-
1
-
-
0035902605
-
Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice
-
DOI 10.1073/pnas.151179498
-
Nicolas G, Bennoun M, Devaux I, Beaumont C, Grandchamp B, et al. (2001) Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc Natl Acad Sci U S A 98: 8780-8785. (Pubitemid 32678104)
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, Issue.15
, pp. 8780-8785
-
-
Nicolas, G.1
Bennoun, M.2
Devaux, I.3
Beaumont, C.4
Grandchamp, B.5
Kahn, A.6
Vaulont, S.7
-
2
-
-
10844258104
-
Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
-
DOI 10.1126/science.1104742
-
Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, et al. (2004) Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 306: 2090-2093. (Pubitemid 40007660)
-
(2004)
Science
, vol.306
, Issue.5704
, pp. 2090-2093
-
-
Nemeth, E.1
Tuttle, M.S.2
Powelson, J.3
Vaughn, M.D.4
Donovan, A.5
Ward, D.M.6
Ganz, T.7
Kaplan, J.8
-
3
-
-
79955958017
-
Hepcidin and iron regulation, 10 years later
-
Ganz T (2011) Hepcidin and iron regulation, 10 years later. Blood 117: 4425- 4433.
-
(2011)
Blood
, vol.117
, pp. 4425-4433
-
-
Ganz, T.1
-
4
-
-
0035896581
-
A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload
-
Pigeon C, Ilyin G, Courselaud B, Leroyer P, Turlin B, et al. (2001) A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem 276: 7811-7819.
-
(2001)
J Biol Chem
, vol.276
, pp. 7811-7819
-
-
Pigeon, C.1
Ilyin, G.2
Courselaud, B.3
Leroyer, P.4
Turlin, B.5
-
5
-
-
0036791486
-
The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation
-
Nicolas G, Chauvet C, Viatte L, Danan JL, Bigard X, et al. (2002) The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J Clin Invest 110: 1037-1044.
-
(2002)
J Clin Invest
, vol.110
, pp. 1037-1044
-
-
Nicolas, G.1
Chauvet, C.2
Viatte, L.3
Danan, J.L.4
Bigard, X.5
-
6
-
-
33646370235
-
Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression
-
Babitt JL, Huang FW, Wrighting DM, Xia Y, Sidis Y, et al. (2006) Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat Genet 38: 531-539.
-
(2006)
Nat Genet
, vol.38
, pp. 531-539
-
-
Babitt, J.L.1
Huang, F.W.2
Wrighting, D.M.3
Xia, Y.4
Sidis, Y.5
-
7
-
-
34447137331
-
Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance
-
DOI 10.1172/JCI31342
-
Babitt JL, Huang FW, Xia Y, Sidis Y, Andrews NC, et al. (2007) Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance. J Clin Invest 117: 1933-1939. (Pubitemid 47036327)
-
(2007)
Journal of Clinical Investigation
, vol.117
, Issue.7
, pp. 1933-1939
-
-
Babitt, J.L.1
Huang, F.W.2
Xia, Y.3
Sidis, Y.4
Andrews, N.C.5
Lin, H.Y.6
-
8
-
-
0038682002
-
Mechanisms of TGF-beta signaling from cell membrane to the nucleus
-
DOI 10.1016/S0092-8674(03)00432-X
-
Shi Y, Massague J (2003) Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 113: 685-700. (Pubitemid 36724933)
-
(2003)
Cell
, vol.113
, Issue.6
, pp. 685-700
-
-
Shi, Y.1
Massague, J.2
-
9
-
-
63449103712
-
BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism
-
Andriopoulos B Jr, Corradini E, Xia Y, Faasse SA, Chen S, et al. (2009) BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism. Nat Genet 41: 482-487.
-
(2009)
Nat Genet
, vol.41
, pp. 482-487
-
-
Andriopoulos Jr., B.1
Corradini, E.2
Xia, Y.3
Faasse, S.A.4
Chen, S.5
-
10
-
-
36849036351
-
Mechanisms of iron loading and toxicity
-
Anderson GJ (2007) Mechanisms of iron loading and toxicity. Am J Hematol 82: 1128-1131.
-
(2007)
Am J Hematol
, vol.82
, pp. 1128-1131
-
-
Anderson, G.J.1
-
11
-
-
51649096725
-
Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver
-
Kautz L, Meynard D, Monnier A, Darnaud V, Bouvet R, et al. (2008) Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver. Blood 112: 1503-1509.
-
(2008)
Blood
, vol.112
, pp. 1503-1509
-
-
Kautz, L.1
Meynard, D.2
Monnier, A.3
Darnaud, V.4
Bouvet, R.5
-
12
-
-
63449122819
-
Lack of the bone morphogenetic protein BMP6 induces massive iron overload
-
Meynard D, Kautz L, Darnaud V, Canonne-Hergaux F, Coppin H, et al. (2009) Lack of the bone morphogenetic protein BMP6 induces massive iron overload. Nat Genet 41: 478-481.
-
(2009)
Nat Genet
, vol.41
, pp. 478-481
-
-
Meynard, D.1
Kautz, L.2
Darnaud, V.3
Canonne-Hergaux, F.4
Coppin, H.5
-
13
-
-
23644444316
-
Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload
-
DOI 10.1172/JCI25683
-
Niederkofler V, Salie R, Arber S (2005) Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload. J Clin Invest 115: 2180-2186. (Pubitemid 41134159)
-
(2005)
Journal of Clinical Investigation
, vol.115
, Issue.8
, pp. 2180-2186
-
-
Niederkofler, V.1
Salie, R.2
Arber, S.3
-
14
-
-
23644460325
-
A mouse model of juvenile hemochromatosis
-
DOI 10.1172/JCI25049
-
Huang FW, Pinkus JL, Pinkus GS, Fleming MD, Andrews NC (2005) A mouse model of juvenile hemochromatosis. J Clin Invest 115: 2187-2191. (Pubitemid 41134160)
-
(2005)
Journal of Clinical Investigation
, vol.115
, Issue.8
, pp. 2187-2191
-
-
Huang, F.W.1
Pinkus, J.L.2
Pinkus, G.S.3
Fleming, M.D.4
Andrews, N.C.5
-
15
-
-
79959437085
-
Skeletal muscle hemojuvelin is dispensable for systemic iron homeostasis
-
Chen W, Huang FW, de Renshaw TB, Andrews NC (2011) Skeletal muscle hemojuvelin is dispensable for systemic iron homeostasis. Blood 117: 6319-6325.
-
(2011)
Blood
, vol.117
, pp. 6319-6325
-
-
Chen, W.1
Huang, F.W.2
De Renshaw, T.B.3
Andrews, N.C.4
-
16
-
-
33644876815
-
A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression
-
Wang RH, Li C, Xu X, Zheng Y, Xiao C, et al. (2005) A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression. Cell Metab 2: 399-409.
-
(2005)
Cell Metab
, vol.2
, pp. 399-409
-
-
Wang, R.H.1
Li, C.2
Xu, X.3
Zheng, Y.4
Xiao, C.5
-
17
-
-
79953757053
-
Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice
-
Ramos E, Kautz L, Rodriguez R, Hansen M, Gabayan V, et al. (2011) Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice. Hepatology 53: 1333-1341.
-
(2011)
Hepatology
, vol.53
, pp. 1333-1341
-
-
Ramos, E.1
Kautz, L.2
Rodriguez, R.3
Hansen, M.4
Gabayan, V.5
-
18
-
-
0032959574
-
Transferrin receptor is necessary for development of erythrocytes and the nervous system
-
DOI 10.1038/7727
-
Levy JE, Jin O, Fujiwara Y, Kuo F, Andrews NC (1999) Transferrin receptor is necessary for development of erythrocytes and the nervous system. Nat Genet 21: 396-399. (Pubitemid 29159576)
-
(1999)
Nature Genetics
, vol.21
, Issue.4
, pp. 396-399
-
-
Levy, J.E.1
Jin, O.2
Fujiwara, Y.3
Kuo, F.4
Andrews, N.C.5
-
19
-
-
32644437864
-
Iron metabolism in the hemoglobin-deficit mouse: Correlation of diferric transferrin with hepcidin expression
-
DOI 10.1182/blood-2005-07-2614
-
Wilkins SJ, Frazer DM, Millard KN, McLaren GD, Anderson GJ (2006) Iron metabolism in the hemoglobin-deficit mouse: correlation of diferric transferrin with hepcidin expression. Blood 107: 1659-1664. (Pubitemid 43242406)
-
(2006)
Blood
, vol.107
, Issue.4
, pp. 1659-1664
-
-
Wilkins, S.J.1
Frazer, D.M.2
Millard, K.N.3
McLaren, G.D.4
Anderson, G.J.5
-
20
-
-
0034254752
-
The molecular defect in hypotransferrinemic mice
-
Trenor CC 3rd, Campagna DR, Sellers VM, Andrews NC, Fleming MD (2000) The molecular defect in hypotransferrinemic mice. Blood 96: 1113-1118. (Pubitemid 30616881)
-
(2000)
Blood
, vol.96
, Issue.3
, pp. 1113-1118
-
-
Trenor III, C.C.1
Campagna, D.R.2
Sellers, V.M.3
Andrews, N.C.4
Fleming, M.D.5
-
21
-
-
0027360042
-
Studies on familial hypotransferrinemia: Unique clinical course and molecular pathology
-
Hayashi A, Wada Y, Suzuki T, Shimizu A (1993) Studies on familial hypotransferrinemia: unique clinical course and molecular pathology. Am J Hum Genet 53: 201-213. (Pubitemid 23313751)
-
(1993)
American Journal of Human Genetics
, vol.53
, Issue.1
, pp. 201-213
-
-
Hayashi, A.1
Wada, Y.2
Suzuki, T.3
Shimizu, A.4
-
22
-
-
78751558997
-
Transferrin is a major determinant of hepcidin expression in hypotransferrinemic mice
-
Bartnikas TB, Andrews NC, Fleming MD (2011) Transferrin is a major determinant of hepcidin expression in hypotransferrinemic mice. Blood 117: 630-637.
-
(2011)
Blood
, vol.117
, pp. 630-637
-
-
Bartnikas, T.B.1
Andrews, N.C.2
Fleming, M.D.3
-
23
-
-
79959562083
-
Serum and liver iron differently regulate the bone morphogenetic protein 6 (BMP6)-SMAD signaling pathway in mice
-
Corradini E, Meynard D, Wu Q, Chen S, Ventura P, et al. (2011) Serum and liver iron differently regulate the bone morphogenetic protein 6 (BMP6)-SMAD signaling pathway in mice. Hepatology 54: 273-284.
-
(2011)
Hepatology
, vol.54
, pp. 273-284
-
-
Corradini, E.1
Meynard, D.2
Wu, Q.3
Chen, S.4
Ventura, P.5
-
24
-
-
39649115776
-
The Transferrin Receptor Modulates Hfe-Dependent Regulation of Hepcidin Expression
-
DOI 10.1016/j.cmet.2007.11.016, PII S1550413107003737
-
Schmidt PJ, Toran PT, Giannetti AM, Bjorkman PJ, Andrews NC (2008) The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression. Cell Metab 7: 205-214. (Pubitemid 351285524)
-
(2008)
Cell Metabolism
, vol.7
, Issue.3
, pp. 205-214
-
-
Schmidt, P.J.1
Toran, P.T.2
Giannetti, A.M.3
Bjorkman, P.J.4
Andrews, N.C.5
-
25
-
-
0001376313
-
HFE gene knockout produces mouse model of hereditary hemochromatosis
-
DOI 10.1073/pnas.95.5.2492
-
Zhou XY, Tomatsu S, Fleming RE, Parkkila S, Waheed A, et al. (1998) HFE gene knockout produces mouse model of hereditary hemochromatosis. Proc Natl Acad Sci U S A 95: 2492-2497. (Pubitemid 28145969)
-
(1998)
Proceedings of the National Academy of Sciences of the United States of America
, vol.95
, Issue.5
, pp. 2492-2497
-
-
Zhou, X.Y.1
Tomatsu, S.2
Fleming, R.E.3
Parkkila, S.4
Waheed, A.5
Jiang, J.6
Fei, Y.7
Brunt, E.M.8
Ruddy, D.A.9
Prass, C.E.10
Schatzman, R.C.11
O'Neill, R.12
Britton, R.S.13
Bacon, B.R.14
Sly, W.S.15
-
26
-
-
0036678091
-
Targeted mutagenesis of the murine transferrin receptor-2 gene produces hemochromatosis
-
Fleming RE, Ahmann JR, Migas MC, Waheed A, Koeffler HP, et al. (2002) Targeted mutagenesis of the murine transferrin receptor-2 gene produces hemochromatosis. Proc Natl Acad Sci U S A 99: 10653-10658.
-
(2002)
Proc Natl Acad Sci U S a
, vol.99
, pp. 10653-10658
-
-
Fleming, R.E.1
Ahmann, J.R.2
Migas, M.C.3
Waheed, A.4
Koeffler, H.P.5
-
27
-
-
73149083742
-
Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload
-
Wallace DF, Summerville L, Crampton EM, Frazer DM, Anderson GJ, et al. (2009) Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload. Hepatology 50: 1992-2000.
-
(2009)
Hepatology
, vol.50
, pp. 1992-2000
-
-
Wallace, D.F.1
Summerville, L.2
Crampton, E.M.3
Frazer, D.M.4
Anderson, G.J.5
-
28
-
-
84865565820
-
Ferroportin1 in hepatocytes and macrophages is required for the efficient mobilization of body iron stores in mice
-
Zhang Z, Zhang F, Guo X, An P, Tao Y, et al. (2012) Ferroportin1 in hepatocytes and macrophages is required for the efficient mobilization of body iron stores in mice. Hepatology 56: 961-971.
-
(2012)
Hepatology
, vol.56
, pp. 961-971
-
-
Zhang, Z.1
Zhang, F.2
Guo, X.3
An, P.4
Tao, Y.5
-
29
-
-
0035865048
-
Tie2-Cre transgenic mice: A new model for endothelial cell-lineage analysis in vivo
-
Kisanuki YY, Hammer RE, Miyazaki J, Williams SC, Richardson JA, et al. (2001) Tie2-Cre transgenic mice: a new model for endothelial cell-lineage analysis in vivo. Dev Biol 230: 230-242.
-
(2001)
Dev Biol
, vol.230
, pp. 230-242
-
-
Kisanuki, Y.Y.1
Hammer, R.E.2
Miyazaki, J.3
Williams, S.C.4
Richardson, J.A.5
-
30
-
-
0035911253
-
Conditional vascular cell adhesion molecule 1 deletion in mice: Impaired lymphocyte migration to bone marrow
-
Koni PA, Joshi SK, Temann UA, Olson D, Burkly L, et al. (2001) Conditional vascular cell adhesion molecule 1 deletion in mice: impaired lymphocyte migration to bone marrow. J Exp Med 193: 741-754.
-
(2001)
J Exp Med
, vol.193
, pp. 741-754
-
-
Koni, P.A.1
Joshi, S.K.2
Temann, U.A.3
Olson, D.4
Burkly, L.5
-
31
-
-
80051895753
-
Ferroportin1 deficiency in mouse macrophages impairs iron homeostasis and inflammatory responses
-
Zhang Z, Zhang F, An P, Guo X, Shen Y, et al. (2011) Ferroportin1 deficiency in mouse macrophages impairs iron homeostasis and inflammatory responses. Blood 118: 1912-1922.
-
(2011)
Blood
, vol.118
, pp. 1912-1922
-
-
Zhang, Z.1
Zhang, F.2
An, P.3
Guo, X.4
Shen, Y.5
-
32
-
-
33751175421
-
Interleukin-6 induces hepcidin expression through STAT3
-
Wrighting DM, Andrews NC (2006) Interleukin-6 induces hepcidin expression through STAT3. Blood 108: 3204-3209.
-
(2006)
Blood
, vol.108
, pp. 3204-3209
-
-
Wrighting, D.M.1
Andrews, N.C.2
-
33
-
-
33845245942
-
Suppression of hepcidin during anemia requires erythropoietic activity
-
DOI 10.1182/blood-2006-06-028787
-
Pak M, Lopez MA, Gabayan V, Ganz T, Rivera S (2006) Suppression of hepcidin during anemia requires erythropoietic activity. Blood 108: 3730-3735. (Pubitemid 44864551)
-
(2006)
Blood
, vol.108
, Issue.12
, pp. 3730-3735
-
-
Pak, M.1
Lopez, M.A.2
Gabayan, V.3
Ganz, T.4
Rivera, S.5
-
34
-
-
47049116150
-
Erythropoietin mediates hepcidin expression in hepatocytes through EPOR signaling and regulation of C/EBPalpha
-
Pinto JP, Ribeiro S, Pontes H, Thowfeequ S, Tosh D, et al. (2008) Erythropoietin mediates hepcidin expression in hepatocytes through EPOR signaling and regulation of C/EBPalpha. Blood 111: 5727-5733.
-
(2008)
Blood
, vol.111
, pp. 5727-5733
-
-
Pinto, J.P.1
Ribeiro, S.2
Pontes, H.3
Thowfeequ, S.4
Tosh, D.5
-
35
-
-
77950300851
-
Effect of erythropoietin on hepcidin expression in hemojuvelin-mutant mice
-
Krijt J, Jonasova A, Neuwirtova R, Necas E (2010) Effect of erythropoietin on hepcidin expression in hemojuvelin-mutant mice. Blood Cells Mol Dis 44: 257-261.
-
(2010)
Blood Cells Mol Dis
, vol.44
, pp. 257-261
-
-
Krijt, J.1
Jonasova, A.2
Neuwirtova, R.3
Necas, E.4
-
36
-
-
84862531062
-
Ferritin upregulates hepatic expression of bone morphogenetic protein 6 and hepcidin in mice
-
Feng Q, Migas MC, Waheed A, Britton RS, Fleming RE (2012) Ferritin upregulates hepatic expression of bone morphogenetic protein 6 and hepcidin in mice. Am J Physiol Gastrointest Liver Physiol 302: G1397-1404.
-
(2012)
Am J Physiol Gastrointest Liver Physiol
, vol.302
-
-
Feng, Q.1
Migas, M.C.2
Waheed, A.3
Britton, R.S.4
Fleming, R.E.5
-
37
-
-
79551629285
-
Suppression of hepatic hepcidin expression in response to acute iron deprivation is associated with an increase of matriptase-2 protein
-
Zhang AS, Anderson SA, Wang J, Yang F, DeMaster K, et al. (2011) Suppression of hepatic hepcidin expression in response to acute iron deprivation is associated with an increase of matriptase-2 protein. Blood 117: 1687-1699.
-
(2011)
Blood
, vol.117
, pp. 1687-1699
-
-
Zhang, A.S.1
Anderson, S.A.2
Wang, J.3
Yang, F.4
DeMaster, K.5
-
38
-
-
84856423238
-
Hemojuvelin is essential for transferrindependent and transferrin-independent hepcidin expression in mice
-
Bartnikas TB, Fleming MD (2012) Hemojuvelin is essential for transferrindependent and transferrin-independent hepcidin expression in mice. Haematologica 97: 189-192.
-
(2012)
Haematologica
, vol.97
, pp. 189-192
-
-
Bartnikas, T.B.1
Fleming, M.D.2
-
39
-
-
76349118307
-
Transferrin therapy ameliorates disease in beta-thalassemic mice
-
Li H, Rybicki AC, Suzuka SM, von Bonsdorff L, Breuer W, et al. (2010) Transferrin therapy ameliorates disease in beta-thalassemic mice. Nat Med 16: 177-182.
-
(2010)
Nat Med
, vol.16
, pp. 177-182
-
-
Li, H.1
Rybicki, A.C.2
Suzuka, S.M.3
Von Bonsdorff, L.4
Breuer, W.5
-
40
-
-
66749183353
-
Cross-talk between the mitogen activated protein kinase and bone morphogenetic protein/hemojuvelin pathways is required for the induction of hepcidin by holotransferrin in primary mouse hepatocytes
-
Ramey G, Deschemin JC, Vaulont S (2009) Cross-talk between the mitogen activated protein kinase and bone morphogenetic protein/hemojuvelin pathways is required for the induction of hepcidin by holotransferrin in primary mouse hepatocytes. Haematologica 94: 765-772.
-
(2009)
Haematologica
, vol.94
, pp. 765-772
-
-
Ramey, G.1
Deschemin, J.C.2
Vaulont, S.3
-
41
-
-
84859336675
-
Decreased hepcidin expression in murine beta-thalassemia is associated with suppression of Bmp/Smad signaling
-
Parrow NL, Gardenghi S, Ramos P, Casu C, Grady RW, et al. (2012) Decreased hepcidin expression in murine beta-thalassemia is associated with suppression of Bmp/Smad signaling. Blood 119: 3187-3189.
-
(2012)
Blood
, vol.119
, pp. 3187-3189
-
-
Parrow, N.L.1
Gardenghi, S.2
Ramos, P.3
Casu, C.4
Grady, R.W.5
-
42
-
-
84860842095
-
Stimulated erythropoiesis with secondary iron loading leads to a decrease in hepcidin despite an increase in bone morphogenetic protein 6 expression
-
Frazer DM, Wilkins SJ, Darshan D, Badrick AC, McLaren GD, et al. (2012) Stimulated erythropoiesis with secondary iron loading leads to a decrease in hepcidin despite an increase in bone morphogenetic protein 6 expression. Br J Haematol 157: 615-626.
-
(2012)
Br J Haematol
, vol.157
, pp. 615-626
-
-
Frazer, D.M.1
Wilkins, S.J.2
Darshan, D.3
Badrick, A.C.4
McLaren, G.D.5
|