Hepcidin Bound to α2-Macroglobulin Reduces Ferroportin-1 Expression and Enhances Its Activity at Reducing Serum Iron Levels

Journal of Biological Chemistry

Volumn 288, Issue 35, 2013, Pages 25450-25465

  Huang, Michael Li Hsuan ^a   Austin, Christopher J D ^a   Sari, Marie Agnès ^b   Rahmanto, Yohan Suryo ^a   Ponka, Prem ^c   Vyoral, Daniel ^d,e   Richardson, Des R ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c MCGILL UNIVERSITY   (Canada)

^d INSTITUTE OF HEMATOLOGY AND BLOOD TRANSFUSION   (Czech Republic)

^e CHARLES UNIVERSITY   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

HEPCIDIN; IRON METABOLISM; MACROGLOBULIN;

BODY FLUIDS;

IRON;

ALPHA 2 MACROGLOBULIN; FERROPORTIN 1; HEPCIDIN; IRON; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; METHYLAMINE; SEPHADEX;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; FEMALE; GLOMERULUS FILTRATION; IN VITRO STUDY; IN VIVO STUDY; IRON BLOOD LEVEL; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PLASMA CLEARANCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN SECRETION; PROTEIN TRANSPORT; ULTRAFILTRATION; URINARY EXCRETION;

Α2-MACROGLOBULIN; IRON; IRON METABOLISM; METALLOPROTEINS; METALS; PROTEIN METAL ION INTERACTION;

ALPHA-MACROGLOBULINS; ANIMALS; CATION TRANSPORT PROTEINS; CELL LINE; GENE EXPRESSION REGULATION; HEPCIDINS; HUMANS; IRON; LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN-1; MICE; MICE, KNOCKOUT; MODELS, BIOLOGICAL; MULTIPROTEIN COMPLEXES; RECEPTORS, LDL; TUMOR SUPPRESSOR PROTEINS;

EID: 84883380705     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.471573     Document Type: Article

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