Plasma hepcidin concentrations significantly predict interindividual variation in iron absorption in healthy men

American Journal of Clinical Nutrition

Volumn 89, Issue 4, 2009, Pages 1088-1091

  Roe, Mark A ^a   Collings, Rachel ^b   Dainty, Jack R ^a   Swinkels, Dorine W ^c   Fairweather Tait, Susan J ^b,d  

^a INSTITUTE OF FOOD RESEARCH   (United Kingdom)

^b UNIVERSITY OF EAST ANGLIA   (United Kingdom)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^d UNIVERSITY OF EAST ANGLIA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

FERRITIN; HEPCIDIN; HEPCIDIN 25; IRON; UNCLASSIFIED DRUG; ANTIMICROBIAL CATIONIC PEPTIDE; BIOLOGICAL MARKER; HEMOGLOBIN;

ADULT; AGED; ARTICLE; BIOAVAILABILITY; BLOOD ANALYSIS; BLOOD SAMPLING; CONTROLLED STUDY; CORRELATION ANALYSIS; DIET RESTRICTION; FERRITIN BLOOD LEVEL; GENETIC VARIABILITY; GENOTYPE; HORMONE BLOOD LEVEL; HUMAN; IRON ABSORPTION; MALE; MULTIPLE LINEAR REGRESSION ANALYSIS; NORMAL HUMAN; ANALYSIS OF VARIANCE; BLOOD; DRUG EFFECT; INTESTINE ABSORPTION; IRON INTAKE; MIDDLE AGED; NUTRITIONAL STATUS; ORAL DRUG ADMINISTRATION; PHYSIOLOGY; STATISTICAL MODEL;

ADMINISTRATION, ORAL; AGED; ANALYSIS OF VARIANCE; ANTIMICROBIAL CATIONIC PEPTIDES; BIOLOGICAL AVAILABILITY; BIOLOGICAL MARKERS; FERRITINS; GENOTYPE; HEMOGLOBINS; HUMANS; INTESTINAL ABSORPTION; IRON ISOTOPES; IRON, DIETARY; LINEAR MODELS; MALE; MIDDLE AGED; NUTRITIONAL STATUS;

EID: 63649105326     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.3945/ajcn.2008.27297     Document Type: Article

References (19)

1. Leong W-I, Lonnerdal B. Hepcidin, the recently identified peptide that appears to regulate iron absorption. J Nutr 2004;134:1-4.
2. Oates PS. The relevance of the intestinal crypt and enterocytes in regulating iron absorption. Pflugers Arch 2007;455:201-13.
3. Nemeth E, Tuttle MS, Powelson J, et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 2004;306:2090-3.
4. Mena NP, Esparza A, Tapia V, Valdez P, Nunez MT. Hepcidin inhibits apical iron uptake in intestinal cells. Am J Physiol Gastrointest Liver Physiol 2008;294:G192-8.
5. Anderson GJ, Darshan D, Wilkins SJ, Frazer DM. Regulation of systemic iron homeostasis: how the body responds to changes in iron demand. Biometals 2007;20:665-74.
6. Schulze KJ, Christian P, Ruczinski I, et al. Hepcidin and iron status among pregnant women in Bangladesh. Asia Pac J Clin Nutr 2008;17:451-6.
7. Swinkels DW, Girelli D, Laarakkers C, et al. Improvements to quantitative hepcidin measurements by mass spectrometry. PLoS One 2008;3:e2706.
8. Ganz T, Olbina G, Girelli D, Nemeth E, Westerman M. Immunoassay for human serum hepcidin. Blood 2008;112:4292-7.
9. Swinkels DW, Drenth JPH. Hepcidin in the management of patients with mild non-hemochromatotic iron overload: fact or fiction? J Hepatol 2008;49:680-5.
10. Young MF, Glahn RP, Ariza-Nieto, et al. Serum hepcidin is significantly associated with iron absorption from food and supplemental sources in healthy young men. Am J Clin Nutr 2008;89:533-8.
11. Roe MA, Heath A-LM, Oyston SL, et al. Iron absorption in male C282Y heterzygotes. Am J Clin Nutr 2005;81:814-21.
12. Kemna EHJM, Tjalsma H, Podust VN, Swinkels DW. Mass spectrometry-based hepcidin measurements in serum and urine: analytical aspects and clinical implications. Clin Chem 2007;53:620-8.
13. R Development Core Team. R: a language and environment for statistical computing. 2006R Foundation for Statistical Computing, Vienna, Austria. ISBN 3-900051-07-0. Available from: http://www.R-project.org(cited 12 Aug 2008).
14. Andrews NC. Forging a field: the golden age of iron biology. Blood 2008;112:219-30.
15. Yamaji S, Sharp P, Ramesh B, Srai SK. Inhibition of iron transport across human intestinal epithelial cells by hepcidin. Blood 2004;104:2178-80.
16. Frazer DM, Wilkins SJ, Becker EM, et al. Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats. Gastroenterology 2002;123:835-44.
17. Laftah AH, Ramesh B, Simpson RJ, et al. Effect of hepcidin on intestinal iron absorption in mice. Blood 2004;103:3940-4.
18. Magnusson B, Björn-Rassmussen E, Hallberg L, Rossander L. Iron absorption in relation to iron status. Model proposed to express results to food iron absorption measurements. Scand J Haematol 1981;27:201-8.
19. Hallberg L, Hultén L, Gramatkovski E. Iron absorption from the whole diet in men: how effective is the regulation of iron absorption? Am J Clin Nutr 1997;66:347-56.