Systematic Mapping of Protein Mutational Space by Prolonged Drift Reveals the Deleterious Effects of Seemingly Neutral Mutations

PLoS Computational Biology

Volumn 11, Issue 8, 2015, Pages

  Rockah Shmuel, Liat ^a   Tóth Petróczy, Ágnes ^a   Tawfik, Dan S ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

MAPPING; PURGING;

AMINO ACID SUBSTITUTION; DELETERIOUS EFFECTS; DNA-METHYLTRANSFERASE; GENE ENSEMBLES; MULTIPLE MUTATIONS; PROTEIN MUTATIONS; RANDOM MUTAGENESIS; RANDOM SELECTION; RELATIVE EFFECTS; SYSTEMATIC MAPPING;

PROTEINS;

DNA METHYLTRANSFERASE; BACTERIAL PROTEIN; PROTEIN;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; FRAMESHIFT MUTATION; GENE MUTATION; GENETIC ALGORITHM; GENETIC DRIFT; GENETIC VARIABILITY; HAEMOPHILUS; HAEMOPHILUS AEGYPTIUS; INDEL MUTATION; MUTATIONAL ANALYSIS; NONHUMAN; NONSENSE MUTATION; PEPTIDE MAPPING; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; STOP CODON; BIOLOGICAL MODEL; BIOLOGY; GENETICS; MOLECULAR EVOLUTION; MUTATION; PHYSIOLOGY; PROCEDURES;

BACTERIAL PROTEINS; COMPUTATIONAL BIOLOGY; DNA MODIFICATION METHYLASES; EVOLUTION, MOLECULAR; GENETIC DRIFT; HAEMOPHILUS; MODELS, GENETIC; MUTATION; PROTEINS;

EID: 84940768845     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1004421     Document Type: Article

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