudomonas aeruginosa induces apoptosis in T lymphocytes
    • Bruno TF, Woods DE, Mody CH: Exoenzyme S from Pseudomonas aeruginosa induces apoptosis in T lymphocytes. J Leukoc Biol 2000; 67:808-816
    • (2000) J Leukoc Biol , vol.67 , pp. 808-816
    • Bruno, T.F.1    Woods, D.E.2    Mody, C.H.3
  • 34
    • 0031423761 scopus 로고    scopus 로고
    • MyD88: An adapter that recruits IRAK to the IL-1 receptor complex
    • Wesche H, Henzel WJ, Shillinglaw W, et al: MyD88: An adapter that recruits IRAK to the IL-1 receptor complex. Immunity 1997; 7:837-847
    • (1997) Immunity , vol.7 , pp. 837-847
    • Wesche, H.1    Henzel, W.J.2    Shillinglaw, W.3
  • 35
    • 33748339203 scopus 로고    scopus 로고
    • Dynamic redox control of NF-kappaB through glutaredoxin-regulated S-glutathionylation of inhibitory kappaB kinase beta
    • Reynaert NL, van der Vliet A, Guala AS, et al: Dynamic redox control of NF-kappaB through glutaredoxin-regulated S-glutathionylation of inhibitory kappaB kinase beta. Proc Natl Acad Sci USA 2006; 103: 13086-13091
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 13086-13091
    • Reynaert, N.L.1    van der Vliet, A.2    Guala, A.S.3
  • 36
    • 0033596121 scopus 로고    scopus 로고
    • Activators and target genes of rel/ NF-kappaB transcription factors
    • Pahl HL: Activators and target genes of rel/ NF-kappaB transcription factors. Oncogene 1999; 18:6853-6866
    • (1999) Oncogene , vol.18 , pp. 6853-6866
    • Pahl, H.L.1
  • 37
    • 0033825860 scopus 로고    scopus 로고
    • Multiorgan nuclear factor kappa B activation in a transgenic mouse model of systemic inflammation
    • Blackwell TS, Yull FE, Chen CL, et al: Multiorgan nuclear factor kappa B activation in a transgenic mouse model of systemic inflammation. Am J Respir Crit Care Med 2000; 162:1095-1101
    • (2000) Am J Respir Crit Care Med , vol.162 , pp. 1095-1101
    • Blackwell, T.S.1    Yull, F.E.2    Chen, C.L.3
  • 38
    • 33745138167 scopus 로고    scopus 로고
    • Variant IRAK-1 haplotype is associated with increased nuclear factor-kappaB activation and worse outcomes in sepsis
    • Arcaroli J, Silva E, Maloney JP, et al: Variant IRAK-1 haplotype is associated with increased nuclear factor-kappaB activation and worse outcomes in sepsis. Am J Respir Crit Care Med 2006; 173:1335-1341
    • (2006) Am J Respir Crit Care Med , vol.173 , pp. 1335-1341
    • Arcaroli, J.1    Silva, E.2    Maloney, J.P.3
  • 39
    • 33947573767 scopus 로고    scopus 로고
    • Epithelial cell-intrinsic IKK-beta expression regulates intestinal immune homeostasis
    • Zaph C, Troy AE, Taylor BC, et al: Epithelial cell-intrinsic IKK-beta expression regulates intestinal immune homeostasis. Nature 2007; 446:552-556
    • (2007) Nature , vol.446 , pp. 552-556
    • Zaph, C.1    Troy, A.E.2    Taylor, B.C.3
  • 40
    • 34247891512 scopus 로고    scopus 로고
    • TSLP: An epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation
    • Liu YJ, Soumelis V, Watanabe N, et al: TSLP: An epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation. Annu Rev Immunol 2007; 25:193-219
    • (2007) Annu Rev Immunol , vol.25 , pp. 193-219
    • Liu, Y.J.1    Soumelis, V.2    Watanabe, N.3
  • 41
    • 44449165650 scopus 로고    scopus 로고
    • Deletion of MyD88 markedly attenuates sepsis-induced T and B lymphocyte apoptosis but worsens survival
    • Peck-Palmer OM, Unsinger J, Chang KC, et al: Deletion of MyD88 markedly attenuates sepsis-induced T and B lymphocyte apoptosis but worsens survival. J Leukoc Biol 2008; 83:1009-1018
    • (2008) J Leukoc Biol , vol.83 , pp. 1009-1018
    • Peck-Palmer, O.M.1    Unsinger, J.2    Chang, K.C.3
  • 42
    • 0037205048 scopus 로고    scopus 로고
    • The phosphoinositide 3-kinase pathway
    • Cantley LC. The phosphoinositide 3-kinase pathway. Science 2002; 296:1655-1657
    • (2002) Science , vol.296 , pp. 1655-1657
    • Cantley, L.C.1
  • 43
    • 0043033208 scopus 로고    scopus 로고
    • Janus kinase2 is involved in lipopolysaccharide-induced activation of macrophages
    • Okugawa S, Ota Y, Kitazawa T, et al: Janus kinase2 is involved in lipopolysaccharide-induced activation of macrophages. Am J Physiol Cell Physiol 2003; 285:C399-C408
    • (2003) Am J Physiol Cell Physiol , vol.285
    • Okugawa, S.1    Ota, Y.2    Kitazawa, T.3
  • 44
    • 0037352702 scopus 로고    scopus 로고
    • Phosphatidylinositol kinase is involved in Toll-like receptor 4-mediated cytokine expression in mouse macrophages
    • Ojaniemi M, Glumoff V, Harju K, et al: Phosphatidylinositol kinase is involved in Toll-like receptor 4-mediated cytokine expression in mouse macrophages. Eur J Immunol 2003; 335:97-605
    • (2003) Eur J Immunol , vol.335 , pp. 97-605
    • Ojaniemi, M.1    Glumoff, V.2    Harju, K.3
  • 45
    • 14044267522 scopus 로고    scopus 로고
    • Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus
    • Guillot L, Le GofficR, BlochS, et al: Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus. J Biol Chem 2005; 280:5571-5580
    • (2005) J Biol Chem , vol.280 , pp. 5571-5580
    • Guillot, L.1    GofficR, L.2    BlochS3
  • 46
    • 34247643153 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase signaling pathway exerts protective effects during sepsis by controlling C5a-mediated activation of innate immune functions
    • Wrann CD, Tabriz NA, Barkhausen T, et al: The phosphatidylinositol 3-kinase signaling pathway exerts protective effects during sepsis by controlling C5a-mediated activation of innate immune functions. J Immunol 2007; 178:5940-5948
    • (2007) J Immunol , vol.178 , pp. 5940-5948
    • Wrann, C.D.1    Tabriz, N.A.2    Barkhausen, T.3
  • 47
    • 0037199972 scopus 로고    scopus 로고
    • The PI3K-Akt pathway limits LPS activation of signaling pathways and expression of inflammatory mediators in human monocytic cells
    • Guha M, Mackman N: The PI3K-Akt pathway limits LPS activation of signaling pathways and expression of inflammatory mediators in human monocytic cells. J Biol Chem 2002; 277:32124-32132
    • (2002) J Biol Chem , vol.277 , pp. 32124-32132
    • Guha, M.1    Mackman, N.2
  • 48
    • 5344249335 scopus 로고    scopus 로고
    • PI3K-Akt pathway suppresses coagulation and inflammation in endotoxemic mice
    • Schabbaue G, Tencati M, Pedersen B, et al: PI3K-Akt pathway suppresses coagulation and inflammation in endotoxemic mice. Arterioscler Thromb Vasc Biol 2004; 24: 1963-1969
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 1963-1969
    • Schabbaue, G.1    Tencati, M.2    Pedersen, B.3
  • 49
    • 33644506745 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced production of interleukin-10 is promoted by the serin threonine kinase Akt
    • Pengal RA, Ganesan LP, Wei G, et al: Lipopolysaccharide-induced production of interleukin-10 is promoted by the serin threonine kinase Akt. Mol Immunol 2006; 43: 1557-1156
    • (2006) Mol Immunol , vol.43 , pp. 1557-1156
    • Pengal, R.A.1    Ganesan, L.P.2    Wei, G.3
  • 50
    • 0037629646 scopus 로고    scopus 로고
    • PI3K and negative regulation of TLR signaling
    • Fukao T, Koyasu S: PI3K and negative regulation of TLR signaling. Trends Immunol 2003; 24:358-363
    • (2003) Trends Immunol , vol.24 , pp. 358-363
    • Fukao, T.1    Koyasu, S.2
  • 51
    • 2942527148 scopus 로고    scopus 로고
    • Akt decreases lymphocyte apoptosis and improves survival in sepsis
    • Bommhardt U, Chang KC, Swanson PE, et al: Akt decreases lymphocyte apoptosis and improves survival in sepsis. J Immunol 2004; 172:7583-7591
    • (2004) J Immunol , vol.172 , pp. 7583-7591
    • Bommhardt, U.1    Chang, K.C.2    Swanson, P.E.3
  • 52
    • 38949168061 scopus 로고    scopus 로고
    • Peptide-mediated activation of Akt and extracellular regulated kinase signaling prevents lymphocyte apoptosis
    • Mc Dunn JE, Muenzer JT, Rachdi L, et al: Peptide-mediated activation of Akt and extracellular regulated kinase signaling prevents lymphocyte apoptosis. FASEB J 2008; 22:561-568
    • (2008) FASEB J , vol.22 , pp. 561-568
    • Mc Dunn, J.E.1    Muenzer, J.T.2    Rachdi, L.3
  • 53
    • 0032559362 scopus 로고    scopus 로고
    • Pases and the actin cytoskeleton
    • Hall A: Rho GT. Pases and the actin cytoskeleton. Science 1998; 279:509-514
    • (1998) Science , vol.279 , pp. 509-514
    • Hall, A.1    Rho, G.T.2
  • 54
    • 33646896934 scopus 로고    scopus 로고
    • New players in TLR-mediated innate immunity
    • Ruse M, Knaus UG: New players in TLR-mediated innate immunity. Immunologic Res 2006; 34:33-48
    • (2006) Immunologic Res , vol.34 , pp. 33-48
    • Ruse, M.1    Knaus, U.G.2
  • 55
    • 0034577944 scopus 로고    scopus 로고
    • Toll-like receptor 2-mediated NF-kappa B activation requires a Racl dependenpt pathway
    • Arbibe L, Mira JP, Teusch N, et al: Toll-like receptor 2-mediated NF-kappa B activation requires a Racl dependenpt pathway. Nat Immunol 2000; 1:533-540
    • (2000) Nat Immunol , vol.1 , pp. 533-540
    • Arbibe, L.1    Mira, J.P.2    Teusch, N.3
  • 56
    • 1542283713 scopus 로고    scopus 로고
    • Rho activation promotes transendothelial migration of monocytes via ROCK
    • Honing H, van den Berg TK, van der Pol SM, et al: Rho activation promotes transendothelial migration of monocytes via ROCK. J Leukoc Biol 2004; 75:523-528
    • (2004) J Leukoc Biol , vol.75 , pp. 523-528
    • Honing, H.1    van den Berg, T.K.2    van der Pol, S.M.3
  • 57
    • 20044374702 scopus 로고    scopus 로고
    • Attenuation of endotoxin-induced acute lung injury by the Rho-associated kinase inhibitor, Y-27632
    • Tasaka S, Koh H, Yamada W, et al: Attenuation of endotoxin-induced acute lung injury by the Rho-associated kinase inhibitor, Y-27632. Am J Respir Cell Mol Biol 2005; 32:504-510
    • (2005) Am J Respir Cell Mol Biol , vol.32 , pp. 504-510
    • Tasaka, S.1    Koh, H.2    Yamada, W.3
  • 58
    • 33745326435 scopus 로고    scopus 로고
    • Protective effect of fasudil, a Rho-kinase inhibitor, on chemokine expression, leukocyte recruitment, and hepatocellular apoptosis in septic liver injury
    • Thorlacius K, Slotta JE, Laschke MW, et al: Protective effect of fasudil, a Rho-kinase inhibitor, on chemokine expression, leukocyte recruitment, and hepatocellular apoptosis in septic liver injury. J Leukoc Biol 2006; 79:923-931
    • (2006) J Leukoc Biol , vol.79 , pp. 923-931
    • Thorlacius, K.1    Slotta, J.E.2    Laschke, M.W.3
  • 59
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor FoxP3
    • Hori S, Nomura T, Sakaguchi S: Control of regulatory T cell development by the transcription factor FoxP3. Science 2003; 299: 1057-1061
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 60
    • 1242267910 scopus 로고    scopus 로고
    • CD4+ and CD8+ regulatory T cells generated ex vivo with IL-2 and TGF-beta suppress a stimulatory Graft-versus- Host disease with a Lupus-like syndrome
    • Zheng SG, Wang JH, Koss MN, et al: CD4+ and CD8+ regulatory T cells generated ex vivo with IL-2 and TGF-beta suppress a stimulatory Graft-versus- Host disease with a Lupus-like syndrome. J Immunol 2004; 172:1531-1539
    • (2004) J Immunol , vol.172 , pp. 1531-1539
    • Zheng, S.G.1    Wang, J.H.2    Koss, M.N.3
  • 61
    • 27144540463 scopus 로고    scopus 로고
    • Are innate immune signaling pathways in plants and animals conserved?
    • Ausubel FM: Are innate immune signaling pathways in plants and animals conserved? Nat Immunol 2005; 6:973-979
    • (2005) Nat Immunol , vol.6 , pp. 973-979
    • Ausubel, F.M.1
  • 62
    • 0037450804 scopus 로고    scopus 로고
    • Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide
    • Caramalho I, Lopes-Carvalho T, Ostler D, et al: Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide. J Exp Med 2003; 197: 403-411
    • (2003) J Exp Med , vol.197 , pp. 403-411
    • Caramalho, I.1    Lopes-Carvalho, T.2    Ostler, D.3
  • 63
    • 32444432610 scopus 로고    scopus 로고
    • Toll-like receptor 2 controls expansion and function of regulatory T cells
    • Sutmuller RPM, den Brok MH, Kramer M, et al: Toll-like receptor 2 controls expansion and function of regulatory T cells. J Clin Invest 2006; 116:485-494
    • (2006) J Clin Invest , vol.116 , pp. 485-494
    • Sutmuller, R.P.M.1    den Brok, M.H.2    Kramer, M.3
  • 64
    • 33646487278 scopus 로고    scopus 로고
    • Toll-like receptor 2 signaling modulates the functions of CD4+CD25+ regulatory T cells
    • Liu H, Komai-Koma M, Xu D, et al: Toll-like receptor 2 signaling modulates the functions of CD4+CD25+ regulatory T cells. Proc Natl Acad Sci USA 2006; 103: 7048-7053
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 7048-7053
    • Liu, H.1    Komai-Koma, M.2    Xu, D.3
  • 65
    • 0036857530 scopus 로고    scopus 로고
    • The role of suppressor T cells in regulation of immune responses
    • McHugh RS, Shevach EM: The role of suppressor T cells in regulation of immune responses. J Allergy Clin Immunol 2002; 110:693-702
    • (2002) J Allergy Clin Immunol , vol.110 , pp. 693-702
    • McHugh, R.S.1    Shevach, E.M.2
  • 66
    • 14044269484 scopus 로고    scopus 로고
    • + regulatory T cells control innate immune reactivity after injury
    • + regulatory T cells control innate immune reactivity after injury. J Immunol 2005; 174:2957-2963
    • (2005) J Immunol , vol.174 , pp. 2957-2963
    • Murphy, T.J.1    Choileain, N.N.2    Zang, Y.3
  • 67
    • 0041365362 scopus 로고    scopus 로고
    • Marked elevation of human circulating CD4+CD25+ regulatory T cells in sepsis-induced immunoparalysis
    • Monneret G, Debard AL, Venet F, et al: Marked elevation of human circulating CD4+CD25+ regulatory T cells in sepsis-induced immunoparalysis. Crit Care Med 2003; 31:2068-2071
    • (2003) Crit Care Med , vol.31 , pp. 2068-2071
    • Monneret, G.1    Debard, A.L.2    Venet, F.3
  • 68
    • 8544236263 scopus 로고    scopus 로고
    • Increased percentage of CD4+CD25+ regulatory T cells during septic shock is due to the decrease of CD4+CD25-lymphocytes
    • Venet F, Pachot A, Debard AL, et al: Increased percentage of CD4+CD25+ regulatory T cells during septic shock is due to the decrease of CD4+CD25-lymphocytes. Crit Care Med 2004; 32:2329-2331
    • (2004) Crit Care Med , vol.32 , pp. 2329-2331
    • Venet, F.1    Pachot, A.2    Debard, A.L.3
  • 69
    • 3442892236 scopus 로고    scopus 로고
    • Influence of systemic inflammatory response syndrome on host resistance against bacterial infections
    • Takahashi H, Tsuda Y, Takeuchi D, et al: Influence of systemic inflammatory response syndrome on host resistance against bacterial infections. Crit Care Med 2004; 32:1879-1885
    • (2004) Crit Care Med , vol.32 , pp. 1879-1885
    • Takahashi, H.1    Tsuda, Y.2    Takeuchi, D.3
  • 70
    • 37649015079 scopus 로고    scopus 로고
    • CD4+CD25+Foxp3+ regulatory T cells induce alternative activation of human monocytes/macrophages
    • Tiemessen MM, Jagger AL, Evans HG, et al: CD4+CD25+Foxp3+ regulatory T cells induce alternative activation of human monocytes/macrophages. Proc Natl Acad Sci USA 2007; 104:19446-19451
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 19446-19451
    • Tiemessen, M.M.1    Jagger, A.L.2    Evans, H.G.3
  • 71
    • 33847011663 scopus 로고    scopus 로고
    • The contribution of CD4+ CD25+ T-regulatory-cells to immune suppression in sepsis
    • Wisnoski N, Chung CS, Chen Y, et al: The contribution of CD4+ CD25+ T-regulatory-cells to immune suppression in sepsis. Shock 2007; 27:251-257
    • (2007) Shock , vol.27 , pp. 251-257
    • Wisnoski, N.1    Chung, C.S.2    Chen, Y.3
  • 72
    • 46949091694 scopus 로고    scopus 로고
    • Toll-like receptor signalling on Tregs: To suppress or not to suppress?
    • van Maren WW, Jacobs JF, de Vries IJ, et al: Toll-like receptor signalling on Tregs: To suppress or not to suppress? Immunology 2008; 124:445-452.
    • (2008) Immunology , vol.124 , pp. 445-452
    • van Maren, W.W.1    Jacobs, J.F.2    de Vries, I.J.3
  • 73
    • 18944371642 scopus 로고    scopus 로고
    • + regulatory T cells increases bacterial clearance and improves survival in polymicrobial sepsis
    • + regulatory T cells increases bacterial clearance and improves survival in polymicrobial sepsis. J Immunol 2005; 174:7141-7146
    • (2005) J Immunol , vol.174 , pp. 7141-7146
    • Heuer, J.G.1    Zhang, T.2    Zhao, J.3
  • 74
    • 33750306678 scopus 로고    scopus 로고
    • Human CD4+CD25+ regulatory T lymphocytes inhibit lipopolysaccharide-induced monocyte survival through a Fas/Fas ligand-dependent mechanism
    • Venet F, Pachot A, Debard AL, et al: Human CD4+CD25+ regulatory T lymphocytes inhibit lipopolysaccharide-induced monocyte survival through a Fas/Fas ligand-dependent mechanism. J Immunol 2006; 177: 6540-6547
    • (2006) J Immunol , vol.177 , pp. 6540-6547
    • Venet, F.1    Pachot, A.2    Debard, A.L.3
  • 75
    • 33745617094 scopus 로고    scopus 로고
    • Neutrophils in development of multiple organ failure in sepsis
    • Brown KA, Brain SD, Pearson JD, et al: Neutrophils in development of multiple organ failure in sepsis. Lancet 2006; 368: 157-169
    • (2006) Lancet , vol.368 , pp. 157-169
    • Brown, K.A.1    Brain, S.D.2    Pearson, J.D.3
  • 76
    • 33750097562 scopus 로고    scopus 로고
    • The pathogenesis and molecular biology of sepsis
    • Marshal JC: The pathogenesis and molecular biology of sepsis. Crit Care Resusc 2006; 8:227-229
    • (2006) Crit Care Resusc , vol.8 , pp. 227-229
    • Marshal, J.C.1
  • 77
    • 33645888427 scopus 로고    scopus 로고
    • Sepsis: Emerging role of nitric oxide and selectins
    • Chandra A, Enkhbaatar P, Nakano Y, et al: Sepsis: Emerging role of nitric oxide and selectins. Clinics 2006; 61:71-76
    • (2006) Clinics , vol.61 , pp. 71-76
    • Chandra, A.1    Enkhbaatar, P.2    Nakano, Y.3
  • 78
    • 67650370217 scopus 로고    scopus 로고
    • ICAM-1 dependent neutrophil adhesion to endothelial cells increases caveolae-mediated pulmonary vascular albumin permeability
    • Hu G, Predescu D, Vogel SM: ICAM-1 dependent neutrophil adhesion to endothelial cells increases caveolae-mediated pulmonary vascular albumin permeability. Crit Care Med 2007; 34 (Suppl 12): A31
    • (2007) Crit Care Med , vol.34 , Issue.SUPPL. 12
    • Hu, G.1    Predescu, D.2    Vogel, S.M.3
  • 79
    • 33749154295 scopus 로고    scopus 로고
    • Caveolin-1 regulates NF-kB activation and lung inflammatory response to sepsis induced by lipopolysaccharide
    • Garrean S, Gao X-P, Brovkovych V, et al: Caveolin-1 regulates NF-kB activation and lung inflammatory response to sepsis induced by lipopolysaccharide. J Immunol 2006 177: 4853-4860
    • (2006) J Immunol , vol.177 , pp. 4853-4860
    • Garrean, S.1    Gao, X.-P.2    Brovkovych, V.3
  • 80
    • 33645663531 scopus 로고    scopus 로고
    • Caveolin-1 confers antiinflammatory effects in murine macrophages via the MKK3/p38 MAPK pathway
    • Wang XM, Kim HP, Song R, et al: Caveolin-1 confers antiinflammatory effects in murine macrophages via the MKK3/p38 MAPK pathway. Am J Respir Cell Mol Biol 2006; 34:434-442
    • (2006) Am J Respir Cell Mol Biol , vol.34 , pp. 434-442
    • Wang, X.M.1    Kim, H.P.2    Song, R.3
  • 81
    • 33845507080 scopus 로고    scopus 로고
    • Caveolin-1 deficient mice show defects in innate immunity and inflammatory immune response during Salmonella enterica serovar typhimurium infection
    • Medina FA, de Almeida CJ, Dew E, et al: Caveolin-1 deficient mice show defects in innate immunity and inflammatory immune response during Salmonella enterica serovar typhimurium infection. Infect Immun 2006; 74:6665-6674
    • (2006) Infect Immun , vol.74 , pp. 6665-6674
    • Medina, F.A.1    de Almeida, C.J.2    Dew, E.3
  • 82
    • 33847404968 scopus 로고    scopus 로고
    • Immune dysfunction in caveolin-1 null mice following infection with Trypanosoma cruzi (Tulahuen strain)
    • Medina FA, Cohen AW, de Almeida CJ, et al: Immune dysfunction in caveolin-1 null mice following infection with Trypanosoma cruzi (Tulahuen strain). Microbes Infect 2007; 9:325-333
    • (2007) Microbes Infect , vol.9 , pp. 325-333
    • Medina, F.A.1    Cohen, A.W.2    de Almeida, C.J.3
  • 83
    • 0028796672 scopus 로고
    • Microvascular function and rheologic changes in hyperdynamic sepsis
    • Astiz ME, DeGent GE, Lin RY, et al: Microvascular function and rheologic changes in hyperdynamic sepsis. Crit Care Med 1995; 23:265-271
    • (1995) Crit Care Med , vol.23 , pp. 265-271
    • Astiz, M.E.1    DeGent, G.E.2    Lin, R.Y.3
  • 84
    • 0038113408 scopus 로고    scopus 로고
    • The protective effect of N-acetylcysteine on apoptotic lung injury in cecal ligation and puncture-induced sepsis model
    • Ozdulger A, Cinel I, Koksel O, et al: The protective effect of N-acetylcysteine on apoptotic lung injury in cecal ligation and puncture-induced sepsis model. Shock 2003; 19:366-372
    • (2003) Shock , vol.19 , pp. 366-372
    • Ozdulger, A.1    Cinel, I.2    Koksel, O.3
  • 85
    • 38349166112 scopus 로고    scopus 로고
    • Effects of IgM enriched solution on polymorphonuclear neutrophil function, bacterial clearance, and lung histology in endotoxemia
    • Stehr SN, Knels L, Weissflog C, et al: Effects of IgM enriched solution on polymorphonuclear neutrophil function, bacterial clearance, and lung histology in endotoxemia. Shock 2007; 29:167-172
    • (2007) Shock , vol.29 , pp. 167-172
    • Stehr, S.N.1    Knels, L.2    Weissflog, C.3
  • 86
    • 33846164128 scopus 로고    scopus 로고
    • Interleukin-10 gene transfer: Prevention of multiple organ injury in a murine cecal ligation and puncture model of sepsis
    • Kabay B, Kocaefe C, Baykal A, et al: Interleukin-10 gene transfer: Prevention of multiple organ injury in a murine cecal ligation and puncture model of sepsis. World J Surg 2007; 31:105-115
    • (2007) World J Surg , vol.31 , pp. 105-115
    • Kabay, B.1    Kocaefe, C.2    Baykal, A.3
  • 87
    • 0036417282 scopus 로고    scopus 로고
    • Poly (ADP-ribose) synthetase inhibition prevents lipopolysaccharide-induced peroxynitrite mediated damage in diaphragm
    • Ozdulger A, Cinel I, Unlu A, et al: Poly (ADP-ribose) synthetase inhibition prevents lipopolysaccharide-induced peroxynitrite mediated damage in diaphragm. Pharmacol Res 2002; 46:67-73
    • (2002) Pharmacol Res , vol.46 , pp. 67-73
    • Ozdulger, A.1    Cinel, I.2    Unlu, A.3
  • 88
    • 0035431101 scopus 로고    scopus 로고
    • Poly (ADP-ribose) synthetase inhibition reduces bacterial translocation in rats after endotoxin challenge
    • Taner S, Cinel I, Ozer L, et al: Poly (ADP-ribose) synthetase inhibition reduces bacterial translocation in rats after endotoxin challenge. Shock 2001; 16:159-162
    • (2001) Shock , vol.16 , pp. 159-162
    • Taner, S.1    Cinel, I.2    Ozer, L.3
  • 89
    • 0036417213 scopus 로고    scopus 로고
    • The role of poly (ADP-ribose) synthetase inhibition in preventing endotoxemia-induced intestinal epithelial apoptosis
    • Cinel I, Buyukafsar K, Cinel L, et al: The role of poly (ADP-ribose) synthetase inhibition in preventing endotoxemia-induced intestinal epithelial apoptosis. Pharmacol Res 2002; 46:119-127
    • (2002) Pharmacol Res , vol.46 , pp. 119-127
    • Cinel, I.1    Buyukafsar, K.2    Cinel, L.3
  • 90
    • 0031004487 scopus 로고    scopus 로고
    • Apoptosis in resolution of inflammation
    • Savill J: Apoptosis in resolution of inflammation. J Leukoc Biol 1997; 61:375-380
    • (1997) J Leukoc Biol , vol.61 , pp. 375-380
    • Savill, J.1
  • 91
    • 0742306781 scopus 로고    scopus 로고
    • Functional characterization of mitochondria in neutrophils: A role restricted to apoptosis
    • Maianski NA, Geissler J, Srinivasula SM, et al: Functional characterization of mitochondria in neutrophils: A role restricted to apoptosis. Cell Death Differ 2004; 11: 143-153
    • (2004) Cell Death Differ , vol.11 , pp. 143-153
    • Maianski, N.A.1    Geissler, J.2    Srinivasula, S.M.3
  • 93
    • 0036154973 scopus 로고    scopus 로고
    • A novel therapeutic strategy for attenuating neutrophil-mediated lung injury in vivo
    • Sookhai S, Wang JJ, McCourt M, et al: A novel therapeutic strategy for attenuating neutrophil-mediated lung injury in vivo. Ann Surg 2002; 235:285-291
    • (2002) Ann Surg , vol.235 , pp. 285-291
    • Sookhai, S.1    Wang, J.J.2    McCourt, M.3
  • 94
    • 3142704153 scopus 로고    scopus 로고
    • Delayed neutrophil apoptosis in sepsis is associated with maintenance of mitochondrial transmembrane potential and reduced caspase-9 activity
    • Taneja R, Parodo J, Kapus A, et al: Delayed neutrophil apoptosis in sepsis is associated with maintenance of mitochondrial transmembrane potential and reduced caspase-9 activity. Crit Care Med 2004; 32:1460-1469
    • (2004) Crit Care Med , vol.32 , pp. 1460-1469
    • Taneja, R.1    Parodo, J.2    Kapus, A.3
  • 95
    • 0032519925 scopus 로고    scopus 로고
    • Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF, PGE2, and PAF
    • Fadok VA, Bratton DL, Konowal A, et al: Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF, PGE2, and PAF. J Clin Invest 1998; 101:890-898
    • (1998) J Clin Invest , vol.101 , pp. 890-898
    • Fadok, V.A.1    Bratton, D.L.2    Konowal, A.3
  • 96
    • 31544436673 scopus 로고    scopus 로고
    • Abnormal apoptosis in chronic granulomatous disease and autoantibody production characteristic of lupus
    • Sanford AN, Suriano AR, Herche D, et al: Abnormal apoptosis in chronic granulomatous disease and autoantibody production characteristic of lupus. Rheumatology 2006; 45:178-181
    • (2006) Rheumatology , vol.45 , pp. 178-181
    • Sanford, A.N.1    Suriano, A.R.2    Herche, D.3
  • 97
    • 0142218366 scopus 로고    scopus 로고
    • Regulation of transbilayer plasma membrane phospholipid asymmetry
    • Daleke DL: Regulation of transbilayer plasma membrane phospholipid asymmetry. J Lipid Res 2003; 44:233-242
    • (2003) J Lipid Res , vol.44 , pp. 233-242
    • Daleke, D.L.1
  • 98
    • 45549094799 scopus 로고    scopus 로고
    • Bench-to-bedside review: Mitochondrial injury, oxidative stress and apoptosis - there is nothing more practical than a good theory
    • Bayir H, Kagan VE: Bench-to-bedside review: Mitochondrial injury, oxidative stress and apoptosis - there is nothing more practical than a good theory. Crit Care 2008; 12:206
    • (2008) Crit Care , vol.12 , pp. 206
    • Bayir, H.1    Kagan, V.E.2
  • 99
    • 34247235049 scopus 로고    scopus 로고
    • Nitrosative stress inhibits the aminophospholipid translocase resulting in phosphati-dylserine externalization and macrophage engulfment: Implications for the resolution of inflammation
    • Tyurina YY, Basova LV, Konduru NV, et al: Nitrosative stress inhibits the aminophospholipid translocase resulting in phosphati-dylserine externalization and macrophage engulfment: Implications for the resolution of inflammation. J Biol Chem 2007; 282: 8498-8509
    • (2007) J Biol Chem , vol.282 , pp. 8498-8509
    • Tyurina, Y.Y.1    Basova, L.V.2    Konduru, N.V.3
  • 100
    • 34547594227 scopus 로고    scopus 로고
    • Polymicrobial sepsis enhances clearance of apoptotic immune cells by splenic macrophages
    • Swan R, Chung CS, Albina J, et al: Polymicrobial sepsis enhances clearance of apoptotic immune cells by splenic macrophages. Surgery 2007; 142:253-261
    • (2007) Surgery , vol.142 , pp. 253-261
    • Swan, R.1    Chung, C.S.2    Albina, J.3
  • 101
    • 0037311807 scopus 로고    scopus 로고
    • Oxidative stress and gene expression in sepsis
    • Macdonald J, Galley HF, Webster NR: Oxidative stress and gene expression in sepsis. Br J Anaest 2003; 90:221-232
    • (2003) Br J Anaest , vol.90 , pp. 221-232
    • Macdonald, J.1    Galley, H.F.2    Webster, N.R.3
  • 102
    • 33845697586 scopus 로고    scopus 로고
    • Effects of combining inducible nitric oxide synthase inhibitor and radical scavenger during porcine bacteremia
    • Matejovic M, Krouzecky A, Rokyta R Jr, et al: Effects of combining inducible nitric oxide synthase inhibitor and radical scavenger during porcine bacteremia. Shock 2007; 27: 61-68
    • (2007) Shock , vol.27 , pp. 61-68
    • Matejovic, M.1    Krouzecky, A.2    Rokyta Jr, R.3
  • 103
    • 33845724468 scopus 로고    scopus 로고
    • Reactive oxygen and nitrogen species as signaling molecules regulating neutrophil function
    • Fialkow L, Wang Y, Downey GP: Reactive oxygen and nitrogen species as signaling molecules regulating neutrophil function. Free Radic Biol Med 2007; 42:153-164
    • (2007) Free Radic Biol Med , vol.42 , pp. 153-164
    • Fialkow, L.1    Wang, Y.2    Downey, G.P.3
  • 104
    • 0029860081 scopus 로고    scopus 로고
    • Xanthine oxidase activity and free radical generation in patients with sepsis syndrome
    • Galley HF, Davies MJ, Webster NR: Xanthine oxidase activity and free radical generation in patients with sepsis syndrome. Crit Care Med 1996; 24:1649-1653
    • (1996) Crit Care Med , vol.24 , pp. 1649-1653
    • Galley, H.F.1    Davies, M.J.2    Webster, N.R.3
  • 105
    • 33645805025 scopus 로고    scopus 로고
    • Potential role of poly (adenosine 5′-diphosphate-ribose) polymerase activation in the pathogenesis of myocardial contractile dysfunction associated with human septic shock
    • Soriano FG, Nogueira AC, Caldini EG, et al: Potential role of poly (adenosine 5′-diphosphate-ribose) polymerase activation in the pathogenesis of myocardial contractile dysfunction associated with human septic shock. Crit Care Med 2006; 34: 1073-1079
    • (2006) Crit Care Med , vol.34 , pp. 1073-1079
    • Soriano, F.G.1    Nogueira, A.C.2    Caldini, E.G.3
  • 106
    • 13244288781 scopus 로고    scopus 로고
    • The "cytokine profile": A code for sepsis
    • Ulloa L, Tracey KJ: The "cytokine profile": A code for sepsis. Trends Mol Med 2005; 11: 56-63
    • (2005) Trends Mol Med , vol.11 , pp. 56-63
    • Ulloa, L.1    Tracey, K.J.2
  • 107
    • 18444362106 scopus 로고    scopus 로고
    • Native versus recombinant high-mobility group B1 proteins: Functional activity in vitro
    • Zimmermann K, Volkel D, Pable S, et al: Native versus recombinant high-mobility group B1 proteins: functional activity in vitro. Inflammation 2004; 28:221-229
    • (2004) Inflammation , vol.28 , pp. 221-229
    • Zimmermann, K.1    Volkel, D.2    Pable, S.3
  • 108
    • 33845893860 scopus 로고    scopus 로고
    • Pivotal advance: Analysis of proinflammatory activity of highly purified eukaryotic recombinant HMGB1 (amphoterin)
    • Rouhiainen A, Tumova S, Valmu L, et al: Pivotal advance: Analysis of proinflammatory activity of highly purified eukaryotic recombinant HMGB1 (amphoterin). J Leukocyte Biol 2007; 81:49-58
    • (2007) J Leukocyte Biol , vol.81 , pp. 49-58
    • Rouhiainen, A.1    Tumova, S.2    Valmu, L.3
  • 109
    • 0142137129 scopus 로고    scopus 로고
    • Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion
    • Bonaldi T, Talamo F, Scaffidi P, et al: Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion. EMBO J 2003; 22:5551-5560
    • (2003) EMBO J , vol.22 , pp. 5551-5560
    • Bonaldi, T.1    Talamo, F.2    Scaffidi, P.3
  • 110
    • 33751584837 scopus 로고    scopus 로고
    • Nucleocytoplasmic shuttling of HMGB1 is regulated by phosphorylation that redirects it toward secretion
    • Youn JH, Shin JS: Nucleocytoplasmic shuttling of HMGB1 is regulated by phosphorylation that redirects it toward secretion. J Immunol 2006; 177:7889-7897
    • (2006) J Immunol , vol.177 , pp. 7889-7897
    • Youn, J.H.1    Shin, J.S.2
  • 111
    • 33845333359 scopus 로고    scopus 로고
    • The extracellular release of HMGB1 during apoptotic cell death
    • Bell CW, Jiang W, Reich CF III, et al: The extracellular release of HMGB1 during apoptotic cell death. Am J Physiol Cell Physiol 2006; 291:C1318-C1325
    • (2006) Am J Physiol Cell Physiol , vol.291
    • Bell, C.W.1    Jiang, W.2    Reich III, C.F.3
  • 112
    • 33745854493 scopus 로고    scopus 로고
    • Role of HMGB1 in apoptosis-mediated sepsis lethality
    • Qin S, Wang H, Yuan R, et al: Role of HMGB1 in apoptosis-mediated sepsis lethality. J Exp Med 2006; 203:1637-1642
    • (2006) J Exp Med , vol.203 , pp. 1637-1642
    • Qin, S.1    Wang, H.2    Yuan, R.3
  • 113
    • 0028851635 scopus 로고
    • The receptor for advanced glycation end products (RAGE) is a cellular binding site for amphoterin: Mediation of neurite outgrowth and co-expression of rage and amphoterin in the developing nervous system
    • Hori O, Brett J, Slattery T, et al: The receptor for advanced glycation end products (RAGE) is a cellular binding site for amphoterin: Mediation of neurite outgrowth and co-expression of rage and amphoterin in the developing nervous system. J Biol Chem 1995; 270:25752-25761
    • (1995) J Biol Chem , vol.270 , pp. 25752-25761
    • Hori, O.1    Brett, J.2    Slattery, T.3
  • 114
    • 1542380035 scopus 로고    scopus 로고
    • Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein
    • Park JS, Svetkauskaite D, He Q, et al: Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein. J Biol Chem 2004; 279: 7370-7377
    • (2004) J Biol Chem , vol.279 , pp. 7370-7377
    • Park, J.S.1    Svetkauskaite, D.2    He, Q.3
  • 115
    • 0033538467 scopus 로고    scopus 로고
    • HMG-1 as a late mediator of endotoxin lethality in mice
    • Wang H, Bloom O, Zhang M, et al: HMG-1 as a late mediator of endotoxin lethality in mice. Science 1999; 285:248-251
    • (1999) Science , vol.285 , pp. 248-251
    • Wang, H.1    Bloom, O.2    Zhang, M.3
  • 116
    • 29644441337 scopus 로고    scopus 로고
    • Cutting edge: Extracellular high mobility group box-1 protein is a proangiogenic cytokine
    • Mitola S, Belleri M, Urbinati C, et al: Cutting edge: Extracellular high mobility group box-1 protein is a proangiogenic cytokine. J Immunol 2006; 176:12-15
    • (2006) J Immunol , vol.176 , pp. 12-15
    • Mitola, S.1    Belleri, M.2    Urbinati, C.3
  • 117
    • 41549145719 scopus 로고    scopus 로고
    • Negative inotropic effects of high-mobility group box 1 protein in isolated contracting cardiac myocytes
    • Tzeng HP, Fan J, Vallejo JG, et al: Negative inotropic effects of high-mobility group box 1 protein in isolated contracting cardiac myocytes. Am J Physiol Heart Circ Physiol 2008; 294:H1490-H1496
    • (2008) Am J Physiol Heart Circ Physiol , vol.294
    • Tzeng, H.P.1    Fan, J.2    Vallejo, J.G.3
  • 118
    • 0037461768 scopus 로고    scopus 로고
    • Nicotinic acetylcholine receptor α7 receptor is an essential regulator of inflammation
    • Wang H, Yu M, Ochani M, et al: Nicotinic acetylcholine receptor α7 receptor is an essential regulator of inflammation. Nature 2003; 421:384-388
    • (2003) Nature , vol.421 , pp. 384-388
    • Wang, H.1    Yu, M.2    Ochani, M.3
  • 119
    • 0142178155 scopus 로고    scopus 로고
    • The cholinergic anti-inflammatory pathway: A missing link in neuromodulation
    • Pavlov VA, Wang H, Czura CJ, et al: The cholinergic anti-inflammatory pathway: A missing link in neuromodulation. Mol Med 2003; 9:125-134
    • (2003) Mol Med , vol.9 , pp. 125-134
    • Pavlov, V.A.1    Wang, H.2    Czura, C.J.3
  • 120
    • 9144263639 scopus 로고    scopus 로고
    • Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis
    • Wang H, Liao H, Ochani M, et al: Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis. Nat Med 2004; 10:1216-1221
    • (2004) Nat Med , vol.10 , pp. 1216-1221
    • Wang, H.1    Liao, H.2    Ochani, M.3
  • 121
    • 36448948021 scopus 로고    scopus 로고
    • Transcutaneous vagus nerve stimulation reduces serum high mobility group box 1 levels and improves survival in murine sepsis
    • Huston JM, Gallowitsch-Puerta M, Ochani M, et al: Transcutaneous vagus nerve stimulation reduces serum high mobility group box 1 levels and improves survival in murine sepsis. Crit Care Med 2007; 35: 2762-2768
    • (2007) Crit Care Med , vol.35 , pp. 2762-2768
    • Huston, J.M.1    Gallowitsch-Puerta, M.2    Ochani, M.3
  • 122
    • 34250620898 scopus 로고    scopus 로고
    • Cholinergic anti-inflammatory pathway activity and High Mobility Group Box-1 (HMGB1) serum levels in patients with rheumatoid arthritis
    • Goldstein RS, Bruchfeld A, Yang L, et al: Cholinergic anti-inflammatory pathway activity and High Mobility Group Box-1 (HMGB1) serum levels in patients with rheumatoid arthritis. Mol Med 2007; 13(3-4):210-215
    • (2007) Mol Med , vol.13 , Issue.3-4 , pp. 210-215
    • Goldstein, R.S.1    Bruchfeld, A.2    Yang, L.3
  • 123
    • 44449162626 scopus 로고    scopus 로고
    • High Mobility Group Box 1 protein binding to lipopolysaccharide facilitates transfer of lipopolysaccharide to CD14 and enhances lipopolysaccharide-mediated TNF-{alpha} production in human monocytes
    • Youn JH, Oh YJ, Kim ES, et al: High Mobility Group Box 1 protein binding to lipopolysaccharide facilitates transfer of lipopolysaccharide to CD14 and enhances lipopolysaccharide-mediated TNF-{alpha} production in human monocytes. J Immunol 2008; 180:5067-5074
    • (2008) J Immunol , vol.180 , pp. 5067-5074
    • Youn, J.H.1    Oh, Y.J.2    Kim, E.S.3
  • 124
    • 42149192003 scopus 로고    scopus 로고
    • HMGB1 develops enhanced proinflammatory activity by binding to cytokines
    • Sha Y, Zmijewski J, Xu Z, et al: HMGB1 develops enhanced proinflammatory activity by binding to cytokines. J Immunol 2008; 180:2531-2537
    • (2008) J Immunol , vol.180 , pp. 2531-2537
    • Sha, Y.1    Zmijewski, J.2    Xu, Z.3
  • 125
    • 20144380566 scopus 로고    scopus 로고
    • Persistent elevation of high mobility group box-1 protein (HMGB1) in patients with severe sepsis and septic shock
    • Sunden-Cullberg J, Norrby-Teglund A, Rouhiainen A, et al: Persistent elevation of high mobility group box-1 protein (HMGB1) in patients with severe sepsis and septic shock. Crit Care Med 2005; 33: 564-573
    • (2005) Crit Care Med , vol.33 , pp. 564-573
    • Sunden-Cullberg, J.1    Norrby-Teglund, A.2    Rouhiainen, A.3
  • 126
    • 34547094102 scopus 로고    scopus 로고
    • High-mobility group box 1 protein plasma concentrations during septic shock
    • Gibot S, Massin F, Cravoisy A, et al: High-mobility group box 1 protein plasma concentrations during septic shock. Intensive Care Med 2007; 33:1347-1353
    • (2007) Intensive Care Med , vol.33 , pp. 1347-1353
    • Gibot, S.1    Massin, F.2    Cravoisy, A.3
  • 127
    • 46149118623 scopus 로고    scopus 로고
    • HMGB1 as a predictor of organ dysfunction and outcome in patients with severe sepsis
    • Karlsson S, Pettilä V, Tenhunen J, et al: HMGB1 as a predictor of organ dysfunction and outcome in patients with severe sepsis. Intensive Care Med 2008; 34:1046-1053.
    • (2008) Intensive Care Med , vol.34 , pp. 1046-1053
    • Karlsson, S.1    Pettilä, V.2    Tenhunen, J.3
  • 128
    • 33747751590 scopus 로고    scopus 로고
    • Alarmin(g) news about danger
    • Harris HE, Raucci A: Alarmin(g) news about danger. EMBO Rep 2006; 7:774-778
    • (2006) EMBO Rep , vol.7 , pp. 774-778
    • Harris, H.E.1    Raucci, A.2
  • 129
    • 10744229528 scopus 로고    scopus 로고
    • The pattern recognition receptor (RAGE) is a counterreceptor for leukocyte integrins: A novel pathway for inflammatory cell recruitment
    • Chavakis T, Bierhaus A, Al-Fakhri N, et al: The pattern recognition receptor (RAGE) is a counterreceptor for leukocyte integrins: A novel pathway for inflammatory cell recruitment. J Exp Med 2003; 198:1507-1515
    • (2003) J Exp Med , vol.198 , pp. 1507-1515
    • Chavakis, T.1    Bierhaus, A.2    Al-Fakhri, N.3
  • 130
    • 37749005803 scopus 로고    scopus 로고
    • Inhibition of the RAGE products increases survival in experimental models of severe sepsis and systemic infection
    • Lutterloh EC, Opal SM, Pittman DD, et al: Inhibition of the RAGE products increases survival in experimental models of severe sepsis and systemic infection. Crit Care 2007; 11:R122
    • (2007) Crit Care , vol.11
    • Lutterloh, E.C.1    Opal, S.M.2    Pittman, D.D.3
  • 131
    • 0029143676 scopus 로고
    • MIF as a glucocorticoid-induced modulator of cytokine production
    • Calandra T, Bernhagen J, Metz CN, et al: MIF as a glucocorticoid-induced modulator of cytokine production. Nature 1995; 377: 68-71
    • (1995) Nature , vol.377 , pp. 68-71
    • Calandra, T.1    Bernhagen, J.2    Metz, C.N.3
  • 132
    • 0001611329 scopus 로고    scopus 로고
    • Protection from septic shock by neutralization of macrophage migration inhibitory factor
    • Calandra T, Echtenacher B, Roy DL, et al: Protection from septic shock by neutralization of macrophage migration inhibitory factor. Nat Med 2000; 6:164-170
    • (2000) Nat Med , vol.6 , pp. 164-170
    • Calandra, T.1    Echtenacher, B.2    Roy, D.L.3
  • 133
    • 0033579884 scopus 로고    scopus 로고
    • Targeted disruption of migration inhibitory factor gene reveals its critical role in sepsis
    • Bozza M, Satoskar AR, Lin G, et al: Targeted disruption of migration inhibitory factor gene reveals its critical role in sepsis. J Exp Med 1999; 189:341-346
    • (1999) J Exp Med , vol.189 , pp. 341-346
    • Bozza, M.1    Satoskar, A.R.2    Lin, G.3
  • 134
    • 0035924325 scopus 로고    scopus 로고
    • MIF regulates innate immune responses through modulation of Toll-like receptor 4
    • Roger T, David J, Glauser MP, et al: MIF regulates innate immune responses through modulation of Toll-like receptor 4. Nature 2001; 414:920-924
    • (2001) Nature , vol.414 , pp. 920-924
    • Roger, T.1    David, J.2    Glauser, M.P.3
  • 135
    • 0037039308 scopus 로고    scopus 로고
    • Macrophage migration inhibitory factor (MIF) sustains macrophage proinflammatory function by inhibiting p53: Regulatory role in the innate immune response
    • Mitchell RA, Liao H, Chesney J, et al: Macrophage migration inhibitory factor (MIF) sustains macrophage proinflammatory function by inhibiting p53: Regulatory role in the innate immune response. Proc Natl Acad Sci USA 2002; 99:345-350
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 345-350
    • Mitchell, R.A.1    Liao, H.2    Chesney, J.3
  • 136
    • 0027255030 scopus 로고
    • Oxygen consumption and resting metabolic rate in sepsis, sepsis syndrome, and septic shock
    • Kreymann G, Grosser S, Buggisch P, et al: Oxygen consumption and resting metabolic rate in sepsis, sepsis syndrome, and septic shock. Crit Care Med 1993; 21:1012-1019
    • (1993) Crit Care Med , vol.21 , pp. 1012-1019
    • Kreymann, G.1    Grosser, S.2    Buggisch, P.3
  • 137
    • 0029622365 scopus 로고
    • Oxygen tension in the bladder epithelium rises in both high and low cardiac output endotoxemic sepsis
    • Rosser DM, Stidwill RP, Jacobson D, et al: Oxygen tension in the bladder epithelium rises in both high and low cardiac output endotoxemic sepsis. J Appl Physiol 1995; 79:1878-1882
    • (1995) J Appl Physiol , vol.79 , pp. 1878-1882
    • Rosser, D.M.1    Stidwill, R.P.2    Jacobson, D.3
  • 138
    • 0032770246 scopus 로고    scopus 로고
    • Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction
    • Hotchkiss RS, Swanson PE, Freeman BD, et al: Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction. Crit Care Med 1999; 27:1230-1251
    • (1999) Crit Care Med , vol.27 , pp. 1230-1251
    • Hotchkiss, R.S.1    Swanson, P.E.2    Freeman, B.D.3
  • 139
    • 1342331785 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in a long-term rodent model of sepsis and organ failure
    • Brealey D, et al: Mitochondrial dysfunction in a long-term rodent model of sepsis and organ failure. Am J Physiol Regul Integr Comp Physiol 2004; 286:R491-R497
    • (2004) Am J Physiol Regul Integr Comp Physiol , vol.286
    • Brealey, D.1
  • 140
    • 10644281080 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in septic shock and multiple organ dysfunction syndrome
    • Crouser ED: Mitochondrial dysfunction in septic shock and multiple organ dysfunction syndrome. Mitochondrion 2004; 4:729-741
    • (2004) Mitochondrion , vol.4 , pp. 729-741
    • Crouser, E.D.1
  • 141
    • 0035115951 scopus 로고    scopus 로고
    • Cytopathic hypoxia. Mitochondrial dysfunction as mechanism contributing to organ dysfunction in sepsis
    • Fink MP: Cytopathic hypoxia. Mitochondrial dysfunction as mechanism contributing to organ dysfunction in sepsis. Crit Care Clinics 2001; 17:219-237
    • (2001) Crit Care Clinics , vol.17 , pp. 219-237
    • Fink, M.P.1
  • 142
    • 0037142987 scopus 로고    scopus 로고
    • Association between mitochondrial dysfunction and severity and outcome of septic shock
    • Brealey D, Brand M, Hargreaves I, et al: Association between mitochondrial dysfunction and severity and outcome of septic shock. Lancet 2002; 360:219-223
    • (2002) Lancet , vol.360 , pp. 219-223
    • Brealey, D.1    Brand, M.2    Hargreaves, I.3
  • 143
    • 0036174522 scopus 로고    scopus 로고
    • Endotoxin-induced mitochondrial damage correlates with impaired respiratory activity
    • Crouser ED, Julian MW, Blaho DV, et al: Endotoxin-induced mitochondrial damage correlates with impaired respiratory activity. Crit Care Med 2002; 30:276-284
    • (2002) Crit Care Med , vol.30 , pp. 276-284
    • Crouser, E.D.1    Julian, M.W.2    Blaho, D.V.3
  • 144
    • 4644282833 scopus 로고    scopus 로고
    • Competitive and noncompetitive inhibition of myocardial cytochrome C oxidase in sepsis
    • Levy PJ, Vijayasarathy C, Raj NR, et al: Competitive and noncompetitive inhibition of myocardial cytochrome C oxidase in sepsis. Shock 2004; 21:110-114
    • (2004) Shock , vol.21 , pp. 110-114
    • Levy, P.J.1    Vijayasarathy, C.2    Raj, N.R.3
  • 145
    • 4344661699 scopus 로고    scopus 로고
    • Human septic myopathy: Induction of cyclooxygenase, heme oxygenase and activation of the ubiquitin proteolytic pathway
    • Rabuel C, Renaud E, Brealey D, et al: Human septic myopathy: Induction of cyclooxygenase, heme oxygenase and activation of the ubiquitin proteolytic pathway. Anesthesiology 2004; 101:583-590
    • (2004) Anesthesiology , vol.101 , pp. 583-590
    • Rabuel, C.1    Renaud, E.2    Brealey, D.3
  • 146
    • 33745685397 scopus 로고    scopus 로고
    • Inhibition of mitochondrial permeability transition prevents sepsis-induced myocardial dysfunction and mortality
    • Larche J, Lancel S, Hassoun SM, et al: Inhibition of mitochondrial permeability transition prevents sepsis-induced myocardial dysfunction and mortality. J Am Coll Cardiol 2006; 48:377-385
    • (2006) J Am Coll Cardiol , vol.48 , pp. 377-385
    • Larche, J.1    Lancel, S.2    Hassoun, S.M.3
  • 147
    • 0033584457 scopus 로고    scopus 로고
    • Disseminated intravascular coagulation
    • Levi M, Ten Cate H: Disseminated intravascular coagulation. N Engl J Med 1999; 341: 586-592
    • (1999) N Engl J Med , vol.341 , pp. 586-592
    • Levi, M.1    Ten Cate, H.2
  • 148
    • 43349096795 scopus 로고    scopus 로고
    • Inflammation, endothelium, and coagulation in sepsis
    • Schouten M, Wiersinga WJ, Levi M, et al: Inflammation, endothelium, and coagulation in sepsis. J Leukoc Biol 2008; 83: 536-545
    • (2008) J Leukoc Biol , vol.83 , pp. 536-545
    • Schouten, M.1    Wiersinga, W.J.2    Levi, M.3
  • 149
    • 2342420998 scopus 로고    scopus 로고
    • The nexus between systemic inflammation and disordered coagulation in sepsis
    • Opal SM: The nexus between systemic inflammation and disordered coagulation in sepsis. J Endotoxin Res 2004; 10:125-129
    • (2004) J Endotoxin Res , vol.10 , pp. 125-129
    • Opal, S.M.1
  • 150
    • 0034651718 scopus 로고    scopus 로고
    • Are natural anticoagulants candidates for modulating the inflammatory response to endotoxin?
    • Esmon CT: Are natural anticoagulants candidates for modulating the inflammatory response to endotoxin? Blood 2000; 95: 1113-1116
    • (2000) Blood , vol.95 , pp. 1113-1116
    • Esmon, C.T.1
  • 151
    • 0032525041 scopus 로고    scopus 로고
    • Potential mechanisms for a proinflammatory vascular cytokine response to coagulation activation
    • Johnson K, Choi Y, DeGroot E, et al: Potential mechanisms for a proinflammatory vascular cytokine response to coagulation activation. J Immunol 1998; 160: 5130-5135
    • (1998) J Immunol , vol.160 , pp. 5130-5135
    • Johnson, K.1    Choi, Y.2    DeGroot, E.3
  • 152
    • 0029964844 scopus 로고    scopus 로고
    • Interleukin-6 stimulates coagulation, not fibrinolysis, in humans
    • Stouthard JM, Levi M, Hack CE, et al: Interleukin-6 stimulates coagulation, not fibrinolysis, in humans. Thromb Haemost 1996; 76:738-742
    • (1996) Thromb Haemost , vol.76 , pp. 738-742
    • Stouthard, J.M.1    Levi, M.2    Hack, C.E.3
  • 153
    • 0030896981 scopus 로고    scopus 로고
    • The significance of shed membrane particles during programmed cell death in vitro, and in vivo, in HIV-1 infection
    • Aupeix K, Hugel B, Martin T, et al: The significance of shed membrane particles during programmed cell death in vitro, and in vivo, in HIV-1 infection. J Clin Invest 1997; 99:1546-1554
    • (1997) J Clin Invest , vol.99 , pp. 1546-1554
    • Aupeix, K.1    Hugel, B.2    Martin, T.3
  • 154
    • 27944507708 scopus 로고    scopus 로고
    • Levels of endothelial and platelet microparticles and their interactions with leukocytes negatively correlate with organ dysfunction and predict mortality in severe sepsis
    • Soriano AO, Jy W, Chirinos JA, et al: Levels of endothelial and platelet microparticles and their interactions with leukocytes negatively correlate with organ dysfunction and predict mortality in severe sepsis. Crit Care Med 2005; 33:2540-2546
    • (2005) Crit Care Med , vol.33 , pp. 2540-2546
    • Soriano, A.O.1    Jy, W.2    Chirinos, J.A.3
  • 155
    • 0036119842 scopus 로고    scopus 로고
    • Activated polymorphonuclear leukocytes enhance production of leukocyte microparticles with increased adhesion molecules in patients with sepsis
    • Fujimi S, Ogura H, Tanaka H, et al: Activated polymorphonuclear leukocytes enhance production of leukocyte microparticles with increased adhesion molecules in patients with sepsis. J Trauma 2002; 52: 443-448
    • (2002) J Trauma , vol.52 , pp. 443-448
    • Fujimi, S.1    Ogura, H.2    Tanaka, H.3
  • 157
    • 0031929812 scopus 로고    scopus 로고
    • Derangements of coagulation and fibrinolysis in critically ill patients with sepsis and septic shock
    • Vervloet MG, Thijs LG, Hack CE: Derangements of coagulation and fibrinolysis in critically ill patients with sepsis and septic shock. Semin Thromb Hemost 1998; 24: 33-44
    • (1998) Semin Thromb Hemost , vol.24 , pp. 33-44
    • Vervloet, M.G.1    Thijs, L.G.2    Hack, C.E.3
  • 158
    • 0034917322 scopus 로고    scopus 로고
    • Activated protein C versus protein C in severe sepsis
    • Yan SB, Dhainut JF: Activated protein C versus protein C in severe sepsis. Crit Care Med 2001; 29(Suppl):S69-S74
    • (2001) Crit Care Med , vol.29 , Issue.SUPPL.
    • Yan, S.B.1    Dhainut, J.F.2
  • 159
    • 34250372944 scopus 로고    scopus 로고
    • Protein C is an autocrine growth factor for human skin keratinocytes
    • Xue M, Campbell D, Jackson CJ: Protein C is an autocrine growth factor for human skin keratinocytes, J Biol Chem 2007; 282: 13610-13616
    • (2007) J Biol Chem , vol.282 , pp. 13610-13616
    • Xue, M.1    Campbell, D.2    Jackson, C.J.3
  • 160
    • 36749017585 scopus 로고    scopus 로고
    • Endothelial protein C receptor is overexpressed in rheumatoid arthritic (RA) synovium and mediates the anti-inflammatory effects of activated protein C in RA monocytes
    • Xue M, March L, Sambrook PN, et al: Endothelial protein C receptor is overexpressed in rheumatoid arthritic (RA) synovium and mediates the anti-inflammatory effects of activated protein C in RA monocytes. Ann Rheum Dis 2007; 66: 1574-1580
    • (2007) Ann Rheum Dis , vol.66 , pp. 1574-1580
    • Xue, M.1    March, L.2    Sambrook, P.N.3
  • 161
    • 0030036189 scopus 로고    scopus 로고
    • The endothelial cell protein C receptor: Inhibition of activated protein C anticoagulant function without modulation of reaction with proteinase inhibitors
    • Regan LM, Steams-Kurosawa DJ, Kurosawa S, et al: The endothelial cell protein C receptor: Inhibition of activated protein C anticoagulant function without modulation of reaction with proteinase inhibitors. J Biol Chem 1996; 271:17499-17503
    • (1996) J Biol Chem , vol.271 , pp. 17499-17503
    • Regan, L.M.1    Steams-Kurosawa, D.J.2    Kurosawa, S.3
  • 162
    • 0031973176 scopus 로고    scopus 로고
    • Plasma levels of endothelial cell protein C receptor are elevated in patients with sepsis and systemic lupus erythematosus: Lack of correlation with thrombomodulin suggests involvement of different pathological processes
    • Kurosawa S, Steams-Kurosawa DJ, Carson CW, et al: Plasma levels of endothelial cell protein C receptor are elevated in patients with sepsis and systemic lupus erythematosus: Lack of correlation with thrombomodulin suggests involvement of different pathological processes. Blood 1998; 91: 725-727
    • (1998) Blood , vol.91 , pp. 725-727
    • Kurosawa, S.1    Steams-Kurosawa, D.J.2    Carson, C.W.3
  • 163
    • 0034834039 scopus 로고    scopus 로고
    • Low levels of protein C are associated with poor outcome in severe sepsis
    • Yan SB, Helterbrand JD, Hartman DL, et al: Low levels of protein C are associated with poor outcome in severe sepsis. Chest 2001; 120:915-922
    • (2001) Chest , vol.120 , pp. 915-922
    • Yan, S.B.1    Helterbrand, J.D.2    Hartman, D.L.3
  • 164
    • 29344470521 scopus 로고    scopus 로고
    • Decreased protein C, protein S, and antithrombin levels are predictive of poor outcome in Gram-negative sepsis caused by Burkholderia pseudomallei
    • LaRosa SP, Opal SM, Utterback B, et al: Decreased protein C, protein S, and antithrombin levels are predictive of poor outcome in Gram-negative sepsis caused by Burkholderia pseudomallei. Int J Infect Dis 2006; 10:25-31
    • (2006) Int J Infect Dis , vol.10 , pp. 25-31
    • LaRosa, S.P.1    Opal, S.M.2    Utterback, B.3
  • 165
    • 0034917322 scopus 로고    scopus 로고
    • Activated protein C versus protein C in severe sepsis
    • Yan SB, Dhainaut JF: Activated protein C versus protein C in severe sepsis. Crit Care Med 2001; 29(Suppl):S69-S74
    • (2001) Crit Care Med , vol.29 , Issue.SUPPL.
    • Yan, S.B.1    Dhainaut, J.F.2
  • 166
    • 0035815747 scopus 로고    scopus 로고
    • Gene expression profile of antithrombotic protein C defines new mechanisms modulating inflammation and apoptosis
    • Joyce DE, Gelbert L, Ciaccia A, et al: Gene expression profile of antithrombotic protein C defines new mechanisms modulating inflammation and apoptosis. J Biol Chem 2001; 14:11199-111203
    • (2001) J Biol Chem , vol.14 , pp. 11199-111203
    • Joyce, D.E.1    Gelbert, L.2    Ciaccia, A.3
  • 167
    • 51449117497 scopus 로고    scopus 로고
    • Activated protein C-An anticoagulant that does more than stop clots
    • Jackson CJ, Xue M: Activated protein C-An anticoagulant that does more than stop clots. Int J Biochem Cell Biol 2008; 40: 2692-2697
    • (2008) Int J Biochem Cell Biol , vol.40 , pp. 2692-2697
    • Jackson, C.J.1    Xue, M.2
  • 168
    • 38949115609 scopus 로고    scopus 로고
    • The yin-yang of thrombin and activated protein C
    • Dutt T, Toh CH: The yin-yang of thrombin and activated protein C. Br J Haematology 2008; 140:505-515
    • (2008) Br J Haematology , vol.140 , pp. 505-515
    • Dutt, T.1    Toh, C.H.2
  • 169
    • 21244502159 scopus 로고    scopus 로고
    • Protease-activated receptor-1 signaling by activated protein C in cytokine-perturbed endothelial cells is distinct from thrombin signaling
    • Riewald M, Ruf W: Protease-activated receptor-1 signaling by activated protein C in cytokine-perturbed endothelial cells is distinct from thrombin signaling. J Biol Chem 2005; 280:19808-19814
    • (2005) J Biol Chem , vol.280 , pp. 19808-19814
    • Riewald, M.1    Ruf, W.2
  • 170
    • 33847329718 scopus 로고    scopus 로고
    • Receptors of the protein C activation and activated protein C signaling pathways are colocalized in lipid rafts of endothelial cells
    • Bae JS, Yang L, Rezaie AR: Receptors of the protein C activation and activated protein C signaling pathways are colocalized in lipid rafts of endothelial cells. Proc Natl Acad Sci USA 2007; 104:2867-2872
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 2867-2872
    • Bae, J.S.1    Yang, L.2    Rezaie, A.R.3
  • 171
    • 37049012509 scopus 로고    scopus 로고
    • The ligand occupancy of endothelial protein C receptor switches the protease-activated receptor 1-dependent signaling specificity of thrombin from a permeability-enhancing to a barrier-protective response in endothelial cells
    • Bae JS, Yang L, Manithody C, et al: The ligand occupancy of endothelial protein C receptor switches the protease-activated receptor 1-dependent signaling specificity of thrombin from a permeability-enhancing to a barrier-protective response in endothelial cells. Blood 2007; 110: 3909-3916
    • (2007) Blood , vol.110 , pp. 3909-3916
    • Bae, J.S.1    Yang, L.2    Manithody, C.3
  • 172
    • 34247550884 scopus 로고    scopus 로고
    • Protein C concentrations in severe sepsis: An early directional change in plasma levels predicts outcome
    • Shorr AF, Bernard GR, Dhainaut JF, et al: Protein C concentrations in severe sepsis: An early directional change in plasma levels predicts outcome. Crit Care 2006; 10:R92
    • (2006) Crit Care , vol.10
    • Shorr, A.F.1    Bernard, G.R.2    Dhainaut, J.F.3
  • 173
  • 174
    • 37549020378 scopus 로고    scopus 로고
    • Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008
    • Dellinger RP, Levy MM, Carlet JM, et al: Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med 2008; 36:296-327
    • (2008) Crit Care Med , vol.36 , pp. 296-327
    • Dellinger, R.P.1    Levy, M.M.2    Carlet, J.M.3
  • 175
    • 34247882129 scopus 로고    scopus 로고
    • Engineering a disulfide bond to stabilize the calcium binding loop of activated protein C eliminates its anticoagulant but not protective signaling properties
    • Bae JS, Yang L, Manithody C, et al: Engineering a disulfide bond to stabilize the calcium binding loop of activated protein C eliminates its anticoagulant but not protective signaling properties. J Biol Chem 2007; 282:9251-9259
    • (2007) J Biol Chem , vol.282 , pp. 9251-9259
    • Bae, J.S.1    Yang, L.2    Manithody, C.3
  • 176
    • 34948866150 scopus 로고    scopus 로고
    • Endotoxemia and sepsis mortality reduction by non-anticoagulant activated protein C
    • Kerschen EJ, Fernandez JA, Cooley BC, et al: Endotoxemia and sepsis mortality reduction by non-anticoagulant activated protein C. J Exp Med 2007; 204:2439-2448
    • (2007) J Exp Med , vol.204 , pp. 2439-2448
    • Kerschen, E.J.1    Fernandez, J.A.2    Cooley, B.C.3
  • 177
    • 0037158606 scopus 로고    scopus 로고
    • Thrombotic microangiopathies
    • Moake JL: Thrombotic microangiopathies. N Engl J Med 2002; 347:589-600
    • (2002) N Engl J Med , vol.347 , pp. 589-600
    • Moake, J.L.1
  • 178
    • 0141498240 scopus 로고    scopus 로고
    • Von Willebrand factor, platelets and endothelial cell interactions
    • Ruggeri ZM: Von Willebrand factor, platelets and endothelial cell interactions. J Thromb Haemost 2003; 1:1335-1342
    • (2003) J Thromb Haemost , vol.1 , pp. 1335-1342
    • Ruggeri, Z.M.1
  • 179
    • 0032569884 scopus 로고    scopus 로고
    • von Willebrand factor-cleaving protease in thrombotic thrombocytopenic purpura and the hemolytic-uremic syndrome
    • Furlan M, Robles R, Galbusera M, et al: von Willebrand factor-cleaving protease in thrombotic thrombocytopenic purpura and the hemolytic-uremic syndrome. New Engl J Med 1998; 339:1578-1584
    • (1998) New Engl J Med , vol.339 , pp. 1578-1584
    • Furlan, M.1    Robles, R.2    Galbusera, M.3
  • 180
    • 0036624844 scopus 로고    scopus 로고
    • Ultralarge multimers of von Willebrand factor form spontaneous high-strength bonds with the platelet glycoprotein Ib-IX complex: Studies using optical tweezers
    • Arya M, Anvari B, Romo GM, et al: Ultralarge multimers of von Willebrand factor form spontaneous high-strength bonds with the platelet glycoprotein Ib-IX complex: Studies using optical tweezers. Blood 2002; 99:3971-3977
    • (2002) Blood , vol.99 , pp. 3971-3977
    • Arya, M.1    Anvari, B.2    Romo, G.M.3
  • 181
    • 0037100531 scopus 로고    scopus 로고
    • Von Willebrand factor-cleaving protease (AD-AMTS13) in thrombocytopenic disorders: A severely deficient activity is specific for thrombotic thrombocytopenic purpura
    • Bianchi V, Robles R, Alberio L, et al: Von Willebrand factor-cleaving protease (AD-AMTS13) in thrombocytopenic disorders: A severely deficient activity is specific for thrombotic thrombocytopenic purpura. Blood 2002; 100:710-713
    • (2002) Blood , vol.100 , pp. 710-713
    • Bianchi, V.1    Robles, R.2    Alberio, L.3
  • 182
    • 30444461242 scopus 로고    scopus 로고
    • Severe secondary deficiency of von Willebrand factor-cleaving protease (ADAMTS13) in patients with sepsis-induced disseminated intravascular coagulation: Its correlation with development of renal failure
    • Ono T, Mimuro J, Madoiwa S, et al: Severe secondary deficiency of von Willebrand factor-cleaving protease (ADAMTS13) in patients with sepsis-induced disseminated intravascular coagulation: Its correlation with development of renal failure. Blood 2006; 107:528-534
    • (2006) Blood , vol.107 , pp. 528-534
    • Ono, T.1    Mimuro, J.2    Madoiwa, S.3
  • 183
    • 33846901167 scopus 로고    scopus 로고
    • Acquired ADAMTS-13 deficiency in pediatric patients with severe sepsis
    • Nguyen TC, Liu A, Liu L, et al: Acquired ADAMTS-13 deficiency in pediatric patients with severe sepsis. Haematologica 2007; 92:121-124
    • (2007) Haematologica , vol.92 , pp. 121-124
    • Nguyen, T.C.1    Liu, A.2    Liu, L.3
  • 184
    • 35448943220 scopus 로고    scopus 로고
    • ADAMTS-13, von Willebrand factor and related parameters in severe sepsis and septic shock
    • Kremer Hovinga JA, Zeerleder S, Kessler P, et al: ADAMTS-13, von Willebrand factor and related parameters in severe sepsis and septic shock. J Thromb Haemost 2007; 5:2284-2290
    • (2007) J Thromb Haemost , vol.5 , pp. 2284-2290
    • Kremer Hovinga, J.A.1    Zeerleder, S.2    Kessler, P.3
  • 185
    • 38549170997 scopus 로고    scopus 로고
    • Inflammation-associated ADAMTS13 deficiency promotes formation of ultra-large von Willebrand factor
    • Bockmeyer CL, Claus RA, Budde U, et al: Inflammation-associated ADAMTS13 deficiency promotes formation of ultra-large von Willebrand factor. Haematologica 2008; 93:137-140
    • (2008) Haematologica , vol.93 , pp. 137-140
    • Bockmeyer, C.L.1    Claus, R.A.2    Budde, U.3
  • 186
    • 15344341949 scopus 로고    scopus 로고
    • Changes in ADAMTS13 (von-Willebrand factor-cleaving protease) activity after induced release of von Willebrand factor during acute systemic inflammation
    • Reiter RA, Varadi K, Turecek PL, et al: Changes in ADAMTS13 (von-Willebrand factor-cleaving protease) activity after induced release of von Willebrand factor during acute systemic inflammation. Thromb Haemost 2005; 93:554-558
    • (2005) Thromb Haemost , vol.93 , pp. 554-558
    • Reiter, R.A.1    Varadi, K.2    Turecek, P.L.3
  • 187
    • 34748855578 scopus 로고    scopus 로고
    • Decreased ADAMTS-13 (A disintegrin-like and metalloprotease with thrombospondin type 1 repeats) is associated with a poor prognosis in sepsis-induced organ failure
    • Martin K, Borgel D, Lerolle N, et al: Decreased ADAMTS-13 (A disintegrin-like and metalloprotease with thrombospondin type 1 repeats) is associated with a poor prognosis in sepsis-induced organ failure. Crit Care Med 2007; 35:2375-2382
    • (2007) Crit Care Med , vol.35 , pp. 2375-2382
    • Martin, K.1    Borgel, D.2    Lerolle, N.3
  • 188
    • 44949215813 scopus 로고    scopus 로고
    • The Ashwell receptor mitigates the lethal coagulopathy of sepsis
    • Grewal PK, Uchiyama S, Ditto D, et al: The Ashwell receptor mitigates the lethal coagulopathy of sepsis. Nat Med 2008; 14:648-655
    • (2008) Nat Med , vol.14 , pp. 648-655
    • Grewal, P.K.1    Uchiyama, S.2    Ditto, D.3
  • 189
    • 44949241584 scopus 로고    scopus 로고
    • Keeping blood clots at bay in sepsis
    • van't Veer C, van der Poll T. Keeping blood clots at bay in sepsis. Nat Med 2008; 14: 606-608
    • (2008) Nat Med , vol.14 , pp. 606-608
    • van't Veer, C.1    van der Poll, T.2
  • 190
    • 44049093984 scopus 로고    scopus 로고
    • Resuscitating the microcirculation in severe sepsis: The central role of nitric oxide, emerging concepts for novel therapies, and challenges for clinical trials
    • Treziack S, Cinel I, Dellinger RP, et al: Resuscitating the microcirculation in severe sepsis: The central role of nitric oxide, emerging concepts for novel therapies, and challenges for clinical trials. Acad Emerg Med 2008; 15:1-15
    • (2008) Acad Emerg Med , vol.15 , pp. 1-15
    • Treziack, S.1    Cinel, I.2    Dellinger, R.P.3


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