Residue mutations and their impact on protein structure and function: Detecting beneficial and pathogenic changes

Biochemical Journal

Volumn 449, Issue 3, 2013, Pages 581-594

  Studer, Romain A ^a   Dessailly, Benoit H ^b   Orengo, Christine A ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b NATIONAL INSTITUTE OF BIOMEDICAL INNOVATION   (Japan)

Author keywords

Amino acid mutation; Deletion; Insertion; Protein evolution; Protein function; Structure

Indexed keywords

GLOBULAR PROTEIN;

CANCER CELL; GENE DELETION; GENE INSERTION; GENE MUTATION; GENOME; HUMAN; INFECTION; MOLECULAR EVOLUTION; MUTATION; NATURAL SELECTION; NONHUMAN; PHENOTYPE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; REVIEW;

ADAPTATION, PHYSIOLOGICAL; AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; DATABASES, GENETIC; EVOLUTION, MOLECULAR; FEMALE; GENETIC DISEASES, INBORN; HUMANS; INDEL MUTATION; INFECTION; MALE; MODELS, GENETIC; MODELS, MOLECULAR; MUTATION; NEOPLASMS; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN STABILITY; PROTEINS;

ANIMALIA;

EID: 84872474093     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20121221     Document Type: Review

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