Iron metabolism in patients with anorexia nervosa: Elevated serum hepcidin concentrations in the absence of inflammation

American Journal of Clinical Nutrition

Volumn 95, Issue 3, 2012, Pages 548-554

  Papillard Marechal, Solesne ^a   Sznajder, Marc ^a   Hurtado Nedelec, Margarita ^b   Alibay, Yasmin ^a   Martin Schmitt, Caroline ^a,c   Dehoux, Monique ^b   Westerman, Mark ^d   Beaumont, Carole ^c   Chevallier, Bertrand ^a,e   Puy, Herve ^b,c   Stheneur, Chantal ^a,f  

^a HÔPITAL AMBROISE PARÉ   (France)

^b BICHAT HOSPITAL   (France)

^c CENTRE DE RECHERCHE BIOMÉDICALE BICHAT BEAUJON CRB3   (France)

^d Intrinsic Life Sciences   (United States)

^e LABORATOIRE DES SCIENCES DU CLIMAT ET DE L ENVIRONNEMENT   (France)

^f Universite Paris Sud   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CYANOCOBALAMIN; CYTOKINE; FERRITIN; FOLIC ACID; HEMOGLOBIN; HEPCIDIN;

ADOLESCENT; ANOREXIA NERVOSA; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HEMATOLOGIC DISEASE; HOSPITALIZATION; HUMAN; HYPERFERRITINEMIA; IRON BLOOD LEVEL; IRON METABOLISM; LIVER CELL; MALE; MALNUTRITION; NUTRITIONAL HEALTH; PEDIATRIC HOSPITAL; PEDIATRIC INTENSIVE CARE NURSING;

ADOLESCENT; ANOREXIA NERVOSA; ANTIMICROBIAL CATIONIC PEPTIDES; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CHILD; CYTOKINES; FEMALE; FERRITINS; FOLLOW-UP STUDIES; HOSPITALIZATION; HUMANS; INFLAMMATION; IRON METABOLISM DISORDERS; IRON, DIETARY; MALE;

EID: 84857873727     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.111.025817     Document Type: Article

References (48)

1. Hoek HW. Incidence, prevalence and mortality of anorexia nervosa and other eating disorders. Curr Opin Psychiatry 2006;19:389-94. (Pubitemid 44317865)
2. Hudson JI, Hiripi E, Pope HG Jr, Kessler RC. The prevalence and correlates of eating disorders in the National Comorbidity Survey Replication. Biol Psychiatry 2007;61:348-58. (Pubitemid 46108682)
3. Sullivan PF. Mortality in anorexia nervosa. Am J Psychiatry 1995;152: 1073-4.
4. Nova E, Lopez-Vidriero I, Varela P, Toro O, Casas JJ, Marcos AA. Indicators of nutritional status in restricting-type anorexia nervosa patients: a 1-year follow-up study. Clin Nutr 2004;23:1353-9. (Pubitemid 39517628)
5. Kennedy A, Kohn M, Lammi A, Clarke S. Iron status and haematological changes in adolescent female inpatients with anorexia nervosa. J Paediatr Child Health 2004;40:430-2. (Pubitemid 39070710)
6. Tajiri K, Shimizu Y, Tsuneyama K, Sugiyama T. A case report of oxidative stress in a patient with anorexia nervosa. Int J Eat Disord 2006;39:616-8. (Pubitemid 44621820)
7. Van Binsbergen CJ, Odink J, Van den Berg H, Koppeschaar H, Coelingh Bennink HJ. Nutritional status in anorexia nervosa: clinical chemistry, vitamins, iron and zinc. Eur J Clin Nutr 1988;42:929-37. (Pubitemid 19003788)
8. Krause A, Neitz S, Magert HJ, Schulz A, Forssmann WG, Schulz- Knappe P, Adermann K. LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity. FEBS Lett 2000;480: 147-50.
9. Park CH, Valore EV, Waring AJ, Ganz T. Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem 2001;276: 7806-10.
10. Pigeon C, Ilyin G, Courselaud B, Leroyer P, Turlin B, Brissot P, Loreal O. A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem 2001;276:7811-9.
11. Nicolas G, Bennoun M, Devaux I, Beaumont C, Grandchamp B, Kahn A, Vaulont S. Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc Natl Acad Sci USA 2001;98:8780-5. (Pubitemid 32678104)
12. Nemeth E, Ganz T. The role of hepcidin in iron metabolism. Acta Haematol 2009;122:78-86.
13. Delaby C, Pilard N, Goncalves AS, Beaumont C, Canonne-Hergaux F. Presence of the iron exporter ferroportin at the plasma membrane of macrophages is enhanced by iron loading and down-regulated by hepcidin. Blood 2005;106:3979-84. (Pubitemid 41739041)
14. De Domenico I, Ward DM, Langelier C, Vaughn MB, Nemeth E, Sundquist W, Ganz T, Musci G, Kaplan J. The molecular mechanism of hepcidin-mediated ferroportin down-regulation. Mol Biol Cell 2007; 18:2569-78. (Pubitemid 47025722)
15. Brasse-Lagnel C, Karim Z, Letteron P, Bekri S, Bado A, Beaumont C. Intestinal DMT1 cotransporter is downregulated by hepcidin via proteasome-internalization and degradation. Gastroenterology 2011; 140:1261-71.
16. Xia Y, Babitt JL, Sidis Y, Chung RT, Lin HY. Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin. Blood 2008;111:5195-204.
17. Nemeth E. Iron regulation and erythropoiesis. Curr Opin Hematol 2008;15:169-75. (Pubitemid 351507567)
18. Ganz T. Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation. Blood 2003;102:783-8. (Pubitemid 36917762)
19. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th ed. Washington, DC: Masson, 1996.
20. Rolland-Cachera MF, Cole TJ, Sempe M, Tichet J, Rossignol C, Charraud A. Body Mass Index variations: centiles from birth to 87 years. Eur J Clin Nutr 1991;45:13-21.
21. Kannengiesser C, Jouanolle AM, Hetet G, Mosser A, Muzeau F, Henry D, Bardou-Jacquet E, Mornet M, Brissot P, Deugnier Y, et al. A new missense mutation in the L ferritin coding sequence associated with elevated levels of glycosylated ferritin in serum and absence of iron overload. Haematologica 2009;94:335-9.
22. Cook JW, Karakozis S, Kim D, Provido H, Gongora E, Kirkpatrick JR. Interleukin-10 attenuates proinflammatory cytokine production and improves survival in lethal pancreatitis. Am Surg 2001;67:237-41, discussion 241-2.
23. Ganz T, Olbina G, Girelli D, Nemeth E, Westerman M. Immunoassay for human serum hepcidin. Blood 2008;112:4292-7.
24. Casper RC, Kirschner B, Sandstead HH, Jacob RA, Davis JM. An evaluation of trace metals, vitamins, and taste function in anorexia nervosa. Am J Clin Nutr 1980;33:1801-8. (Pubitemid 11215389)
25. Thibault L, Roberge AG. The nutritional status of subjects with anorexia nervosa. Int J Vitam Nutr Res 1987;57:447-52.
26. van der Ster Wallin G, Norring C, Lennernas MA, Holmgren S. Food selection in anorectics and bulimics: food items, nutrient content and nutrient density. J Am Coll Nutr 1995;14:271-7.
27. Misra M, Miller KK, Tsai P, Stewart V, End A, Freed N, Herzog DB, Goldstein M, Riggs S, Klibanski A. Uncoupling of cardiovascular risk markers in adolescent girls with anorexia nervosa. J Pediatr 2006;149: 763-9.
28. Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM, Ganz T, Kaplan J. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 2004; 306:2090-3. (Pubitemid 40007660)
29. Fohlin L, Freyschuss U, Bjarke B, Davies CT, Thoren C. Function and dimensions of the circulatory system in anorexia nervosa. Acta Paediatr Scand 1978;67:11-6. (Pubitemid 8277804)
30. Lambert M, Hubert C, Depresseux G, Vande Berg B, Thissen JP, Nagant de Deuxchaisnes C, Devogelaer JP. Hematological changes in anorexia nervosa are correlated with total body fat mass depletion. Int J Eat Disord 1997;21:329-34. (Pubitemid 27184001)
31. Miller KK, Grinspoon SK, Ciampa J, Hier J, Herzog D, Klibanski A. Medical findings in outpatients with anorexia nervosa. Arch Intern Med 2005;165:561-6. (Pubitemid 40344389)
32. Misra M, Aggarwal A, Miller KK, Almazan C, Worley M, Soyka LA, Herzog DB, Klibanski A. Effects of anorexia nervosa on clinical, hematologic, biochemical, and bone density parameters in community-dwelling adolescent girls. Pediatrics 2004;114:1574-83. (Pubitemid 41754920)
33. Barbe P, Bennet A, Stebenet M, Perret B, Louvet JP. Sex-hormone-binding globulin and protein-energy malnutrition indexes as indicators of nutritional status in women with anorexia nervosa. Am J Clin Nutr 1993;57:319-22. (Pubitemid 23083641)
34. Wyatt RJ, Farrell M, Berry PL, Forristal J, Maloney MJ, West CD. Reduced alternative complement pathway control protein levels in anorexia nervosa: response to parenteral alimentation. Am J Clin Nutr 1982;35:973-80. (Pubitemid 12051194)
35. Russell DM, Prendergast PJ, Darby PL, Garfinkel PE, Whitwell J, Jeejeebhoy KN. A comparison between muscle function and body composition in anorexia nervosa: the effect of refeeding. Am J Clin Nutr 1983;38:229-37.
36. Pomeroy C, Eckert E, Hu S, Eiken B, Mentink M, Crosby RD, Chao CC. Role of interleukin-6 and transforming growth factor-beta in anorexia nervosa. Biol Psychiatry 1994;36:836-9.
37. Corcos M, Guilbaud O, Chaouat G, Cayol V, Speranza M, Chambry J, Paterniti S, Moussa M, Flament M, Jeammet P. Cytokines and anorexia nervosa. Psychosom Med 2001;63:502-4. (Pubitemid 32467126)
38. Fong HF, Divasta AD, Difabio D, Ringelheim J, Jonas MM, Gordon CM. Prevalence and predictors of abnormal liver enzymes in young women with anorexia nervosa. J Pediatr 2008;153:247-53.
39. Hentze MW, Muckenthaler MU, Galy B, Camaschella C. Two to tango: regulation of Mammalian iron metabolism. Cell 2010;142:24-38.
40. Nemeth E, Rivera S, Gabayan V, Keller C, Taudorf S, Pedersen BK, Ganz T. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest 2004; 113:1271-6. (Pubitemid 39069926)
41. Arruda SF, Siqueira EM, de Valencia FF. Vitamin A deficiency increases hepcidin expression and oxidative stress in rat. Nutrition 2009;25:472-8.
42. Bekri S, Gual P, Anty R, Luciani N, Dahman M, Ramesh B, Iannelli A, Staccini-Myx A, Casanova D, Ben Amor I, et al. Increased adipose tissue expression of hepcidin in severe obesity is independent from diabetes and NASH. Gastroenterology 2006;131:788-96. (Pubitemid 44316823)
43. Grinspoon S, Gulick T, Askari H, Landt M, Lee K, Anderson E, Ma Z, Vignati L, Bowsher R, Herzog D, et al. Serum leptin levels in women with anorexia nervosa. J Clin Endocrinol Metab 1996;81:3861-3. (Pubitemid 26380387)
44. Polito A, Fabbri A, Ferro-Luzzi A, Cuzzolaro M, Censi L, Ciarapica D, Fabbrini E, Giannini D. Basal metabolic rate in anorexia nervosa: relation to body composition and leptin concentrations. Am J Clin Nutr 2000;71:1495-502. (Pubitemid 30395896)
45. Satoh Y, Shimizu T, Lee T, Nishizawa K, Iijima M, Yamashiro Y. Resting energy expenditure and plasma leptin levels in adolescent girls with anorexia nervosa. Int J Eat Disord 2003;34:156-61. (Pubitemid 36648837)
46. Misra M, Miller KK, Almazan C, Ramaswamy K, Aggarwal A, Herzog DB, Neubauer G, Breu J, Klibanski A. Hormonal and body composition predictors of soluble leptin receptor, leptin, and free leptin index in adolescent girls with anorexia nervosa and controls and relation to insulin sensitivity. J Clin Endocrinol Metab 2004;89:3486-95. (Pubitemid 38951925)
47. Dolezalova R, Lacinova Z, Dolinkova M, Kleiblova P, Haluzikova D, Housa D, Papezova H, Haluzik M. Changes of endocrine function of adipose tissue in anorexia nervosa: comparison of circulating levels versus subcutaneous mRNA expression. Clin Endocrinol (Oxf) 2007;67:674-8. (Pubitemid 47620431)
48. Chung B, Matak P, McKie AT, Sharp P. Leptin increases the expression of the iron regulatory hormone hepcidin in HuH7 human hepatoma cells. J Nutr 2007;137:2366-70. (Pubitemid 350058702)