Most rare missense alleles are deleterious in humans: Implications for complex disease and association studies

American Journal of Human Genetics

Volumn 80, Issue 4, 2007, Pages 727-739

  Kryukov, Gregory V ^a   Pennacchio, Len A ^b,c   Sunyaev, Shamil R ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^c DOE JOINT GENOME INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID;

ALLELE; ARTICLE; CHIMPANZEE; CONTROLLED STUDY; DELETION MUTANT; GENE FREQUENCY; GENE SEQUENCE; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC EPIDEMIOLOGY; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE PHENOTYPE CORRELATION; HUMAN; MISSENSE MUTATION; MUTATIONAL ANALYSIS; PREVALENCE; PRIORITY JOURNAL;

PAN;

EID: 34147116715     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/513473     Document Type: Article

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