메뉴 건너뛰기




Volumn 9, Issue 1, 2014, Pages

Bmp6 expression can be regulated independently of liver iron in mice

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN 6; ERYTHROPOIETIN; FERROPORTIN 1; HAMP1 PROTEIN; IRON; MESSENGER RNA; REGULATOR PROTEIN; SMAD1 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN; TRANSFERRIN; UNCLASSIFIED DRUG;

EID: 84897994449     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0084906     Document Type: Article
Times cited : (11)

References (42)
  • 2
    • 10844258104 scopus 로고    scopus 로고
    • Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
    • DOI 10.1126/science.1104742
    • Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, et al. (2004) Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 306: 2090-2093. (Pubitemid 40007660)
    • (2004) Science , vol.306 , Issue.5704 , pp. 2090-2093
    • Nemeth, E.1    Tuttle, M.S.2    Powelson, J.3    Vaughn, M.D.4    Donovan, A.5    Ward, D.M.6    Ganz, T.7    Kaplan, J.8
  • 3
    • 79955958017 scopus 로고    scopus 로고
    • Hepcidin and iron regulation, 10 years later
    • Ganz T (2011) Hepcidin and iron regulation, 10 years later. Blood 117: 4425- 4433.
    • (2011) Blood , vol.117 , pp. 4425-4433
    • Ganz, T.1
  • 4
    • 0035896581 scopus 로고    scopus 로고
    • A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload
    • Pigeon C, Ilyin G, Courselaud B, Leroyer P, Turlin B, et al. (2001) A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem 276: 7811-7819.
    • (2001) J Biol Chem , vol.276 , pp. 7811-7819
    • Pigeon, C.1    Ilyin, G.2    Courselaud, B.3    Leroyer, P.4    Turlin, B.5
  • 5
    • 0036791486 scopus 로고    scopus 로고
    • The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation
    • Nicolas G, Chauvet C, Viatte L, Danan JL, Bigard X, et al. (2002) The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J Clin Invest 110: 1037-1044.
    • (2002) J Clin Invest , vol.110 , pp. 1037-1044
    • Nicolas, G.1    Chauvet, C.2    Viatte, L.3    Danan, J.L.4    Bigard, X.5
  • 6
    • 33646370235 scopus 로고    scopus 로고
    • Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression
    • Babitt JL, Huang FW, Wrighting DM, Xia Y, Sidis Y, et al. (2006) Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat Genet 38: 531-539.
    • (2006) Nat Genet , vol.38 , pp. 531-539
    • Babitt, J.L.1    Huang, F.W.2    Wrighting, D.M.3    Xia, Y.4    Sidis, Y.5
  • 7
    • 34447137331 scopus 로고    scopus 로고
    • Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance
    • DOI 10.1172/JCI31342
    • Babitt JL, Huang FW, Xia Y, Sidis Y, Andrews NC, et al. (2007) Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance. J Clin Invest 117: 1933-1939. (Pubitemid 47036327)
    • (2007) Journal of Clinical Investigation , vol.117 , Issue.7 , pp. 1933-1939
    • Babitt, J.L.1    Huang, F.W.2    Xia, Y.3    Sidis, Y.4    Andrews, N.C.5    Lin, H.Y.6
  • 8
    • 0038682002 scopus 로고    scopus 로고
    • Mechanisms of TGF-beta signaling from cell membrane to the nucleus
    • DOI 10.1016/S0092-8674(03)00432-X
    • Shi Y, Massague J (2003) Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 113: 685-700. (Pubitemid 36724933)
    • (2003) Cell , vol.113 , Issue.6 , pp. 685-700
    • Shi, Y.1    Massague, J.2
  • 9
    • 63449103712 scopus 로고    scopus 로고
    • BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism
    • Andriopoulos B Jr, Corradini E, Xia Y, Faasse SA, Chen S, et al. (2009) BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism. Nat Genet 41: 482-487.
    • (2009) Nat Genet , vol.41 , pp. 482-487
    • Andriopoulos Jr., B.1    Corradini, E.2    Xia, Y.3    Faasse, S.A.4    Chen, S.5
  • 10
    • 36849036351 scopus 로고    scopus 로고
    • Mechanisms of iron loading and toxicity
    • Anderson GJ (2007) Mechanisms of iron loading and toxicity. Am J Hematol 82: 1128-1131.
    • (2007) Am J Hematol , vol.82 , pp. 1128-1131
    • Anderson, G.J.1
  • 11
    • 51649096725 scopus 로고    scopus 로고
    • Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver
    • Kautz L, Meynard D, Monnier A, Darnaud V, Bouvet R, et al. (2008) Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver. Blood 112: 1503-1509.
    • (2008) Blood , vol.112 , pp. 1503-1509
    • Kautz, L.1    Meynard, D.2    Monnier, A.3    Darnaud, V.4    Bouvet, R.5
  • 12
    • 63449122819 scopus 로고    scopus 로고
    • Lack of the bone morphogenetic protein BMP6 induces massive iron overload
    • Meynard D, Kautz L, Darnaud V, Canonne-Hergaux F, Coppin H, et al. (2009) Lack of the bone morphogenetic protein BMP6 induces massive iron overload. Nat Genet 41: 478-481.
    • (2009) Nat Genet , vol.41 , pp. 478-481
    • Meynard, D.1    Kautz, L.2    Darnaud, V.3    Canonne-Hergaux, F.4    Coppin, H.5
  • 13
    • 23644444316 scopus 로고    scopus 로고
    • Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload
    • DOI 10.1172/JCI25683
    • Niederkofler V, Salie R, Arber S (2005) Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload. J Clin Invest 115: 2180-2186. (Pubitemid 41134159)
    • (2005) Journal of Clinical Investigation , vol.115 , Issue.8 , pp. 2180-2186
    • Niederkofler, V.1    Salie, R.2    Arber, S.3
  • 15
    • 79959437085 scopus 로고    scopus 로고
    • Skeletal muscle hemojuvelin is dispensable for systemic iron homeostasis
    • Chen W, Huang FW, de Renshaw TB, Andrews NC (2011) Skeletal muscle hemojuvelin is dispensable for systemic iron homeostasis. Blood 117: 6319-6325.
    • (2011) Blood , vol.117 , pp. 6319-6325
    • Chen, W.1    Huang, F.W.2    De Renshaw, T.B.3    Andrews, N.C.4
  • 16
    • 33644876815 scopus 로고    scopus 로고
    • A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression
    • Wang RH, Li C, Xu X, Zheng Y, Xiao C, et al. (2005) A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression. Cell Metab 2: 399-409.
    • (2005) Cell Metab , vol.2 , pp. 399-409
    • Wang, R.H.1    Li, C.2    Xu, X.3    Zheng, Y.4    Xiao, C.5
  • 17
    • 79953757053 scopus 로고    scopus 로고
    • Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice
    • Ramos E, Kautz L, Rodriguez R, Hansen M, Gabayan V, et al. (2011) Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice. Hepatology 53: 1333-1341.
    • (2011) Hepatology , vol.53 , pp. 1333-1341
    • Ramos, E.1    Kautz, L.2    Rodriguez, R.3    Hansen, M.4    Gabayan, V.5
  • 18
    • 0032959574 scopus 로고    scopus 로고
    • Transferrin receptor is necessary for development of erythrocytes and the nervous system
    • DOI 10.1038/7727
    • Levy JE, Jin O, Fujiwara Y, Kuo F, Andrews NC (1999) Transferrin receptor is necessary for development of erythrocytes and the nervous system. Nat Genet 21: 396-399. (Pubitemid 29159576)
    • (1999) Nature Genetics , vol.21 , Issue.4 , pp. 396-399
    • Levy, J.E.1    Jin, O.2    Fujiwara, Y.3    Kuo, F.4    Andrews, N.C.5
  • 19
    • 32644437864 scopus 로고    scopus 로고
    • Iron metabolism in the hemoglobin-deficit mouse: Correlation of diferric transferrin with hepcidin expression
    • DOI 10.1182/blood-2005-07-2614
    • Wilkins SJ, Frazer DM, Millard KN, McLaren GD, Anderson GJ (2006) Iron metabolism in the hemoglobin-deficit mouse: correlation of diferric transferrin with hepcidin expression. Blood 107: 1659-1664. (Pubitemid 43242406)
    • (2006) Blood , vol.107 , Issue.4 , pp. 1659-1664
    • Wilkins, S.J.1    Frazer, D.M.2    Millard, K.N.3    McLaren, G.D.4    Anderson, G.J.5
  • 21
    • 0027360042 scopus 로고
    • Studies on familial hypotransferrinemia: Unique clinical course and molecular pathology
    • Hayashi A, Wada Y, Suzuki T, Shimizu A (1993) Studies on familial hypotransferrinemia: unique clinical course and molecular pathology. Am J Hum Genet 53: 201-213. (Pubitemid 23313751)
    • (1993) American Journal of Human Genetics , vol.53 , Issue.1 , pp. 201-213
    • Hayashi, A.1    Wada, Y.2    Suzuki, T.3    Shimizu, A.4
  • 22
    • 78751558997 scopus 로고    scopus 로고
    • Transferrin is a major determinant of hepcidin expression in hypotransferrinemic mice
    • Bartnikas TB, Andrews NC, Fleming MD (2011) Transferrin is a major determinant of hepcidin expression in hypotransferrinemic mice. Blood 117: 630-637.
    • (2011) Blood , vol.117 , pp. 630-637
    • Bartnikas, T.B.1    Andrews, N.C.2    Fleming, M.D.3
  • 23
    • 79959562083 scopus 로고    scopus 로고
    • Serum and liver iron differently regulate the bone morphogenetic protein 6 (BMP6)-SMAD signaling pathway in mice
    • Corradini E, Meynard D, Wu Q, Chen S, Ventura P, et al. (2011) Serum and liver iron differently regulate the bone morphogenetic protein 6 (BMP6)-SMAD signaling pathway in mice. Hepatology 54: 273-284.
    • (2011) Hepatology , vol.54 , pp. 273-284
    • Corradini, E.1    Meynard, D.2    Wu, Q.3    Chen, S.4    Ventura, P.5
  • 24
    • 39649115776 scopus 로고    scopus 로고
    • The Transferrin Receptor Modulates Hfe-Dependent Regulation of Hepcidin Expression
    • DOI 10.1016/j.cmet.2007.11.016, PII S1550413107003737
    • Schmidt PJ, Toran PT, Giannetti AM, Bjorkman PJ, Andrews NC (2008) The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression. Cell Metab 7: 205-214. (Pubitemid 351285524)
    • (2008) Cell Metabolism , vol.7 , Issue.3 , pp. 205-214
    • Schmidt, P.J.1    Toran, P.T.2    Giannetti, A.M.3    Bjorkman, P.J.4    Andrews, N.C.5
  • 26
    • 0036678091 scopus 로고    scopus 로고
    • Targeted mutagenesis of the murine transferrin receptor-2 gene produces hemochromatosis
    • Fleming RE, Ahmann JR, Migas MC, Waheed A, Koeffler HP, et al. (2002) Targeted mutagenesis of the murine transferrin receptor-2 gene produces hemochromatosis. Proc Natl Acad Sci U S A 99: 10653-10658.
    • (2002) Proc Natl Acad Sci U S a , vol.99 , pp. 10653-10658
    • Fleming, R.E.1    Ahmann, J.R.2    Migas, M.C.3    Waheed, A.4    Koeffler, H.P.5
  • 27
    • 73149083742 scopus 로고    scopus 로고
    • Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload
    • Wallace DF, Summerville L, Crampton EM, Frazer DM, Anderson GJ, et al. (2009) Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload. Hepatology 50: 1992-2000.
    • (2009) Hepatology , vol.50 , pp. 1992-2000
    • Wallace, D.F.1    Summerville, L.2    Crampton, E.M.3    Frazer, D.M.4    Anderson, G.J.5
  • 28
    • 84865565820 scopus 로고    scopus 로고
    • Ferroportin1 in hepatocytes and macrophages is required for the efficient mobilization of body iron stores in mice
    • Zhang Z, Zhang F, Guo X, An P, Tao Y, et al. (2012) Ferroportin1 in hepatocytes and macrophages is required for the efficient mobilization of body iron stores in mice. Hepatology 56: 961-971.
    • (2012) Hepatology , vol.56 , pp. 961-971
    • Zhang, Z.1    Zhang, F.2    Guo, X.3    An, P.4    Tao, Y.5
  • 29
    • 0035865048 scopus 로고    scopus 로고
    • Tie2-Cre transgenic mice: A new model for endothelial cell-lineage analysis in vivo
    • Kisanuki YY, Hammer RE, Miyazaki J, Williams SC, Richardson JA, et al. (2001) Tie2-Cre transgenic mice: a new model for endothelial cell-lineage analysis in vivo. Dev Biol 230: 230-242.
    • (2001) Dev Biol , vol.230 , pp. 230-242
    • Kisanuki, Y.Y.1    Hammer, R.E.2    Miyazaki, J.3    Williams, S.C.4    Richardson, J.A.5
  • 30
    • 0035911253 scopus 로고    scopus 로고
    • Conditional vascular cell adhesion molecule 1 deletion in mice: Impaired lymphocyte migration to bone marrow
    • Koni PA, Joshi SK, Temann UA, Olson D, Burkly L, et al. (2001) Conditional vascular cell adhesion molecule 1 deletion in mice: impaired lymphocyte migration to bone marrow. J Exp Med 193: 741-754.
    • (2001) J Exp Med , vol.193 , pp. 741-754
    • Koni, P.A.1    Joshi, S.K.2    Temann, U.A.3    Olson, D.4    Burkly, L.5
  • 31
    • 80051895753 scopus 로고    scopus 로고
    • Ferroportin1 deficiency in mouse macrophages impairs iron homeostasis and inflammatory responses
    • Zhang Z, Zhang F, An P, Guo X, Shen Y, et al. (2011) Ferroportin1 deficiency in mouse macrophages impairs iron homeostasis and inflammatory responses. Blood 118: 1912-1922.
    • (2011) Blood , vol.118 , pp. 1912-1922
    • Zhang, Z.1    Zhang, F.2    An, P.3    Guo, X.4    Shen, Y.5
  • 32
    • 33751175421 scopus 로고    scopus 로고
    • Interleukin-6 induces hepcidin expression through STAT3
    • Wrighting DM, Andrews NC (2006) Interleukin-6 induces hepcidin expression through STAT3. Blood 108: 3204-3209.
    • (2006) Blood , vol.108 , pp. 3204-3209
    • Wrighting, D.M.1    Andrews, N.C.2
  • 33
    • 33845245942 scopus 로고    scopus 로고
    • Suppression of hepcidin during anemia requires erythropoietic activity
    • DOI 10.1182/blood-2006-06-028787
    • Pak M, Lopez MA, Gabayan V, Ganz T, Rivera S (2006) Suppression of hepcidin during anemia requires erythropoietic activity. Blood 108: 3730-3735. (Pubitemid 44864551)
    • (2006) Blood , vol.108 , Issue.12 , pp. 3730-3735
    • Pak, M.1    Lopez, M.A.2    Gabayan, V.3    Ganz, T.4    Rivera, S.5
  • 34
    • 47049116150 scopus 로고    scopus 로고
    • Erythropoietin mediates hepcidin expression in hepatocytes through EPOR signaling and regulation of C/EBPalpha
    • Pinto JP, Ribeiro S, Pontes H, Thowfeequ S, Tosh D, et al. (2008) Erythropoietin mediates hepcidin expression in hepatocytes through EPOR signaling and regulation of C/EBPalpha. Blood 111: 5727-5733.
    • (2008) Blood , vol.111 , pp. 5727-5733
    • Pinto, J.P.1    Ribeiro, S.2    Pontes, H.3    Thowfeequ, S.4    Tosh, D.5
  • 35
    • 77950300851 scopus 로고    scopus 로고
    • Effect of erythropoietin on hepcidin expression in hemojuvelin-mutant mice
    • Krijt J, Jonasova A, Neuwirtova R, Necas E (2010) Effect of erythropoietin on hepcidin expression in hemojuvelin-mutant mice. Blood Cells Mol Dis 44: 257-261.
    • (2010) Blood Cells Mol Dis , vol.44 , pp. 257-261
    • Krijt, J.1    Jonasova, A.2    Neuwirtova, R.3    Necas, E.4
  • 37
    • 79551629285 scopus 로고    scopus 로고
    • Suppression of hepatic hepcidin expression in response to acute iron deprivation is associated with an increase of matriptase-2 protein
    • Zhang AS, Anderson SA, Wang J, Yang F, DeMaster K, et al. (2011) Suppression of hepatic hepcidin expression in response to acute iron deprivation is associated with an increase of matriptase-2 protein. Blood 117: 1687-1699.
    • (2011) Blood , vol.117 , pp. 1687-1699
    • Zhang, A.S.1    Anderson, S.A.2    Wang, J.3    Yang, F.4    DeMaster, K.5
  • 38
    • 84856423238 scopus 로고    scopus 로고
    • Hemojuvelin is essential for transferrindependent and transferrin-independent hepcidin expression in mice
    • Bartnikas TB, Fleming MD (2012) Hemojuvelin is essential for transferrindependent and transferrin-independent hepcidin expression in mice. Haematologica 97: 189-192.
    • (2012) Haematologica , vol.97 , pp. 189-192
    • Bartnikas, T.B.1    Fleming, M.D.2
  • 39
    • 76349118307 scopus 로고    scopus 로고
    • Transferrin therapy ameliorates disease in beta-thalassemic mice
    • Li H, Rybicki AC, Suzuka SM, von Bonsdorff L, Breuer W, et al. (2010) Transferrin therapy ameliorates disease in beta-thalassemic mice. Nat Med 16: 177-182.
    • (2010) Nat Med , vol.16 , pp. 177-182
    • Li, H.1    Rybicki, A.C.2    Suzuka, S.M.3    Von Bonsdorff, L.4    Breuer, W.5
  • 40
    • 66749183353 scopus 로고    scopus 로고
    • Cross-talk between the mitogen activated protein kinase and bone morphogenetic protein/hemojuvelin pathways is required for the induction of hepcidin by holotransferrin in primary mouse hepatocytes
    • Ramey G, Deschemin JC, Vaulont S (2009) Cross-talk between the mitogen activated protein kinase and bone morphogenetic protein/hemojuvelin pathways is required for the induction of hepcidin by holotransferrin in primary mouse hepatocytes. Haematologica 94: 765-772.
    • (2009) Haematologica , vol.94 , pp. 765-772
    • Ramey, G.1    Deschemin, J.C.2    Vaulont, S.3
  • 41
    • 84859336675 scopus 로고    scopus 로고
    • Decreased hepcidin expression in murine beta-thalassemia is associated with suppression of Bmp/Smad signaling
    • Parrow NL, Gardenghi S, Ramos P, Casu C, Grady RW, et al. (2012) Decreased hepcidin expression in murine beta-thalassemia is associated with suppression of Bmp/Smad signaling. Blood 119: 3187-3189.
    • (2012) Blood , vol.119 , pp. 3187-3189
    • Parrow, N.L.1    Gardenghi, S.2    Ramos, P.3    Casu, C.4    Grady, R.W.5
  • 42
    • 84860842095 scopus 로고    scopus 로고
    • Stimulated erythropoiesis with secondary iron loading leads to a decrease in hepcidin despite an increase in bone morphogenetic protein 6 expression
    • Frazer DM, Wilkins SJ, Darshan D, Badrick AC, McLaren GD, et al. (2012) Stimulated erythropoiesis with secondary iron loading leads to a decrease in hepcidin despite an increase in bone morphogenetic protein 6 expression. Br J Haematol 157: 615-626.
    • (2012) Br J Haematol , vol.157 , pp. 615-626
    • Frazer, D.M.1    Wilkins, S.J.2    Darshan, D.3    Badrick, A.C.4    McLaren, G.D.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.