In vitro evolution goes deep

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 20, 2011, Pages 8071-8072

  Moses, Alan M ^a   Davidson, Alan R ^b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

HEAT SHOCK PROTEIN 90;

AMINO ACID SUBSTITUTION; CODON; DNA SEQUENCE; GENE FREQUENCY; GENE MUTATION; GENETIC DRIFT; GENETIC POLYMORPHISM; GENETIC SELECTION; GENOME; MOLECULAR EVOLUTION; MOLECULAR LIBRARY; NOTE; PHENOTYPE; PRIORITY JOURNAL;

BIOLOGICAL EVOLUTION; CODON; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; MODELS, GENETIC; MUTAGENESIS, SITE-DIRECTED; PROTEINS;

EID: 79957786626     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1104843108     Document Type: Note

References (16)

1. Bowie JU, Reidhaar-Olson JF, Lim WA, Sauer RT (1990) Deciphering the message in protein sequences: Tolerance to amino acid substitutions. Science 247:1306-1310.
2. Milla ME, Brown BM, Sauer RT (1994) Protein stability effects of a complete set of alanine substitutions in Arc repressor. Nat Struct Biol 1:518-523.
3. Rennell D, Bouvier SE, Hardy LW, Poteete AR (1991) Systematic mutation of bacteriophage T4 lysozyme. J Mol Biol 222:67-88. (Pubitemid 121003989)
4. Hietpas RT, Jensen JD, Bolon DNA (2011) Experimental illumination of a fitness landscape. Proc Natl Acad Sci USA 108:7896-7901.
5. Ohta T (1973) Slightly deleterious mutant substitutions in evolution. Nature 246:96-98.
6. Kimura M (1983) The Neutral Theory of Molecular Evolution (Cambridge Univ Press, Cambridge, UK).
7. Eyre-Walker A, Keightley PD (2007) The distribution of fitness effects of new mutations. Nat Rev Genet 8:610-618. (Pubitemid 47077280)
8. Dougherty MJ, Arnold FH (2009) Directed evolution: New parts and optimized function. Curr Opin Biotechnol 20:486-491.
9. Romero PA, Arnold FH (2009) Exploring protein fitness landscapes by directed evolution. Nat Rev Mol Cell Biol 10:866-876.
10. Tokuriki N, Stricher F, Serrano L, Tawfik DS (2008) How protein stability and new functions trade off. PLOS Comput Biol 4:e1000002.
11. Orr HA (2005) The genetic theory of adaptation: A brief history. Nat Rev Genet 6:119-127.
12. Li Z, et al. (2011) Systematic exploration of essential yeast gene function with temperature-sensitive mutants. Nat Biotechnol 29:361-367.
13. Barrick JE, et al. (2009) Genome evolution and adaptation in a long-term experiment with Escherichia coli. Nature 461:1243-1247.
14. Anderson JB, et al. (2010) Determinants of divergent adaptation and Dobzhansky-Muller interaction in experimental yeast populations. Curr Biol 20:1383-1388.
15. Parts L, et al. (March 21, 2011) Revealing the genetic structure of a trait by sequencing a population under selection. Genome Res, 10.1101/gr.116731.110.
16. Keightley PD, et al. (2009) Analysis of the genome sequences of three Drosophila melanogaster spontaneous mutation accumulation lines. Genome Res 19:1195-1201.