A Multi-Scale Model of Hepcidin Promoter Regulation Reveals Factors Controlling Systemic Iron Homeostasis

PLoS Computational Biology

Volumn 10, Issue 1, 2014, Pages

  Casanovas, Guillem ^a,b,c   Banerji, Anashua ^d,e   d'Alessio, Flavia ^a,b,c   Muckenthaler, Martina U ^a,b,c   Legewie, Stefan ^d,e  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^b Molecular Medicine Partnership Unit   (Germany)

^c EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^d Quantitative Proteomics   (Germany)

^e UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

FEEDBACK; PATHOLOGY; PEPTIDES; PHYSIOLOGY; TRANSCRIPTION; TRANSCRIPTION FACTORS;

BLOOD LEVELS; EXPRESSION LEVELS; FEEDBACK CIRCUITS; HAEMOCHROMATOSIS; HEPCIDIN; IRON HOMEOSTASIS; MULTISCALE MODELING; PEPTIDE HORMONES; REPORTER-GENE EXPRESSION; SIGNALING CASCADES;

IRON;

BONE MORPHOGENETIC PROTEIN; HEPCIDIN; INTERLEUKIN 6; LUCIFERASE; RNA POLYMERASE; SMAD1 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN; STAT3 PROTEIN; TRANSCRIPTION FACTOR;

ANTIBODY SPECIFICITY; ARTICLE; BINDING SITE; CONTROLLED STUDY; DENSITOMETRY; ENZYME ACTIVITY; HOMEOSTASIS; HUMAN; HUMAN CELL; IRON HOMEOSTASIS; MATHEMATICAL MODEL; MUTAGENESIS; NEGATIVE FEEDBACK; PROMOTER REGION; PROTEIN CROSS LINKING; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; QUANTITATIVE ANALYSIS; SIGNAL TRANSDUCTION; THERMODYNAMICS; TRANSCRIPTION INITIATION SITE; TRANSCRIPTION REGULATION;

ALGORITHMS; BONE MORPHOGENETIC PROTEINS; CELL LINE, TUMOR; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENES, REPORTER; HEPCIDINS; HOMEOSTASIS; HUMANS; INFLAMMATION; INTERLEUKIN-6; IRON; MODELS, THEORETICAL; MUTAGENESIS; PEPTIDES; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; SIGNAL TRANSDUCTION; THERMODYNAMICS; TRANSCRIPTION FACTORS;

EID: 84896735777     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1003421     Document Type: Article

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