A fundamental protein property, thermodynamic stability, revealed solely from large-scale measurements of protein function

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 42, 2012, Pages 16858-16863

  Araya, Carlos L ^a,c   Fowler, Douglas M ^a   Chen, Wentao ^b   Muniez, Ike ^a   Kelly, Jeffery W ^b   Fields, Stanley ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c STANFORD UNIVERSITY   (United States)

Author keywords

Deep mutational scanning; Epistasis; High throughput DNA sequencing

Indexed keywords

PROTEIN VARIANT;

ARTICLE; GENE MUTATION; MEASUREMENT; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DENATURATION; PROTEIN DOMAIN; PROTEIN FUNCTION; THERMODYNAMICS; WW DOMAIN;

EPISTASIS, GENETIC; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; MODELS, MOLECULAR; MUTATION; PROTEIN STABILITY; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS;

EID: 84867644046     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1209751109     Document Type: Article

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