Rennet Coagulation and Cheesemaking Properties of Thermally Processed Milk: Overview and Recent Developments

Journal of Agricultural and Food Chemistry

Volumn 63, Issue 43, 2015, Pages 9389-9403

  Kethireddipalli, Prashanti ^a   Hill, Arthur R ^a  

^a UNIVERSITY OF GUELPH   (Canada)

Author keywords

casein micelles; cheese; rennet coagulation of milk; thermally processed milk; whey protein casein complexes

Indexed keywords

CASEIN; COAGULATION; DAIRY PRODUCTS; PROTEINS;

CASEIN MICELLES; FUNCTIONAL ATTRIBUTE; MICROPARTICULATED WHEY PROTEINS; RENNET COAGULATION; THERMALLY INDUCED; THERMALLY PROCESSED MILK; WATER HOLDING CAPACITY; WHEY PROTEINS;

CHEESES;

CHYMOSIN; RENNET;

ANALYSIS; ANIMAL; CHEESE; CHEMISTRY; FOOD HANDLING; MILK; PROCEDURES; TEMPERATURE;

ANIMALS; CHEESE; CHYMOSIN; FOOD HANDLING; MILK; TEMPERATURE;

EID: 84946600107     PISSN: 00218561     EISSN: 15205118     Source Type: Journal    
DOI: 10.1021/jf504167v     Document Type: Article

References (182)

1. Kelly, A. L.; Huppertz, T.; Sheehan, J. J. Pre-treatment of cheese milk: principles and developments Dairy Sci. Technol. 2008, 88, 549-572
2. Lucey, J. A. Effect of heat treatment on the rennet coagulability of milk. In Heat-Induced Changes in Milk, 2 nd ed.; IDF Special Issue 9501; International Dairy Federation: Brussels, Belgium, 1995; pp 171-187.
3. Singh, H.; Waungana, A. Influence of heat treatment of milk on cheesemaking properties Int. Dairy J. 2001, 11, 543-551
4. Guyomarćh, F. Formation of heat-induced protein aggregates in milk as a means to recover the whey protein fraction in cheese manufacture, and potential of heat-treating milk at alkaline pH values in order to keep its rennet coagulation properties. A review Lait 2006, 86, 1-20
5. Dalgleish, D. G.; Corredig, M. The structure of the casein micelle of milk and its changes during processing Annu. Rev. Food Sci. Technol. 2012, 3, 449-467
6. Dalgleish, D. G. Proteolysis and aggregation of casein micelles treated with immobilized or soluble chymosin J. Dairy Res. 1979, 46, 653-661
7. Sandra, S.; Dalgleish, D. G. The effect of ultra high-pressure homogenization (UHPH) on rennet coagulation properties of unheated and heated fresh skimmed milk Int. Dairy J. 2007, 17, 1043-1052
8. Kethireddipalli, P.; Hill, A. R.; Dalgleish, D. G. Protein interactions in heat-treated milk and effect on rennet coagulation Int. Dairy J. 2010, 20, 838-843
9. Bringe, N. A.; Kinsella, J. E. Influence of calcium chloride on the chymosin initiated coagulation of casein micelles J. Dairy Res. 1986, 53, 371-379
10. Sandra, S.; Ho, M.; Alexander, M.; Corredig, M. Effect of soluble calcium on the renneting properties of casein micelles as measured by rheology and diffusing wave spectroscopy J. Dairy Sci. 2012, 95, 75-82
11. Dalgleish, D. G. Coagulation of renneted bovine casein micelles-dependence on temperature, calcium ion concentration and ionic strength J. Dairy Res. 1983, 50, 331-340
12. Landfeld, A.; Novotna, P.; Houska, M. Influence of the amount of rennet, calcium chloride addition, temperature, and high-pressure treatment on the course of milk coagulation Czech J. Food Sci. 2002, 20, 237-244
13. Udabage, P.; McKinnon, I. R.; Augustin, M. A. Effects of mineral salts and calcium chelating agents on the gelation of renneted skim milk J. Dairy Sci. 2001, 84, 1569-1575
14. Choi, J.; Horne, D. S.; Lucey, J. A. Effect of insoluble calcium concentration on rennet coagulation properties of milk J. Dairy Sci. 2007, 90, 2612-2623
15. Anema, S. G.; McKenna, A. B. Reaction kinetics of thermal denaturation of whey proteins in heated reconstituted whole milk J. Agric. Food Chem. 1996, 44, 422-428
16. Dannenberg, F.; Kessler, H. G. Reaction kinetics of the denaturation of whey proteins in milk J. Food Sci. 1988, 53, 258-263
17. del Angel, C. R.; Dalgleish, D. G. Structures and some properties of soluble protein complexes formed by the heating of reconstituted skim milk powder Food Res. Int. 2006, 39, 472-479
18. Guyomarćh, F.; Law, A. J. R.; Dalgleish, D. G. Formation of soluble and micelle-bound protein aggregates in heated milk J. Agric. Food Chem. 2003, 51, 4652-4660
19. Anema, S. G.; Li, Y. Association of denatured whey proteins with casein micelles in heated reconstituted skim milk and its effect on casein micelle size J. Dairy Res. 2003, 70, 73-83
20. Donato, L.; Dalgleish, D. G. Effect of the pH of heating on the qualitative and quantitative compositions of the sera of reconstituted skim milks and on the mechanisms of formation of soluble aggregates J. Agric. Food Chem. 2006, 54, 7804-7811
21. Visser, J.; Minihan, A.; Smits, P.; Tjan, S. B.; Heertje, I. Effects of pH and temperature on the milk salt system Neth. Milk Dairy J. 1986, 40, 351-368
22. Anema, S. G.; Kim Lee, S.; Klostermeyer, H. Effect of pH at heat treatment on the hydrolysis of Κ-casein and the gelation of skim milk by chymosin LWT-Food Sci. Technol. 2007, 40, 99-106
23. Vasbinder, A. J.; Alting, A. C.; de Kruif, K. G. Quantification of heat-induced casein-whey protein interactions in milk and its relation to gelation kinetics Colloids Surf., B 2003, 31, 115-123
24. Vasbinder, A. J.; de Kruif, C. G. Casein-whey protein interactions in heated milk: the influence of pH Int. Dairy J. 2003, 13, 669-677
25. Anema, S. G.; Li, Y. Further studies on the heat-induced, pH-dependent dissociation of casein from the micelles in reconstituted skim milk Lebensmittelwissenschaft 2000, 33, 335-343
26. Donato, L.; Guyomarćh, F. Formation and properties of the whey protein/Κ-casein complexes in heated skim milk-a review Dairy Sci. Technol. 2009, 89, 3-29
27. Holt, C. Inorganic constituents of milk. 3. The colloidal calcium-phosphate of cow's milk J. Dairy Res. 1982, 49, 29-38
28. Walstra, P.; Wouters, J. T. M.; Geurts, T. J. Heat treatment. In Dairy Science and Technology, 2 nd ed.; Walstra, P.; Wouters, J. T. M.; Geurts, T. J., Eds.; CRC Press: Boca Raton, FL, USA, 2006; pp 225-272.
29. Pouliot, Y.; Boulet, M.; Paquin, P. Observations on the heat-induced salt balance changes in milk. 2. Reversibility on cooling J. Dairy Res. 1989, 56, 193-199
30. Raynal, K.; Remeuf, F. The effect of heating on physicochemical and renneting properties of milk: a comparison between caprine, ovine and bovine milk Int. Dairy J. 1998, 8, 695-706
31. Anema, S. G. Effect of milk solids concentration on the pH, soluble calcium and soluble phosphate levels of milk during heating Dairy Sci. Technol. 2009, 89, 501-510
32. Pouliot, Y.; Boulet, M.; Paquin, P. Observations on the heat-induced salt balance changes in milk. 1. Effect of heating time between 4°C and 90°C J. Dairy Res. 1989, 56, 185-192
33. Rose, D.; Tessier, H. Composition of ultrafiltrates from milk heated at 80 to 230°F in relation to heat stability J. Dairy Sci. 1959, 42, 969-980
34. Holt, C. Effect of heating and cooling on the milk salts and their interaction with casein. In Heat-Induced Changes in Milk; IDF Special Issue 9501; International Dairy Federation: Brussels, Belgium, 1995; pp 105-133.
35. Aoki, T.; Umeda, T.; Kako, Y. Cleavage of the linkage between colloidal calcium-phosphate and casein on heating milk at higherature J. Dairy Res. 1990, 57, 349-354
36. Holt, C. An equilibrium thermodynamic model of the sequestration of calcium phosphate by casein micelles and its application to the calculation of the partition of salts in milk Eur. Biophys. J. Biophys. 2004, 33, 421-434
37. Hindle, E. J.; Wheelock, J. V. Primary phase of rennin action in heat-sterilized milk J. Dairy Res. 1970, 37, 389
38. Wilson, G. A.; Wheelock, J. V. Factors affecting action of rennin in heated milk J. Dairy Res. 1972, 39, 413
39. Wheelock, J. V.; Kirk, A. Role of β-lactoglobulin in primary phase of rennin action on heated casein micelles and heated milk J. Dairy Res. 1974, 41, 367-372
40. van Hooydonk, A. C. M.; de Koster, P. G.; Boerrigter, I. J. The renneting properties of heated milk Neth. Milk Dairy J. 1987, 41, 3-18
41. Vasbinder, A. J.; Rollema, H. S.; de Kruif, C. G. Impaired rennetability of heated milk; study of enzymatic hydrolysis and gelation kinetics J. Dairy Sci. 2003, 86, 1548-1555
42. Schreiber, R. Heat-induced modifications in casein dispersions affecting their rennetability Int. Dairy J. 2001, 11, 553-558
43. Dalgleish, D. G. Denaturation and aggregation of serum proteins and caseins in heated milk J. Agric. Food Chem. 1990, 38, 1995-1999
44. Waungana, A.; Singh, H.; Bennett, R. J. Influence of denaturation and aggregation of β-lactoglobulin on rennet coagulation properties of skim milk and ultrafiltered milk Food Res. Int. 1996, 29, 715-721
45. Anema, S. G.; Lee, S. K.; Klostermeyer, H. Rennet-induced aggregation of heated pH-adjusted skim milk J. Agric. Food Chem. 2011, 59, 8413-8422
46. Menard, O.; Camier, B.; Guyomarćh, F. Effect of heat treatment at alkaline pH on the rennet coagulation properties of skim milk Lait 2005, 85, 515-526
47. Leaver, J.; Law, A. J. R.; Horne, D. S.; Banks, J. M. Influence of heating regime and pH on the primary phase of renneting of whole milk Int. Dairy J. 1995, 5, 129-140
48. Kethireddipalli, P.; Hill, A. R.; Dalgleish, D. G. Interaction between casein micelles and whey protein/Κ-casein complexes during renneting of heat-treated reconstituted skim milk powder and casein micelle/serum mixtures J. Agric. Food Chem. 2011, 59, 1442-1448
49. Martin, G. J. O.; Williams, R. P. W.; Choong, C.; Lee, B.; Dunstan, D. E. Comparison of rennet gelation using raw and reconstituted skim milk Int. Dairy J. 2008, 18, 1077-1080
50. Patel, H. A.; Anema, S. G.; Holroyd, S. E.; Singh, H.; Creamer, L. K. Methods to determine denaturation and aggregation of proteins in low-, medium- and high-heat skim milk powders Lait 2007, 87, 251-268
51. Lucey, J. A.; Fox, P. F. Importance of calcium and phosphate in cheese manufacture-a review J. Dairy Sci. 1993, 76, 1714-1724
52. Banks, J. M. Improving cheese yield by the incorporation of whey powder Dairy Ind. Int. 1990, 55, 37-41
53. Singh, H.; Shalabi, S. I.; Fox, P. F.; Flynn, A.; Barry, A. Rennet coagulation of heated milk-influence of pH adjustment before or after heating J. Dairy Res. 1988, 55, 205-215
54. 2 acidification J. Dairy Sci. 2002, 85, 2098-2105
55. Philippe, M.; Gaucheron, F.; Le Graet, Y.; Michel, F.; Garem, A. Physicochemical characterization of calcium-supplemented skim milk Lait 2003, 83, 45-59
56. Dalgleish, D. G.; Law, A. J. R. pH-induced dissociation of bovine casein micelles. 2. Mineral solubilization and its relation to casein release J. Dairy Res. 1989, 56, 727-735
57. van Hooydonk, A. C. M.; Hagedoorn, H. G.; Boerrigter, J. pH-induced physicochemical changes of casein micelles in milk and their effect on renneting. 1. Effect of acidification on physico chemical properties Neth. Milk Dairy J. 1986, 40, 281-296
58. Legraet, Y.; Brule, G. Effects of pH and ionic-strength on distribution of mineral salts in milk Lait 1993, 73, 51-60
59. Lucey, J. A.; Gorry, C.; Fox, P. F. Acid-base buffering properties of heated milk Milchwissenschaft 1993, 48, 438-441
60. de Roos, A. L.; Geurts, T. J.; Walstra, P. The association of chymosin with artificial casein micelles Int. Dairy J. 2000, 10, 225-232
61. Creamer, L. K.; Lawrence, R. C.; Gilles, J. Effect of acidification of cheese milk on the resultant Cheddar cheese N. Z. J. Dairy Sci. 1985, 20, 185-203
62. Holmes, D. G.; Duersch, J. W.; Ernstrom, C. A. Distribution of milk clotting enzymes between curd and whey and their survival during Cheddar cheese making J. Dairy Sci. 1977, 60, 862-869
63. Garnot, P.; Molle, D.; Piot, M. Influence of pH, type of enzyme and ultrafiltration on the retention of milk clotting enzymes in Camembert cheese J. Dairy Res. 1987, 54, 315-320
64. Banks, J. M.; Stewart, G.; Muir, D. D.; West, I. G. Increasing the yield of Cheddar cheese by the acidification of milk containing heat-denatured whey protein Milchwissenschaft 1987, 42, 212-215
65. Banks, J. M.; Law, A. J. R.; Leaver, J.; Horne, D. S. Sensory and functional properties of cheese-incorporation of whey proteins by pH manipulation and heat-treatment J. Soc. Dairy Technol. 1994, 47, 124-131
66. Imafidon, G. I.; Farkye, N. Y. Rennet coagulability of high-heat treated milk influenced by time of pH adjustment J. Food Sci. 1993, 58, 1300-1302
67. Imafidon, G. I.; Farkye, N. Y.; Tong, P. S. Effect of high-heat treatment and different acidulants on the physicochemical properties of rennet-treated milk J. Dairy Sci. 1992, 75, 120-120
68. Lucey, J. A.; Gorry, C.; ÓKennedy, B.; Kalab, M.; TanKinita, R.; Fox, P. F. Effect of acidification and neutralization of milk on some physico-chemical properties of casein micelles Int. Dairy J. 1996, 6, 257-272
69. 2-acidified skim milk Int. Dairy J. 2004, 14, 437-443
70. 2 acidification cycles, calcium supplementation, pH adjustment and chilled storage on physico-chemical and rennet coagulation properties of reconstituted low- and medium-heat skim milk powders Food Hydrocolloids 2009, 23, 806-815
71. 2 reversible acidification: impact of carbonation temperature and chilled storage time Int. Dairy J. 2008, 18, 221-227
72. Gevaudan, S.; Lagaude, A.; DeLaFuente, B. T.; Cuq, J. L. Effect of treatment by gaseous carbon dioxide on the colloidal phase of skim milk J. Dairy Sci. 1996, 79, 1713-1721
73. Jimenez-Lopez, A. J. E.; Leconte, N.; Dehainault, O.; Geneste, C.; Fromont, L.; Gesan-Guiziou, G. Role of milk constituents on critical conditions and deposit structure in skim milk microfiltration (0.1 μm) Sep. Purif. Technol. 2008, 61, 33-43
74. Karlsson, A. O.; Ipsen, R.; Schrader, K.; Ardo, Y. Relationship between physical properties of casein micelles and rheology of skim milk concentrate J. Dairy Sci. 2005, 88, 3784-3797
75. Singh, H. Interactions of milk proteins during the manufacture of milk powders Lait 2007, 87, 413-423
76. Karlsson, A. O.; Ipsen, R.; Ardo, Y. Rheological properties and microstructure during rennet induced coagulation of UF concentrated skim milk Int. Dairy J. 2007, 17, 674-682
77. Sharma, S. K.; Mittal, G. S.; Hill, A. R. Effect of milk concentration, pH and temperature on Κ-casein hydrolysis at aggregation, coagulation and curd cutting times of ultrafiltered milk Milchwissenschaft 1994, 49, 450-453
78. Waungana, A.; Singh, H.; Bennett, R. J. Rennet coagulation properties of skim milk concentrated by ultrafiltration: effects of heat treatment and pH adjustment Food Res. Int. 1998, 31, 645-651
79. Salaun, F.; Mietton, B.; Gaucheron, F. Buffering capacity of dairy products Int. Dairy J. 2005, 15, 95-109
80. Srilaorkul, S.; Ozimek, L.; Wolfe, F.; Dziuba, J. The effect of ultrafiltration on physiochemical properties of retentate Can. Inst. Food Sci. Technol. J. 1989, 22, 56-62
81. Le Graet, Y.; Gaucheron, F. pH-induced solubilization of minerals from casein micelles: influence of casein concentration and ionic strength J. Dairy Res. 1999, 66, 215-224
82. Mistry, V. V. Membrane processing in cheese manufacture. In Encyclopaedia of Dairy Sciences; Roginski, H.; Fuquay, J. W.; Fox, P. F., Eds.; Academic Press: Amsterdam, The Netherlands, 2003; pp 300-306.
83. Mistry, V. V.; Maubois, J. L. Application of membrane separation technology in cheese production. In Cheese: Chemistry, Physics and Microbiology 1: General Aspects; Fox, P. F.; McSweeney, P. L. H.; Cogan, T. M.; Guinee, T. P., Eds.; Academic Press: Amsterdam, The Netherlands, 2004; pp 261-285.
84. Ferrer, M. A.; Alexander, M.; Corredig, M. Does ultrafiltration have a lasting effect on the physico-chemical properties of the casein micelles? Dairy Sci. Technol. 2011, 91, 151-170
85. Bouchoux, A.; Cayemitte, P.; Jardin, J.; Gesan-Guiziou, G.; Cabane, B. Casein micelle dispersions under osmotic stress Biophys. J. 2009, 96, 693-706
86. Bouchoux, A.; Debbou, B.; Gesan-Guiziou, G.; Famelart, M.-H.; Doublier, J.-L.; Cabane, B. Rheology and phase behavior of dense casein micelle dispersions J. Chem. Phys. 2009, 131, 1-11 10.1063/1.3245956
87. Dahbi, L.; Alexander, M.; Trappe, V.; Dhont, J. K. G.; Schurtenberger, P. Rheology and structural arrest of casein suspensions J. Colloid Interface Sci. 2010, 342, 564-570
88. Benfeldt, C. Ultrafiltration of cheese milk: effect on plasmin activity and proteolysis during cheese ripening Int. Dairy J. 2006, 16, 600-608
89. Hesari, J.; Ehsani, M. R.; Mosavi, M. A. E.; McSweeney, P. L. H. Proteolysis in ultra-filtered and conventional Iranian white cheese during ripening Int. J. Dairy Technol. 2007, 60, 211-220
90. Calvo, M. M.; Espinoza, N. A. Syneresis rate of cow's, ewés, and goat's curd. Effect of thermal treatment and ultrafiltration J. Agric. Food Chem. 1999, 47, 883-886
91. Casiraghi, E.; Lucisano, M.; Piazza, L. Rennet coagulation of milk retentates. 1. Effect of thermal and mechanical stresses associated with ultrafiltration J. Dairy Sci. 1989, 72, 2452-2456
92. Casiraghi, E.; Lucisano, M.; Peri, C. Rennet coagulation of milk retentates. 2. The combined effect of heat treatments and protein concentration J. Dairy Sci. 1989, 72, 2457-2463
93. Green, M. L. The cheese-making potential of milk concentrated up to 4-fold by ultrafiltration and heated in the range 90-97°C J. Dairy Res. 1990, 57, 549-557
94. Guinee, T. P.; ÓCallaghan, D. J.; Pudja, P. D.; ÓBrien, N. Rennet coagulation properties of retentates obtained by ultrafiltration of skim milks heated to different temperatures Int. Dairy J. 1996, 6, 581-596
95. McMahon, D. J.; Yousif, B. H.; Kalab, M. Effect of whey protein denaturation on structure of casein micelles and their rennetability after ultra-high temperature processing of milk with or without ultrafiltration Int. Dairy J. 1993, 3, 239-256
96. Schreiber, R.; Hinrichs, J. Rennet coagulation of heated milk concentrates Lait 2000, 80, 33-42
97. Sharma, S. K.; Hill, A. R.; Goff, H. D. The effect of heat-treatment of ultrafiltered milk on its coagulation properties Milchwissenschaft 1990, 45, 432-435
98. Sharma, S. K.; Hill, A. R.; Mittal, G. S. Effect of milk concentration, pH and temperature on aggregation kinetics and coagulation properties of ultrafiltered (UF) milk Food Res. Int. 1993, 26, 81-87
99. Mistry, V. V.; Maubois, J. L. Application of membrane separation technology in cheese production. In Cheese: Chemistry, Physics and Microbiology; Fox, P. F., Ed.; Chapman and Hall: New York, 1993; Vol. 1, pp 493-522.
100. Korolczuk, J.; Mahaut, M. Consistency of acid fresh cheese-role of whey proteins Milchwissenschaft 1991, 46, 153-156
101. Korolczuk, J.; Mahaut, M. Effect of whey proteins and heat treatment of milk on the consistency of UF fresh cheese Milchwissenschaft 1991, 46, 435-437
102. Mahaut, M.; Korolczuk, J. Effect of whey protein addition and heat treatment of milk on the viscosity of UF fresh cheeses Milchwissenschaft 1992, 47, 157-159
103. Pomprasirt, V.; Singh, H.; Lucey, J. A. Effect of heat treatment on the rennet coagulation properties of recombined high total solids milk made from milk protein concentrate powder Int. J. Dairy Technol. 1998, 51, 65-71
104. Bulca, S.; Tolkach, A.; Kupfer, J.; Kulozik, U. Impact of casein and whey protein content on the renneting properties of UHT-treated microfiltrated milk concentrates Milchwissenschaft 2010, 65, 365-368
105. Guinee, T. P.; Gorry, C. B.; ÓCallaghan, D. J.; ÓKennedy, B. T.; ÓBrien, N.; Fenelon, M. A. The effects of composition and some processing treatments on the rennet coagulation properties of milk Int. J. Dairy Technol. 1997, 50, 99-106
106. Guinee, T. P.; Fenelon, M. A.; Mulholland, E. O.; ÓKennedy, B. T.; ÓBrien, N.; Reville, W. J. The influence of milk pasteurization temperature and pH at curd milling on the composition, texture and maturation of reduced fat cheddar cheese Int. J. Dairy Technol. 1998, 51, 1-10
107. Marshall, R. J. Increasing cheese yields by high heat-treatment of milk J. Dairy Res. 1986, 53, 313-322
108. Pearse, M. J.; Linklater, P. M.; Hall, R. J.; Mackinlay, A. G. Effect of heat-induced interaction between β-lactoglobulin and Κ-casein on syneresis J. Dairy Res. 1985, 52, 159-165
109. Rynne, N. M.; Beresford, T. P.; Kelly, A. L.; Guinee, T. P. Effect of milk pasteurization temperature and in situ whey protein denaturation on the composition, texture and heat-induced functionality of half-fat Cheddar cheese Int. Dairy J. 2004, 14, 989-1001
110. Walstra, P.; Vandijk, H. J. M.; Guerts, T. J. The syneresis of curd. 1. General considerations and literature review Neth. Milk Dairy J. 1985, 39, 209-246
111. Pearse, M. J.; Mackinlay, A. G. Biochemical aspects of syneresis-a review J. Dairy Sci. 1989, 72, 1401-1407
112. Guinee, T. P.; Pudja, P. D.; Reville, W. J.; Harrington, D.; Mulholland, E. O.; Cotter, M.; Cogan, T. M. Composition, microstructure, and maturation of semihard cheeses from high-protein ultrafiltered milk retentates with different levels of denatured whey protein Int. Dairy J. 1995, 5, 543-568
113. Rynne, N. M.; Beresford, T. P.; Kelly, A. L.; Guinee, T. P. Effect of milk pasteurisation temperature on age-related changes in lactose metabolism, pH and the growth of non-starter lactic acid bacteria in half-fat Cheddar cheese Food Chem. 2007, 100, 375-382
114. Hinrichs, J. Incorporation of whey proteins in cheese Int. Dairy J. 2001, 11, 495-503
115. Lucey, J. A.; Tamehana, M.; Singh, H.; Munro, P. A. Effect of heat treatment on the physical properties of milk gels made with both rennet and acid Int. Dairy J. 2001, 11, 559-565
116. Lucey, J. A.; Gorry, C.; Fox, P. F. Changes in the acid-base buffering curves during the ripening of Emmentaler cheese Milchwissenschaft 1993, 48, 183-186
117. Jameson, G. W.; Lelievre, J. Effects of whey proteins on cheese characteristics Bull. IDF 1996, 313, 3-8
118. Hickey, D. K.; Kilcawley, K. N.; Beresford, T. P.; Wilkinson, M. G. Lipolysis in cheddar cheese made from raw, thermized, and pasteurized milks J. Dairy Sci. 2007, 90, 47-56
119. Lefevere, I.; Dewettinck, K.; Huyghebaert, A. Cheese fat as driving force in cheese flow upon melting Milchwissenschaft 2000, 55, 563-566
120. Rowney, M. K.; Hickey, M. W.; Roupas, P.; Everett, D. W. The effect of homogenization and milk fat fractions on the functionality of Mozzarella cheese J. Dairy Sci. 2003, 86, 712-718
121. Lucey, J. A.; Johnson, M. E.; Horne, D. S. Invited review: Perspectives on the basis of the rheology and texture properties of cheese J. Dairy Sci. 2003, 86, 2725-2743
122. Mistry, V. V.; Kasperson, K. M. Influence of salt on the quality of reduced fat Cheddar cheese J. Dairy Sci. 1998, 81, 1214-1221
123. Upadhyay, V. K.; McSweeney, P. L. H.; Magboul, A. A. A.; Fox, P. F. Proteolysis in cheese during ripening. In Cheese: Chemistry, Physics and Microbiology, 3rd ed.; Fox, P. F.; McSweeney, P. L. H.; Cogan, T. M.; Guinee, T. P., Eds.; Elsevier Academic Press: Amsterdam, The Netherlands, 2004; Vol. 1, pp 391-433.
124. McSweeney, P. L. H. Biochemistry of cheese ripening Int. J. Dairy Technol. 2004, 57, 127-144
125. S1-casein in model systems: influence of whey proteins J. Dairy Sci. 1997, 80, 615-619
126. Hayes, M. G.; McSweeney, P. L. H.; Kelly, A. L. The influence of native and heat-denatured whey proteins on enzyme activity. 1. Plasmin Milchwissenschaft 2002, 57, 208-211
127. Harper, J.; Iyer, M.; Knighton, D.; Lelievre, J. Effects of whey proteins on the proteolysis of Cheddar cheese slurries (a model for the maturation of cheeses made from ultrafiltered milk) J. Dairy Sci. 1989, 72, 333-341
128. Kelly, A. L.; Foley, J. Proteolysis and storage stability of UHT milk as influenced by milk plasmin activity, plasmin/β-lactoglobulin complexation, plasminogen activation and somatic cell count Int. Dairy J. 1997, 7, 411-420
129. Farkye, N.; Fox, P. F. Contribution of plasmin to Cheddar cheese ripening-effect of added plasmin J. Dairy Res. 1992, 59, 209-216
130. Benfeldt, C.; Sorensen, J.; Ellegard, K. H.; Petersen, T. E. Heat treatment of cheese milk: effect on plasmin activity and proteolysis during cheese ripening Int. Dairy J. 1997, 7, 723-731
131. Madsen, J. S.; Qvist, K. B. The effect of added proteolytic enzymes on meltability of Mozzarella cheese manufactured by ultrafiltration Lait 1998, 78, 259-272
132. Santoro, M.; Faccia, M. Degradation of the protein fraction in a cheese fortified with whey proteins Neth. Milk Dairy J. 1996, 50, 61-68
133. Feldstein, F. J.; Westhoff, D. C. The influence of heat treatment of milk on starter activity: what about UHT? Cultured Dairy Prod. J. 1979, 14, 11-15
134. Krause, I.; Bockhardt, A.; Klostermeyer, H. Characterization of cheese ripening by free amino acids and biogenic amines and influence of bactofugation and heat treatment of milk Lait 1997, 77, 101-108
135. Banks, J. M.; Law, A. J. R.; Leaver, J.; Horne, D. S. Sensory and functional properties of cheese-incorporation of whey proteins by pH manipulation and heat treatment J. Soc. Dairy Technol. 1994, 47, 124-131
136. Fox, P. F.; Singh, T. K.; McSweeney, P. L. H. Biogenesis of flavor compounds in cheese. In Chemistry of Structure/Function Relationships in Cheese; Malin, E. L.; Tunick, M. H., Eds.; Plenum Press: London, UK, 1995; pp 59-98.
137. Fox, P. F.; ÓConnor, T. P.; McSweeney, P. L. H.; Guinee, T. P.; ÓBrien, N. M. Cheese: physical, biochemical and nutritional aspects Adv. Food Nutr. Res. 1996, 39, 163-328
138. Fox, P. F.; Guinee, T. P.; Cogan, T. M.; McSweeney, P. L. H. Biochemistry of cheese ripening. In Fundamentals of Cheese Science; Aspen Publishers: Gaithersburg, MD, USA, 2000; pp 236-281.
139. McSweeney, P. L. H. Biochemistry of cheese ripening: introduction and overview. In Cheese: Chemistry, Physics and Microiology; Fox, P. F.; McSweeney, P. L. H.; Cogan, T. M.; Guinee, T. P., Eds.; Elsevier Academic Press: San Diego, CA, USA, 2004; Vol. 1, pp 347-360.
140. Fox, P. F.; Wallace, J. M. Formation of flavor compounds in cheese Adv. Appl. Microbiol. 1997, 45, 17-85
141. McSweeney, P. L. H.; Sousa, M. J. Biochemical pathways for the production of flavour compounds in cheeses during ripening: a review Lait 2000, 80, 293-324
142. Fox, P. F.; McSweeney, P. L. H. Chemistry and biochemistry of cheese manufacture and ripening Food Sci. Technol. 2006, 20, 28-32
143. Mackey, K. L.; Desai, N. Rheology of reduced-fat cheese containing a fat substitute. In Chemistry of Structure-Function Relationships in Cheese; Malin, E. L.; Tunick, M. H., Eds.; Plenum Press: London, UK, 1995; pp 21-26.
144. Schenkel, P.; Samudrala, R.; Hinrichs, J. The effect of adding whey protein particles as inert filler on thermophysical properties of fat-reduced semihard cheese type Gouda Int. J. Dairy Technol. 2013, 66, 220-230
145. Kethireddipalli, P. The Physico-chemical Aspects of the Impaired Rennet Coagulation Properties of Heat-Treated Milk; Dissertation, University of Guelph, 2011; pp 116 - 113.
146. Fenelon, M. A.; Guinee, T. P. The compositional, textural and maturation characteristics of reduced-fat Cheddar made from milk containing added Dairy-Lo (TM) Milchwissenschaft 1997, 52, 385-389
147. Lucey, J. A.; Gorry, C. Effect of Simplesse 100 on the manufacture of low-fat Cheddar cheese. In Cheese Yield and Factors Affecting Its Control; International Dairy Federation: Brussels, Belgium, 1994; pp 439-447.
148. Desai, N.; Nolting, J. Microstructure studies of reduced-fat cheeses containing fat substitute. In Chemistry of Structure-Function Relationships in Cheese; Malin, E. L.; Tunick, M. H., Eds.; Plenum Press: London, UK, 1995; pp 295-302.
149. Lopez-Fandino, R. High pressure-induced changes in milk proteins and possible applications in dairy technology Int. Dairy J. 2006, 16, 1119-1131
150. van den Berg, R. W.; Hoogland, H.; Lelieveld, H. L. M.; van Schepdael, L. High pressure equipment designs for food processing applications. In Ultra High Pressure Treatments of Foods, Hendrickx, M. E. G.; Knorr, D., Eds.; Food Engineering Series; Springer: Berlin, Germany, 2002; pp 297-313.
151. Anema, S. G.; Lowe, E. K.; Stockmann, R. Particle size changes and casein solubilisation in high pressure treated skim milk Food Hydrocolloids 2005, 19, 257-267
152. Gaucheron, F.; Famelart, M. H.; Mariette, F.; Raulot, K.; Michel, F.; LeGraet, Y. Combined effects of temperature and high pressure treatments on physicochemical characteristics of skim milk Food Chem. 1997, 59, 439-447
153. Huppertz, T.; Fox, P. F.; Kelly, A. L. Effects of high pressure treatment on the yield of cheese curd from bovine milk Innovative Food Sci. Emerging Technol. 2004, 5, 1-8
154. Schrader, K.; Buchheim, W.; Morr, C. V. High pressure effects on the colloidal calcium phosphate and the structural integrity of micellar casein in milk. 1. High pressure dissolution of colloidal calcium phosphate in heated milk systems Nahrung-Food 1997, 41, 133-138
155. Hinrichs, J.; Rademacher, B. Kinetics of combined thermal and pressure-induced whey protein denaturation in bovine skim milk Int. Dairy J. 2005, 15, 315-323
156. Huppertz, T.; Fox, P. F.; Kelly, A. L. Dissociation of caseins in high pressure treated bovine milk Int. Dairy J. 2004, 14, 675-680
157. Lopez-Fandino, R.; Olano, A. Effects of high pressures combined with moderate temperatures on the rennet coagulation properties of milk Int. Dairy J. 1998, 8, 623-627
158. Considine, T.; Patel, H. A.; Anema, S. G.; Singh, H.; Creamer, L. K. Interactions of milk proteins during heat and high hydrostatic pressure treatments-a review Innovative Food Sci. Emerging Technol. 2007, 8, 1-23
159. Huppertz, T.; Fox, P. F.; Kelly, A. L. Properties of casein micelles in high pressure-treated bovine milk Food Chem. 2004, 87, 103-110
160. Huppertz, T.; Hinz, K.; Zobrist, M. R.; Uniacke, T.; Kelly, A. L.; Fox, P. F. Effects of high pressure treatment on the rennet coagulation and cheese-making properties of heated milk Innovative Food Sci. Emerging Technol. 2005, 6, 279-285
161. Voigt, D. D.; Donaghy, J. A.; Patterson, M. F.; Stephan, S.; Kelly, A. L. Manufacture of Cheddar cheese from high pressure treated whole milk Innovative Food Sci. Emerging Technol. 2010, 11, 574-579
162. Voigt, D. D.; Chevalier, F.; Donaghy, J. A.; Patterson, M. F.; Qian, M. C.; Kelly, A. L. Effect of high pressure treatment of milk for cheese manufacture on proteolysis, lipolysis, texture and functionality of Cheddar cheese during ripening Innovative Food Sci. Emerging Technol. 2012, 13, 23-30
163. Drake, M. A.; Harrison, S. L.; Asplund, M.; Barbosa-Canovas, G.; Swanson, B. G. High pressure treatment of milk and effects on microbiological and sensory quality of Cheddar cheese J. Food Sci. 1997, 62, 843-860
164. Buffa, M.; Guamis, B.; Trujillo, A. J. Specific effect of high pressure treatment of milk on cheese proteolysis J. Dairy Res. 2005, 72, 385-392
165. San Martin-Gonzalez, M. F.; Rodriguez, J. J.; Gurram, S.; Clark, S.; Swanson, B. G.; Barbosa-Canovas, G. V. Yield, composition and rheological characteristics of Cheddar cheese made with high pressure processed milk LWT-Food Sci.Technol. 2007, 40, 697-705
166. Molina, E.; Alvarez, M. D.; Ramos, M.; Olano, A.; Lopez-Fandino, R. Use of high pressure treated milk for the production of reduced-fat cheese Int. Dairy J. 2000, 10, 467-475
167. Linton, M.; Mackle, A. B.; Upadhyay, V. K.; Kelly, A. L.; Patterson, M. F. The fate of Listeria monocytogenes during the manufacture of Camembert-type cheese: a comparison between raw milk and milk treated with high hydrostatic pressure Innovative Food Sci. Emerging Technol. 2008, 9, 423-428
168. Sandra, S.; Stanford, M. A.; Meunier Goddik, L. The use of high-pressure processing in the production of Queso Fresco cheese J. Food Sci. 2004, 69, 153-158
169. Kethireddipalli, P. The Physico-Chemical Aspects of the Impaired Rennet Coagulation Properties of Heat-Treated Milk; Dissertation, University of Guelph, 2011; pp 53-54
170. Banks, J. M. Elimination of the development of bitter flavor in Cheddar cheese made from milk containing heat-denatured whey protein J. Soc. Dairy Technol. 1988, 41, 37-41
171. Banks, J. M.; Law, A. J. R.; Leaver, J.; Horne, D. S. The inclusion of whey proteins in cheese-an overview. In Cheese Yield and Factors Affecting its Control, special issue; International Dairy Federation: Brussels, Belgium, 1993; pp 387-401.
172. Guinee, T. P.; Pudja, P. D.; Mulholland, E. O. Effect of milk protein standardization, by ultrafiltration, on the manufacture, composition and maturation of Cheddar cheese J. Dairy Res. 1994, 61, 117-131
173. Rynne, N. M.; Beresford, T. P.; Kelly, A. L.; Tunick, M. H.; Malin, E. L.; Guinee, T. P. Effect of exopolysaccharide-producing adjunct starter cultures on the manufacture, composition and yield of half-fat Cheddar cheese Aust. J. Dairy Technol. 2007, 62, 12-18
174. Marshall, R. J. Increasing cheese yields by high heat treatment of milk J. Dairy Res. 1986, 53, 313-322
175. Lo, C. G.; Bastian, E. D. Incorporation of native and denatured whey proteins into cheese curd for manufacture of reduced fat, Havarti-type cheese J. Dairy Sci. 1998, 81, 16-24
176. Hougaard, A. B.; Ardo, Y.; Ipsen, R. H. Cheese made from instant infusion pasteurized milk: rennet coagulation, cheese composition, texture and ripening Int. Dairy J. 2010, 20, 449-458
177. Chromik, C.; Partschefeld, C.; Jaros, D.; Henle, T.; Rohm, H. Adjustment of vat milk treatment to optimize whey protein transfer into semi-hard cheese: a case study J. Food Eng. 2010, 100, 496-503
178. Benfeldt, C.; Sorensen, J. Heat treatment of cheese milk: effect on proteolysis during cheese ripening Int. Dairy J. 2001, 11, 567-574
179. Schafer, H. W.; Olson, N. F. Characteristics of Mozzarella cheese made by direct acidification from ultra-higherature processed milk J. Dairy Sci. 1975, 58, 494-501
180. Kumar, S.; Kanawijia, S. K.; Kumar, S. Effect of different degree of heat treatments on sensory and biochemical characteristics of buffalo Feta type cheese during ripening Milchwissenschaft 2011, 66, 290-293
181. Ghosh, B. C.; Steffl, A.; Hinrichs, J.; Kessler, H. G. Effect of heat treatment and homogenization of milk on Camembert-type cheese Egyptian J. Dairy Sci. 1999, 27, 331-343
182. Shammet, K. M.; McMahon, D. J.; Ernstrom, C. A. Effect of acidification and heat-treatment on the quality of white soft cheese from ultrafiltered whole milk retentate Milchwissenschaft 1992, 47, 553-557