Serum prohepcidin levels in chronic inflammatory bowel diseases

Journal of Crohn's and Colitis

Volumn 4, Issue 6, 2010, Pages 649-653

  Nagy, Judit ^a   Lakner, Lilla ^b   Poor Viktor S V S ^a   Pandur, Edina ^a   Mózsik, Gyula ^a   Miseta, Attila ^a   Sipos, Katalin ^a  

^a UNIVERSITY OF PÉCS   (Hungary)

^b Markusovszky Teaching Hospital   (Hungary)

Author keywords

Anemia; Crohn's disease; ; Iron; ; Prohepcidin; ; Ulcerative colitis;

Indexed keywords

ALBUMIN; C REACTIVE PROTEIN; PROHEPCIDIN; TRANSFERRIN;

ALBUMIN BLOOD LEVEL; ANEMIA; ARTICLE; CONTROLLED STUDY; CROHN DISEASE; DIAGNOSTIC VALUE; DISEASE ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HOMEOSTASIS; HUMAN; IRON BINDING CAPACITY; IRON BLOOD LEVEL; IRON METABOLISM; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROGNOSIS; PROTEIN BLOOD LEVEL; ULCERATIVE COLITIS;

ADULT; AGED; AGED, 80 AND OVER; ANEMIA; ANTIMICROBIAL CATIONIC PEPTIDES; BLOOD SEDIMENTATION; C-REACTIVE PROTEIN; COLITIS, ULCERATIVE; CROHN DISEASE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; INFLAMMATORY BOWEL DISEASES; IRON; LEUKOCYTE COUNT; MALE; MIDDLE AGED; PROTEIN PRECURSORS; SEVERITY OF ILLNESS INDEX; YOUNG ADULT;

EID: 78649523824     PISSN: 18739946     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.crohns.2010.07.010     Document Type: Article

References (25)

1. Thoreson R., Cullen J.J. Pathophysiology of inflammatory bowel disease: an overview. Surg Clin North Am 2007, 87:575-585.
2. Hendrickson B.A., Gokhale R., Cho J.H. Clinical aspects and pathophysiology of inflammatory bowel disease. Clin Microbiol Rev 2002, 15:79-94.
3. Neuman M.G. Immune dysfunction in inflammatory bowel disease. Transl Res 2007, 149:173-186.
4. Wehkamp J., Fellermann K., Stange E.F. Human defensins in Crohn's disease. Chem Immunol Allergy 2005, 86:42-54.
5. Weiss G. Iron metabolism in the anemia of chronic disease. Biochim Biophys Acta 2009, 1790:682-693.
6. Ganz T. Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation. Blood 2003, 102:783-788.
7. Detivaud L., Nemeth E., Boudjema K., Turlin B., Troadec M.B., Leroyer P., et al. Hepcidin levels in humans are correlated with hepatic iron stores, hemoglobin levels, and hepatic function. Blood 2005, 106:746-748.
8. Nemeth E., Valore E.V., Territo M., Schiller G., Lichtenstein A., Ganz T. Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood 2003, 101:2461-2463.
9. Park C.H., Valore E.V., Waring A.J., Ganz T. Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem 2001, 276:7806-7810.
10. Pandur E., Nagy J., Poor V.S., Sarnyai A., Huszar A., Miseta A., et al. Alpha-1 antitrypsin binds preprohepcidin intracellularly and prohepcidin in the serum. FEBS J 2009, 276:2012-2021.
11. Nemeth E., Tuttle M.S., Powelson J., Vaughn M.B., Donovan A., Ward D.M., et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 2004, 306:2090-2093.
12. Best W.R. Predicting the Crohn's disease activity index from the Harvey-Bradshaw Index. Inflamm Bowel Dis 2006, 12:304-310.
13. Gurel S., Kiyici M. Ulcerative colitis activity index: a useful prognostic factor for predicting ulcerative colitis outcome. J Int Med Res 2005, 33:103-110.
14. Langhorst J., Elsenbruch S., Koelzer J., Rueffer A., Michalsen A., Dobos G.J. Noninvasive markers in the assessment of intestinal inflammation in inflammatory bowel diseases: performance of fecal lactoferrin, calprotectin, and PMN-elastase, CRP, and clinical indices. Am J Gastroenterol 2008, 103:162-169.
15. Fellermann K., Stange E.F. Defensins - innate immunity at the epithelial frontier. Eur J Gastroenterol Hepatol 2001, 13:771-776.
16. Wehkamp J., Fellermann K., Herrlinger K.R., Baxmann S., Schmidt K., Schwind B., et al. Human beta-defensin 2 but not beta-defensin 1 is expressed preferentially in colonic mucosa of inflammatory bowel disease. Eur J Gastroenterol Hepatol 2002, 14:745-752.
17. Theurl I., Fritsche G., Ludwiczek S., Garimorth K., Bellmann-Weiler R., Weiss G. The macrophage: a cellular factory at the interphase between iron and immunity for the control of infections. Biometals 2005, 18:359-367.
18. Oldenburg B., Koningsberger J.C., Berge Henegouwen G.P., Van Asbeck B.S., Marx J.J. Iron and inflammatory bowel disease. Aliment Pharmacol Ther 2001, 15:429-438.
19. Denis M.A., Reenaers C., Fontaine F., Belaiche J., Louis E. Assessment of endoscopic activity index and biological inflammatory markers in clinically active Crohn's disease with normal C-reactive protein serum level. Inflamm Bowel Dis 2007, 13:1100-1105.
20. Semrin G., Fishman D.S., Bousvaros A., Zholudev A., Saunders A.C., Correia C.E., et al. Impaired intestinal iron absorption in Crohn's disease correlates with disease activity and markers of inflammation. Inflamm Bowel Dis 2006, 12:1101-1106.
21. Kijima H., Sawada T., Tomosugi N., Kubota K. Expression of hepcidin mRNA is uniformly suppressed in hepatocellular carcinoma. BMC Cancer 2008, 8:167.
22. Harrison-Findik D.D., Schafer D., Klein E., Timchenko N.A., Kulaksiz H., Clemens D., et al. Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression. J Biol Chem 2006, 281:22974-22982.
23. Fujita N., Sugimoto R., Takeo M., Urawa N., Mifuji R., Tanaka H., et al. Hepcidin expression in the liver: relatively low level in patients with chronic hepatitis C. Mol Med 2007, 13:97-104.
24. Malyszko J., Malyszko J.S., Pawlak K., Mysliwiec M. Hepcidin, iron status, and renal function in chronic renal failure, kidney transplantation, and hemodialysis. Am J Hematol 2006, 81:832-837.
25. Koca S.S., Isik A., Ustundag B., Metin K., Aksoy K. Serum pro-hepcidin levels in rheumatoid arthritis and systemic lupus erythematosus. Inflammation 2008, 31:146-153.