Decreased Serum Hepcidin Concentration Correlates with Brain Iron Deposition in Patients with HBV-Related Cirrhosis

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Lin, Dong ^a   Ding, Jing ^a   Liu, Jian Ying ^a   He, Yi Feng ^a   Dai, Zhi ^a   Chen, Cai Zhong ^a   Cheng, Wei Zhong ^a   Zhou, Jian ^a,b   Wang, Xin ^a  

^a FUDAN UNIVERSITY   (China)

^b Shanghai Key Laboratory of Organ Transplantation   (China)

Author keywords

[No Author keywords available]

Indexed keywords

FERRITIN; HEPCIDIN; IRON; TRANSFERRIN;

ADULT; ARTICLE; BRAIN; BRAIN LEVEL; CAUDATE NUCLEUS; CONTROLLED STUDY; FEMALE; HEPATITIS B; HEPATITIS B VIRUS; HORMONE BLOOD LEVEL; HUMAN; IRON BINDING CAPACITY; IRON STORAGE; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; PROTEIN BLOOD LEVEL; PUTAMEN; RED NUCLEUS; SUBSTANTIA NIGRA; THALAMUS;

ADULT; AGED; BRAIN; FEMALE; HEPATITIS B; HEPATITIS B VIRUS; HEPCIDINS; HUMANS; IRON; LIVER CIRRHOSIS; MALE; MIDDLE AGED;

HEPATITIS B VIRUS;

EID: 84878955221     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0065551     Document Type: Article

References (54)

1. Weissenborn K, Bokemeyer M, Krause J, Ennen J, Ahl B, (2005) Neurological and neuropsychiatric syndromes associated with liver disease. AIDS 19Suppl 3: S93-S98.
2. Pantiga C, Rodrigo LR, Cuesta M, Lopez L, Arias JL, (2003) Cognitive deficits in patients with hepatic cirrhosis and in liver transplant recipients. J Neuropsychiatry Clin Neurosci 15: 84-89.
3. Klos KJ, Ahlskog JE, Josephs KA, Fealey RD, Cowl CT, et al. (2005) Neurologic spectrum of chronic liver failure and basal ganglia T1 hyperintensity on magnetic resonance imaging: probable manganese neurotoxicity. Arch Neurol 62: 1385-1390.
4. Burkhard PR, Delavelle J, Du Pasquier R, Spahr L, (2003) Chronic parkinsonism associated with cirrhosis: a distinct subset of acquired hepatocerebral degeneration. Arch Neurol 60: 521-528.
5. Jalan R, Gooday R, O'Carroll RE, Redhead DN, Elton RA, et al. (1995) A prospective evaluation of changes in neuropsychological and liver function tests following transjugular intrahepatic portosystemic stent-shunt. J Hepatol 23: 697-705.
6. Das A, Dhiman RK, Saraswat VA, Verma M, Naik SR, (2001) Prevalence and natural history of subclinical hepatic encephalopathy in cirrhosis. J Gastroenterol Hepatol 16: 531-535.
7. Groeneweg M, Quero JC, De Bruijn I, Hartmann IJ, Essink-bot ML, et al. (1998) Subclinical hepatic encephalopathy impairs daily functioning. Hepatology 28: 45-49.
8. Jones EA, Weissenborn K, (1997) Neurology and the liver. J Neurol Neurosurg Psychiatry 63: 279-293.
9. Zecca L, Youdim MB, Riederer P, Connor JR, Crichton RR, (2004) Iron, brain ageing and neurodegenerative disorders. Nat Rev Neurosci 5: 863-873.
10. Wypijewska A, Galazka-Friedman J, Bauminger ER, Wszolek ZK, Schweitzer KJ, et al. (2010) Iron and reactive oxygen species activity in parkinsonian substantia nigra. Parkinsonism Relat Disord 16: 329-333.
11. Honda K, Casadesus G, Petersen RB, Perry G, Smith MA, (2004) Oxidative stress and redox-active iron in Alzheimer's disease. Ann N Y Acad Sci 1012: 179-182.
12. Abo-Krysha N, Rashed L, (2008) The role of iron dysregulation in the pathogenesis of multiple sclerosis: an Egyptian study. Mult Scler 14: 602-608.
13. Gordon N, (2000) Friedreich's ataxia and iron metabolism. Brain Dev 22: 465-468.
14. Crompton DE, Chinnery PF, Fey C, Curtis AR, Morris CM, et al. (2002) Neuroferritinopathy: a window on the role of iron in neurodegeneration. Blood Cells Mol Dis 29: 522-531.
15. Hayflick SJ, (2003) Unraveling the Hallervorden-Spatz syndrome: pantothenate kinase-associated neurodegeneration is the name. Curr Opin Pediatr 15: 572-577.
16. Liu JY, Ding J, Lin D, He YF, Dai Z, et al. (2013) T2* MRI of minimal hepatic encephalopathy and cognitive correlates in vivo. J Magn Reson Imaging 37: 179-186.
17. Yonal O, Akyuz F, Demir K, Ciftci S, Keskin F, et al. (2010) Decreased prohepcidin levels in patients with HBV-related liver disease: relation with ferritin levels. Dig Dis Sci 55: 3548-3551.
18. Martinelli AL, Filho AB, Franco RF, Tavella MH, Ramalho LN, et al. (2004) Liver iron deposits in hepatitis B patients: association with severity of liver disease but not with hemochromatosis gene mutations. J Gastroenterol Hepatol 19: 1036-1041.
19. Nagashima M, Kudo M, Chung H, Ishikawa E, Hagiwara S, et al. (2006) Regulatory failure of serum prohepcidin levels in patients with hepatitis C. Hepatol Res. 36: 288-293.
20. House MJ, St PT, Milward EA, Bruce DG, Olynyk JK, (2010) Relationship between brain R(2) and liver and serum iron concentrations in elderly men. Magn Reson Med 63: 275-281.
21. Haacke EM, Cheng NY, House MJ, Liu Q, Neelavalli J, et al. (2005) Imaging iron stores in the brain using magnetic resonance imaging. Magn Reson Imaging 23: 1-25.
22. Haacke EM, Miao Y, Liu M, Habib CA, Katkuri Y, et al. (2010) Correlation of putative iron content as represented by changes in R2* and phase with age in deep gray matter of healthy adults. J Magn Reson Imaging 32: 561-576.
23. Cade JE, Moreton JA, O'Hara B, Greenwood DC, Moor J, et al. (2005) Diet and genetic factors associated with iron status in middle-aged women. Am J Clin Nutr 82: 813-820.
24. World Health Organization, Centers for Disease Control and Prevention (2007) Assessing the iron status of populations. Available: http://www.who.int/nutrition/publications/micronutrients/anaemia_iron_deficiency/9789241596107/en/index.html.
25. Zhu WZ, Zhong WD, Wang W, Zhan CJ, Wang CY, et al. (2009) Quantitative MR phase-corrected imaging to investigate increased brain iron deposition of patients with Alzheimer disease. Radiology 253: 497-504.
26. HALLGREN B, SOURANDER P, (1958) The effect of age on the non-haemin iron in the human brain. J Neurochem 3: 41-51.
27. Pfefferbaum A, Adalsteinsson E, Rohlfing T, Sullivan EV, (2009) MRI estimates of brain iron concentration in normal aging: comparison of field-dependent (FDRI) and phase (SWI) methods. Neuroimage 47: 493-500.
28. Berg D, Hoggenmuller U, Hofmann E, Fischer R, Kraus M, et al. (2000) The basal ganglia in haemochromatosis. Neuroradiology 42: 9-13.
29. Di Bisceglie AM, Axiotis CA, Hoofnagle JH, Bacon BR, (1992) Measurements of iron status in patients with chronic hepatitis. Gastroenterology 102: 2108-2113.
30. Bonkovsky HL, Banner BF, Rothman AL, (1997) Iron and chronic viral hepatitis. Hepatology 25: 759-768.
31. Eng SC, Taylor SL, Reyes V, Raaka S, Berger J, et al. (2005) Hepatic iron overload in alcoholic end-stage liver disease is associated with iron deposition in other organs in the absence of HFE-1 hemochromatosis. Liver Int 25: 513-517.
32. Haacke EM, Mittal S, Wu Z, Neelavalli J, Cheng YC, (2009) Susceptibility-weighted imaging: technical aspects and clinical applications, part 1. AJNR Am J Neuroradiol 30: 19-30.
33. Mittal S, Wu Z, Neelavalli J, Haacke EM, (2009) Susceptibility-weighted imaging: technical aspects and clinical applications, part 2. AJNR Am J Neuroradiol 30: 232-252.
34. Langkammer C, Krebs N, Goessler W, Scheurer E, Ebner F, et al. (2010) Quantitative MR imaging of brain iron: a postmortem validation study. Radiology 257: 455-462.
35. Yao B, Li TQ, Gelderen P, Shmueli K, de Zwart JA, et al. (2009) Susceptibility contrast in high field MRI of human brain as a function of tissue iron content. Neuroimage 44: 1259-1266.
36. Zhang J, Zhang Y, Wang J, Cai P, Luo C, et al. (2010) Characterizing iron deposition in Parkinson's disease using susceptibility-weighted imaging: an in vivo MR study. Brain Res 1330: 124-130.
37. Haacke EM, Makki M, Ge Y, Maheshwari M, Sehgal V, et al. (2009) Characterizing iron deposition in multiple sclerosis lesions using susceptibility weighted imaging. J Magn Reson Imaging 29: 537-544.
38. Corengia C, Galimberti S, Bovo G, Vergani A, Arosio C, et al. (2005) Iron accumulation in chronic hepatitis C: relation of hepatic iron distribution, HFE genotype, and disease course. Am J Clin Pathol 124: 846-853.
39. Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, et al. (2004) Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 306: 2090-2093.
40. Singh B, Arora S, Agrawal P, Gupta SK, (2011) Hepcidin: a novel peptide hormone regulating iron metabolism. Clin Chim Acta 412: 823-830.
41. Ramey G, Deschemin JC, Durel B, Canonne-Hergaux F, Nicolas G, et al. (2010) Hepcidin targets ferroportin for degradation in hepatocytes. Haematologica 95: 501-504.
42. Hadley KB, Johnson LK, Hunt JR, (2006) Iron absorption by healthy women is not associated with either serum or urinary prohepcidin. Am J Clin Nutr 84: 150-155.
43. van Deuren M, Kroot JJ, Swinkels DW, (2009) Time-course analysis of serum hepcidin, iron and cytokines in a C282Y homozygous patient with Schnitzler's syndrome treated with IL-1 receptor antagonist. Haematologica 94: 1297-1300.
44. Fujita N, Sugimoto R, Takeo M, Urawa N, Mifuji R, et al. (2007) Hepcidin expression in the liver: relatively low level in patients with chronic hepatitis C. Mol Med. 13: 97-104.
45. Atanasiu V, Manolescu B, Stoian I, (2007) Hepcidin-central regulator of iron metabolism. Eur J Haematol 78: 1-10.
46. Siciliano M, Tomasello D, Milani A, Ricerca BM, Storti S, et al. (1995) Reduced serum levels of immunoreactive erythropoietin in patients with cirrhosis and chronic anemia. Hepatology 22: 1132-1135.
47. Lee WC, Lin HC, Hou MC, Lee FY, Chang FY, et al. (1999) Effect of anaemia on haemodynamics in patients with cirrhosis. J Gastroenterol Hepatol 14: 370-375.
48. Vokurka M, Krijt J, Sulc K, Necas E, (2006) Hepcidin mRNA levels in mouse liver respond to inhibition of erythropoiesis. Physiol Res 55: 667-674.
49. Kohgo Y, Niitsu Y, Kondo H, Kato J, Tsushima N, et al. (1987) Serum transferrin receptor as a new index of erythropoiesis. Blood 70: 1955-1958.
50. Worwood M, (1997) The laboratory assessment of iron status-an update. Clin Chim Acta 259: 3-23.
51. Burdo JR, Connor JR, (2003) Brain iron uptake and homeostatic mechanisms: an overview. Biometals 16: 63-75.
52. Ke Y, Qian ZM, (2007) Brain iron metabolism: neurobiology and neurochemistry. Prog Neurobiol 83: 149-173.
53. Casanova MF, Araque JM, (2003) Mineralization of the basal ganglia: implications for neuropsychiatry, pathology and neuroimaging. Psychiatry Res 121: 59-87.
54. Ke Y, Ming QZ, (2003) Iron misregulation in the brain: a primary cause of neurodegenerative disorders. Lancet Neurol 2: 246-253.