Hepcidin Suppresses Brain Iron Accumulation by Downregulating Iron Transport Proteins in Iron-Overloaded Rats

Molecular Neurobiology

Volumn 52, Issue 1, 2015, Pages 101-114

  Du, Fang ^a,b   Qian, Zhong Ming ^a   Luo, Qianqian ^a   Yung, Wing Ho ^b   Ke, Ya ^b  

^a FUDAN UNIVERSITY   (China)

^b Prince of Wales Hospital   (Hong Kong)

Author keywords

Brain iron homeostasis; Brain microvascular endothelial cell (BMEC); Divalent metal transporter 1 (DMT1); Ferroportin 1 (Fpn1); Hepcidin; Iron overload; Non transferrin bound iron (NTBI); Transferrin receptor 1 (TfR1); Transferrin bound iron (Tf Fe)

Indexed keywords

CARRIER PROTEIN; CD71 ANTIGEN; FERROPORTIN 1; HEPCIDIN; IRON; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; VIRUS VECTOR; CATION TRANSPORT PROTEIN; HOLOTRANSFERRIN; LEUKOCYTE ANTIGEN; METAL TRANSPORTING PROTEIN 1; SOLUTE CARRIER FAMILY 11- (PROTON-COUPLED DIVALENT METAL ION TRANSPORTERS), MEMBER 2; TRANSFERRIN; TRANSFERRIN RECEPTOR;

ADENOVIRIDAE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; BIOACCUMULATION; BLOOD BRAIN BARRIER; BRAIN NERVE CELL; CAPILLARY ENDOTHELIAL CELL; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; IRON KINETICS; IRON OVERLOAD; IRON TRANSPORT; MALE; NONHUMAN; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; ANIMAL; BIOLOGICAL MODEL; BRAIN; CELL CULTURE; ENDOTHELIUM CELL; HUMAN; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; METABOLISM; NERVE CELL; SPRAGUE DAWLEY RAT; TRANSPORT AT THE CELLULAR LEVEL;

ADENOVIRIDAE; ANIMALS; ANTIGENS, CD; BIOLOGICAL TRANSPORT; BRAIN; CATION TRANSPORT PROTEINS; CELLS, CULTURED; DOWN-REGULATION; ENDOTHELIAL CELLS; HEPCIDINS; HUMANS; INJECTIONS, INTRAVENTRICULAR; IRON; IRON OVERLOAD; MALE; MODELS, BIOLOGICAL; NEURONS; RATS, SPRAGUE-DAWLEY; RECEPTORS, TRANSFERRIN; TRANSFERRIN;

EID: 84937919683     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-014-8847-x     Document Type: Article

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