메뉴 건너뛰기




Volumn 126, Issue 4, 2013, Pages 541-549

Inflammation alters the expression of DMT1, FPN1 and hepcidin, and it causes iron accumulation in central nervous system cells

Author keywords

DMT1; FPN1; hepcidin; inflammation; iron accumulation; neurodegeneration

Indexed keywords

FERROPORTIN 1; HEPCIDIN; INTERLEUKIN 6; IRON; LIPOPOLYSACCHARIDE; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; TUMOR NECROSIS FACTOR ALPHA; ANTIMICROBIAL CATIONIC PEPTIDE; CATION TRANSPORT PROTEIN; DMT1 PROTEIN, RAT; MESSENGER RNA; METAL TRANSPORTING PROTEIN 1;

EID: 84885953717     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.12244     Document Type: Article
Times cited : (284)

References (50)
  • 2
    • 84864914669 scopus 로고    scopus 로고
    • The dopamine metabolite aminochrome inhibits mitochondrial complex i and modifies the expression of iron transporters DMT1 and FPN1
    • Aguirre P., Urrutia P., Tapia V., Villa M., Paris I., Segura-Aguilar J., and, Núñez M. T., (2012) The dopamine metabolite aminochrome inhibits mitochondrial complex I and modifies the expression of iron transporters DMT1 and FPN1. Biometals 25, 795-803.
    • (2012) Biometals , vol.25 , pp. 795-803
    • Aguirre, P.1    Urrutia, P.2    Tapia, V.3    Villa, M.4    Paris, I.5    Segura-Aguilar, J.6    Núñez, M.T.7
  • 4
    • 84857977037 scopus 로고    scopus 로고
    • Alzheimer's disease: Redox dysregulation as a common denominator for diverse pathogenic mechanisms
    • von Bernhardi R., and, Eugenin J., (2012) Alzheimer's disease: redox dysregulation as a common denominator for diverse pathogenic mechanisms. Antioxid. Redox Signal. 16, 974-1031.
    • (2012) Antioxid. Redox Signal. , vol.16 , pp. 974-1031
    • Von Bernhardi, R.1    Eugenin, J.2
  • 5
    • 79953223315 scopus 로고    scopus 로고
    • Intestinal DMT1 cotransporter is down-regulated by hepcidin via proteasome internalization and degradation
    • Brasse-Lagnel C., Karim Z., Letteron P., Bekri S., Bado A., and, Beaumont C., (2011) Intestinal DMT1 cotransporter is down-regulated by hepcidin via proteasome internalization and degradation. Gastroenterology 140, e1261.
    • (2011) Gastroenterology , vol.140
    • Brasse-Lagnel, C.1    Karim, Z.2    Letteron, P.3    Bekri, S.4    Bado, A.5    Beaumont, C.6
  • 6
    • 67349276645 scopus 로고    scopus 로고
    • Amyloid precursor protein and alpha synuclein translation, implications for iron and inflammation in neurodegenerative diseases
    • Cahill C. M., Lahiri D. K., Huang X., and, Rogers J. T., (2009) Amyloid precursor protein and alpha synuclein translation, implications for iron and inflammation in neurodegenerative diseases. Biochim. Biophys. Acta 1790, 615-628.
    • (2009) Biochim. Biophys. Acta , vol.1790 , pp. 615-628
    • Cahill, C.M.1    Lahiri, D.K.2    Huang, X.3    Rogers, J.T.4
  • 7
    • 39649097642 scopus 로고    scopus 로고
    • Evidence for differential effects of hepcidin in macrophages and intestinal epithelial cells
    • Chaston T., Chung B., Mascarenhas M., Marks J., Patel B., Srai S. K., and, Sharp P., (2008) Evidence for differential effects of hepcidin in macrophages and intestinal epithelial cells. Gut 57, 374-382.
    • (2008) Gut , vol.57 , pp. 374-382
    • Chaston, T.1    Chung, B.2    Mascarenhas, M.3    Marks, J.4    Patel, B.5    Srai, S.K.6    Sharp, P.7
  • 8
    • 84869086650 scopus 로고    scopus 로고
    • The iron regulatory hormone hepcidin inhibits expression of iron release as well as iron uptake proteins in J774 cells
    • Du F., Qian Z. M., Gong Q., Zhu Z. J., Lu L., and, Ke Y., (2012) The iron regulatory hormone hepcidin inhibits expression of iron release as well as iron uptake proteins in J774 cells. J. Nutr. Biochem. 23, 1694-1700.
    • (2012) J. Nutr. Biochem. , vol.23 , pp. 1694-1700
    • Du, F.1    Qian, Z.M.2    Gong, Q.3    Zhu, Z.J.4    Lu, L.5    Ke, Y.6
  • 9
    • 79960891356 scopus 로고    scopus 로고
    • Hepcidin expression in human airway epithelial cells is regulated by interferon-gamma
    • Frazier M. D., Mamo L. B., Ghio A. J., and, Turi J. L., (2011) Hepcidin expression in human airway epithelial cells is regulated by interferon-gamma. Respir. Res. 12, 100.
    • (2011) Respir. Res. , vol.12 , pp. 100
    • Frazier, M.D.1    Mamo, L.B.2    Ghio, A.J.3    Turi, J.L.4
  • 10
    • 84861355868 scopus 로고    scopus 로고
    • Hepcidin and iron homeostasis
    • Ganz T., and, Nemeth E., (2012) Hepcidin and iron homeostasis. Biochim. Biophys. Acta 1823, 1434-1443.
    • (2012) Biochim. Biophys. Acta , vol.1823 , pp. 1434-1443
    • Ganz, T.1    Nemeth, E.2
  • 11
    • 71749089888 scopus 로고    scopus 로고
    • The iron regulatory hormone hepcidin reduces ferroportin 1 content and iron release in H9C2 cardiomyocytes
    • Ge X. H., Wang Q., Qian Z. M., Zhu L., Du F., Yung W. H., Yang L., and, Ke Y., (2009) The iron regulatory hormone hepcidin reduces ferroportin 1 content and iron release in H9C2 cardiomyocytes. J. Nutr. Biochem. 20, 860-865.
    • (2009) J. Nutr. Biochem. , vol.20 , pp. 860-865
    • Ge, X.H.1    Wang, Q.2    Qian, Z.M.3    Zhu, L.4    Du, F.5    Yung, W.H.6    Yang, L.7    Ke, Y.8
  • 12
    • 41649120714 scopus 로고    scopus 로고
    • Hepcidin expression in mouse retina and its regulation via lipopolysaccharide/Toll-like receptor-4 pathway independent of Hfe
    • Gnana-Prakasam J. P., Martin P. M., Mysona B. A., Roon P., Smith S. B., and, Ganapathy V., (2008) Hepcidin expression in mouse retina and its regulation via lipopolysaccharide/Toll-like receptor-4 pathway independent of Hfe. Biochem. J. 411, 79-88.
    • (2008) Biochem. J. , vol.411 , pp. 79-88
    • Gnana-Prakasam, J.P.1    Martin, P.M.2    Mysona, B.A.3    Roon, P.4    Smith, S.B.5    Ganapathy, V.6
  • 13
    • 80052315340 scopus 로고    scopus 로고
    • Toll-like receptors in health and disease in the brain: Mechanisms and therapeutic potential
    • Hanke M. L., and, Kielian T., (2011) Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential. Clin. Sci. (Lond.) 121, 367-387.
    • (2011) Clin. Sci. (Lond.) , vol.121 , pp. 367-387
    • Hanke, M.L.1    Kielian, T.2
  • 14
    • 0037126002 scopus 로고    scopus 로고
    • Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: Implications for regulation and cellular function
    • Hubert N., and, Hentze M. W., (2002) Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: implications for regulation and cellular function. Proc. Natl Acad. Sci. USA 99, 12345-12350.
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 12345-12350
    • Hubert, N.1    Hentze, M.W.2
  • 15
    • 0037378023 scopus 로고    scopus 로고
    • Neuroinflammatory processes in Parkinson's disease
    • discussion S58-60.
    • Hunot S., and, Hirsch E. C., (2003) Neuroinflammatory processes in Parkinson's disease. Ann. Neurol. 53 (Suppl 3), S49-S58; discussion S58-60.
    • (2003) Ann. Neurol. , vol.53 , Issue.SUPPL. 3
    • Hunot, S.1    Hirsch, E.C.2
  • 16
    • 77449095292 scopus 로고    scopus 로고
    • Inflammation and age-related iron accumulation in F344 rats
    • Hunter R. L., Liu M., Choi D. Y., Cass W. A., and, Bing G., (2008) Inflammation and age-related iron accumulation in F344 rats. Curr. Aging Sci. 1, 112-121.
    • (2008) Curr. Aging Sci. , vol.1 , pp. 112-121
    • Hunter, R.L.1    Liu, M.2    Choi, D.Y.3    Cass, W.A.4    Bing, G.5
  • 17
    • 80055078417 scopus 로고    scopus 로고
    • Importance of iron chelation in free radical-induced oxidative stress and human disease
    • Jomova K., and, Valko M., (2011) Importance of iron chelation in free radical-induced oxidative stress and human disease. Curr. Pharm. Des. 17, 3460-3473.
    • (2011) Curr. Pharm. Des. , vol.17 , pp. 3460-3473
    • Jomova, K.1    Valko, M.2
  • 18
    • 34548864370 scopus 로고    scopus 로고
    • Culturing hippocampal neurons
    • Kaech S., and, Banker G., (2006) Culturing hippocampal neurons. Nat. Protoc. 1, 2406-2415.
    • (2006) Nat. Protoc. , vol.1 , pp. 2406-2415
    • Kaech, S.1    Banker, G.2
  • 19
    • 39849083520 scopus 로고    scopus 로고
    • Mechanisms of microglia-mediated neurotoxicity in a new model of the stroke penumbra
    • Kaushal V., and, Schlichter L. C., (2008) Mechanisms of microglia-mediated neurotoxicity in a new model of the stroke penumbra. J. Neurosci. 28, 2221-2230.
    • (2008) J. Neurosci. , vol.28 , pp. 2221-2230
    • Kaushal, V.1    Schlichter, L.C.2
  • 20
    • 0344154421 scopus 로고    scopus 로고
    • Labile iron pool: The main determinant of cellular response to oxidative stress
    • Kruszewski M., (2003) Labile iron pool: the main determinant of cellular response to oxidative stress. Mutat. Res. 531, 81-92.
    • (2003) Mutat. Res. , vol.531 , pp. 81-92
    • Kruszewski, M.1
  • 21
    • 13844307889 scopus 로고    scopus 로고
    • Regulation of hepcidin transcription by interleukin-1 and interleukin-6
    • Lee P., Peng H., Gelbart T., Wang L., and, Beutler E., (2005) Regulation of hepcidin transcription by interleukin-1 and interleukin-6. Proc. Natl Acad. Sci. USA 102, 1906-1910.
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 1906-1910
    • Lee, P.1    Peng, H.2    Gelbart, T.3    Wang, L.4    Beutler, E.5
  • 23
    • 82455192361 scopus 로고    scopus 로고
    • Hepcidin treatment modulates the expression of divalent metal transporter-1, ceruloplasmin, and ferroportin-1 in the rat cerebral cortex and hippocampus
    • Li L., Holscher C., Chen B. B., Zhang Z. F., and, Liu Y. Z., (2011) Hepcidin treatment modulates the expression of divalent metal transporter-1, ceruloplasmin, and ferroportin-1 in the rat cerebral cortex and hippocampus. Biol. Trace Elem. Res. 143, 1581-1593.
    • (2011) Biol. Trace Elem. Res. , vol.143 , pp. 1581-1593
    • Li, L.1    Holscher, C.2    Chen, B.B.3    Zhang, Z.F.4    Liu, Y.Z.5
  • 24
    • 21544449756 scopus 로고    scopus 로고
    • Regulation of hepcidin and ferroportin expression by lipopolysaccharide in splenic macrophages
    • Liu X. B., Nguyen N. B., Marquess K. D., Yang F., and, Haile D. J., (2005) Regulation of hepcidin and ferroportin expression by lipopolysaccharide in splenic macrophages. Blood Cells Mol. Dis. 35, 47-56.
    • (2005) Blood Cells Mol. Dis. , vol.35 , pp. 47-56
    • Liu, X.B.1    Nguyen, N.B.2    Marquess, K.D.3    Yang, F.4    Haile, D.J.5
  • 26
    • 84868258078 scopus 로고    scopus 로고
    • Sustained submicromolar H2O2 levels induce hepcidin via signal transducer and activator of transcription 3 (STAT3)
    • Millonig G., Ganzleben I., Peccerella T., et al,. (2012) Sustained submicromolar H2O2 levels induce hepcidin via signal transducer and activator of transcription 3 (STAT3). J. Biol. Chem. 287, 37472-37482.
    • (2012) J. Biol. Chem. , vol.287 , pp. 37472-37482
    • Millonig, G.1    Ganzleben, I.2    Peccerella, T.3
  • 27
    • 0028171374 scopus 로고
    • Interleukin-1 beta, interleukin-6, epidermal growth factor and transforming growth factor-alpha are elevated in the brain from parkinsonian patients
    • Mogi M., Harada M., Kondo T., Riederer P., Inagaki H., Minami M., and, Nagatsu T., (1994a) Interleukin-1 beta, interleukin-6, epidermal growth factor and transforming growth factor-alpha are elevated in the brain from parkinsonian patients. Neurosci. Lett. 180, 147-150.
    • (1994) Neurosci. Lett. , vol.180 , pp. 147-150
    • Mogi, M.1    Harada, M.2    Kondo, T.3    Riederer, P.4    Inagaki, H.5    Minami, M.6    Nagatsu, T.7
  • 28
    • 0028178281 scopus 로고
    • Tumor necrosis factor-alpha (TNF-alpha) increases both in the brain and in the cerebrospinal fluid from parkinsonian patients
    • Mogi M., Harada M., Riederer P., Narabayashi H., Fujita K., and, Nagatsu T., (1994b) Tumor necrosis factor-alpha (TNF-alpha) increases both in the brain and in the cerebrospinal fluid from parkinsonian patients. Neurosci. Lett. 165, 208-210.
    • (1994) Neurosci. Lett. , vol.165 , pp. 208-210
    • Mogi, M.1    Harada, M.2    Riederer, P.3    Narabayashi, H.4    Fujita, K.5    Nagatsu, T.6
  • 29
    • 0030582991 scopus 로고    scopus 로고
    • Interleukin (IL)-1 beta, IL-2, IL-4, IL-6 and transforming growth factor-alpha levels are elevated in ventricular cerebrospinal fluid in juvenile parkinsonism and Parkinson's disease
    • Mogi M., Harada M., Narabayashi H., Inagaki H., Minami M., and, Nagatsu T., (1996) Interleukin (IL)-1 beta, IL-2, IL-4, IL-6 and transforming growth factor-alpha levels are elevated in ventricular cerebrospinal fluid in juvenile parkinsonism and Parkinson's disease. Neurosci. Lett. 211, 13-16.
    • (1996) Neurosci. Lett. , vol.211 , pp. 13-16
    • Mogi, M.1    Harada, M.2    Narabayashi, H.3    Inagaki, H.4    Minami, M.5    Nagatsu, T.6
  • 30
    • 79953898190 scopus 로고    scopus 로고
    • Iron mediates N-methyl-D-aspartate receptor-dependent stimulation of calcium-induced pathways and hippocampal synaptic plasticity
    • Muñoz P., Humeres A., Elgueta C., Kirkwood A., Hidalgo C., and, Núñez M. T., (2011) Iron mediates N-methyl-D-aspartate receptor-dependent stimulation of calcium-induced pathways and hippocampal synaptic plasticity. J. Biol. Chem. 286, 13382-13392.
    • (2011) J. Biol. Chem. , vol.286 , pp. 13382-13392
    • Muñoz, P.1    Humeres, A.2    Elgueta, C.3    Kirkwood, A.4    Hidalgo, C.5    Núñez, M.T.6
  • 31
    • 10844258104 scopus 로고    scopus 로고
    • Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
    • Nemeth E., Tuttle M. S., Powelson J., Vaughn M. B., Donovan A., Ward D. M., Ganz T., and, Kaplan J., (2004) Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 306, 2090-2093.
    • (2004) Science , vol.306 , pp. 2090-2093
    • Nemeth, E.1    Tuttle, M.S.2    Powelson, J.3    Vaughn, M.B.4    Donovan, A.5    Ward, D.M.6    Ganz, T.7    Kaplan, J.8
  • 33
    • 32444439095 scopus 로고    scopus 로고
    • Iron, neuroinflammation, and Alzheimer's disease
    • discussion 209-115.
    • Ong W. Y., and, Farooqui A. A., (2005) Iron, neuroinflammation, and Alzheimer's disease. J. Alzheimers Dis. 8, 183-200; discussion 209-115.
    • (2005) J. Alzheimers Dis. , vol.8 , pp. 183-200
    • Ong, W.Y.1    Farooqui, A.A.2
  • 34
    • 32944477219 scopus 로고    scopus 로고
    • Post-translational and transcriptional regulation of DMT1 during P19 embryonic carcinoma cell differentiation by retinoic acid
    • Paradkar P. N., and, Roth J. A., (2006) Post-translational and transcriptional regulation of DMT1 during P19 embryonic carcinoma cell differentiation by retinoic acid. Biochem. J. 394, 173-183.
    • (2006) Biochem. J. , vol.394 , pp. 173-183
    • Paradkar, P.N.1    Roth, J.A.2
  • 35
    • 84858078783 scopus 로고    scopus 로고
    • Iron homeostasis in astrocytes and microglia is differentially regulated by TNF-alpha and TGF-beta1
    • Rathore K. I., Redensek A., and, David S., (2012) Iron homeostasis in astrocytes and microglia is differentially regulated by TNF-alpha and TGF-beta1. Glia 60, 738-750.
    • (2012) Glia , vol.60 , pp. 738-750
    • Rathore, K.I.1    Redensek, A.2    David, S.3
  • 36
    • 0034814056 scopus 로고    scopus 로고
    • Microglial chemotaxis, activation, and phagocytosis of amyloid beta-peptide as linked phenomena in Alzheimer's disease
    • Rogers J., and, Lue L. F., (2001) Microglial chemotaxis, activation, and phagocytosis of amyloid beta-peptide as linked phenomena in Alzheimer's disease. Neurochem. Int. 39, 333-340.
    • (2001) Neurochem. Int. , vol.39 , pp. 333-340
    • Rogers, J.1    Lue, L.F.2
  • 38
    • 80051801621 scopus 로고    scopus 로고
    • The relevance of iron in the pathogenesis of Parkinson's disease
    • Sian-Hulsmann J., Mandel S., Youdim M. B., and, Riederer P., (2011) The relevance of iron in the pathogenesis of Parkinson's disease. J. Neurochem. 118, 939-957.
    • (2011) J. Neurochem. , vol.118 , pp. 939-957
    • Sian-Hulsmann, J.1    Mandel, S.2    Youdim, M.B.3    Riederer, P.4
  • 39
    • 84155162481 scopus 로고    scopus 로고
    • Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases
    • Smith J. A., Das A., Ray S. K., and, Banik N. L., (2012) Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases. Brain Res. Bull. 87, 10-20.
    • (2012) Brain Res. Bull. , vol.87 , pp. 10-20
    • Smith, J.A.1    Das, A.2    Ray, S.K.3    Banik, N.L.4
  • 40
    • 43249092898 scopus 로고    scopus 로고
    • Preparation and coculture of neurons and glial cells
    • Chapter 2, Unit 2.7.
    • Viviani B., (2006) Preparation and coculture of neurons and glial cells. Curr. Protoc. Cell Biol. Chapter 2, Unit 2.7.
    • (2006) Curr. Protoc. Cell Biol.
    • Viviani, B.1
  • 41
    • 79952498248 scopus 로고    scopus 로고
    • TNFR1-induced activation of the classical NF-kappaB pathway
    • Wajant H., and, Scheurich P., (2011) TNFR1-induced activation of the classical NF-kappaB pathway. FEBS J. 278, 862-876.
    • (2011) FEBS J. , vol.278 , pp. 862-876
    • Wajant, H.1    Scheurich, P.2
  • 42
    • 47949130644 scopus 로고    scopus 로고
    • Lipopolysaccharide induces a significant increase in expression of iron regulatory hormone hepcidin in the cortex and substantia nigra in rat brain
    • Wang Q., Du F., Qian Z. M., Ge X. H., Zhu L., Yung W. H., Yang L., and, Ke Y., (2008) Lipopolysaccharide induces a significant increase in expression of iron regulatory hormone hepcidin in the cortex and substantia nigra in rat brain. Endocrinology 149, 3920-3925.
    • (2008) Endocrinology , vol.149 , pp. 3920-3925
    • Wang, Q.1    Du, F.2    Qian, Z.M.3    Ge, X.H.4    Zhu, L.5    Yung, W.H.6    Yang, L.7    Ke, Y.8
  • 43
    • 73749085208 scopus 로고    scopus 로고
    • Role of hepcidin in murine brain iron metabolism
    • Wang S. M., Fu L. J., Duan X. L., et al,. (2010) Role of hepcidin in murine brain iron metabolism. Cell. Mol. Life Sci. 67, 123-133.
    • (2010) Cell. Mol. Life Sci. , vol.67 , pp. 123-133
    • Wang, S.M.1    Fu, L.J.2    Duan, X.L.3
  • 46
    • 33751175421 scopus 로고    scopus 로고
    • Interleukin-6 induces hepcidin expression through STAT3
    • Wrighting D. M., and, Andrews N. C., (2006) Interleukin-6 induces hepcidin expression through STAT3. Blood 108, 3204-3209.
    • (2006) Blood , vol.108 , pp. 3204-3209
    • Wrighting, D.M.1    Andrews, N.C.2
  • 47
    • 1342322891 scopus 로고    scopus 로고
    • Hepcidin regulation of ferroportin 1 expression in the liver and intestine of the rat
    • Yeh K. Y., Yeh M., and, Glass J., (2004) Hepcidin regulation of ferroportin 1 expression in the liver and intestine of the rat. Am. J. Physiol. Gastrointest. Liver Physiol. 286, G385-G394.
    • (2004) Am. J. Physiol. Gastrointest. Liver Physiol. , vol.286
    • Yeh, K.Y.1    Yeh, M.2    Glass, J.3
  • 48
    • 33748569185 scopus 로고    scopus 로고
    • Distribution of the iron-regulating protein hepcidin in the murine central nervous system
    • Zechel S., Huber-Wittmer K., and, von Bohlen und Halbach O., (2006) Distribution of the iron-regulating protein hepcidin in the murine central nervous system. J. Neurosci. Res. 84, 790-800.
    • (2006) J. Neurosci. Res. , vol.84 , pp. 790-800
    • Zechel, S.1    Huber-Wittmer, K.2    Von, B.3    Halbach, O.4
  • 50
    • 79959406713 scopus 로고    scopus 로고
    • Iron deposition and inflammation in multiple sclerosis. Which one comes first?
    • Zivadinov R., Weinstock-Guttman B., and, Pirko I., (2011) Iron deposition and inflammation in multiple sclerosis. Which one comes first? BMC Neurosci. 12, 60.
    • (2011) BMC Neurosci. , vol.12 , pp. 60
    • Zivadinov, R.1    Weinstock-Guttman, B.2    Pirko, I.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.