Polychlorinated biphenyls (PCBs) inhibit hepcidin expression through an estrogen-like effect associated with disordered systemic iron homeostasis

Chemical Research in Toxicology

Volumn 28, Issue 4, 2015, Pages 629-640

  Qian, Yi ^a,b   Zhang, Shuping ^b,c   Guo, Wenli ^b   Ma, Juan ^b   Chen, Yue ^b   Wang, Lei ^b   Zhao, Meirong ^a   Liu, Sijin ^b  

^a ZHEJIANG UNIVERSITY OF TECHNOLOGY   (China)

^b RESEARCH CENTER FOR ECO ENVIRONMENTAL SCIENCES   (China)

^c Massachusetts Institute of Technology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,2',4,4',5,5' HEXACHLOROBIPHENYL; 3,3',4,4',5 PENTACHLOROBIPHENYL; BONE MORPHOGENETIC PROTEIN 6; ESTRADIOL; ESTROGEN; FAT DROPLET; HEPCIDIN; IRON; BMP6 PROTEIN, HUMAN; POLYCHLORINATED BIPHENYL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; ESTROGEN ACTIVITY; ESTROGEN RESPONSIVE ELEMENT; FEMALE; GENE EXPRESSION REGULATION; GENE REPRESSION; HEPG2 CELL LINE; HUMAN; INFLAMMATION; IRON BLOOD LEVEL; IRON METABOLISM; IRON METABOLISM DISORDER; LIPID HOMEOSTASIS; LIPID LIVER LEVEL; LIPID STORAGE; LIVER CELL; MOUSE; NONHUMAN; OXIDATIVE STRESS; PROMOTER REGION; TRANSCRIPTION REGULATION; WILD TYPE; ANIMAL; C57BL MOUSE; CHEMICALLY INDUCED; DRUG EFFECTS; GENE EXPRESSION; GENETICS; HOMEOSTASIS; METABOLISM; PHYSIOLOGY;

MUS;

ANIMALS; BONE MORPHOGENETIC PROTEIN 6; ESTROGENS; FEMALE; GENE EXPRESSION; HEP G2 CELLS; HEPCIDINS; HOMEOSTASIS; HUMANS; INFLAMMATION; IRON; MICE; MICE, INBRED C57BL; OXIDATIVE STRESS; POLYCHLORINATED BIPHENYLS;

EID: 84928501223     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx500428r     Document Type: Article

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