Release of active TGF-β1 from the Latent TGF-β1/GARP complex on T regulatory cells is mediated by integrin β8

Journal of Immunology

Volumn 193, Issue 6, 2014, Pages 2843-2849

  Edwards, Justin P ^a   Thornton, Angela M ^a   Shevach, Ethan M ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTEGRIN; ALPHAVBETA8 INTEGRIN; BETA INTEGRIN; BETA8 INTEGRIN; CELL PROTEIN; GARP MOLECULE; HELIOS PROTEIN; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; DNA BINDING PROTEIN; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, MOUSE; GREEN FLUORESCENT PROTEIN; INTEGRIN; INTEGRIN ALPHAVBETA8; INTEGRIN BETA8; LRRC32 PROTEIN, MOUSE; MEMBRANE PROTEIN; TRANSCRIPTION FACTOR; ZFPN1A2 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOAVAILABILITY; CELL DIFFERENTIATION; CELL SURFACE; COLITIS; CONTROLLED STUDY; CYTOKINE RELEASE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REGULATORY T LYMPHOCYTE; TH17 CELL; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; LYMPHOCYTE ACTIVATION; SECRETION (PROCESS);

ANIMALS; BIOLOGICAL MARKERS; CELL DIFFERENTIATION; COLITIS; DNA-BINDING PROTEINS; FORKHEAD TRANSCRIPTION FACTORS; GREEN FLUORESCENT PROTEINS; INTEGRIN BETA CHAINS; INTEGRINS; LYMPHOCYTE ACTIVATION; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; T-LYMPHOCYTES, REGULATORY; TH17 CELLS; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84907066418     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1401102     Document Type: Article

References (22)

1. Edwards, J. P., H. Fujii, A. X. Zhou, J. Creemers, D. Unutmaz, and E. M. Shevach. 2013. Regulation of the expression of GARP/latent TGF-b1 complexes on mouse T cells and their role in regulatory T cell and T h17 differentiation. J. Immunol. 190: 5506-5515
2. Ahamed, J., N. Burg, K. Yoshinaga, C. A. Janczak, D. B. Rifkin, and B. S. Coller. 2008. In vitro and in vivo evidence for shear-induced activation of latent transforming growth factor-b1. Blood 112: 3650-3660
3. Mu, D., S. Cambier, L. Fjellbirkeland, J. L. Baron, J. S. Munger, H. Kawakatsu, D. Sheppard, V. C. Broaddus, and S . L. Nishimura. 2002. The integrin avb8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1. J. Cell Biol. 157: 493-507
4. Travis, M. A., B. Reizis, A. C. Melton, E. Mastelle r, Q. Tang, J. M. Proctor, Y.Wang, X. Bernstein, X. Huang, L. F. Reichardt, et al. 2007. Loss of integrin avb8 on dendritic cells causes autoimmunity and colitis in mice. Nature 449: 361-365
5. Melton, A. C., S. L. Bailey-Bucktrout, M. A. Travis, B. T. Fife, J. A. Bluestone, and D. Sheppard. 2010. Expression of avb8 integrin on dendritic cells regulates Th17 cell development and experimental autoimmune enc ephalomyelitis in mice. J. Clin. Invest. 120: 4436-4444
6. Wang, R., J. Zhu, X. Dong, M. Shi, C. Lu, and T. A. Springer. 2012. GARP regulates the bioavailability and activation of TGFb. Mol. Biol. Cell 23: 1129-1139
7. Proctor, J. M., K. Zang, D. Wang, R. Wang, and L. F. Reichardt. 2005. Vascular development of the brain requires b8 integrin expression in the neuroepithelium. J. Neurosci. 25: 9940-9948
8. Li, M. O., Y. Y. Wan, and R. A. Flavell. 2007. T cell-produced transforming growth factor-b1 controls T cell tolerance and regulates Th1-and Th17-cell differentiation. Immunity 26: 579-591
9. Thornton, A. M., P. E. Korty, D. Q. Tran, E. A. Wohlfert, P. E. Murray, Y. Belkaid, and E. M. Shevach. 2010. Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells. J. Immunol. 184: 3433-3441
10. Chen, Q., Y. C. Kim, A. Laurence, G. A. Punkosdy, and E. M. Shevach. 2011. IL-2 controls the stability of Foxp3 expression in TGF-β-induced Foxp3+ T cells in vivo. J. Immunol. 186: 6329-6337
11. Read, S., V. Malmströ m, and F. Powrie. 2000. Cytotoxic T lymphocyteassoci ated antigen 4 plays an essential role in the function of CD25+CD4+ regulatory cells that control intestinal inflammation. J. Exp. Med. 192: 295-302
12. Thornton, A. M., and E. M. Shevach. 1998. CD4+CD25+ im munoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 188: 287-296
13. Tran, D. Q., J. Andersson, R. Wang, H. Ramsey, D. Unutmaz, and E. M. Shevach. 2009. GARP (LRRC32) is essential for the surface expression of latent TGF-b on platelets and activated FOXP3+ regulatory T cells. Proc. Natl. Acad. Sci. USA 106: 13445-13450
14. Wang, R., L. Kozhaya, F. Mercer, A. Khaitan, H. Fujii, and D. Unutmaz. 2009. Expression of GARP selectively identifies activated human FOXP3+ regulatory T cells. Proc. Natl. Acad. Sci. USA 106: 13439-13444
15. Luo, B. H., C. V. Carman, and T. A. Springer. 2007. Structural basis of integrin regulation and signaling. Annu. Rev. Immunol. 25: 619-647
16. Worthington, J. J., B. I. Czajkowska, A. C. Melton, and M. A. Travis. 2011. Intestinal dendritic cells specialize to activate transforming growth factor-b and induce Foxp3+ regulatory T cells via integrin avb8. Gastroenterology 141: 1802 - 1812.
17. Paidassi H.,M. Acharya,A. Zhang,S. Mukhopadhyay,M. Kwon,C. Chow,L.M. Stuart,J. Savill,A. Lacy-Hulbert, 2011. Preferential expression of integrin avb8 promotes generation of regulatory T cells by mouse CD103+ dendritic cells. Gastroenterology 141, 1813-1820.
18. Fahlé n, L., S. Read, L. Gorelik, S. D. Hurst, R. L. Coffman, R. A. Flavell, and F. Powrie. 2005. T cells that cannot respond to TGF-b escape control by CD4+ CD25+ regulatory T cells. J. Exp. Med. 201: 737-746
19. Diebold, R. J., M. J. Eis, M. Yin, I. Ormsby, G. P. Boivin, B. J. Darrow, J. E. Saffitz, and T. Doetschman. 1995. Early-onset multifocal inflammation in the transforming growth factor b1-null mouse is lymphocyte mediated. Proc. Natl. Acad. Sci. USA 92: 12215-12219
20. Yang, Z., Z. Mu, B. Dabovic, V. Jurukovski, D. Yu, J. Sung, X. Xiong, and J. S. Munger. 2007. Absence of integrin-mediated TGFb1 activation in vivo recapitulates the phenotype of TGFb1-null mice. J. Cell Biol. 176: 787-793
21. Morris, D. G., X. Huang, N. Kaminski, Y. Wang, S. D. Shapiro, G. Dolganov, A. Glick, and D. Sheppard. 2003. Loss of integrin avb6-mediated TGF-b activation causes Mmp12-dependent emphysema. Na ture 422: 169-173
22. Andersson, J., D. Q. Tran, M. Pesu, T. S. Davidson, H. Ramsey, J. J. O'Shea, and E. M. Shevach. 2008. CD4+FoxP3+ regulatory T cells confer infectious tolerance in a TGF-β-dependent manner. J. Exp. Med. 205: 1975-1981