Current status of the measurement of blood hepcidin levels in chronic kidney disease

Clinical Journal of the American Society of Nephrology

Volumn 5, Issue 9, 2010, Pages 1681-1689

  Macdougall, Iain C ^a   Malyszko, Jolanta ^b   Hider, Robert C ^c   Bansal, Sukhvinder S ^c  

^a KING S COLLEGE HOSPITAL   (United Kingdom)

^b MEDICAL UNIVERSITY OF BIALYSTOK   (Poland)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

FERRITIN; HEPCIDIN; TRANSFERRIN;

BINDING ASSAY; CHRONIC KIDNEY DISEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; HEMODIALYSIS; HUMAN; LIGAND BINDING; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; RADIOIMMUNOASSAY; SHORT SURVEY; SURFACE ENHANCED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; UPREGULATION; UREMIA;

ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; BIOLOGICAL MARKERS; CHRONIC DISEASE; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; IRON; KIDNEY DISEASES; MASS SPECTROMETRY; PREDICTIVE VALUE OF TESTS; PROGNOSIS; RADIOIMMUNOASSAY; REPRODUCIBILITY OF RESULTS;

EID: 77957304252     PISSN: 15559041     EISSN: 1555905X     Source Type: Journal    
DOI: 10.2215/CJN.05990809     Document Type: Short Survey

References (48)

1. Krause A, Neitz S, Magert HJ, Schulz A, Forssmann WG, Schulz-Knappe P, Adermann K: LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity. FEBS Lett 480: 147-150, 2000
2. Park CH, Valore EV, Waring AJ, Ganz T: Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem 276: 7806-7810, 2001 (Pubitemid 37385573)
3. Kulaksiz H, Theilig F, Bachmann S, Gehrke SG, Rost D, Janetzko A, Cetin Y, Stremmel W: The iron-regulatory peptide hormone hepcidin: Expression and cellular localization in the mammalian kidney. J Endocrinol 184: 361-370, 2005 (Pubitemid 40340171)
4. Frazer DM, Wilkins SJ, Becker EM, Vulpe CD, McKie AT, Trinder D, Anderson GJ: Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats. Gastroenterology 123: 835-844, 2002 (Pubitemid 34977090)
5. Nemeth E, Valore EV, Territo M, Schiller G, Lichtenstein A, Ganz T: Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood 101: 2461-2463, 2003 (Pubitemid 36857598)
6. Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM, Ganz T, Kaplan J: Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 306: 2090-2093, 2004
7. Nicolas G, Bennoun M, Devaux I, Beaumont C, Grandchamp B, Kahn A, Vaulont S: Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc Natl Acad Sci U S A 98: 8780-8785, 2001
8. Nicolas G, Bennoun M, Porteu A, Mativet S, Beaumont C, Grandchamp B, Sirito M, Sawadogo M, Kahn A, Vaulont S: Severe iron deficiency anemia in transgenic mice expressing liver hepcidin. Proc Natl Acad Sci U S A 99: 4596-4601, 2002
9. Ashby DR, Gale DP, Busbridge M, Murphy KG, Duncan ND, Cairns TD, Taube DH, Bloom SR, Tam FW, Chapman RS, Maxwell PH, Choi P: Plasma hepcidin levels are elevated but responsive to erythropoietin therapy in renal disease. Kidney Int 75: 976-981, 2009
10. Ganz T: Molecular pathogenesis of anemia of chronic disease. Pediatr Blood Cancer 46: 554-557, 2006
11. Viatte L, Vaulont S: Hepcidin, the iron watcher. Biochimie 91: 1223-1228, 2009
12. Zaritsky J, Young B, Wang HJ, Westerman M, Olbina G, Nemeth E, Ganz T, Rivera S, Nissenson AR, Salusky IB: Hepcidin: A potential novel biomarker for iron status in chronic kidney disease. Clin J Am Soc Nephrol 4: 1051-1056, 2009
13. Collins JF, Wessling-Resnick M, Knutson MD: Hepcidin regulation of iron transport. J Nutr 138: 2284-2288, 2008
14. Pigeon C, Ilyin G, Courselaud B, Leroyer P, Turlin B, Brissot P, Loreal O: A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem 276: 7811-7819, 2001
15. Jordan JB, Poppe L, Haniu M, Arvedson T, Syed R, Li V, Kohno H, Kim H, Schnier PD, Harvey TS, Miranda LP, Cheetham J, Sasu BJ: Hepcidin revisited, disulfide connectivity, dynamics, and structure. J Biol Chem 284: 24155-24167, 2009
16. Peslova G, Petrak J, Kuzelova K, Hrdy I, Halada P, Kuchel PW, Soe-Lin S, Ponka P, Sutak R, Becker E, Huang ML, Rahmanto YS, Richardson DR, Vyoral D: Hepcidin, the hormone of iron metabolism, is bound specifically to alpha-2-macroglobulin in blood. Blood 113: 6225-6236, 2009
17. Busbridge M, Griffiths C, Ashby D, Gale D, Jayantha A, Sanwaiya A, Chapman RS: Development of a novel immunoassay for the iron regulatory peptide hepcidin. Br J Biomed Sci 66: 150-157, 2009
18. Grebenchtchikov N, Geurts-Moespot AJ, Kroot JJ, den Heijer M, Tjalsma H, Swinkels DW, Sweep FG: Highsensitive radioimmunoassay for human serum hepcidin. Br J Haematol 146: 317-325, 2009
19. Frazer DM, Anderson GJ: Hepcidin compared with prohepcidin: an absorbing story. Am J Clin Nutr 89: 475-476, 2009
20. Kulaksiz H, Gehrke SG, Janetzko A, Rost D, Bruckner T, Kallinowski B, Stremmel W: Pro-hepcidin: Expression and cell specific localisation in the liver and its regulation in hereditary haemochromatosis, chronic renal insufficiency, and renal anaemia. Gut 53: 735-743, 2004
21. Kemna E, Pickkers P, Nemeth E, van der Hoeven H, Swinkels D: Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS. Blood 106: 1864-1866, 2005
22. Ganz T, Olbina G, Girelli D, Nemeth E, Westerman M: Immunoassay for human serum hepcidin. Blood 112: 4292-4297, 2008
23. Zaritsky JJ, Young BY: The utility of multivariate analysis in the study of hepcidin. Kidney Int 76: 912-913, 2009
24. Koliaraki V, Marinou M, Vassilakopoulos TP, Vavourakis E, Tsochatzis E, Pangalis GA, Papatheodoridis G, Stamoulakatou A, Swinkels DW, Papanikolaou G, Mamalaki A: A novel immunological assay for hepcidin quantification in human serum. PLoS One 4: e4581, 2009
25. Koliaraki V, Marinou M, Samiotaki M, Panayotou G, Pantopoulos K, Mamalaki A: Iron regulatory and bactericidal properties of human recombinant hepcidin expressed in Pichia pastoris. Biochimie 90: 726-735, 2008
26. Kroot JJ, Kemna EH, Bansal SS, Busbridge M, Campostrini N, Girelli D, Hider RC, Koliaraki V, Mamalaki A, Olbina G, Tomosugi N, Tselepis C, Ward DG, Ganz T, Hendriks JC, Swinkels DW: Results of the first international round robin for the quantification of urinary and plasma hepcidin assays: Need for standardization. Haematologica 94: 1748-1752, 2009
27. Peters HP, Laarakkers CM, Swinkels DW, Wetzels JF: Serum hepcidin-25 levels in patients with chronic kidney disease are independent of glomerular filtration rate. Nephrol Dial Transplant 25: 848-853, 2010
28. De Domenico I, Nemeth E, Nelson JM, Phillips JD, Ajioka RS, Kay MS, Kushner JP, Ganz T, Ward DM, Kaplan J: The hepcidin-binding site on ferroportin is evolutionarily conserved. Cell Metab 8: 146-156, 2008
29. Kemna E, Tjalsma H, Laarakkers C, Nemeth E, Willems H, Swinkels D: Novel urine hepcidin assay by mass spectrometry. Blood 106: 3268-3270, 2005
30. Tomosugi N, Kawabata H, Wakatabe R, Higuchi M, Yamaya H, Umehara H, Ishikawa I: Detection of serum hepcidin in renal failure and inflammation by using ProteinChip System. Blood 108: 1381-1387, 2006
31. Kemna EH, Tjalsma H, Podust VN, Swinkels DW: Mass spectrometry-based hepcidin measurements in serum and urine: Analytical aspects and clinical implications. Clin Chem 53: 620-628, 2007
32. Kartikasari AE, Roelofs R, Schaeps RM, Kemna EH, Peters WH, Swinkels DW, Tjalsma H: Secretion of bioactive hepcidin- 25 by liver cells correlates with its gene transcription and points towards synergism between iron and inflammation signaling pathways. Biochim Biophys Acta 1784: 2029-2037, 2008
33. Swinkels DW, Girelli D, Laarakkers C, Kroot J, Campostrini N, Kemna EH, Tjalsma H: Advances in quantitative hepcidin measurements by time-of-flight mass spectrometry. PLoS One 3: e2706, 2008
34. Ward DG, Roberts K, Stonelake P, Goon P, Zampronio CG, Martin A, Johnson PJ, Iqbal T, Tselepis C: SELDI-TOF-MS determination of hepcidin in clinical samples using stable isotope labelled hepcidin as an internal standard. Proteome Sci 6: 28, 2008
35. Bansal SS, Halket JM, Fusova J, Bomford A, Simpson RJ, Vasavda N, Thein SL, Hider RC: Quantification of hepcidin using matrix-assisted laser desorption/ionization time-offlight mass spectrometry. Rapid Commun Mass Spectrom 23: 1531-1542, 2009
36. Anderson DS, Heeney MM, Roth U, Menzel C, Fleming MD, Steen H: High-throughput matrix-assisted laser desorption ionization-time-of-flight mass spectrometry method for quantification of hepcidin in human urine. Anal Chem 82: 1551-1555, 2010
37. Costa E, Swinkels DW, Laarakkers CM, Rocha-Pereira P, Rocha S, Reis F, Teixeira F, Miranda V, do Sameiro FM, Loureiro A, Quintanilha A, Belo L, Santos-Silva A: Hepcidin serum levels and resistance to recombinant human erythropoietin therapy in haemodialysis patients. Acta Haematol 122: 226-229, 2009
38. Gay MCL, Mullaney I, Trinder D, Olynyk JK, Trengove RD: Quantitative assay of urinary hepcidin using MALDITOF mass spectrometry. Analyt Methods 2: 268-274
39. Murphy AT, Witcher DR, Luan P, Wroblewski VJ: Quantitation of hepcidin from human and mouse serum using liquid chromatography tandem mass spectrometry. Blood 110: 1048-1054, 2007
40. Murao N, Ishigai M, Yasuno H, Shimonaka Y, Aso Y: Simple and sensitive quantification of bioactive peptides in biological matrices using liquid chromatography/selected reaction monitoring mass spectrometry coupled with trichloroacetic acid clean-up. Rapid Commun Mass Spectrom 21: 4033-4038, 2007
41. Kobold U, Dulffer T, Dangl M, Escherich A, Kubbies M, Roddiger R, Wright JA: Quantification of hepcidin-25 in human serum by isotope dilution micro-HPLC-tandem mass spectrometry. Clin Chem 54: 1584-1586, 2008
42. Li H, Rose MJ, Tran L, Zhang J, Miranda LP, James CA, Sasu BJ: Development of a method for the sensitive and quantitative determination of hepcidin in human serum using LCMS/ MS. J Pharmacol Toxicol Methods 59: 171-180, 2009
43. Bansal SS, Halket JM, Bomford A, Simpson RJ, Vasavda N, Thein SL, Hider RC: Quantitation of hepcidin in human urine by liquid chromatography-mass spectrometry. Anal Biochem 384: 245-253, 2009
44. Bansal SS, Abbate V, Bomford A, Halket JM, Macdougall IC, Thein SL, Hider RC: Quantitation of hepcidin in serum using ultra-high-pressure liquid chromatography and a linear ion trap mass spectrometer. Rapid Commun Mass Spectrom 24: 1251-1259, 2010
45. Weiss G, Theurl I, Eder S, Koppelstaetter C, Kurz K, Sonnweber T, Kobold U, Mayer G: Serum hepcidin concentration in chronic haemodialysis patients: Associations and effects of dialysis, iron and erythropoietin therapy. Eur J Clin Invest 39: 883-890, 2009
46. Kato A, Tsuji T, Luo J, Sakao Y, Yasuda H, Hishida A: Association of prohepcidin and hepcidin-25 with erythropoietin response and ferritin in hemodialysis patients. Am J Nephrol 28: 115-121, 2008
47. Selby C: Interference in immunoassay. Ann Clin Biochem 36: 704-721, 1999
48. Valenti L, Girelli D, Valenti GF, Castagna A, Corno G, Campostrini N, Rametta R, Dongiovanni P, Messa P, Fargion S: HFE mutations modulate the effect of iron on serum hepcidin-25 in chronic hemodialysis patients. Clin J Am Soc Nephrol 4: 1331-1337, 2009