The spatial architecture of protein function and adaptation

Nature

Volumn 491, Issue 7422, 2012, Pages 138-142

  McLaughlin Jr , Richard N ^a,b,c   Poelwijk, Frank J ^a,b   Raman, Arjun ^a,b   Gosal, Walraj S ^a,b   Ranganathan, Rama ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c Fred Hutchinson Cancer Research Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

POSTSYNAPTIC DENSITY PROTEIN 95;

AMINO ACID; CHEMICAL BINDING; EVOLUTION; MUTATION; PROTEIN; QUANTITATIVE ANALYSIS; STATISTICAL ANALYSIS; THREE-DIMENSIONAL MODELING;

ARTICLE; GENE MUTATION; HIGH THROUGHPUT SCREENING; NONHUMAN; PDZ DOMAIN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STRUCTURE;

ADAPTATION, PHYSIOLOGICAL; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BINDING SITES; EVOLUTION, MOLECULAR; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTANT PROTEINS; MUTATION; PDZ DOMAINS; PROTEINS;

EID: 84868365613     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature11500     Document Type: Article

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