메뉴 건너뛰기




Volumn 43, Issue 2, 2013, Pages 215-224

Iron homeostasis in the Metabolic Syndrome

Author keywords

FPN ferroportin 1; Hepcidin; Iron overload; Metabolic syndrome; Non alcoholic fatty liver disease

Indexed keywords

CERULOPLASMIN; COPPER; DEFEROXAMINE; FERRITIN; FERROPORTIN; GLUCOSE; HEMOGLOBIN A1C; HEPCIDIN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IRON; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; PROTEIN KINASE B; STAT3 PROTEIN; TRANSCRIPTION FACTOR FOXO; TRANSFERRIN RECEPTOR;

EID: 84872613270     PISSN: 00142972     EISSN: 13652362     Source Type: Journal    
DOI: 10.1111/eci.12032     Document Type: Review
Times cited : (144)

References (72)
  • 1
    • 2042546096 scopus 로고    scopus 로고
    • Balancing acts: molecular control of mammalian iron metabolism
    • Hentze MW, Muckenthaler MU, Andrews NC. Balancing acts: molecular control of mammalian iron metabolism. Cell 2004;117:285-97.
    • (2004) Cell , vol.117 , pp. 285-297
    • Hentze, M.W.1    Muckenthaler, M.U.2    Andrews, N.C.3
  • 3
    • 0033861745 scopus 로고    scopus 로고
    • A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation
    • McKie AT, Marciani P, Rolfs A, Brennan K, Wehr K, Barrow D, et al. A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation. Mol Cell 2000;5:299-309.
    • (2000) Mol Cell , vol.5 , pp. 299-309
    • McKie, A.T.1    Marciani, P.2    Rolfs, A.3    Brennan, K.4    Wehr, K.5    Barrow, D.6
  • 4
    • 0032909207 scopus 로고    scopus 로고
    • Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse
    • Vulpe CD, Kuo YM, Murphy TL, Cowley L, Askwith C, Libina N, et al. Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse. Nat Genet 1999;21:195-9.
    • (1999) Nat Genet , vol.21 , pp. 195-199
    • Vulpe, C.D.1    Kuo, Y.M.2    Murphy, T.L.3    Cowley, L.4    Askwith, C.5    Libina, N.6
  • 5
    • 0034733635 scopus 로고    scopus 로고
    • A novel mammalian iron-regulated protein involved in intracellular iron metabolism
    • Abboud S, Haile DJ. A novel mammalian iron-regulated protein involved in intracellular iron metabolism. J Biol Chem 2000;275:19906-12.
    • (2000) J Biol Chem , vol.275 , pp. 19906-19912
    • Abboud, S.1    Haile, D.J.2
  • 6
    • 0036791486 scopus 로고    scopus 로고
    • The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation
    • Nicolas G, Chauvet C, Viatte L, Danan JL, Bigard X, Devaux I, et al. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J Clin Investig 2002;110:1037-44.
    • (2002) J Clin Investig , vol.110 , pp. 1037-1044
    • Nicolas, G.1    Chauvet, C.2    Viatte, L.3    Danan, J.L.4    Bigard, X.5    Devaux, I.6
  • 7
    • 10844258104 scopus 로고    scopus 로고
    • Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
    • Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM, et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science (New York, N.Y) 2004;306:2090-3.
    • (2004) Science (New York, N.Y) , vol.306 , pp. 2090-2093
    • Nemeth, E.1    Tuttle, M.S.2    Powelson, J.3    Vaughn, M.B.4    Donovan, A.5    Ward, D.M.6
  • 8
    • 33748265283 scopus 로고    scopus 로고
    • Increased adipose tissue expression of hepcidin in severe obesity is independent from diabetes and NASH
    • Bekri S, Gual P, Anty R, Luciani N, Dahman M, Ramesh B, et al. Increased adipose tissue expression of hepcidin in severe obesity is independent from diabetes and NASH. Gastroenterology 2006;131:788-96.
    • (2006) Gastroenterology , vol.131 , pp. 788-796
    • Bekri, S.1    Gual, P.2    Anty, R.3    Luciani, N.4    Dahman, M.5    Ramesh, B.6
  • 10
    • 0037460697 scopus 로고    scopus 로고
    • Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis
    • Bridle KR, Frazer DM, Wilkins SJ, Dixon JL, Purdie DM, Crawford DH, et al. Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis. Lancet 2003;361:669-73.
    • (2003) Lancet , vol.361 , pp. 669-673
    • Bridle, K.R.1    Frazer, D.M.2    Wilkins, S.J.3    Dixon, J.L.4    Purdie, D.M.5    Crawford, D.H.6
  • 11
    • 19944427107 scopus 로고    scopus 로고
    • Expression of hepcidin is down-regulated in TfR2 mutant mice manifesting a phenotype of hereditary hemochromatosis
    • Kawabata H, Fleming RE, Gui D, Moon SY, Saitoh T, O'Kelly J, et al. Expression of hepcidin is down-regulated in TfR2 mutant mice manifesting a phenotype of hereditary hemochromatosis. Blood 2005;105:376-81.
    • (2005) Blood , vol.105 , pp. 376-381
    • Kawabata, H.1    Fleming, R.E.2    Gui, D.3    Moon, S.Y.4    Saitoh, T.5    O'Kelly, J.6
  • 12
    • 36349028180 scopus 로고    scopus 로고
    • Hemochromatosis: an endocrine liver disease
    • Pietrangelo A. Hemochromatosis: an endocrine liver disease. Hepatology (Baltimore, Md) 2007;46:1291-301.
    • (2007) Hepatology (Baltimore, Md) , vol.46 , pp. 1291-1301
    • Pietrangelo, A.1
  • 15
    • 67651043722 scopus 로고    scopus 로고
    • Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells
    • Tanno T, Porayette P, Sripichai O, Noh SJ, Byrnes C, Bhupatiraju A, et al. Identification of TWSG1 as a second novel erythroid regulator of hepcidin expression in murine and human cells. Blood 2009;114:181-6.
    • (2009) Blood , vol.114 , pp. 181-186
    • Tanno, T.1    Porayette, P.2    Sripichai, O.3    Noh, S.J.4    Byrnes, C.5    Bhupatiraju, A.6
  • 16
    • 0034767941 scopus 로고    scopus 로고
    • Histologic features of the liver in insulin resistance-associated iron overload. A study of 139 patients
    • Turlin B, Mendler MH, Moirand R, Guyader D, Guillygomarc'h A, Deugnier Y. Histologic features of the liver in insulin resistance-associated iron overload. A study of 139 patients. Am J Clin Pathol 2001;116:263-70.
    • (2001) Am J Clin Pathol , vol.116 , pp. 263-270
    • Turlin, B.1    Mendler, M.H.2    Moirand, R.3    Guyader, D.4    Guillygomarc'h, A.5    Deugnier, Y.6
  • 18
    • 0019434645 scopus 로고
    • Iron and the sex difference in heart disease risk
    • Sullivan JL. Iron and the sex difference in heart disease risk. Lancet 1981;1:1293-4.
    • (1981) Lancet , vol.1 , pp. 1293-1294
    • Sullivan, J.L.1
  • 19
    • 3042569036 scopus 로고    scopus 로고
    • The iron-heart disease connection: is it dead or just hiding?
    • Wood RJ. The iron-heart disease connection: is it dead or just hiding? Ageing Res Rev 2004;3:355-67.
    • (2004) Ageing Res Rev , vol.3 , pp. 355-367
    • Wood, R.J.1
  • 20
    • 0033364044 scopus 로고    scopus 로고
    • Diabetes and serum ferritin concentration among U.S. adults
    • Ford ES, Cogswell ME. Diabetes and serum ferritin concentration among U.S. adults. Diabetes Care 1999;22:1978-83.
    • (1999) Diabetes Care , vol.22 , pp. 1978-1983
    • Ford, E.S.1    Cogswell, M.E.2
  • 21
    • 0035042446 scopus 로고    scopus 로고
    • Gestational diabetes mellitus in the last trimester - a feature of maternal iron excess?
    • Lao TT, Chan PL, Tam KF. Gestational diabetes mellitus in the last trimester - a feature of maternal iron excess? Diabet Med 2001;18:218-23.
    • (2001) Diabet Med , vol.18 , pp. 218-223
    • Lao, T.T.1    Chan, P.L.2    Tam, K.F.3
  • 22
    • 1442314640 scopus 로고    scopus 로고
    • Body iron stores in relation to risk of type 2 diabetes in apparently healthy women
    • Jiang R, Manson JE, Meigs JB, Ma J, Rifai N, Hu FB. Body iron stores in relation to risk of type 2 diabetes in apparently healthy women. JAMA 2004;291:711-17.
    • (2004) JAMA , vol.291 , pp. 711-717
    • Jiang, R.1    Manson, J.E.2    Meigs, J.B.3    Ma, J.4    Rifai, N.5    Hu, F.B.6
  • 23
    • 25644451315 scopus 로고    scopus 로고
    • Serum ferritin is associated with visceral fat area and subcutaneous fat area
    • Iwasaki T, Nakajima A, Yoneda M, Yamada Y, Mukasa K, Fujita K, et al. Serum ferritin is associated with visceral fat area and subcutaneous fat area. Diabetes Care 2005;28:2486-91.
    • (2005) Diabetes Care , vol.28 , pp. 2486-2491
    • Iwasaki, T.1    Nakajima, A.2    Yoneda, M.3    Yamada, Y.4    Mukasa, K.5    Fujita, K.6
  • 24
    • 23444453550 scopus 로고    scopus 로고
    • Iron stores, blood donation, and insulin sensitivity and secretion
    • Fernandez-Real JM, Lopez-Bermejo A, Ricart W. Iron stores, blood donation, and insulin sensitivity and secretion. Clin Chem 2005;51:1201-5.
    • (2005) Clin Chem , vol.51 , pp. 1201-1205
    • Fernandez-Real, J.M.1    Lopez-Bermejo, A.2    Ricart, W.3
  • 26
    • 33645230958 scopus 로고    scopus 로고
    • Serum ferritin, cardiovascular risk factors and ischaemic heart diseases: a prospective analysis in the SU.VI.MAX (SUpplementation en VItamines et Mineraux AntioXydants) cohort
    • Galan P, Noisette N, Estaquio C, Czernichow S, Mennen L, Renversez JC, et al. Serum ferritin, cardiovascular risk factors and ischaemic heart diseases: a prospective analysis in the SU.VI.MAX (SUpplementation en VItamines et Mineraux AntioXydants) cohort. Public Health Nutr 2006;9:70-4.
    • (2006) Public Health Nutr , vol.9 , pp. 70-74
    • Galan, P.1    Noisette, N.2    Estaquio, C.3    Czernichow, S.4    Mennen, L.5    Renversez, J.C.6
  • 27
    • 35148869960 scopus 로고    scopus 로고
    • Insulin resistance and ferritin as major determinants of abnormal serum aminotransferase in severely obese children
    • Dubern B, Girardet JP, Tounian P. Insulin resistance and ferritin as major determinants of abnormal serum aminotransferase in severely obese children. Int J Pediatr Obes 2006;1:77-82.
    • (2006) Int J Pediatr Obes , vol.1 , pp. 77-82
    • Dubern, B.1    Girardet, J.P.2    Tounian, P.3
  • 29
    • 18744376322 scopus 로고    scopus 로고
    • Iron stores and cardiovascular disease risk factors in women of reproductive age in the United States
    • Ramakrishnan U, Kuklina E, Stein AD. Iron stores and cardiovascular disease risk factors in women of reproductive age in the United States. Am J Clin Nutr 2002;76:1256-60.
    • (2002) Am J Clin Nutr , vol.76 , pp. 1256-1260
    • Ramakrishnan, U.1    Kuklina, E.2    Stein, A.D.3
  • 30
    • 68149131547 scopus 로고    scopus 로고
    • Body iron stores and glucose intolerance in premenopausal women: role of hyperandrogenism, insulin resistance, and genomic variants related to inflammation, oxidative stress, and iron metabolism
    • Martinez-Garcia MA, Luque-Ramirez M, San-Millan JL, Escobar-Morreale HF. Body iron stores and glucose intolerance in premenopausal women: role of hyperandrogenism, insulin resistance, and genomic variants related to inflammation, oxidative stress, and iron metabolism. Diabetes Care 2009;32:1525-30.
    • (2009) Diabetes Care , vol.32 , pp. 1525-1530
    • Martinez-Garcia, M.A.1    Luque-Ramirez, M.2    San-Millan, J.L.3    Escobar-Morreale, H.F.4
  • 31
    • 34548417616 scopus 로고    scopus 로고
    • Increased body iron stores of obese women with polycystic ovary syndrome are a consequence of insulin resistance and hyperinsulinism and are not a result of reduced menstrual losses
    • Luque-Ramirez M, Alvarez-Blasco F, Botella-Carretero JI, Sanchon R, San Millan JL, Escobar-Morreale HF. Increased body iron stores of obese women with polycystic ovary syndrome are a consequence of insulin resistance and hyperinsulinism and are not a result of reduced menstrual losses. Diabetes Care 2007;30:2309-13.
    • (2007) Diabetes Care , vol.30 , pp. 2309-2313
    • Luque-Ramirez, M.1    Alvarez-Blasco, F.2    Botella-Carretero, J.I.3    Sanchon, R.4    San Millan, J.L.5    Escobar-Morreale, H.F.6
  • 32
    • 0034891077 scopus 로고    scopus 로고
    • Hyperferritinemia, iron overload, and multiple metabolic alterations identify patients at risk for nonalcoholic steatohepatitis
    • Fargion S, Mattioli M, Fracanzani AL, Sampietro M, Tavazzi D, Fociani P, et al. Hyperferritinemia, iron overload, and multiple metabolic alterations identify patients at risk for nonalcoholic steatohepatitis. Am J Gastroenterol 2001;96:2448-55.
    • (2001) Am J Gastroenterol , vol.96 , pp. 2448-2455
    • Fargion, S.1    Mattioli, M.2    Fracanzani, A.L.3    Sampietro, M.4    Tavazzi, D.5    Fociani, P.6
  • 33
    • 0031915149 scopus 로고    scopus 로고
    • Increased hepatic iron concentration in nonalcoholic steatohepatitis is associated with increased fibrosis
    • George DK, Goldwurm S, MacDonald GA, Cowley LL, Walker NI, Ward PJ, et al. Increased hepatic iron concentration in nonalcoholic steatohepatitis is associated with increased fibrosis. Gastroenterology 1998;114:311-18.
    • (1998) Gastroenterology , vol.114 , pp. 311-318
    • George, D.K.1    Goldwurm, S.2    MacDonald, G.A.3    Cowley, L.L.4    Walker, N.I.5    Ward, P.J.6
  • 35
    • 0141656292 scopus 로고    scopus 로고
    • Increased susceptibility to nonalcoholic fatty liver disease in heterozygotes for the mutation responsible for hereditary hemochromatosis
    • Valenti L, Dongiovanni P, Fracanzani AL, Santorelli G, Fatta E, Bertelli C, et al. Increased susceptibility to nonalcoholic fatty liver disease in heterozygotes for the mutation responsible for hereditary hemochromatosis. Dig Liver Dis 2003;35:172-8.
    • (2003) Dig Liver Dis , vol.35 , pp. 172-178
    • Valenti, L.1    Dongiovanni, P.2    Fracanzani, A.L.3    Santorelli, G.4    Fatta, E.5    Bertelli, C.6
  • 36
    • 0036291809 scopus 로고    scopus 로고
    • HFE mutations, hepatic iron, and fibrosis: ethnic-specific association of NASH with C282Y but not with fibrotic severity
    • Chitturi S, Weltman M, Farrell GC, McDonald D, Kench J, Liddle C, et al. HFE mutations, hepatic iron, and fibrosis: ethnic-specific association of NASH with C282Y but not with fibrotic severity. Hepatology (Baltimore, MD) 2002;36:142-9.
    • (2002) Hepatology (Baltimore, MD) , vol.36 , pp. 142-149
    • Chitturi, S.1    Weltman, M.2    Farrell, G.C.3    McDonald, D.4    Kench, J.5    Liddle, C.6
  • 37
    • 1442281989 scopus 로고    scopus 로고
    • Relative contribution of iron burden, HFE mutations, and insulin resistance to fibrosis in nonalcoholic fatty liver
    • Bugianesi E, Manzini P, D'Antico S, Vanni E, Longo F, Leone N, et al. Relative contribution of iron burden, HFE mutations, and insulin resistance to fibrosis in nonalcoholic fatty liver. Hepatology (Baltimore, MD) 2004;39:179-87.
    • (2004) Hepatology (Baltimore, MD) , vol.39 , pp. 179-187
    • Bugianesi, E.1    Manzini, P.2    D'Antico, S.3    Vanni, E.4    Longo, F.5    Leone, N.6
  • 39
    • 84155188801 scopus 로고    scopus 로고
    • Serum ferritin is an independent predictor of histologic severity and advanced fibrosis in patients with nonalcoholic fatty liver disease
    • Kowdley KV, Belt P, Wilson LA, Yeh MM, Neuschwander-Tetri BA, Chalasani N, et al. Serum ferritin is an independent predictor of histologic severity and advanced fibrosis in patients with nonalcoholic fatty liver disease. Hepatology (Baltimore, MD) 2012;55:77-85.
    • (2012) Hepatology (Baltimore, MD) , vol.55 , pp. 77-85
    • Kowdley, K.V.1    Belt, P.2    Wilson, L.A.3    Yeh, M.M.4    Neuschwander-Tetri, B.A.5    Chalasani, N.6
  • 40
    • 82455188154 scopus 로고    scopus 로고
    • Serum ferritin concentration and transferrin saturation before liver transplantation predict decreased long-term recipient survival
    • Weismuller TJ, Kirchner GI, Scherer MN, Negm AA, Schnitzbauer AA, Lehner F, et al. Serum ferritin concentration and transferrin saturation before liver transplantation predict decreased long-term recipient survival. Hepatology (Baltimore, MD) 2011;54:2114-24.
    • (2011) Hepatology (Baltimore, MD) , vol.54 , pp. 2114-2124
    • Weismuller, T.J.1    Kirchner, G.I.2    Scherer, M.N.3    Negm, A.A.4    Schnitzbauer, A.A.5    Lehner, F.6
  • 42
    • 58149280387 scopus 로고    scopus 로고
    • Liver iron excess in patients with hepatocellular carcinoma developed on non-alcoholic steato-hepatitis
    • Sorrentino P, D'Angelo S, Ferbo U, Micheli P, Bracigliano A, Vecchione R. Liver iron excess in patients with hepatocellular carcinoma developed on non-alcoholic steato-hepatitis. J Hepatol 2009;50:351-7.
    • (2009) J Hepatol , vol.50 , pp. 351-357
    • Sorrentino, P.1    D'Angelo, S.2    Ferbo, U.3    Micheli, P.4    Bracigliano, A.5    Vecchione, R.6
  • 43
    • 80054717696 scopus 로고    scopus 로고
    • Hemochromatosis gene and nonalcoholic fatty liver disease: a systematic review and meta-analysis
    • Hernaez R, Yeung E, Clark JM, Kowdley KV, Brancati FL, Kao WH. Hemochromatosis gene and nonalcoholic fatty liver disease: a systematic review and meta-analysis. J Hepatol 2011;55:1079-85.
    • (2011) J Hepatol , vol.55 , pp. 1079-1085
    • Hernaez, R.1    Yeung, E.2    Clark, J.M.3    Kowdley, K.V.4    Brancati, F.L.5    Kao, W.H.6
  • 44
    • 77957376214 scopus 로고    scopus 로고
    • Beta-globin mutations are associated with parenchymal siderosis and fibrosis in patients with non-alcoholic fatty liver disease
    • Valenti L, Canavesi E, Galmozzi E, Dongiovanni P, Rametta R, Maggioni P, et al. Beta-globin mutations are associated with parenchymal siderosis and fibrosis in patients with non-alcoholic fatty liver disease. J Hepatol 2010;53:927-33.
    • (2010) J Hepatol , vol.53 , pp. 927-933
    • Valenti, L.1    Canavesi, E.2    Galmozzi, E.3    Dongiovanni, P.4    Rametta, R.5    Maggioni, P.6
  • 45
    • 84868213438 scopus 로고    scopus 로고
    • Lower serum hepcidin and greater parenchymal iron in nonalcoholic fatty liver disease patients with C282Y HFE mutations
    • Nelson JE, Brunt EM, Kowdley KV. Lower serum hepcidin and greater parenchymal iron in nonalcoholic fatty liver disease patients with C282Y HFE mutations. Hepatology (Baltimore, MD) 2012;56:1730-40.
    • (2012) Hepatology (Baltimore, MD) , vol.56 , pp. 1730-1740
    • Nelson, J.E.1    Brunt, E.M.2    Kowdley, K.V.3
  • 46
    • 33749827999 scopus 로고    scopus 로고
    • Increased insulin secretory capacity but decreased insulin sensitivity after correction of iron overload by phlebotomy in hereditary haemochromatosis
    • Abraham D, Rogers J, Gault P, Kushner JP, McClain DA. Increased insulin secretory capacity but decreased insulin sensitivity after correction of iron overload by phlebotomy in hereditary haemochromatosis. Diabetologia 2006;49:2546-51.
    • (2006) Diabetologia , vol.49 , pp. 2546-2551
    • Abraham, D.1    Rogers, J.2    Gault, P.3    Kushner, J.P.4    McClain, D.A.5
  • 48
    • 40449120460 scopus 로고    scopus 로고
    • Iron depletion by deferoxamine up-regulates glucose uptake and insulin signaling in hepatoma cells and in rat liver
    • Dongiovanni P, Valenti L, Ludovica Fracanzani A, Gatti S, Cairo G, Fargion S. Iron depletion by deferoxamine up-regulates glucose uptake and insulin signaling in hepatoma cells and in rat liver. Am J Pathol 2008;172:738-47.
    • (2008) Am J Pathol , vol.172 , pp. 738-747
    • Dongiovanni, P.1    Valenti, L.2    Ludovica Fracanzani, A.3    Gatti, S.4    Cairo, G.5    Fargion, S.6
  • 49
    • 33745812430 scopus 로고    scopus 로고
    • Transferrin and iron induce insulin resistance of glucose transport in adipocytes
    • Green A, Basile R, Rumberger JM. Transferrin and iron induce insulin resistance of glucose transport in adipocytes. Metabolism 2006;55:1042-5.
    • (2006) Metabolism , vol.55 , pp. 1042-1045
    • Green, A.1    Basile, R.2    Rumberger, J.M.3
  • 50
    • 77249138221 scopus 로고    scopus 로고
    • Serum ferritin is inversely correlated with serum adiponectin level: population-based cross-sectional study
    • Ku BJ, Kim SY, Lee TY, Park KS. Serum ferritin is inversely correlated with serum adiponectin level: population-based cross-sectional study. Dis Markers 2009;27:303-10.
    • (2009) Dis Markers , vol.27 , pp. 303-310
    • Ku, B.J.1    Kim, S.Y.2    Lee, T.Y.3    Park, K.S.4
  • 51
    • 48249113844 scopus 로고    scopus 로고
    • Circulating RBP4 concentration might reflect insulin resistance-associated iron overload
    • Fernandez-Real JM, Moreno JM, Ricart W. Circulating RBP4 concentration might reflect insulin resistance-associated iron overload. Diabetes 2008;57:1918-25.
    • (2008) Diabetes , vol.57 , pp. 1918-1925
    • Fernandez-Real, J.M.1    Moreno, J.M.2    Ricart, W.3
  • 52
    • 33847629715 scopus 로고    scopus 로고
    • Circulating visfatin is associated with parameters of iron metabolism in subjects with altered glucose tolerance
    • Fernandez-Real JM, Moreno JM, Chico B, Lopez-Bermejo A, Ricart W. Circulating visfatin is associated with parameters of iron metabolism in subjects with altered glucose tolerance. Diabetes Care 2007;30:616-21.
    • (2007) Diabetes Care , vol.30 , pp. 616-621
    • Fernandez-Real, J.M.1    Moreno, J.M.2    Chico, B.3    Lopez-Bermejo, A.4    Ricart, W.5
  • 53
    • 80052940689 scopus 로고    scopus 로고
    • Iron in fatty liver and in the metabolic syndrome: a promising therapeutic target
    • Dongiovanni P, Fracanzani AL, Fargion S, Valenti L. Iron in fatty liver and in the metabolic syndrome: a promising therapeutic target. J Hepatol 2011;55:920-32.
    • (2011) J Hepatol , vol.55 , pp. 920-932
    • Dongiovanni, P.1    Fracanzani, A.L.2    Fargion, S.3    Valenti, L.4
  • 54
    • 35848934560 scopus 로고    scopus 로고
    • Leptin increases the expression of the iron regulatory hormone hepcidin in HuH7 human hepatoma cells
    • Chung B, Matak P, McKie AT, Sharp P. Leptin increases the expression of the iron regulatory hormone hepcidin in HuH7 human hepatoma cells. J Nutr 2007;137:2366-70.
    • (2007) J Nutr , vol.137 , pp. 2366-2370
    • Chung, B.1    Matak, P.2    McKie, A.T.3    Sharp, P.4
  • 55
    • 84855428841 scopus 로고    scopus 로고
    • The relationship between obesity and hypoferraemia in adults: a systematic review
    • Cheng HL, Bryant C, Cook R, O'Connor H, Rooney K, Steinbeck K. The relationship between obesity and hypoferraemia in adults: a systematic review. Obes Rev 2012;13:150-61.
    • (2012) Obes Rev , vol.13 , pp. 150-161
    • Cheng, H.L.1    Bryant, C.2    Cook, R.3    O'Connor, H.4    Rooney, K.5    Steinbeck, K.6
  • 56
    • 44649155598 scopus 로고    scopus 로고
    • Hepcidin and iron-related gene expression in subjects with Dysmetabolic Hepatic Iron Overload
    • Barisani D, Pelucchi S, Mariani R, Galimberti S, Trombini P, Fumagalli D, et al. Hepcidin and iron-related gene expression in subjects with Dysmetabolic Hepatic Iron Overload. J Hepatol 2008;49:123-33.
    • (2008) J Hepatol , vol.49 , pp. 123-133
    • Barisani, D.1    Pelucchi, S.2    Mariani, R.3    Galimberti, S.4    Trombini, P.5    Fumagalli, D.6
  • 57
    • 43549087627 scopus 로고    scopus 로고
    • Pathways underlying iron accumulation in human nonalcoholic fatty liver disease
    • Aigner E, Theurl I, Theurl M, Lederer D, Haufe H, Dietze O, et al. Pathways underlying iron accumulation in human nonalcoholic fatty liver disease. Am J Clin Nutr 2008;87:1374-83.
    • (2008) Am J Clin Nutr , vol.87 , pp. 1374-1383
    • Aigner, E.1    Theurl, I.2    Theurl, M.3    Lederer, D.4    Haufe, H.5    Dietze, O.6
  • 58
    • 33645509481 scopus 로고    scopus 로고
    • Hepcidin inhibits in vitro erythroid colony formation at reduced erythropoietin concentrations
    • Dallalio G, Law E, Means RT, Jr. Hepcidin inhibits in vitro erythroid colony formation at reduced erythropoietin concentrations. Blood 2006;107:2702-4.
    • (2006) Blood , vol.107 , pp. 2702-2704
    • Dallalio, G.1    Law, E.2    Means, R.T.3    Jr4
  • 59
    • 84870472632 scopus 로고    scopus 로고
    • Glucose acts as a regulator of serum iron by increasing serum hepcidin concentrations
    • Aigner E, Felder TK, Oberkofler H, Hahne P, Auer S, Soyal S et al. Glucose acts as a regulator of serum iron by increasing serum hepcidin concentrations. J Nutr Biochem 2013;24:112-7.
    • (2013) J Nutr Biochem , vol.24 , pp. 112-117
    • Aigner, E.1    Felder, T.K.2    Oberkofler, H.3    Hahne, P.4    Auer, S.5    Soyal, S.6
  • 60
    • 48549094554 scopus 로고    scopus 로고
    • Copper availability contributes to iron perturbations in human nonalcoholic fatty liver disease
    • Aigner E, Theurl I, Haufe H, Seifert M, Hohla F, Scharinger L et al. Copper availability contributes to iron perturbations in human nonalcoholic fatty liver disease. Gastroenterology 2008;135:680-8.
    • (2008) Gastroenterology , vol.135 , pp. 680-688
    • Aigner, E.1    Theurl, I.2    Haufe, H.3    Seifert, M.4    Hohla, F.5    Scharinger, L.6
  • 61
    • 67349243502 scopus 로고    scopus 로고
    • Iron absorption in dysmetabolic iron overload syndrome is decreased and correlates with increased plasma hepcidin
    • Ruivard M, Laine F, Ganz T, Olbina G, Westerman M, Nemeth E, et al. Iron absorption in dysmetabolic iron overload syndrome is decreased and correlates with increased plasma hepcidin. J Hepatol 2009;50:1219-25.
    • (2009) J Hepatol , vol.50 , pp. 1219-1225
    • Ruivard, M.1    Laine, F.2    Ganz, T.3    Olbina, G.4    Westerman, M.5    Nemeth, E.6
  • 62
    • 34247844680 scopus 로고    scopus 로고
    • Erythrophagocytosis by liver macrophages (Kupffer cells) promotes oxidative stress, inflammation, and fibrosis in a rabbit model of steatohepatitis: implications for the pathogenesis of human nonalcoholic steatohepatitis
    • Otogawa K, Kinoshita K, Fujii H, Sakabe M, Shiga R, Nakatani K, et al. Erythrophagocytosis by liver macrophages (Kupffer cells) promotes oxidative stress, inflammation, and fibrosis in a rabbit model of steatohepatitis: implications for the pathogenesis of human nonalcoholic steatohepatitis. Am J Pathol 2007;170:967-80.
    • (2007) Am J Pathol , vol.170 , pp. 967-980
    • Otogawa, K.1    Kinoshita, K.2    Fujii, H.3    Sakabe, M.4    Shiga, R.5    Nakatani, K.6
  • 63
    • 0025884356 scopus 로고
    • Transcriptional regulation of ferritin messenger ribonucleic acid levels by insulin in cultured rat glioma cells
    • Yokomori N, Iwasa Y, Aida K, Inoue M, Tawata M, Onaya T. Transcriptional regulation of ferritin messenger ribonucleic acid levels by insulin in cultured rat glioma cells. Endocrinology 1991;128:1474-80.
    • (1991) Endocrinology , vol.128 , pp. 1474-1480
    • Yokomori, N.1    Iwasa, Y.2    Aida, K.3    Inoue, M.4    Tawata, M.5    Onaya, T.6
  • 64
    • 34250800318 scopus 로고    scopus 로고
    • Ferroxidase activity is required for the stability of cell surface ferroportin in cells expressing GPI-ceruloplasmin
    • De Domenico I, Ward DM, di Patti MC, Jeong SY, David S, Musci G, et al. Ferroxidase activity is required for the stability of cell surface ferroportin in cells expressing GPI-ceruloplasmin. EMBO J 2007;26:2823-31.
    • (2007) EMBO J , vol.26 , pp. 2823-2831
    • De Domenico, I.1    Ward, D.M.2    di Patti, M.C.3    Jeong, S.Y.4    David, S.5    Musci, G.6
  • 65
    • 16644387800 scopus 로고    scopus 로고
    • Effects of venesections and restricted diet in patients with the insulin-resistance hepatic iron overload syndrome
    • Piperno A, Vergani A, Salvioni A, Trombini P, Vigano M, Riva A, et al. Effects of venesections and restricted diet in patients with the insulin-resistance hepatic iron overload syndrome. Liver Int 2004;24:471-6.
    • (2004) Liver Int , vol.24 , pp. 471-476
    • Piperno, A.1    Vergani, A.2    Salvioni, A.3    Trombini, P.4    Vigano, M.5    Riva, A.6
  • 66
    • 0031738536 scopus 로고    scopus 로고
    • Effect of phlebotomy on plasma glucose and insulin concentrations
    • Facchini FS. Effect of phlebotomy on plasma glucose and insulin concentrations. Diabetes Care 1998;21:2190.
    • (1998) Diabetes Care , vol.21 , pp. 2190
    • Facchini, F.S.1
  • 67
    • 0035849568 scopus 로고    scopus 로고
    • Iron chelation improves endothelial function in patients with coronary artery disease
    • Duffy SJ, Biegelsen ES, Holbrook M, Russell JD, Gokce N, Keaney JF et al., et al. Iron chelation improves endothelial function in patients with coronary artery disease. Circulation 2001;103:2799-804.
    • (2001) Circulation , vol.103 , pp. 2799-2804
    • Duffy, S.J.1    Biegelsen, E.S.2    Holbrook, M.3    Russell, J.D.4    Gokce, N.5    Keaney, J.F.6
  • 68
    • 0037371891 scopus 로고    scopus 로고
    • Effect of iron depletion in patients with nonalcoholic fatty liver disease without carbohydrate intolerance
    • author reply -7.
    • Valenti L, Fracanzani AL, Fargion S. Effect of iron depletion in patients with nonalcoholic fatty liver disease without carbohydrate intolerance. Gastroenterology 2003;124:866; author reply -7.
    • (2003) Gastroenterology , vol.124 , pp. 866
    • Valenti, L.1    Fracanzani, A.L.2    Fargion, S.3
  • 70
    • 34249098685 scopus 로고    scopus 로고
    • Iron depletion by phlebotomy improves insulin resistance in patients with nonalcoholic fatty liver disease and hyperferritinemia: evidence from a case-control study
    • Valenti L, Fracanzani AL, Dongiovanni P, Bugianesi E, Marchesini G, Manzini P, et al. Iron depletion by phlebotomy improves insulin resistance in patients with nonalcoholic fatty liver disease and hyperferritinemia: evidence from a case-control study. Am J Gastroenterol 2007;102:1251-8.
    • (2007) Am J Gastroenterol , vol.102 , pp. 1251-1258
    • Valenti, L.1    Fracanzani, A.L.2    Dongiovanni, P.3    Bugianesi, E.4    Marchesini, G.5    Manzini, P.6
  • 71
    • 47649090354 scopus 로고    scopus 로고
    • Decreased cancer risk after iron reduction in patients with peripheral arterial disease: results from a randomized trial
    • Zacharski LR, Chow BK, Howes PS, Shamayeva G, Baron JA, Dalman RL, et al. Decreased cancer risk after iron reduction in patients with peripheral arterial disease: results from a randomized trial. J Natl Cancer Inst 2008;100:996-1002.
    • (2008) J Natl Cancer Inst , vol.100 , pp. 996-1002
    • Zacharski, L.R.1    Chow, B.K.2    Howes, P.S.3    Shamayeva, G.4    Baron, J.A.5    Dalman, R.L.6
  • 72
    • 84859365658 scopus 로고    scopus 로고
    • Treatment of hyperferritinemia
    • Beaton MD, Adams PC. Treatment of hyperferritinemia. Ann Hepatol 2012;11:294-300.
    • (2012) Ann Hepatol , vol.11 , pp. 294-300
    • Beaton, M.D.1    Adams, P.C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.