메뉴 건너뛰기




Volumn 39, Issue 11, 2015, Pages 1191-1202

Hepcidin and its potential clinical utility

Author keywords

Diagnostics; Hepcidin; Iron homeostasis; Liver; Prohepcidin

Indexed keywords

BONE MORPHOGENETIC PROTEIN 6; CERULOPLASMIN; FERRITIN; FERROCHELATASE; FERROPORTIN 1; FRATAXIN; HEME OXYGENASE 1; HEMOJUVELIN; HEPCIDIN; INTERLEUKIN 6; IRON; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; PROHEPCIDIN; PROTON COUPLED FOLATE TRANSPORTER; TRANSFERRIN; TRANSFERRIN RECEPTOR; TRANSFERRIN RECEPTOR 2; BIOLOGICAL MARKER;

EID: 84944512035     PISSN: 10656995     EISSN: 10958355     Source Type: Journal    
DOI: 10.1002/cbin.10505     Document Type: Review
Times cited : (11)

References (124)
  • 6
    • 77956055334 scopus 로고    scopus 로고
    • Multiple regulatory mechanisms act in concert to control ferroportin expression and heme iron recycling by macrophages
    • Beaumont C ( 2010) Multiple regulatory mechanisms act in concert to control ferroportin expression and heme iron recycling by macrophages. Haematologica 95:1233-6.
    • (2010) Haematologica , vol.95 , pp. 1233-1236
    • Beaumont, C.1
  • 7
    • 84898541314 scopus 로고    scopus 로고
    • Inhibitory effect of the human liver-derived antimicrobial peptide hepcidin 20 on biofilms of polysaccharide intercellular adhesin (PIA)-positive and PIA-negative strains of Staphylococcus epidermidis
    • Brancatisano FL, Maisetta G, Di Luca M, Esin S, Bottai D, Bizzarri R, Campa M, Batoni G ( 2014) Inhibitory effect of the human liver-derived antimicrobial peptide hepcidin 20 on biofilms of polysaccharide intercellular adhesin (PIA)-positive and PIA-negative strains of Staphylococcus epidermidis. Biofouling 30:435-46.
    • (2014) Biofouling , vol.30 , pp. 435-446
    • Brancatisano, F.L.1    Maisetta, G.2    Di Luca, M.3    Esin, S.4    Bottai, D.5    Bizzarri, R.6    Campa, M.7    Batoni, G.8
  • 8
    • 84872951347 scopus 로고    scopus 로고
    • Hepcidin levels predict nonresponsiveness to oral iron therapy in patients with iron deficiency anemia
    • Bregman DB, Morris D, Koch TA, He A, Goodnough LT ( 2013) Hepcidin levels predict nonresponsiveness to oral iron therapy in patients with iron deficiency anemia. Am J Hematol 88:97-101.
    • (2013) Am J Hematol , vol.88 , pp. 97-101
    • Bregman, D.B.1    Morris, D.2    Koch, T.A.3    He, A.4    Goodnough, L.T.5
  • 10
  • 12
    • 84896735777 scopus 로고    scopus 로고
    • A multi-scale model of hepcidin promoter regulation reveals factors controlling systemic iron homeostasis
    • Casanovas G, Banerji A, d'Alessio F, Muckenthaler MU, Legewie S ( 2014) A multi-scale model of hepcidin promoter regulation reveals factors controlling systemic iron homeostasis. PLoS Comput Biol 10:e1003421.
    • (2014) PLoS Comput Biol , vol.10 , pp. e1003421
    • Casanovas, G.1    Banerji, A.2    d'Alessio, F.3    Muckenthaler, M.U.4    Legewie, S.5
  • 14
    • 0032791847 scopus 로고    scopus 로고
    • Defining optimal body iron
    • Cook JD ( 1999) Defining optimal body iron. Proc Nutr Soc 58:489-95.
    • (1999) Proc Nutr Soc , vol.58 , pp. 489-495
    • Cook, J.D.1
  • 16
    • 80051658907 scopus 로고    scopus 로고
    • Brain iron metabolism and its perturbation in neurological diseases
    • Crichton RR, Dexter DT, Ward RJ ( 2011) Brain iron metabolism and its perturbation in neurological diseases. J Neural Transm 118:301-14.
    • (2011) J Neural Transm , vol.118 , pp. 301-314
    • Crichton, R.R.1    Dexter, D.T.2    Ward, R.J.3
  • 18
    • 80455143532 scopus 로고    scopus 로고
    • The role of ubiquitination in hepcidin-independent and hepcidin-dependent degradation of ferroportin
    • De Domenico I, Lo E, Yang B, Korolnek T, Hamza I, Ward DM, Kaplan J ( 2011a) The role of ubiquitination in hepcidin-independent and hepcidin-dependent degradation of ferroportin. Cell Metab 14:635-46.
    • (2011) Cell Metab , vol.14 , pp. 635-646
    • De Domenico, I.1    Lo, E.2    Yang, B.3    Korolnek, T.4    Hamza, I.5    Ward, D.M.6    Kaplan, J.7
  • 19
    • 80052689794 scopus 로고    scopus 로고
    • Hepcidin and ferroportin: the new players in iron metabolism
    • De Domenico I, Ward DM, Kaplan J ( 2011b) Hepcidin and ferroportin: the new players in iron metabolism. Semin Liver Dis 31:272-9.
    • (2011) Semin Liver Dis , vol.31 , pp. 272-279
    • De Domenico, I.1    Ward, D.M.2    Kaplan, J.3
  • 22
    • 84937919683 scopus 로고    scopus 로고
    • Hepcidin suppresses brain iron accumulation by downregulating iron transport proteins in iron-overloaded rats
    • epub in press
    • Du F, Qian ZM, Luo Q, Yung WH, Ke Y ( 2014) Hepcidin suppresses brain iron accumulation by downregulating iron transport proteins in iron-overloaded rats. Mol Neurobiol 50. epub in press doi: 10.1007/s12035-014-8847-x
    • (2014) Mol Neurobiol , vol.50
    • Du, F.1    Qian, Z.M.2    Luo, Q.3    Yung, W.H.4    Ke, Y.5
  • 23
    • 84876282637 scopus 로고    scopus 로고
    • Regulation of systemic iron homeostasis
    • Finberg KE ( 2013) Regulation of systemic iron homeostasis. Curr Opin Hematol 20:208-14.
    • (2013) Curr Opin Hematol , vol.20 , pp. 208-214
    • Finberg, K.E.1
  • 24
    • 84868219359 scopus 로고    scopus 로고
    • Inflammation and diminished iron status: mechanisms and functional outcomes
    • Gaffney-Stomberg E, McClung JP ( 2012) Inflammation and diminished iron status: mechanisms and functional outcomes. Curr Opin Clin Nutr Metab Care 15:605-13.
    • (2012) Curr Opin Clin Nutr Metab Care , vol.15 , pp. 605-613
    • Gaffney-Stomberg, E.1    McClung, J.P.2
  • 26
    • 26944441309 scopus 로고    scopus 로고
    • Cellular iron: ferroportin is the only way out
    • Ganz T ( 2005) Cellular iron: ferroportin is the only way out. Cell Metab 1:155-7.
    • (2005) Cell Metab , vol.1 , pp. 155-157
    • Ganz, T.1
  • 27
    • 79955958017 scopus 로고    scopus 로고
    • Hepcidin and iron regulation, 10 years later
    • Ganz T ( 2011) Hepcidin and iron regulation, 10 years later. Blood 117:4425-33.
    • (2011) Blood , vol.117 , pp. 4425-4433
    • Ganz, T.1
  • 28
    • 84885768132 scopus 로고    scopus 로고
    • Systemic iron homeostasis
    • Ganz T ( 2013) Systemic iron homeostasis. Physiol Rev 93:1721-41.
    • (2013) Physiol Rev , vol.93 , pp. 1721-1741
    • Ganz, T.1
  • 29
    • 84861355868 scopus 로고    scopus 로고
    • Hepcidin and iron homeostasis
    • Ganz T, Nemeth E ( 2012) Hepcidin and iron homeostasis. Biochim Biophys Acta 1823:1434-43.
    • (2012) Biochim Biophys Acta , vol.1823 , pp. 1434-1443
    • Ganz, T.1    Nemeth, E.2
  • 30
    • 84895536249 scopus 로고    scopus 로고
    • Mitochondrial ferritin in the regulation of brain iron homeostasis and neurodegenerative diseases
    • Gao G, Chang YZ ( 2014) Mitochondrial ferritin in the regulation of brain iron homeostasis and neurodegenerative diseases. Front Pharmacol 5:19.
    • (2014) Front Pharmacol , vol.5 , pp. 19
    • Gao, G.1    Chang, Y.Z.2
  • 33
    • 84886252395 scopus 로고    scopus 로고
    • Peering into the future: hepcidin testing
    • Goyal J, McCleskey B, Adamski J ( 2013) Peering into the future: hepcidin testing. Am J Hematol 88:976-8.
    • (2013) Am J Hematol , vol.88 , pp. 976-978
    • Goyal, J.1    McCleskey, B.2    Adamski, J.3
  • 35
    • 84867907139 scopus 로고    scopus 로고
    • Molecular cloning, recombinant expression and antibacterial activity analysis of hepcidin from Simensis crocodile (Crocodylus siamensis)
    • Hao J, Li YW, Xie MQ, Li AX ( 2012) Molecular cloning, recombinant expression and antibacterial activity analysis of hepcidin from Simensis crocodile (Crocodylus siamensis). Comp Biochem Physiol B Biochem Mol Biol 163:309-15.
    • (2012) Comp Biochem Physiol B Biochem Mol Biol , vol.163 , pp. 309-315
    • Hao, J.1    Li, Y.W.2    Xie, M.Q.3    Li, A.X.4
  • 36
    • 84897365963 scopus 로고    scopus 로고
    • A delicate balance: iron metabolism and diseases of the brain
    • Hare D, Ayton S, Bush A, Lei P ( 2013) A delicate balance: iron metabolism and diseases of the brain. Front Aging Neurosci 5:34.
    • (2013) Front Aging Neurosci , vol.5 , pp. 34
    • Hare, D.1    Ayton, S.2    Bush, A.3    Lei, P.4
  • 37
  • 38
    • 84864124975 scopus 로고    scopus 로고
    • Importance of the disulfide bridges in the antibacterial activity of human hepcidin
    • Hocquellet A, le Senechal C, Garbay B ( 2012) Importance of the disulfide bridges in the antibacterial activity of human hepcidin. Peptides 36:303-7.
    • (2012) Peptides , vol.36 , pp. 303-307
    • Hocquellet, A.1    le Senechal, C.2    Garbay, B.3
  • 40
    • 84883380705 scopus 로고    scopus 로고
    • Hepcidin bound to alpha2-macroglobulin reduces ferroportin-1 expression and enhances its activity at reducing serum iron levels
    • Huang ML, Austin CJ, Sari MA, Rahmanto YS, Ponka P, Vyoral D, Richardson DR ( 2013) Hepcidin bound to alpha2-macroglobulin reduces ferroportin-1 expression and enhances its activity at reducing serum iron levels. J Biol Chem 288:25450-65.
    • (2013) J Biol Chem , vol.288 , pp. 25450-25465
    • Huang, M.L.1    Austin, C.J.2    Sari, M.A.3    Rahmanto, Y.S.4    Ponka, P.5    Vyoral, D.6    Richardson, D.R.7
  • 41
    • 0037020241 scopus 로고    scopus 로고
    • The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis
    • Hunter HN, Fulton DB, Ganz T, Vogel HJ ( 2002) The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis. J Biol Chem 277:37597-603.
    • (2002) J Biol Chem , vol.277 , pp. 37597-37603
    • Hunter, H.N.1    Fulton, D.B.2    Ganz, T.3    Vogel, H.J.4
  • 42
    • 80055078417 scopus 로고    scopus 로고
    • Importance of iron chelation in free radical-induced oxidative stress and human disease
    • Jomova K, Valko M ( 2011) Importance of iron chelation in free radical-induced oxidative stress and human disease. Curr Pharm Des 17:3460-73.
    • (2011) Curr Pharm Des , vol.17 , pp. 3460-3473
    • Jomova, K.1    Valko, M.2
  • 44
    • 54549087621 scopus 로고    scopus 로고
    • Secretion of bioactive hepcidin-25 by liver cells correlates with its gene transcription and points towards synergism between iron and inflammation signaling pathways
    • Kartikasari AE, Roelofs R, Schaeps RM, Kemna EH, Peters WH, Swinkels DW, Tjalsma H ( 2008) Secretion of bioactive hepcidin-25 by liver cells correlates with its gene transcription and points towards synergism between iron and inflammation signaling pathways. Biochim Biophys Acta 1784:2029-37.
    • (2008) Biochim Biophys Acta , vol.1784 , pp. 2029-2037
    • Kartikasari, A.E.1    Roelofs, R.2    Schaeps, R.M.3    Kemna, E.H.4    Peters, W.H.5    Swinkels, D.W.6    Tjalsma, H.7
  • 45
    • 78650217744 scopus 로고    scopus 로고
    • Increased hepcidin-25 and erythropoietin responsiveness in patients with cardio-renal anemia syndrome
    • Kato A ( 2010) Increased hepcidin-25 and erythropoietin responsiveness in patients with cardio-renal anemia syndrome. Future Cardiol 6:769-71.
    • (2010) Future Cardiol , vol.6 , pp. 769-771
    • Kato, A.1
  • 46
    • 84904865496 scopus 로고    scopus 로고
    • Molecular liaisons between erythropoiesis and iron metabolism
    • Kautz L, Nemeth E ( 2014) Molecular liaisons between erythropoiesis and iron metabolism. Blood 124:479-82.
    • (2014) Blood , vol.124 , pp. 479-482
    • Kautz, L.1    Nemeth, E.2
  • 47
    • 23944502314 scopus 로고    scopus 로고
    • Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS
    • Kemna E, Pickkers P, Nemeth E, van der Hoeven H, Swinkels D ( 2005) Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS. Blood 106:1864-6.
    • (2005) Blood , vol.106 , pp. 1864-1866
    • Kemna, E.1    Pickkers, P.2    Nemeth, E.3    van der Hoeven, H.4    Swinkels, D.5
  • 48
    • 34147197662 scopus 로고    scopus 로고
    • Mass spectrometry-based hepcidin measurements in serum and urine: analytical aspects and clinical implications
    • Kemna EH, Tjalsma H, Podust VN, Swinkels DW ( 2007) Mass spectrometry-based hepcidin measurements in serum and urine: analytical aspects and clinical implications. Clin Chem 53:620-8.
    • (2007) Clin Chem , vol.53 , pp. 620-628
    • Kemna, E.H.1    Tjalsma, H.2    Podust, V.N.3    Swinkels, D.W.4
  • 50
    • 73949136955 scopus 로고    scopus 로고
    • Soluble transferrin receptors and iron deficiency, a step beyond ferritin. A systematic review
    • Koulaouzidis A, Said E, Cottier R, Saeed AA ( 2009) Soluble transferrin receptors and iron deficiency, a step beyond ferritin. A systematic review. J Gastrointestin Liver Dis 18:345-52.
    • (2009) J Gastrointestin Liver Dis , vol.18 , pp. 345-352
    • Koulaouzidis, A.1    Said, E.2    Cottier, R.3    Saeed, A.A.4
  • 51
    • 67349113791 scopus 로고    scopus 로고
    • (Pre) analytical imprecision, between-subject variability, and daily variations in serum and urine hepcidin: implications for clinical studies
    • Kroot JJ, Hendriks JC, Laarakkers CM, Klaver SM, Kemna EH, Tjalsma H, Swinkels DW ( 2009) (Pre) analytical imprecision, between-subject variability, and daily variations in serum and urine hepcidin: implications for clinical studies. Anal Biochem 389:124-9.
    • (2009) Anal Biochem , vol.389 , pp. 124-129
    • Kroot, J.J.1    Hendriks, J.C.2    Laarakkers, C.M.3    Klaver, S.M.4    Kemna, E.H.5    Tjalsma, H.6    Swinkels, D.W.7
  • 52
    • 82755195789 scopus 로고    scopus 로고
    • Hepcidin in human iron disorders: diagnostic implications
    • Kroot JJ, Tjalsma H, Fleming RE, Swinkels DW ( 2011) Hepcidin in human iron disorders: diagnostic implications. Clin Chem 57:1650-69.
    • (2011) Clin Chem , vol.57 , pp. 1650-1669
    • Kroot, J.J.1    Tjalsma, H.2    Fleming, R.E.3    Swinkels, D.W.4
  • 56
    • 84899877769 scopus 로고    scopus 로고
    • Iron homeostasis and anemia markers in early breast cancer
    • Lamy PJ, Durigova A, Jacot W ( 2014) Iron homeostasis and anemia markers in early breast cancer. Clin Chim Acta 434:34-40.
    • (2014) Clin Chim Acta , vol.434 , pp. 34-40
    • Lamy, P.J.1    Durigova, A.2    Jacot, W.3
  • 58
    • 84878955221 scopus 로고    scopus 로고
    • Decreased serum hepcidin concentration correlates with brain iron deposition in patients with HBV-related cirrhosis
    • Lin D, Ding J, Liu JY, He YF, Dai Z, Chen CZ, Cheng WZ, Zhou J, Wang X ( 2013) Decreased serum hepcidin concentration correlates with brain iron deposition in patients with HBV-related cirrhosis. PLoS ONE 8:e65551.
    • (2013) PLoS ONE , vol.8 , pp. e65551
    • Lin, D.1    Ding, J.2    Liu, J.Y.3    He, Y.F.4    Dai, Z.5    Chen, C.Z.6    Cheng, W.Z.7    Zhou, J.8    Wang, X.9
  • 59
    • 84870566647 scopus 로고    scopus 로고
    • Hypoxia-inducible factor regulates hepcidin via erythropoietin-induced erythropoiesis
    • Liu Q, Davidoff O, Niss K, Haase VH ( 2012) Hypoxia-inducible factor regulates hepcidin via erythropoietin-induced erythropoiesis. J Clin Invest 122:4635-44.
    • (2012) J Clin Invest , vol.122 , pp. 4635-4644
    • Liu, Q.1    Davidoff, O.2    Niss, K.3    Haase, V.H.4
  • 61
    • 77957304252 scopus 로고    scopus 로고
    • Current status of the measurement of blood hepcidin levels in chronic kidney disease
    • Macdougall IC, Malyszko J, Hider RC, Bansal SS ( 2010) Current status of the measurement of blood hepcidin levels in chronic kidney disease. Clin J Am Soc Nephrol 5:1681-9.
    • (2010) Clin J Am Soc Nephrol , vol.5 , pp. 1681-1689
    • Macdougall, I.C.1    Malyszko, J.2    Hider, R.C.3    Bansal, S.S.4
  • 62
    • 77449086323 scopus 로고    scopus 로고
    • Plasma prohepcidin as a negative acute phase reactant after large cardiac surgery with a deep hypothermic circulatory arrest
    • Maruna P, Lindner J, Kunstyr J, Plocova K, Hubacek J ( 2009) Plasma prohepcidin as a negative acute phase reactant after large cardiac surgery with a deep hypothermic circulatory arrest. Physiol Res 58:827-33.
    • (2009) Physiol Res , vol.58 , pp. 827-833
    • Maruna, P.1    Lindner, J.2    Kunstyr, J.3    Plocova, K.4    Hubacek, J.5
  • 63
    • 79952438102 scopus 로고    scopus 로고
    • The identification of N-glycosylated residues of the human 5-HT3B receptor subunit: importance for cell membrane expression
    • Massoura AN, Dover TJ, Newman AS, Barnes NM ( 2011) The identification of N-glycosylated residues of the human 5-HT3B receptor subunit: importance for cell membrane expression. J Neurochem 116:975-83.
    • (2011) J Neurochem , vol.116 , pp. 975-983
    • Massoura, A.N.1    Dover, T.J.2    Newman, A.S.3    Barnes, N.M.4
  • 64
    • 84895755870 scopus 로고    scopus 로고
    • Glial cell ceruloplasmin and hepcidin differentially regulate iron efflux from brain microvascular endothelial cells
    • McCarthy RC, Kosman DJ ( 2014) Glial cell ceruloplasmin and hepcidin differentially regulate iron efflux from brain microvascular endothelial cells. PLoS ONE 9:e89003.
    • (2014) PLoS ONE , vol.9 , pp. e89003
    • McCarthy, R.C.1    Kosman, D.J.2
  • 66
    • 77952672976 scopus 로고    scopus 로고
    • Mechanisms of brain iron transport: insight into neurodegeneration and CNS disorders
    • Mills E, Dong XP, Wang F, Xu H ( 2010) Mechanisms of brain iron transport: insight into neurodegeneration and CNS disorders. Future Med Chem 2:51-64.
    • (2010) Future Med Chem , vol.2 , pp. 51-64
    • Mills, E.1    Dong, X.P.2    Wang, F.3    Xu, H.4
  • 69
    • 84876295741 scopus 로고    scopus 로고
    • Should we reconsider iron administration based on prevailing ferritin and hepcidin concentrations?
    • Nakanishi T, Kuragano T, Kaibe S, Nagasawa Y, Hasuike Y ( 2012) Should we reconsider iron administration based on prevailing ferritin and hepcidin concentrations? Clin Exp Nephrol 16:819-26.
    • (2012) Clin Exp Nephrol , vol.16 , pp. 819-826
    • Nakanishi, T.1    Kuragano, T.2    Kaibe, S.3    Nagasawa, Y.4    Hasuike, Y.5
  • 70
    • 84877978900 scopus 로고    scopus 로고
    • ZIP14 and DMT1 in the liver, pancreas, and heart are differentially regulated by iron deficiency and overload: implications for tissue iron uptake in iron-related disorders
    • Nam H, Wang CY, Zhang L, Zhang W, Hojyo S, Fukada T, Knutson MD ( 2013) ZIP14 and DMT1 in the liver, pancreas, and heart are differentially regulated by iron deficiency and overload: implications for tissue iron uptake in iron-related disorders. Haematologica 98:1049-57.
    • (2013) Haematologica , vol.98 , pp. 1049-1057
    • Nam, H.1    Wang, C.Y.2    Zhang, L.3    Zhang, W.4    Hojyo, S.5    Fukada, T.6    Knutson, M.D.7
  • 71
    • 30144432585 scopus 로고    scopus 로고
    • The N-terminus of hepcidin is essential for its interaction with ferroportin: structure-function study
    • Nemeth E, Preza GC, Jung CL, Kaplan J, Waring AJ, Ganz T ( 2006) The N-terminus of hepcidin is essential for its interaction with ferroportin: structure-function study. Blood 107:328-33.
    • (2006) Blood , vol.107 , pp. 328-333
    • Nemeth, E.1    Preza, G.C.2    Jung, C.L.3    Kaplan, J.4    Waring, A.J.5    Ganz, T.6
  • 72
    • 2342510407 scopus 로고    scopus 로고
    • IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
    • Nemeth E, Rivera S, Gabayan V, Keller C, Taudorf S, Pedersen BK, Ganz T ( 2004) IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest 113:1271-6.
    • (2004) J Clin Invest , vol.113 , pp. 1271-1276
    • Nemeth, E.1    Rivera, S.2    Gabayan, V.3    Keller, C.4    Taudorf, S.5    Pedersen, B.K.6    Ganz, T.7
  • 73
    • 0035902605 scopus 로고    scopus 로고
    • Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice
    • Nicolas G, Bennoun M, Devaux I, Beaumont C, Grandchamp B, Kahn A, Vaulont S ( 2001) Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc Natl Acad Sci USA 98:8780-5.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 8780-8785
    • Nicolas, G.1    Bennoun, M.2    Devaux, I.3    Beaumont, C.4    Grandchamp, B.5    Kahn, A.6    Vaulont, S.7
  • 77
    • 62149129583 scopus 로고    scopus 로고
    • Alpha-1 antitrypsin binds preprohepcidin intracellularly and prohepcidin in the serum
    • Pandur E, Nagy J, Poor VS, Sarnyai A, Huszar A, Miseta A, Sipos K ( 2009) Alpha-1 antitrypsin binds preprohepcidin intracellularly and prohepcidin in the serum. FEBS J 276:2012-21.
    • (2009) FEBS J , vol.276 , pp. 2012-2021
    • Pandur, E.1    Nagy, J.2    Poor, V.S.3    Sarnyai, A.4    Huszar, A.5    Miseta, A.6    Sipos, K.7
  • 81
    • 0035896642 scopus 로고    scopus 로고
    • Hepcidin, a urinary antimicrobial peptide synthesized in the liver
    • Park CH, Valore EV, Waring AJ, Ganz T ( 2001) Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem 276:7806-10.
    • (2001) J Biol Chem , vol.276 , pp. 7806-7810
    • Park, C.H.1    Valore, E.V.2    Waring, A.J.3    Ganz, T.4
  • 82
    • 84905739777 scopus 로고    scopus 로고
    • SnapShot: eukaryotic Fe-S protein biogenesis
    • 384-3e1
    • Paul VD, Lill R ( 2014) SnapShot: eukaryotic Fe-S protein biogenesis. Cell Metab 20:384-e1.
    • (2014) Cell Metab , vol.20
    • Paul, V.D.1    Lill, R.2
  • 85
    • 0035896581 scopus 로고    scopus 로고
    • A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload
    • Pigeon C, Ilyin G, Courselaud B, Leroyer P, Turlin B, Brissot P, Loreal O ( 2001) A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem 276:7811-9.
    • (2001) J Biol Chem , vol.276 , pp. 7811-7819
    • Pigeon, C.1    Ilyin, G.2    Courselaud, B.3    Leroyer, P.4    Turlin, B.5    Brissot, P.6    Loreal, O.7
  • 86
    • 47049116150 scopus 로고    scopus 로고
    • Erythropoietin mediates hepcidin expression in hepatocytes through EPOR signaling and regulation of C/EBPalpha
    • Pinto JP, Ribeiro S, Pontes H, Thowfeequ S, Tosh D, Carvalho F, Porto G ( 2008) Erythropoietin mediates hepcidin expression in hepatocytes through EPOR signaling and regulation of C/EBPalpha. Blood 111:5727-33.
    • (2008) Blood , vol.111 , pp. 5727-5733
    • Pinto, J.P.1    Ribeiro, S.2    Pontes, H.3    Thowfeequ, S.4    Tosh, D.5    Carvalho, F.6    Porto, G.7
  • 88
    • 78149271252 scopus 로고    scopus 로고
    • Transferrin receptor 2 and HFE regulate furin expression via mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/Erk) signaling. Implications for transferrin-dependent hepcidin regulation
    • Poli M, Luscieti S, Gandini V, Maccarinelli F, Finazzi D, Silvestri L, Roetto A, Arosio P ( 2010) Transferrin receptor 2 and HFE regulate furin expression via mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/Erk) signaling. Implications for transferrin-dependent hepcidin regulation. Haematologica 95: 1832-40.
    • (2010) Haematologica , vol.95 , pp. 1832-1840
    • Poli, M.1    Luscieti, S.2    Gandini, V.3    Maccarinelli, F.4    Finazzi, D.5    Silvestri, L.6    Roetto, A.7    Arosio, P.8
  • 89
    • 84928501223 scopus 로고    scopus 로고
    • Polychlorinated biphenyls (PCBs) inhibit hepcidin expression through an estrogen-like effect associated with disordered systemic iron homeostasis
    • Qian Y, Zhang S, Guo W, Ma J, Chen Y, Wang L, Zhao M, Liu S. ( 2015). Polychlorinated biphenyls (PCBs) inhibit hepcidin expression through an estrogen-like effect associated with disordered systemic iron homeostasis. Chem Res Toxicol 28:629-40.
    • (2015) Chem Res Toxicol , vol.28 , pp. 629-640
    • Qian, Y.1    Zhang, S.2    Guo, W.3    Ma, J.4    Chen, Y.5    Wang, L.6    Zhao, M.7    Liu, S.8
  • 90
    • 85005921759 scopus 로고    scopus 로고
    • The systemic iron-regulatory proteins hepcidin and ferroportin are reduced in the brain in Alzheimer's disease
    • Raha AA, Vaishnav RA, Friedland RP, Bomford A, Raha-Chowdhury R ( 2013) The systemic iron-regulatory proteins hepcidin and ferroportin are reduced in the brain in Alzheimer's disease. Acta Neuropathol Commun 1:55.
    • (2013) Acta Neuropathol Commun , vol.1 , pp. 55
    • Raha, A.A.1    Vaishnav, R.A.2    Friedland, R.P.3    Bomford, A.4    Raha-Chowdhury, R.5
  • 94
    • 63649105326 scopus 로고    scopus 로고
    • Plasma hepcidin concentrations significantly predict interindividual variation in iron absorption in healthy men
    • Roe MA, Collings R, Dainty JR, Swinkels DW, Fairweather-Tait SJ ( 2009) Plasma hepcidin concentrations significantly predict interindividual variation in iron absorption in healthy men. Am J Clin Nutr 89:1088-91.
    • (2009) Am J Clin Nutr , vol.89 , pp. 1088-1091
    • Roe, M.A.1    Collings, R.2    Dainty, J.R.3    Swinkels, D.W.4    Fairweather-Tait, S.J.5
  • 95
    • 84896736426 scopus 로고    scopus 로고
    • The pathophysiology and pharmacology of hepcidin
    • Ruchala P, Nemeth E ( 2014) The pathophysiology and pharmacology of hepcidin. Trends Pharmacol Sci 35:155-61.
    • (2014) Trends Pharmacol Sci , vol.35 , pp. 155-161
    • Ruchala, P.1    Nemeth, E.2
  • 98
    • 84897000909 scopus 로고    scopus 로고
    • Mitochondrial iron-sulfur protein biogenesis and human disease
    • Stehling O, Wilbrecht C, Lill R ( 2014) Mitochondrial iron-sulfur protein biogenesis and human disease. Biochimie 100:61-77.
    • (2014) Biochimie , vol.100 , pp. 61-77
    • Stehling, O.1    Wilbrecht, C.2    Lill, R.3
  • 99
    • 84884976029 scopus 로고    scopus 로고
    • Interleukin-1 receptor antagonist gene polymorphism and hepcidin in rheumatoid arthritis: correlations with clinical and laboratory indices of disease activity
    • Swellam M, Gabal KM, Youssef SS ( 2013) Interleukin-1 receptor antagonist gene polymorphism and hepcidin in rheumatoid arthritis: correlations with clinical and laboratory indices of disease activity. IUBMB Life 65:883-8.
    • (2013) IUBMB Life , vol.65 , pp. 883-888
    • Swellam, M.1    Gabal, K.M.2    Youssef, S.S.3
  • 101
    • 84916882462 scopus 로고    scopus 로고
    • Perturbed iron distribution in Alzheimer's disease serum, cerebrospinal fluid, and selected brain regions: a systematic review and meta-analysis
    • Tao Y, Wang Y, Rogers JT, Wang F ( 2014a) Perturbed iron distribution in Alzheimer's disease serum, cerebrospinal fluid, and selected brain regions: a systematic review and meta-analysis. Cerebrospinal Fluid 679-90.
    • (2014) Cerebrospinal Fluid , pp. 679-690
    • Tao, Y.1    Wang, Y.2    Rogers, J.T.3    Wang, F.4
  • 102
    • 84890044506 scopus 로고    scopus 로고
    • Expression, purification and antibacterial activity of the channel catfish hepcidin mature peptide
    • Tao Y, Zhao DM, Wen Y ( 2014b) Expression, purification and antibacterial activity of the channel catfish hepcidin mature peptide. Protein Expr Purif 94:73-8.
    • (2014) Protein Expr Purif , vol.94 , pp. 73-78
    • Tao, Y.1    Zhao, D.M.2    Wen, Y.3
  • 106
    • 84873467895 scopus 로고    scopus 로고
    • Hepcidin is a potential regulator of iron status in chronic kidney disease
    • Tsuchiya K, Nitta K ( 2013) Hepcidin is a potential regulator of iron status in chronic kidney disease. Ther Apher Dial 17:1-8.
    • (2013) Ther Apher Dial , vol.17 , pp. 1-8
    • Tsuchiya, K.1    Nitta, K.2
  • 107
    • 84885953717 scopus 로고    scopus 로고
    • Inflammation alters the expression of DMT1, FPN1 and hepcidin, and it causes iron accumulation in central nervous system cells
    • Urrutia P, Aguirre P, Esparza A, Tapia V, Mena NP, Arredondo M, Gonzalez-Billault C, Nunez MT ( 2013) Inflammation alters the expression of DMT1, FPN1 and hepcidin, and it causes iron accumulation in central nervous system cells. J Neurochem 126:541-9.
    • (2013) J Neurochem , vol.126 , pp. 541-549
    • Urrutia, P.1    Aguirre, P.2    Esparza, A.3    Tapia, V.4    Mena, N.P.5    Arredondo, M.6    Gonzalez-Billault, C.7    Nunez, M.T.8
  • 108
    • 36549034762 scopus 로고    scopus 로고
    • Posttranslational processing of hepcidin in human hepatocytes is mediated by the prohormone convertase furin
    • Valore EV, Ganz T ( 2008) Posttranslational processing of hepcidin in human hepatocytes is mediated by the prohormone convertase furin. Blood Cells Mol Dis 40:132-8.
    • (2008) Blood Cells Mol Dis , vol.40 , pp. 132-138
    • Valore, E.V.1    Ganz, T.2
  • 109
    • 78751695016 scopus 로고    scopus 로고
    • Diagnosis and management of hereditary haemochromatosis
    • van Bokhoven MA, van Deursen CT, Swinkels DW ( 2011) Diagnosis and management of hereditary haemochromatosis. BMJ 342:c7251.
    • (2011) BMJ , vol.342 , pp. c7251
    • van Bokhoven, M.A.1    van Deursen, C.T.2    Swinkels, D.W.3
  • 111
    • 78650975203 scopus 로고    scopus 로고
    • Inflammation-induced hepcidin-25 is associated with the development of anemia in septic patients: an observational study
    • van Eijk LT, Kroot JJ, Tromp M, van der Hoeven JG, Swinkels DW, Pickkers P ( 2011) Inflammation-induced hepcidin-25 is associated with the development of anemia in septic patients: an observational study. Crit Care 15:R9.
    • (2011) Crit Care , vol.15 , pp. R9
    • van Eijk, L.T.1    Kroot, J.J.2    Tromp, M.3    van der Hoeven, J.G.4    Swinkels, D.W.5    Pickkers, P.6
  • 112
    • 84875582275 scopus 로고    scopus 로고
    • Iron-sulfur cluster synthesis, iron homeostasis and oxidative stress in Friedreich ataxia
    • Vaubel RA, Isaya G ( 2013) Iron-sulfur cluster synthesis, iron homeostasis and oxidative stress in Friedreich ataxia. Mol Cell Neurosci 55:50-61.
    • (2013) Mol Cell Neurosci , vol.55 , pp. 50-61
    • Vaubel, R.A.1    Isaya, G.2
  • 113
    • 84866437586 scopus 로고    scopus 로고
    • Hepcidin as a biomarker for the diagnosis of iron metabolism disorders: a review
    • Vermeulen E, Vermeersch P ( 2012) Hepcidin as a biomarker for the diagnosis of iron metabolism disorders: a review. Acta Clin Belg 67:190-7.
    • (2012) Acta Clin Belg , vol.67 , pp. 190-197
    • Vermeulen, E.1    Vermeersch, P.2
  • 114
    • 84904626934 scopus 로고    scopus 로고
    • The role of TMPRSS6/matriptase-2 in iron regulation and anemia
    • Wang CY, Meynard D, Lin HY ( 2014) The role of TMPRSS6/matriptase-2 in iron regulation and anemia. Front Pharmacol 5:114.
    • (2014) Front Pharmacol , vol.5 , pp. 114
    • Wang, C.Y.1    Meynard, D.2    Lin, H.Y.3
  • 115
    • 47949130644 scopus 로고    scopus 로고
    • Lipopolysaccharide induces a significant increase in expression of iron regulatory hormone hepcidin in the cortex and substantia nigra in rat brain
    • Wang Q, Du F, Qian ZM, Ge XH, Zhu L, Yung WH, Yang L, Ke Y ( 2008) Lipopolysaccharide induces a significant increase in expression of iron regulatory hormone hepcidin in the cortex and substantia nigra in rat brain. Endocrinology 149:3920-5.
    • (2008) Endocrinology , vol.149 , pp. 3920-3925
    • Wang, Q.1    Du, F.2    Qian, Z.M.3    Ge, X.H.4    Zhu, L.5    Yung, W.H.6    Yang, L.7    Ke, Y.8
  • 117
    • 84897930781 scopus 로고    scopus 로고
    • The role of hepatic transferrin receptor 2 in the regulation of iron homeostasis in the body
    • Worthen CA, Enns CA ( 2014) The role of hepatic transferrin receptor 2 in the regulation of iron homeostasis in the body. Front Pharmacol 5:34.
    • (2014) Front Pharmacol , vol.5 , pp. 34
    • Worthen, C.A.1    Enns, C.A.2
  • 119
    • 33748569185 scopus 로고    scopus 로고
    • Distribution of the iron-regulating protein hepcidin in the murine central nervous system
    • Zechel S, Huber-Wittmer K, von Bohlen und Halbach O ( 2006) Distribution of the iron-regulating protein hepcidin in the murine central nervous system. J Neurosci Res 84: 790-800.
    • (2006) J Neurosci Res , vol.84 , pp. 790-800
    • Zechel, S.1    Huber-Wittmer, K.2    von Bohlen und Halbach, O.3
  • 120
    • 77949475176 scopus 로고    scopus 로고
    • Molecular mechanisms of normal iron homeostasis
    • Zhang AS, Enns CA ( 2009) Molecular mechanisms of normal iron homeostasis. Hematology 2009:207-14.
    • (2009) Hematology , vol.2009 , pp. 207-214
    • Zhang, A.S.1    Enns, C.A.2
  • 121
    • 77958483994 scopus 로고    scopus 로고
    • Hepcidin expression by human monocytes in response to adhesion and pro-inflammatory cytokines
    • Zhang X, Rovin BH ( 2010) Hepcidin expression by human monocytes in response to adhesion and pro-inflammatory cytokines. Biochim Biophys Acta 1800:1262-7.
    • (2010) Biochim Biophys Acta , vol.1800 , pp. 1262-1267
    • Zhang, X.1    Rovin, B.H.2
  • 124
    • 84888133550 scopus 로고    scopus 로고
    • Serum hepcidin measured with an improved ELISA correlates with parameters of iron metabolism in patients with myelodysplastic syndrome
    • Zipperer E, Post JG, Herkert M, Kundgen A, Fox F, Haas R, Gattermann N, Germing U ( 2013) Serum hepcidin measured with an improved ELISA correlates with parameters of iron metabolism in patients with myelodysplastic syndrome. Ann Hematol 92:1617-23.
    • (2013) Ann Hematol , vol.92 , pp. 1617-1623
    • Zipperer, E.1    Post, J.G.2    Herkert, M.3    Kundgen, A.4    Fox, F.5    Haas, R.6    Gattermann, N.7    Germing, U.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.