Vascular klotho deficiency potentiates the development of human artery calcification and mediates resistance to fibroblast growth factor 23

Circulation

Volumn 125, Issue 18, 2012, Pages 2243-2255

  Lim, Kenneth ^a,b   Lu, Tzong Shi ^a   Molostvov, Guerman ^b   Lee, Christina ^a   Lam, F T ^c   Zehnder, Daniel ^b,c   Hsiao, Li Li ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b UNIVERSITY OF WARWICK   (United Kingdom)

^c UNIVERSITY HOSPITAL COVENTRY   (United Kingdom)

Author keywords

Chronic kidney disease; Inflammation; Klotho; Vascular calcification; Vitamin D

Indexed keywords

ACTIN; CALCIPOTRIOL; FIBROBLAST GROWTH FACTOR 23; FIBROBLAST GROWTH FACTOR RECEPTOR 1; FIBROBLAST GROWTH FACTOR RECEPTOR 3; KLOTHO PROTEIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MYOCARDIN; PARICALCITOL; PROTEIN KINASE B; SERUM RESPONSE FACTOR; TRANSCRIPTION FACTOR RUNX2; VITAMIN D RECEPTOR;

ARTERY CALCIFICATION; ARTICLE; CARDIOVASCULAR SYSTEM; CELL PROLIFERATION; CHRONIC KIDNEY DISEASE; CHRONIC STRESS; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; METABOLIC DISORDER; METABOLIC STRESS; ORGAN CULTURE; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; TARGET ORGAN; UREMIA;

AORTA; CELL LINE; CELL PROLIFERATION; CORE BINDING FACTOR ALPHA 1 SUBUNIT; FIBROBLAST GROWTH FACTORS; GLUCURONIDASE; HUMANS; MAP KINASE SIGNALING SYSTEM; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; NUCLEAR PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, CALCITRIOL; RENAL INSUFFICIENCY, CHRONIC; SERUM RESPONSE FACTOR; TRANS-ACTIVATORS; VASCULAR CALCIFICATION;

EID: 84860778116     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.111.053405     Document Type: Article

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