메뉴 건너뛰기




Volumn 136, Issue , 2015, Pages 1-33

Transcriptional and Epigenetic Control of Regulatory T Cell Development

Author keywords

DNA methylation; Epigenetic modification; Foxp3; Transcription factors; Treg cell development

Indexed keywords

TRANSCRIPTION FACTOR FOXP3; FORKHEAD TRANSCRIPTION FACTOR;

EID: 84939839985     PISSN: 18771173     EISSN: 18780814     Source Type: Book Series    
DOI: 10.1016/bs.pmbts.2015.07.011     Document Type: Conference Paper
Times cited : (26)

References (107)
  • 1
    • 0014667395 scopus 로고
    • Thymus and reproduction: Sex-linked dysgenesia of the gonad after neonatal thymectomy in mice
    • Y. Nishizuka, and T. Sakakura Thymus and reproduction: sex-linked dysgenesia of the gonad after neonatal thymectomy in mice Science 166 3906 1969 753 755
    • (1969) Science , vol.166 , Issue.3906 , pp. 753-755
    • Nishizuka, Y.1    Sakakura, T.2
  • 2
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • S. Sakaguchi, N. Sakaguchi, M. Asano, M. Itoh, and M. Toda Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases J Immunol 155 3 1995 1151 1164
    • (1995) J Immunol , vol.155 , Issue.3 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3    Itoh, M.4    Toda, M.5
  • 3
    • 0037385330 scopus 로고    scopus 로고
    • Foxp3 programs the development and function of CD4+CD25 + regulatory T cells
    • J.D. Fontenot, M.A. Gavin, and A.Y. Rudensky Foxp3 programs the development and function of CD4+CD25 + regulatory T cells Nat Immunol 4 4 2003 330 336
    • (2003) Nat Immunol , vol.4 , Issue.4 , pp. 330-336
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 4
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • S. Hori, T. Nomura, and S. Sakaguchi Control of regulatory T cell development by the transcription factor Foxp3 Science 299 5609 2003 1057 1061
    • (2003) Science , vol.299 , Issue.5609 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 5
    • 0035162560 scopus 로고    scopus 로고
    • Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
    • M.E. Brunkow, E.W. Jeffery, K.A. Hjerrild, and et al. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse Nat Genet 27 1 2001 68 73
    • (2001) Nat Genet , vol.27 , Issue.1 , pp. 68-73
    • Brunkow, M.E.1    Jeffery, E.W.2    Hjerrild, K.A.3
  • 6
    • 0035167967 scopus 로고    scopus 로고
    • The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3
    • C.L. Bennett, J. Christie, F. Ramsdell, and et al. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3 Nat Genet 27 1 2001 20 21
    • (2001) Nat Genet , vol.27 , Issue.1 , pp. 20-21
    • Bennett, C.L.1    Christie, J.2    Ramsdell, F.3
  • 7
    • 0036346861 scopus 로고    scopus 로고
    • Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome
    • R.S. Wildin, S. Smyk-Pearson, and A.H. Filipovich Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome J Med Genet 39 8 2002 537 545
    • (2002) J Med Genet , vol.39 , Issue.8 , pp. 537-545
    • Wildin, R.S.1    Smyk-Pearson, S.2    Filipovich, A.H.3
  • 8
    • 33846485153 scopus 로고    scopus 로고
    • Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice
    • J.M. Kim, J.P. Rasmussen, and A.Y. Rudensky Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice Nat Immunol 8 2 2007 191 197
    • (2007) Nat Immunol , vol.8 , Issue.2 , pp. 191-197
    • Kim, J.M.1    Rasmussen, J.P.2    Rudensky, A.Y.3
  • 9
    • 84922588496 scopus 로고    scopus 로고
    • Regulatory T-cells in autoimmune diseases: Challenges, controversies and - Yet - unanswered questions
    • C.R. Grant, R. Liberal, G. Mieli-Vergani, D. Vergani, and M.S. Longhi Regulatory T-cells in autoimmune diseases: challenges, controversies and - yet - unanswered questions Autoimmun Rev 14 2 2015 105 116
    • (2015) Autoimmun Rev , vol.14 , Issue.2 , pp. 105-116
    • Grant, C.R.1    Liberal, R.2    Mieli-Vergani, G.3    Vergani, D.4    Longhi, M.S.5
  • 10
    • 43049174722 scopus 로고    scopus 로고
    • Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction
    • Q. Tang, J.Y. Adams, C. Penaranda, and et al. Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction Immunity 28 5 2008 687 697
    • (2008) Immunity , vol.28 , Issue.5 , pp. 687-697
    • Tang, Q.1    Adams, J.Y.2    Penaranda, C.3
  • 11
    • 0027517545 scopus 로고
    • Phenotypically distinct subsets of CD4 + T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice
    • F. Powrie, M.W. Leach, S. Mauze, L.B. Caddle, and R.L. Coffman Phenotypically distinct subsets of CD4 + T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice Int Immunol 5 11 1993 1461 1471
    • (1993) Int Immunol , vol.5 , Issue.11 , pp. 1461-1471
    • Powrie, F.1    Leach, M.W.2    Mauze, S.3    Caddle, L.B.4    Coffman, R.L.5
  • 12
    • 84894038785 scopus 로고    scopus 로고
    • Foxp3(+) T(reg) cells in humoral immunity
    • J.B. Wing, and S. Sakaguchi Foxp3(+) T(reg) cells in humoral immunity Int Immunol 26 2 2014 61 69
    • (2014) Int Immunol , vol.26 , Issue.2 , pp. 61-69
    • Wing, J.B.1    Sakaguchi, S.2
  • 13
    • 84892448554 scopus 로고    scopus 로고
    • Regulatory T cells in cancer immunotherapy
    • H. Nishikawa, and S. Sakaguchi Regulatory T cells in cancer immunotherapy Curr Opin Immunol 27 2014 1 7
    • (2014) Curr Opin Immunol , vol.27 , pp. 1-7
    • Nishikawa, H.1    Sakaguchi, S.2
  • 14
    • 82755184094 scopus 로고    scopus 로고
    • Two modes of immune suppression by Foxp3(+) regulatory T cells under inflammatory or non-inflammatory conditions
    • T. Yamaguchi, J.B. Wing, and S. Sakaguchi Two modes of immune suppression by Foxp3(+) regulatory T cells under inflammatory or non-inflammatory conditions Semin Immunol 23 6 2011 424 430
    • (2011) Semin Immunol , vol.23 , Issue.6 , pp. 424-430
    • Yamaguchi, T.1    Wing, J.B.2    Sakaguchi, S.3
  • 15
    • 79955529454 scopus 로고    scopus 로고
    • Trans-endocytosis of CD80 and CD86: A molecular basis for the cell-extrinsic function of CTLA-4
    • O.S. Qureshi, Y. Zheng, K. Nakamura, and et al. Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4 Science 332 6029 2011 600 603
    • (2011) Science , vol.332 , Issue.6029 , pp. 600-603
    • Qureshi, O.S.1    Zheng, Y.2    Nakamura, K.3
  • 16
    • 53749094183 scopus 로고    scopus 로고
    • CTLA-4 control over Foxp3 + regulatory T cell function
    • K. Wing, Y. Onishi, P. Prieto-Martin, and et al. CTLA-4 control over Foxp3 + regulatory T cell function Science 322 5899 2008 271 275
    • (2008) Science , vol.322 , Issue.5899 , pp. 271-275
    • Wing, K.1    Onishi, Y.2    Prieto-Martin, P.3
  • 17
    • 84918576077 scopus 로고    scopus 로고
    • Regulatory T cells control antigen-specific expansion of Tfh cell number and humoral immune responses via the coreceptor CTLA-4
    • J.B. Wing, W. Ise, T. Kurosaki, and S. Sakaguchi Regulatory T cells control antigen-specific expansion of Tfh cell number and humoral immune responses via the coreceptor CTLA-4 Immunity 41 6 2014 1013 1025
    • (2014) Immunity , vol.41 , Issue.6 , pp. 1013-1025
    • Wing, J.B.1    Ise, W.2    Kurosaki, T.3    Sakaguchi, S.4
  • 18
    • 84918507355 scopus 로고    scopus 로고
    • The coinhibitory receptor CTLA-4 controls B cell responses by modulating T follicular helper, T follicular regulatory, and T regulatory cells
    • P.T. Sage, A.M. Paterson, S.B. Lovitch, and A.H. Sharpe The coinhibitory receptor CTLA-4 controls B cell responses by modulating T follicular helper, T follicular regulatory, and T regulatory cells Immunity 41 6 2014 1026 1039
    • (2014) Immunity , vol.41 , Issue.6 , pp. 1026-1039
    • Sage, P.T.1    Paterson, A.M.2    Lovitch, S.B.3    Sharpe, A.H.4
  • 19
    • 84907909000 scopus 로고    scopus 로고
    • Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4
    • H.S. Kuehn, W. Ouyang, B. Lo, and et al. Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4 Science 345 6204 2014 1623 1627
    • (2014) Science , vol.345 , Issue.6204 , pp. 1623-1627
    • Kuehn, H.S.1    Ouyang, W.2    Lo, B.3
  • 20
    • 84938070889 scopus 로고    scopus 로고
    • Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations
    • D. Schubert, C. Bode, R. Kenefeck, and et al. Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations Nat Med 20 12 2014 1410 1416
    • (2014) Nat Med , vol.20 , Issue.12 , pp. 1410-1416
    • Schubert, D.1    Bode, C.2    Kenefeck, R.3
  • 21
    • 84878734958 scopus 로고    scopus 로고
    • Construction of self-recognizing regulatory T cells from conventional T cells by controlling CTLA-4 and IL-2 expression
    • T. Yamaguchi, A. Kishi, M. Osaki, and et al. Construction of self-recognizing regulatory T cells from conventional T cells by controlling CTLA-4 and IL-2 expression Proc Natl Acad Sci USA 110 23 2013 E2116 E2125
    • (2013) Proc Natl Acad Sci USA , vol.110 , Issue.23 , pp. E2116-E2125
    • Yamaguchi, T.1    Kishi, A.2    Osaki, M.3
  • 22
    • 33746228122 scopus 로고    scopus 로고
    • FOXP3 controls regulatory T cell function through cooperation with NFAT
    • Y. Wu, M. Borde, V. Heissmeyer, and et al. FOXP3 controls regulatory T cell function through cooperation with NFAT Cell 126 2 2006 375 387
    • (2006) Cell , vol.126 , Issue.2 , pp. 375-387
    • Wu, Y.1    Borde, M.2    Heissmeyer, V.3
  • 23
    • 36048978911 scopus 로고    scopus 로고
    • Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature
    • J.A. Hill, M. Feuerer, K. Tash, and et al. Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature Immunity 27 5 2007 786 800
    • (2007) Immunity , vol.27 , Issue.5 , pp. 786-800
    • Hill, J.A.1    Feuerer, M.2    Tash, K.3
  • 24
    • 84866533054 scopus 로고    scopus 로고
    • A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells
    • W. Fu, A. Ergun, T. Lu, and et al. A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells Nat Immunol 13 10 2012 972 980
    • (2012) Nat Immunol , vol.13 , Issue.10 , pp. 972-980
    • Fu, W.1    Ergun, A.2    Lu, T.3
  • 25
    • 84898025820 scopus 로고    scopus 로고
    • Differential roles of epigenetic changes and Foxp3 expression in regulatory T cell-specific transcriptional regulation
    • H. Morikawa, N. Ohkura, A. Vandenbon, and et al. Differential roles of epigenetic changes and Foxp3 expression in regulatory T cell-specific transcriptional regulation Proc Natl Acad Sci USA 111 14 2014 5289 5294
    • (2014) Proc Natl Acad Sci USA , vol.111 , Issue.14 , pp. 5289-5294
    • Morikawa, H.1    Ohkura, N.2    Vandenbon, A.3
  • 26
    • 84901233628 scopus 로고    scopus 로고
    • Inflammation-induced repression of chromatin bound by the transcription factor Foxp3 in regulatory T cells
    • A. Arvey, J. van der Veeken, R.M. Samstein, Y. Feng, J.A. Stamatoyannopoulos, and A.Y. Rudensky Inflammation-induced repression of chromatin bound by the transcription factor Foxp3 in regulatory T cells Nat Immunol 15 6 2014 580 587
    • (2014) Nat Immunol , vol.15 , Issue.6 , pp. 580-587
    • Arvey, A.1    Van Der Veeken, J.2    Samstein, R.M.3    Feng, Y.4    Stamatoyannopoulos, J.A.5    Rudensky, A.Y.6
  • 27
    • 33847242598 scopus 로고    scopus 로고
    • Foxp3 occupancy and regulation of key target genes during T-cell stimulation
    • A. Marson, K. Kretschmer, G.M. Frampton, and et al. Foxp3 occupancy and regulation of key target genes during T-cell stimulation Nature 445 7130 2007 931 935
    • (2007) Nature , vol.445 , Issue.7130 , pp. 931-935
    • Marson, A.1    Kretschmer, K.2    Frampton, G.M.3
  • 28
    • 34247215187 scopus 로고    scopus 로고
    • Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
    • M. Ono, H. Yaguchi, N. Ohkura, and et al. Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1 Nature 446 7136 2007 685 689
    • (2007) Nature , vol.446 , Issue.7136 , pp. 685-689
    • Ono, M.1    Yaguchi, H.2    Ohkura, N.3
  • 29
    • 80052023563 scopus 로고    scopus 로고
    • Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation
    • M. Beyer, Y. Thabet, R.U. Muller, and et al. Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation Nat Immunol 12 9 2011 898 907
    • (2011) Nat Immunol , vol.12 , Issue.9 , pp. 898-907
    • Beyer, M.1    Thabet, Y.2    Muller, R.U.3
  • 30
    • 33847153417 scopus 로고    scopus 로고
    • Foxp3-dependent programme of regulatory T-cell differentiation
    • M.A. Gavin, J.P. Rasmussen, J.D. Fontenot, and et al. Foxp3-dependent programme of regulatory T-cell differentiation Nature 445 7129 2007 771 775
    • (2007) Nature , vol.445 , Issue.7129 , pp. 771-775
    • Gavin, M.A.1    Rasmussen, J.P.2    Fontenot, J.D.3
  • 31
    • 84866975037 scopus 로고    scopus 로고
    • Foxp3 exploits a pre-existent enhancer landscape for regulatory T cell lineage specification
    • R.M. Samstein, A. Arvey, S.Z. Josefowicz, and et al. Foxp3 exploits a pre-existent enhancer landscape for regulatory T cell lineage specification Cell 151 1 2012 153 166
    • (2012) Cell , vol.151 , Issue.1 , pp. 153-166
    • Samstein, R.M.1    Arvey, A.2    Josefowicz, S.Z.3
  • 32
    • 17044393922 scopus 로고    scopus 로고
    • Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells
    • E. Bettelli, M. Dastrange, and M. Oukka Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells Proc Natl Acad Sci USA 102 14 2005 5138 5143
    • (2005) Proc Natl Acad Sci USA , vol.102 , Issue.14 , pp. 5138-5143
    • Bettelli, E.1    Dastrange, M.2    Oukka, M.3
  • 33
    • 69549120242 scopus 로고    scopus 로고
    • Eos mediates Foxp3-dependent gene silencing in CD4 + regulatory T cells
    • F. Pan, H. Yu, E.V. Dang, and et al. Eos mediates Foxp3-dependent gene silencing in CD4 + regulatory T cells Science 325 5944 2009 1142 1146
    • (2009) Science , vol.325 , Issue.5944 , pp. 1142-1146
    • Pan, F.1    Yu, H.2    Dang, E.V.3
  • 34
    • 84866548843 scopus 로고    scopus 로고
    • Transcription factor Foxp3 and its protein partners form a complex regulatory network
    • D. Rudra, P. deRoos, A. Chaudhry, and et al. Transcription factor Foxp3 and its protein partners form a complex regulatory network Nat Immunol 13 10 2012 1010 1019
    • (2012) Nat Immunol , vol.13 , Issue.10 , pp. 1010-1019
    • Rudra, D.1    DeRoos, P.2    Chaudhry, A.3
  • 35
    • 84861424521 scopus 로고    scopus 로고
    • An N-terminal mutation of the Foxp3 transcription factor alleviates arthritis but exacerbates diabetes
    • J. Darce, D. Rudra, L. Li, and et al. An N-terminal mutation of the Foxp3 transcription factor alleviates arthritis but exacerbates diabetes Immunity 36 5 2012 731 741
    • (2012) Immunity , vol.36 , Issue.5 , pp. 731-741
    • Darce, J.1    Rudra, D.2    Li, L.3
  • 36
    • 84902332541 scopus 로고    scopus 로고
    • Dynamic interactions between TIP60 and p300 regulate FOXP3 function through a structural switch defined by a single lysine on TIP60
    • Y. Xiao, Y. Nagai, G. Deng, and et al. Dynamic interactions between TIP60 and p300 regulate FOXP3 function through a structural switch defined by a single lysine on TIP60 Cell Reports 7 5 2014 1471 1480
    • (2014) Cell Reports , vol.7 , Issue.5 , pp. 1471-1480
    • Xiao, Y.1    Nagai, Y.2    Deng, G.3
  • 37
    • 62649165369 scopus 로고    scopus 로고
    • Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses
    • Y. Zheng, A. Chaudhry, A. Kas, and et al. Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses Nature 458 7236 2009 351 356
    • (2009) Nature , vol.458 , Issue.7236 , pp. 351-356
    • Zheng, Y.1    Chaudhry, A.2    Kas, A.3
  • 38
  • 39
    • 70449706325 scopus 로고    scopus 로고
    • Runx proteins regulate Foxp3 expression
    • L. Bruno, L. Mazzarella, M. Hoogenkamp, and et al. Runx proteins regulate Foxp3 expression J Exp Med 206 11 2009 2329 2337
    • (2009) J Exp Med , vol.206 , Issue.11 , pp. 2329-2337
    • Bruno, L.1    Mazzarella, L.2    Hoogenkamp, M.3
  • 40
    • 80555139651 scopus 로고    scopus 로고
    • Critical role of Bcl11b in suppressor function of T regulatory cells and prevention of inflammatory bowel disease
    • J. Vanvalkenburgh, D.I. Albu, C. Bapanpally, and et al. Critical role of Bcl11b in suppressor function of T regulatory cells and prevention of inflammatory bowel disease J Exp Med 208 10 2011 2069 2081
    • (2011) J Exp Med , vol.208 , Issue.10 , pp. 2069-2081
    • Vanvalkenburgh, J.1    Albu, D.I.2    Bapanpally, C.3
  • 41
    • 84908123494 scopus 로고    scopus 로고
    • Continuous requirement for the TCR in regulatory T cell function
    • A.G. Levine, A. Arvey, W. Jin, and A.Y. Rudensky Continuous requirement for the TCR in regulatory T cell function Nat Immunol 15 11 2014 1070 1078
    • (2014) Nat Immunol , vol.15 , Issue.11 , pp. 1070-1078
    • Levine, A.G.1    Arvey, A.2    Jin, W.3    Rudensky, A.Y.4
  • 42
    • 78049240315 scopus 로고    scopus 로고
    • Histone acetyltransferase mediated regulation of FOXP3 acetylation and Treg function
    • Y. Xiao, B. Li, Z. Zhou, W.W. Hancock, H. Zhang, and M.I. Greene Histone acetyltransferase mediated regulation of FOXP3 acetylation and Treg function Curr Opin Immunol 22 5 2010 583 591
    • (2010) Curr Opin Immunol , vol.22 , Issue.5 , pp. 583-591
    • Xiao, Y.1    Li, B.2    Zhou, Z.3    Hancock, W.W.4    Zhang, H.5    Greene, M.I.6
  • 43
    • 77649225958 scopus 로고    scopus 로고
    • Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization
    • J. van Loosdregt, Y. Vercoulen, T. Guichelaar, and et al. Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization Blood 115 5 2010 965 974
    • (2010) Blood , vol.115 , Issue.5 , pp. 965-974
    • Van Loosdregt, J.1    Vercoulen, Y.2    Guichelaar, T.3
  • 44
    • 79952274915 scopus 로고    scopus 로고
    • Sirtuin-1 targeting promotes Foxp3 + T-regulatory cell function and prolongs allograft survival
    • U.H. Beier, L. Wang, T.R. Bhatti, and et al. Sirtuin-1 targeting promotes Foxp3 + T-regulatory cell function and prolongs allograft survival Mol Cell Biol 31 5 2011 1022 1029
    • (2011) Mol Cell Biol , vol.31 , Issue.5 , pp. 1022-1029
    • Beier, U.H.1    Wang, L.2    Bhatti, T.R.3
  • 45
    • 84875153425 scopus 로고    scopus 로고
    • Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-alpha in rheumatoid arthritis
    • H. Nie, Y. Zheng, R. Li, and et al. Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-alpha in rheumatoid arthritis Nat Med 19 3 2013 322 328
    • (2013) Nat Med , vol.19 , Issue.3 , pp. 322-328
    • Nie, H.1    Zheng, Y.2    Li, R.3
  • 46
    • 33748460087 scopus 로고    scopus 로고
    • Foxp3-dependent and -independent molecules specific for CD25+CD4 + natural regulatory T cells revealed by DNA microarray analysis
    • N. Sugimoto, T. Oida, K. Hirota, and et al. Foxp3-dependent and -independent molecules specific for CD25+CD4 + natural regulatory T cells revealed by DNA microarray analysis Int Immunol 18 8 2006 1197 1209
    • (2006) Int Immunol , vol.18 , Issue.8 , pp. 1197-1209
    • Sugimoto, N.1    Oida, T.2    Hirota, K.3
  • 47
    • 33947600584 scopus 로고    scopus 로고
    • Regulatory T cell development in the absence of functional Foxp3
    • W. Lin, D. Haribhai, L.M. Relland, and et al. Regulatory T cell development in the absence of functional Foxp3 Nat Immunol 8 4 2007 359 368
    • (2007) Nat Immunol , vol.8 , Issue.4 , pp. 359-368
    • Lin, W.1    Haribhai, D.2    Relland, L.M.3
  • 48
    • 84869148187 scopus 로고    scopus 로고
    • T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development
    • N. Ohkura, M. Hamaguchi, H. Morikawa, and et al. T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development Immunity 37 5 2012 785 799
    • (2012) Immunity , vol.37 , Issue.5 , pp. 785-799
    • Ohkura, N.1    Hamaguchi, M.2    Morikawa, H.3
  • 49
    • 84869872964 scopus 로고    scopus 로고
    • Novel Foxo1-dependent transcriptional programs control T(reg) cell function
    • W. Ouyang, W. Liao, C.T. Luo, and et al. Novel Foxo1-dependent transcriptional programs control T(reg) cell function Nature 491 7425 2012 554 559
    • (2012) Nature , vol.491 , Issue.7425 , pp. 554-559
    • Ouyang, W.1    Liao, W.2    Luo, C.T.3
  • 50
    • 84865369147 scopus 로고    scopus 로고
    • DNA methylation dynamics during in vivo differentiation of blood and skin stem cells
    • C. Bock, I. Beerman, W.H. Lien, and et al. DNA methylation dynamics during in vivo differentiation of blood and skin stem cells Mol Cell 47 4 2012 633 647
    • (2012) Mol Cell , vol.47 , Issue.4 , pp. 633-647
    • Bock, C.1    Beerman, I.2    Lien, W.H.3
  • 51
    • 69049107358 scopus 로고    scopus 로고
    • Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo
    • X. Zhou, S.L. Bailey-Bucktrout, L.T. Jeker, and et al. Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo Nat Immunol 10 9 2009 1000 1007
    • (2009) Nat Immunol , vol.10 , Issue.9 , pp. 1000-1007
    • Zhou, X.1    Bailey-Bucktrout, S.L.2    Jeker, L.T.3
  • 52
    • 84887512828 scopus 로고    scopus 로고
    • Self-antigen-driven activation induces instability of regulatory T cells during an inflammatory autoimmune response
    • S.L. Bailey-Bucktrout, M. Martinez-Llordella, X. Zhou, and et al. Self-antigen-driven activation induces instability of regulatory T cells during an inflammatory autoimmune response Immunity 39 5 2013 949 962
    • (2013) Immunity , vol.39 , Issue.5 , pp. 949-962
    • Bailey-Bucktrout, S.L.1    Martinez-Llordella, M.2    Zhou, X.3
  • 53
    • 77957371028 scopus 로고    scopus 로고
    • Stability of the regulatory T cell lineage in vivo
    • Y.P. Rubtsov, R.E. Niec, S. Josefowicz, and et al. Stability of the regulatory T cell lineage in vivo Science 329 5999 2010 1667 1671
    • (2010) Science , vol.329 , Issue.5999 , pp. 1667-1671
    • Rubtsov, Y.P.1    Niec, R.E.2    Josefowicz, S.3
  • 54
    • 84857416489 scopus 로고    scopus 로고
    • Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells
    • T. Miyao, S. Floess, R. Setoguchi, and et al. Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells Immunity 36 2 2012 262 275
    • (2012) Immunity , vol.36 , Issue.2 , pp. 262-275
    • Miyao, T.1    Floess, S.2    Setoguchi, R.3
  • 55
    • 66949171924 scopus 로고    scopus 로고
    • Functional delineation and differentiation dynamics of human CD4 + T cells expressing the FoxP3 transcription factor
    • M. Miyara, Y. Yoshioka, A. Kitoh, and et al. Functional delineation and differentiation dynamics of human CD4 + T cells expressing the FoxP3 transcription factor Immunity 30 6 2009 899 911
    • (2009) Immunity , vol.30 , Issue.6 , pp. 899-911
    • Miyara, M.1    Yoshioka, Y.2    Kitoh, A.3
  • 56
    • 34047174849 scopus 로고    scopus 로고
    • Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production
    • S.E. Allan, S.Q. Crome, N.K. Crellin, and et al. Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production Int Immunol 19 4 2007 345 354
    • (2007) Int Immunol , vol.19 , Issue.4 , pp. 345-354
    • Allan, S.E.1    Crome, S.Q.2    Crellin, N.K.3
  • 57
    • 0348223787 scopus 로고    scopus 로고
    • Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25 + regulatory T cells by TGF-beta induction of transcription factor Foxp3
    • W. Chen, W. Jin, N. Hardegen, and et al. Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25 + regulatory T cells by TGF-beta induction of transcription factor Foxp3 J Exp Med 198 12 2003 1875 1886
    • (2003) J Exp Med , vol.198 , Issue.12 , pp. 1875-1886
    • Chen, W.1    Jin, W.2    Hardegen, N.3
  • 58
    • 76749133610 scopus 로고    scopus 로고
    • Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate
    • Y. Zheng, S. Josefowicz, A. Chaudhry, X.P. Peng, K. Forbush, and A.Y. Rudensky Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate Nature 463 7282 2010 808 812
    • (2010) Nature , vol.463 , Issue.7282 , pp. 808-812
    • Zheng, Y.1    Josefowicz, S.2    Chaudhry, A.3    Peng, X.P.4    Forbush, K.5    Rudensky, A.Y.6
  • 59
    • 78149408519 scopus 로고    scopus 로고
    • Methylation matters: Binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells
    • J.K. Polansky, L. Schreiber, C. Thelemann, and et al. Methylation matters: binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells J Mol Med 88 10 2010 1029 1040
    • (2010) J Mol Med , vol.88 , Issue.10 , pp. 1029-1040
    • Polansky, J.K.1    Schreiber, L.2    Thelemann, C.3
  • 60
    • 34447265236 scopus 로고    scopus 로고
    • CREB/ATF-dependent T cell receptor-induced FoxP3 gene expression: A role for DNA methylation
    • H.P. Kim, and W.J. Leonard CREB/ATF-dependent T cell receptor-induced FoxP3 gene expression: a role for DNA methylation J Exp Med 204 7 2007 1543 1551
    • (2007) J Exp Med , vol.204 , Issue.7 , pp. 1543-1551
    • Kim, H.P.1    Leonard, W.J.2
  • 61
    • 70350451993 scopus 로고    scopus 로고
    • Runx-CBFbeta complexes control expression of the transcription factor Foxp3 in regulatory T cells
    • D. Rudra, T. Egawa, M.M. Chong, P. Treuting, D.R. Littman, and A.Y. Rudensky Runx-CBFbeta complexes control expression of the transcription factor Foxp3 in regulatory T cells Nat Immunol 10 11 2009 1170 1177
    • (2009) Nat Immunol , vol.10 , Issue.11 , pp. 1170-1177
    • Rudra, D.1    Egawa, T.2    Chong, M.M.3    Treuting, P.4    Littman, D.R.5    Rudensky, A.Y.6
  • 62
    • 80053130719 scopus 로고    scopus 로고
    • An essential role of the transcription factor GATA-3 for the function of regulatory T cells
    • Y. Wang, M.A. Su, and Y.Y. Wan An essential role of the transcription factor GATA-3 for the function of regulatory T cells Immunity 35 3 2011 337 348
    • (2011) Immunity , vol.35 , Issue.3 , pp. 337-348
    • Wang, Y.1    Su, M.A.2    Wan, Y.Y.3
  • 63
    • 84908401913 scopus 로고    scopus 로고
    • Function of a Foxp3 cis-element in protecting regulatory T cell identity
    • X. Li, Y. Liang, M. LeBlanc, C. Benner, and Y. Zheng Function of a Foxp3 cis-element in protecting regulatory T cell identity Cell 158 4 2014 734 748
    • (2014) Cell , vol.158 , Issue.4 , pp. 734-748
    • Li, X.1    Liang, Y.2    LeBlanc, M.3    Benner, C.4    Zheng, Y.5
  • 64
    • 84908403082 scopus 로고    scopus 로고
    • Control of the inheritance of regulatory T cell identity by a cis element in the Foxp3 locus
    • Y. Feng, A. Arvey, T. Chinen, J. van der Veeken, G. Gasteiger, and A.Y. Rudensky Control of the inheritance of regulatory T cell identity by a cis element in the Foxp3 locus Cell 158 4 2014 749 763
    • (2014) Cell , vol.158 , Issue.4 , pp. 749-763
    • Feng, Y.1    Arvey, A.2    Chinen, T.3    Van Der Veeken, J.4    Gasteiger, G.5    Rudensky, A.Y.6
  • 65
    • 79952534189 scopus 로고    scopus 로고
    • Regulation of chromatin by histone modifications
    • A.J. Bannister, and T. Kouzarides Regulation of chromatin by histone modifications Cell Res 21 3 2011 381 395
    • (2011) Cell Res , vol.21 , Issue.3 , pp. 381-395
    • Bannister, A.J.1    Kouzarides, T.2
  • 66
    • 58149214356 scopus 로고    scopus 로고
    • Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4 + T cells
    • G. Wei, L. Wei, J. Zhu, and et al. Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4 + T cells Immunity 30 1 2009 155 167
    • (2009) Immunity , vol.30 , Issue.1 , pp. 155-167
    • Wei, G.1    Wei, L.2    Zhu, J.3
  • 67
    • 67650090496 scopus 로고    scopus 로고
    • Lineage-specific DNA methylation in T cells correlates with histone methylation and enhancer activity
    • C. Schmidl, M. Klug, T.J. Boeld, and et al. Lineage-specific DNA methylation in T cells correlates with histone methylation and enhancer activity Genome Res 19 7 2009 1165 1174
    • (2009) Genome Res , vol.19 , Issue.7 , pp. 1165-1174
    • Schmidl, C.1    Klug, M.2    Boeld, T.J.3
  • 68
    • 45549098562 scopus 로고    scopus 로고
    • T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR
    • S. Sauer, L. Bruno, A. Hertweck, and et al. T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR Proc Natl Acad Sci USA 105 22 2008 7797 7802
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.22 , pp. 7797-7802
    • Sauer, S.1    Bruno, L.2    Hertweck, A.3
  • 69
    • 84898022503 scopus 로고    scopus 로고
    • The enhancer and promoter landscape of human regulatory and conventional T-cell subpopulations
    • C. Schmidl, L. Hansmann, T. Lassmann, and et al. The enhancer and promoter landscape of human regulatory and conventional T-cell subpopulations Blood 123 17 2014 e68 e78
    • (2014) Blood , vol.123 , Issue.17 , pp. e68-e78
    • Schmidl, C.1    Hansmann, L.2    Lassmann, T.3
  • 70
    • 84922999148 scopus 로고    scopus 로고
    • The chromatin-modifying enzyme Ezh2 is critical for the maintenance of regulatory T cell identity after activation
    • M. DuPage, G. Chopra, J. Quiros, and et al. The chromatin-modifying enzyme Ezh2 is critical for the maintenance of regulatory T cell identity after activation Immunity 42 2 2015 227 238
    • (2015) Immunity , vol.42 , Issue.2 , pp. 227-238
    • DuPage, M.1    Chopra, G.2    Quiros, J.3
  • 71
    • 60349089645 scopus 로고    scopus 로고
    • Nucleosome positioning and gene regulation: Advances through genomics
    • C. Jiang, and B.F. Pugh Nucleosome positioning and gene regulation: advances through genomics Nat Rev Genet 10 3 2009 161 172
    • (2009) Nat Rev Genet , vol.10 , Issue.3 , pp. 161-172
    • Jiang, C.1    Pugh, B.F.2
  • 72
    • 84928581675 scopus 로고    scopus 로고
    • Regulatory T cells generated early in life play a distinct role in maintaining self-tolerance
    • S. Yang, N. Fujikado, D. Kolodin, C. Benoist, and D. Mathis Regulatory T cells generated early in life play a distinct role in maintaining self-tolerance Science 348 6234 2015 589 594
    • (2015) Science , vol.348 , Issue.6234 , pp. 589-594
    • Yang, S.1    Fujikado, N.2    Kolodin, D.3    Benoist, C.4    Mathis, D.5
  • 73
    • 84863619688 scopus 로고    scopus 로고
    • Extrathymic generation of regulatory T cells in placental mammals mitigates maternal-fetal conflict
    • R.M. Samstein, S.Z. Josefowicz, A. Arvey, P.M. Treuting, and A.Y. Rudensky Extrathymic generation of regulatory T cells in placental mammals mitigates maternal-fetal conflict Cell 150 1 2012 29 38
    • (2012) Cell , vol.150 , Issue.1 , pp. 29-38
    • Samstein, R.M.1    Josefowicz, S.Z.2    Arvey, A.3    Treuting, P.M.4    Rudensky, A.Y.5
  • 74
    • 79960453738 scopus 로고    scopus 로고
    • A requisite role for induced regulatory T cells in tolerance based on expanding antigen receptor diversity
    • D. Haribhai, J.B. Williams, S. Jia, and et al. A requisite role for induced regulatory T cells in tolerance based on expanding antigen receptor diversity Immunity 35 1 2011 109 122
    • (2011) Immunity , vol.35 , Issue.1 , pp. 109-122
    • Haribhai, D.1    Williams, J.B.2    Jia, S.3
  • 75
    • 84867899425 scopus 로고    scopus 로고
    • Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3 + T reg cells
    • S1721
    • J.M. Weiss, A.M. Bilate, M. Gobert, and et al. Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3 + T reg cells J Exp Med 209 10 2012 1723 1742 S1721
    • (2012) J Exp Med , vol.209 , Issue.10 , pp. 1723-1742
    • Weiss, J.M.1    Bilate, A.M.2    Gobert, M.3
  • 76
    • 84867901322 scopus 로고    scopus 로고
    • Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo
    • S1711-1719
    • M. Yadav, C. Louvet, D. Davini, and et al. Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo J Exp Med 209 10 2012 1713 1722 S1711-1719
    • (2012) J Exp Med , vol.209 , Issue.10 , pp. 1713-1722
    • Yadav, M.1    Louvet, C.2    Davini, D.3
  • 77
    • 84907066418 scopus 로고    scopus 로고
    • Release of active TGF-beta1 from the latent TGF-beta1/GARP complex on T regulatory cells is mediated by integrin beta8
    • J.P. Edwards, A.M. Thornton, and E.M. Shevach Release of active TGF-beta1 from the latent TGF-beta1/GARP complex on T regulatory cells is mediated by integrin beta8 J Immunol 193 6 2014 2843 2849
    • (2014) J Immunol , vol.193 , Issue.6 , pp. 2843-2849
    • Edwards, J.P.1    Thornton, A.M.2    Shevach, E.M.3
  • 78
    • 37849009964 scopus 로고    scopus 로고
    • A two-step process for thymic regulatory T cell development
    • C.W. Lio, and C.S. Hsieh A two-step process for thymic regulatory T cell development Immunity 28 1 2008 100 111
    • (2008) Immunity , vol.28 , Issue.1 , pp. 100-111
    • Lio, C.W.1    Hsieh, C.S.2
  • 79
    • 84862814979 scopus 로고    scopus 로고
    • Selection of regulatory T cells in the thymus
    • C.S. Hsieh, H.M. Lee, and C.W. Lio Selection of regulatory T cells in the thymus Nat Rev Immunol 12 3 2012 157 167
    • (2012) Nat Rev Immunol , vol.12 , Issue.3 , pp. 157-167
    • Hsieh, C.S.1    Lee, H.M.2    Lio, C.W.3
  • 80
    • 77953415548 scopus 로고    scopus 로고
    • CD28 facilitates the generation of Foxp3(-) cytokine responsive regulatory T cell precursors
    • C.W. Lio, L.F. Dodson, C.M. Deppong, C.S. Hsieh, and J.M. Green CD28 facilitates the generation of Foxp3(-) cytokine responsive regulatory T cell precursors J Immunol 184 11 2010 6007 6013
    • (2010) J Immunol , vol.184 , Issue.11 , pp. 6007-6013
    • Lio, C.W.1    Dodson, L.F.2    Deppong, C.M.3    Hsieh, C.S.4    Green, J.M.5
  • 81
    • 13944260538 scopus 로고    scopus 로고
    • CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2
    • X. Tai, M. Cowan, L. Feigenbaum, and A. Singer CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2 Nat Immunol 6 2 2005 152 162
    • (2005) Nat Immunol , vol.6 , Issue.2 , pp. 152-162
    • Tai, X.1    Cowan, M.2    Feigenbaum, L.3    Singer, A.4
  • 82
    • 84879601640 scopus 로고    scopus 로고
    • Foxp3 transcription factor is proapoptotic and lethal to developing regulatory T cells unless counterbalanced by cytokine survival signals
    • X. Tai, B. Erman, A. Alag, and et al. Foxp3 transcription factor is proapoptotic and lethal to developing regulatory T cells unless counterbalanced by cytokine survival signals Immunity 38 6 2013 1116 1128
    • (2013) Immunity , vol.38 , Issue.6 , pp. 1116-1128
    • Tai, X.1    Erman, B.2    Alag, A.3
  • 83
    • 65549123867 scopus 로고    scopus 로고
    • Natural and adaptive foxp3 + regulatory T cells: More of the same or a division of labor?
    • M.A. Curotto de Lafaille, and J.J. Lafaille Natural and adaptive foxp3 + regulatory T cells: more of the same or a division of labor? Immunity 30 5 2009 626 635
    • (2009) Immunity , vol.30 , Issue.5 , pp. 626-635
    • Curotto De Lafaille, M.A.1    Lafaille, J.J.2
  • 84
    • 85027947787 scopus 로고    scopus 로고
    • Induction of colonic regulatory T cells by indigenous Clostridium species
    • K. Atarashi, T. Tanoue, T. Shima, and et al. Induction of colonic regulatory T cells by indigenous Clostridium species Science 331 6015 2011 337 341
    • (2011) Science , vol.331 , Issue.6015 , pp. 337-341
    • Atarashi, K.1    Tanoue, T.2    Shima, T.3
  • 85
    • 84890564250 scopus 로고    scopus 로고
    • Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
    • Y. Furusawa, Y. Obata, S. Fukuda, and et al. Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells Nature 504 7480 2013 446 450
    • (2013) Nature , vol.504 , Issue.7480 , pp. 446-450
    • Furusawa, Y.1    Obata, Y.2    Fukuda, S.3
  • 86
    • 84890550163 scopus 로고    scopus 로고
    • Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
    • N. Arpaia, C. Campbell, X. Fan, and et al. Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation Nature 504 7480 2013 451 455
    • (2013) Nature , vol.504 , Issue.7480 , pp. 451-455
    • Arpaia, N.1    Campbell, C.2    Fan, X.3
  • 87
    • 78149277909 scopus 로고    scopus 로고
    • How tolerogenic dendritic cells induce regulatory T cells
    • R.A. Maldonado, and U.H. von Andrian How tolerogenic dendritic cells induce regulatory T cells Adv Immunol 108 2010 111 165
    • (2010) Adv Immunol , vol.108 , pp. 111-165
    • Maldonado, R.A.1    Von Andrian, U.H.2
  • 88
    • 10344220512 scopus 로고    scopus 로고
    • CD25- T cells generate CD25+Foxp3 + regulatory T cells by peripheral expansion
    • M.A. Curotto de Lafaille, A.C. Lino, N. Kutchukhidze, and J.J. Lafaille CD25- T cells generate CD25+Foxp3 + regulatory T cells by peripheral expansion J Immunol 173 12 2004 7259 7268
    • (2004) J Immunol , vol.173 , Issue.12 , pp. 7259-7268
    • Curotto De Lafaille, M.A.1    Lino, A.C.2    Kutchukhidze, N.3    Lafaille, J.J.4
  • 89
    • 71749094333 scopus 로고    scopus 로고
    • Development of Foxp3(+) regulatory T cells is driven by the c-Rel enhanceosome
    • Q. Ruan, V. Kameswaran, Y. Tone, and et al. Development of Foxp3(+) regulatory T cells is driven by the c-Rel enhanceosome Immunity 31 6 2009 932 940
    • (2009) Immunity , vol.31 , Issue.6 , pp. 932-940
    • Ruan, Q.1    Kameswaran, V.2    Tone, Y.3
  • 90
    • 71749088574 scopus 로고    scopus 로고
    • Nuclear factor-kappaB modulates regulatory T cell development by directly regulating expression of Foxp3 transcription factor
    • M. Long, S.G. Park, I. Strickland, M.S. Hayden, and S. Ghosh Nuclear factor-kappaB modulates regulatory T cell development by directly regulating expression of Foxp3 transcription factor Immunity 31 6 2009 921 931
    • (2009) Immunity , vol.31 , Issue.6 , pp. 921-931
    • Long, M.1    Park, S.G.2    Strickland, I.3    Hayden, M.S.4    Ghosh, S.5
  • 91
    • 77749245828 scopus 로고    scopus 로고
    • C-Rel is crucial for the induction of Foxp3(+) regulatory CD4(+) T cells but not T(H)17 cells
    • A. Visekruna, M. Huber, A. Hellhund, and et al. c-Rel is crucial for the induction of Foxp3(+) regulatory CD4(+) T cells but not T(H)17 cells Eur J Immunol 40 3 2010 671 676
    • (2010) Eur J Immunol , vol.40 , Issue.3 , pp. 671-676
    • Visekruna, A.1    Huber, M.2    Hellhund, A.3
  • 92
    • 85027932757 scopus 로고    scopus 로고
    • Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis
    • T. Sekiya, I. Kashiwagi, R. Yoshida, and et al. Nr4a receptors are essential for thymic regulatory T cell development and immune homeostasis Nat Immunol 14 3 2013 230 237
    • (2013) Nat Immunol , vol.14 , Issue.3 , pp. 230-237
    • Sekiya, T.1    Kashiwagi, I.2    Yoshida, R.3
  • 93
    • 79953769170 scopus 로고    scopus 로고
    • The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4 + T cells
    • T. Sekiya, I. Kashiwagi, N. Inoue, and et al. The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4 + T cells Nat Commun 2 2011 269
    • (2011) Nat Commun , vol.2 , pp. 269
    • Sekiya, T.1    Kashiwagi, I.2    Inoue, N.3
  • 94
    • 84857989935 scopus 로고    scopus 로고
    • Nuclear receptor Nr4a1 modulates both regulatory T-cell (Treg) differentiation and clonal deletion
    • M.S. Fassett, W. Jiang, A.M. D'Alise, D. Mathis, and C. Benoist Nuclear receptor Nr4a1 modulates both regulatory T-cell (Treg) differentiation and clonal deletion Proc Natl Acad Sci USA 109 10 2012 3891 3896
    • (2012) Proc Natl Acad Sci USA , vol.109 , Issue.10 , pp. 3891-3896
    • Fassett, M.S.1    Jiang, W.2    D'Alise, A.M.3    Mathis, D.4    Benoist, C.5
  • 95
    • 79958251745 scopus 로고    scopus 로고
    • T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse
    • A.E. Moran, K.L. Holzapfel, Y. Xing, and et al. T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse J Exp Med 208 6 2011 1279 1289
    • (2011) J Exp Med , vol.208 , Issue.6 , pp. 1279-1289
    • Moran, A.E.1    Holzapfel, K.L.2    Xing, Y.3
  • 96
    • 77953811224 scopus 로고    scopus 로고
    • Foxo proteins cooperatively control the differentiation of Foxp3 + regulatory T cells
    • W. Ouyang, O. Beckett, Q. Ma, J.H. Paik, R.A. DePinho, and M.O. Li Foxo proteins cooperatively control the differentiation of Foxp3 + regulatory T cells Nat Immunol 11 7 2010 618 627
    • (2010) Nat Immunol , vol.11 , Issue.7 , pp. 618-627
    • Ouyang, W.1    Beckett, O.2    Ma, Q.3    Paik, J.H.4    DePinho, R.A.5    Li, M.O.6
  • 97
    • 33845935950 scopus 로고    scopus 로고
    • IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3 + regulatory T cells
    • M.A. Burchill, J. Yang, C. Vogtenhuber, B.R. Blazar, and M.A. Farrar IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3 + regulatory T cells J Immunol 178 1 2007 280 290
    • (2007) J Immunol , vol.178 , Issue.1 , pp. 280-290
    • Burchill, M.A.1    Yang, J.2    Vogtenhuber, C.3    Blazar, B.R.4    Farrar, M.A.5
  • 98
    • 33747801470 scopus 로고    scopus 로고
    • IL-2 regulates FOXP3 expression in human CD4+CD25 + regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo
    • E. Zorn, E.A. Nelson, M. Mohseni, and et al. IL-2 regulates FOXP3 expression in human CD4+CD25 + regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo Blood 108 5 2006 1571 1579
    • (2006) Blood , vol.108 , Issue.5 , pp. 1571-1579
    • Zorn, E.1    Nelson, E.A.2    Mohseni, M.3
  • 99
    • 77957724587 scopus 로고    scopus 로고
    • The Ets-1 transcription factor controls the development and function of natural regulatory T cells
    • E. Mouly, K. Chemin, H.V. Nguyen, and et al. The Ets-1 transcription factor controls the development and function of natural regulatory T cells J Exp Med 207 10 2010 2113 2125
    • (2010) J Exp Med , vol.207 , Issue.10 , pp. 2113-2125
    • Mouly, E.1    Chemin, K.2    Nguyen, H.V.3
  • 100
    • 84879685794 scopus 로고    scopus 로고
    • BACH2 represses effector programs to stabilize T(reg)-mediated immune homeostasis
    • R. Roychoudhuri, K. Hirahara, K. Mousavi, and et al. BACH2 represses effector programs to stabilize T(reg)-mediated immune homeostasis Nature 498 7455 2013 506 510
    • (2013) Nature , vol.498 , Issue.7455 , pp. 506-510
    • Roychoudhuri, R.1    Hirahara, K.2    Mousavi, K.3
  • 101
    • 77955498891 scopus 로고    scopus 로고
    • Smad2 and Smad3 are redundantly essential for the TGF-beta-mediated regulation of regulatory T plasticity and Th1 development
    • T. Takimoto, Y. Wakabayashi, T. Sekiya, and et al. Smad2 and Smad3 are redundantly essential for the TGF-beta-mediated regulation of regulatory T plasticity and Th1 development J Immunol 185 2 2010 842 855
    • (2010) J Immunol , vol.185 , Issue.2 , pp. 842-855
    • Takimoto, T.1    Wakabayashi, Y.2    Sekiya, T.3
  • 102
    • 84866403123 scopus 로고    scopus 로고
    • Smad3 binding to the foxp3 enhancer is dispensable for the development of regulatory T cells with the exception of the gut
    • S.M. Schlenner, B. Weigmann, Q. Ruan, Y. Chen, and H. von Boehmer Smad3 binding to the foxp3 enhancer is dispensable for the development of regulatory T cells with the exception of the gut J Exp Med 209 9 2012 1529 1535
    • (2012) J Exp Med , vol.209 , Issue.9 , pp. 1529-1535
    • Schlenner, S.M.1    Weigmann, B.2    Ruan, Q.3    Chen, Y.4    Von Boehmer, H.5
  • 103
    • 44049087148 scopus 로고    scopus 로고
    • A critical function for TGF-beta signaling in the development of natural CD4+CD25+Foxp3 + regulatory T cells
    • Y. Liu, P. Zhang, J. Li, A.B. Kulkarni, S. Perruche, and W. Chen A critical function for TGF-beta signaling in the development of natural CD4+CD25+Foxp3 + regulatory T cells Nat Immunol 9 6 2008 632 640
    • (2008) Nat Immunol , vol.9 , Issue.6 , pp. 632-640
    • Liu, Y.1    Zhang, P.2    Li, J.3    Kulkarni, A.B.4    Perruche, S.5    Chen, W.6
  • 104
    • 84875458605 scopus 로고    scopus 로고
    • Active demethylation of the Foxp3 locus leads to the generation of stable regulatory T cells within the thymus
    • A. Toker, D. Engelbert, G. Garg, and et al. Active demethylation of the Foxp3 locus leads to the generation of stable regulatory T cells within the thymus J Immunol 190 7 2013 3180 3188
    • (2013) J Immunol , vol.190 , Issue.7 , pp. 3180-3188
    • Toker, A.1    Engelbert, D.2    Garg, G.3
  • 105
    • 66149146320 scopus 로고    scopus 로고
    • Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1
    • M. Tahiliani, K.P. Koh, Y. Shen, and et al. Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1 Science 324 5929 2009 930 935
    • (2009) Science , vol.324 , Issue.5929 , pp. 930-935
    • Tahiliani, M.1    Koh, K.P.2    Shen, Y.3
  • 106
    • 84886860116 scopus 로고    scopus 로고
    • TET enzymes, TDG and the dynamics of DNA demethylation
    • R.M. Kohli, and Y. Zhang TET enzymes, TDG and the dynamics of DNA demethylation Nature 502 7472 2013 472 479
    • (2013) Nature , vol.502 , Issue.7472 , pp. 472-479
    • Kohli, R.M.1    Zhang, Y.2
  • 107
    • 84871069553 scopus 로고    scopus 로고
    • Epigenetic regulation by long noncoding RNAs
    • J.T. Lee Epigenetic regulation by long noncoding RNAs Science 338 6113 2012 1435 1439
    • (2012) Science , vol.338 , Issue.6113 , pp. 1435-1439
    • Lee, J.T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.