-
1
-
-
84873638532
-
Aging, cellular senescence, and cancer
-
Campisi J (2013) Aging, cellular senescence, and cancer. Annu Rev Physiol 75:685-705
-
(2013)
Annu Rev Physiol
, vol.75
, pp. 685-705
-
-
Campisi, J.1
-
2
-
-
79951912532
-
Four faces of cellular senescence
-
Rodier F, Campisi J (2011) Four faces of cellular senescence. J Cell Biol 192(4):547-603
-
(2011)
J Cell Biol
, vol.192
, Issue.4
, pp. 547-603
-
-
Rodier, F.1
Campisi, J.2
-
3
-
-
0033013980
-
Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts
-
Stein G, Drullinger L, Soulard A, Dulic V (1999) Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts. Mol Cell Biol 19(3):2109-2117
-
(1999)
Mol Cell Biol
, vol.19
, Issue.3
, pp. 2109-2117
-
-
Stein, G.1
Drullinger, L.2
Soulard, A.3
Dulic, V.4
-
4
-
-
2442511752
-
Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16 (INK4a)
-
Herbig U, Jobling W, Chen B, Chen D, Sedivy J (2004) Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16 (INK4a). Mol Cell 14(4):501-513
-
(2004)
Mol Cell
, vol.14
, Issue.4
, pp. 501-513
-
-
Herbig, U.1
Jobling, W.2
Chen, B.3
Chen, D.4
Sedivy, J.5
-
5
-
-
0345932931
-
Mitogenactivated protein kinase p38 defines the common senescence-signalling pathway
-
Iwasa H, Han J, Ishikawa F (2003) Mitogenactivated protein kinase p38 defines the common senescence-signalling pathway. Genes Cells 8(2):131-144
-
(2003)
Genes Cells
, vol.8
, Issue.2
, pp. 131-144
-
-
Iwasa, H.1
Han, J.2
Ishikawa, F.3
-
6
-
-
77956699438
-
Transcriptional factor HBP1 targets P16 (INK4A), upregulating its expression and consequently is involved in Ras-induced premature senescence
-
Li H, Wang W, Liu X, Paulson K, Yee A, Zhang X (2010) Transcriptional factor HBP1 targets P16 (INK4A), upregulating its expression and consequently is involved in Ras-induced premature senescence. Oncogene 29(36):5083-5094
-
(2010)
Oncogene
, vol.29
, Issue.36
, pp. 5083-5094
-
-
Li, H.1
Wang, W.2
Liu, X.3
Paulson, K.4
Yee, A.5
Zhang, X.6
-
7
-
-
0030477686
-
Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts
-
Alcorta DA, Xiong Y, Phelps D, Hannon G, Beach D, Barrett JC (1996) Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts. Proc Natl Acad Sci U S A 93(24):13742-13747
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, Issue.24
, pp. 13742-13747
-
-
Alcorta, D.A.1
Xiong, Y.2
Phelps, D.3
Hannon, G.4
Beach, D.5
Barrett, J.C.6
-
8
-
-
0346373567
-
Stress-induced premature senescence in hTERT-expressing ataxia telangiectasia fibroblasts
-
Naka K, Tachibana A, Ikeda K, Motoyama N (2004) Stress-induced premature senescence in hTERT-expressing ataxia telangiectasia fibroblasts. J Biol Chem 279(3):2030-2037
-
(2004)
J Biol Chem
, vol.279
, Issue.3
, pp. 2030-2037
-
-
Naka, K.1
Tachibana, A.2
Ikeda, K.3
Motoyama, N.4
-
9
-
-
79955017452
-
P38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype
-
Freund A, Patil C, Campisi J (2011) p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype. EMBO J 30(8):1536-1548
-
(2011)
EMBO J
, vol.30
, Issue.8
, pp. 1536-1548
-
-
Freund, A.1
Patil, C.2
Campisi, J.3
-
10
-
-
0344622606
-
The serial cultivation of human diploid cell strains
-
Hayflick L, Moorhead P (1961) The serial cultivation of human diploid cell strains. Exp Cell Res 25:585-621
-
(1961)
Exp Cell Res
, vol.25
, pp. 585-621
-
-
Hayflick, L.1
Moorhead, P.2
-
11
-
-
50549218525
-
The limited in vitro lifetime of human diploid strains
-
Hayflick L (1965) The limited in vitro lifetime of human diploid strains. Exp Cell Res 37:614-636
-
(1965)
Exp Cell Res
, vol.37
, pp. 614-636
-
-
Hayflick, L.1
-
12
-
-
0029047362
-
A biomarker that identifies senescent human cells in culture and in aging skin in vivo
-
Dimri G, Lee X, Basile G, Acosta M, Scott G, Roskelley C, Medrano E, Linskens M, Rubelj I, Pereira-Smith O (1995) A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci U S A 92(20):9363-9367
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, Issue.20
, pp. 9363-9367
-
-
Dimri, G.1
Lee, X.2
Basile, G.3
Acosta, M.4
Scott, G.5
Roskelley, C.6
Medrano, E.7
Linskens, M.8
Rubelj, I.9
Pereira-Smith, O.10
-
13
-
-
0344441890
-
A DNA damage checkpoint response in telomere-initiated senescence
-
D'Adda Di Fagagna F, Reaper P, Clay-Farrace L, Fiegler H, Carr P, Von Zglinicki T, Saretzki G, Carter N, Jackson S (2003) A DNA damage checkpoint response in telomere-initiated senescence. Nature 426(6963):194-198
-
(2003)
Nature
, vol.426
, Issue.6963
, pp. 194-198
-
-
D'Adda Di Fagagna, F.1
Reaper, P.2
Clay-Farrace, L.3
Fiegler, H.4
Carr, P.5
Von Zglinicki, T.6
Saretzki, G.7
Carter, N.8
Jackson, S.9
-
14
-
-
78651104478
-
DNA-SCARS: Distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion
-
Rodier F, Munoz DP, Teachenor R, Chu V, Le O, Bhaumik D, Coppe JP, Campeau E, Beausejour CM, Kim SH, Davalos AR, Campisi J (2011) DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion. J Cell Sci 124(Pt 1):68-81
-
(2011)
J Cell Sci
, vol.124
, Issue.PART 1
, pp. 68-81
-
-
Rodier, F.1
Munoz, D.P.2
Teachenor, R.3
Chu, V.4
Le, O.5
Bhaumik, D.6
Coppe, J.P.7
Campeau, E.8
Beausejour, C.M.9
Kim, S.H.10
Davalos, A.R.11
Campisi, J.12
-
15
-
-
34147182401
-
Remodeling of chromatin structure in senescent cells and its potential impact on tumor suppression and aging
-
Adams PD (2007) Remodeling of chromatin structure in senescent cells and its potential impact on tumor suppression and aging. Gene 397(1-2):84-93
-
(2007)
Gene
, vol.397
, Issue.1-2
, pp. 84-93
-
-
Adams, P.D.1
-
16
-
-
0036242247
-
Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence
-
Wang W, Chen JX, Liao R, Deng Q, Zhou JJ, Huang S, Sun P (2002) Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence. Mol Cell Biol 22(10):3389-3403
-
(2002)
Mol Cell Biol
, vol.22
, Issue.10
, pp. 3389-3403
-
-
Wang, W.1
Chen, J.X.2
Liao, R.3
Deng, Q.4
Zhou, J.J.5
Huang, S.6
Sun, P.7
-
17
-
-
84861673276
-
Lamin B1 loss is a senescenceassociated biomarker
-
Freund A, Laberge R-M, Demaria M, Campisi J (2012) Lamin B1 loss is a senescenceassociated biomarker. Mol Biol Cell 23(11):2066-2075
-
(2012)
Mol Biol Cell
, vol.23
, Issue.11
, pp. 2066-2075
-
-
Freund, A.1
Laberge, R.-M.2
Demaria, M.3
Campisi, J.4
-
18
-
-
51649098243
-
A role for fibroblasts in mediating the effects of tobacco-induced epithelial cell growth and invasion
-
Coppe JP, Boysen M, Sun CH, Wong BJ, Kang MK, Park NH, Desprez PY, Campisi J, Krtolica A (2008) A role for fibroblasts in mediating the effects of tobacco-induced epithelial cell growth and invasion. Mol Cancer Res 6(7):1085-1098
-
(2008)
Mol Cancer Res
, vol.6
, Issue.7
, pp. 1085-1098
-
-
Coppe, J.P.1
Boysen, M.2
Sun, C.H.3
Wong, B.J.4
Kang, M.K.5
Park, N.H.6
Desprez, P.Y.7
Campisi, J.8
Krtolica, A.9
-
19
-
-
84891713034
-
Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor
-
Coppe JP, Patil CK, Rodier F, Sun Y, Munoz DP, Goldstein J, Nelson PS, Desprez PY, Campisi J (2008) Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol 6(12):2853-2868
-
(2008)
PLoS Biol
, vol.6
, Issue.12
, pp. 2853-2868
-
-
Coppe, J.P.1
Patil, C.K.2
Rodier, F.3
Sun, Y.4
Munoz, D.P.5
Goldstein, J.6
Nelson, P.S.7
Desprez, P.Y.8
Campisi, J.9
-
20
-
-
0037667702
-
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence
-
Narita M, Nunez S, Heard E, Narita M, Lin A, Hearn S, Spector D, Hannon G, Lowe S (2003) Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell 113(6):703-716
-
(2003)
Cell
, vol.113
, Issue.6
, pp. 703-716
-
-
Narita, M.1
Nunez, S.2
Heard, E.3
Narita, M.4
Lin, A.5
Hearn, S.6
Spector, D.7
Hannon, G.8
Lowe, S.9
-
21
-
-
68249096784
-
Persistent DNA damage signalling triggers senescenceassociated inflammatory cytokine secretion
-
Rodier F, Coppe JP, Patil CK, Hoeijmakers WA, Munoz DP, Raza SR, Freund A, Campeau E, Davalos AR, Campisi J (2009) Persistent DNA damage signalling triggers senescenceassociated inflammatory cytokine secretion. Nat Cell Biol 11(8):973-979
-
(2009)
Nat Cell Biol
, vol.11
, Issue.8
, pp. 973-979
-
-
Rodier, F.1
Coppe, J.P.2
Patil, C.K.3
Hoeijmakers, W.A.4
Munoz, D.P.5
Raza, S.R.6
Freund, A.7
Campeau, E.8
Davalos, A.R.9
Campisi, J.10
-
22
-
-
80054682555
-
Tumor suppressor and aging biomarker p16 (INK4a) induces cellular senescence without the associated inflammatory secretory phenotype
-
Coppe JP, Rodier F, Patil CK, Freund A, Desprez PY, Campisi J (2011) Tumor suppressor and aging biomarker p16 (INK4a) induces cellular senescence without the associated inflammatory secretory phenotype. J Biol Chem 286(42):36396-36403
-
(2011)
J Biol Chem
, vol.286
, Issue.42
, pp. 36396-36403
-
-
Coppe, J.P.1
Rodier, F.2
Patil, C.K.3
Freund, A.4
Desprez, P.Y.5
Campisi, J.6
-
23
-
-
0018876664
-
Aging, natural death, and the compression of morbidity
-
Fries J (1980) Aging, natural death, and the compression of morbidity. N Engl J Med 303(3):130-135
-
(1980)
N Engl J Med
, vol.303
, Issue.3
, pp. 130-135
-
-
Fries, J.1
-
24
-
-
0025279931
-
Telomeres shorten during ageing of human fibroblasts
-
Harley C, Futcher A, Greider C (1990) Telomeres shorten during ageing of human fibroblasts. Nature 345(6274):458-460
-
(1990)
Nature
, vol.345
, Issue.6274
, pp. 458-460
-
-
Harley, C.1
Futcher, A.2
Greider, C.3
-
25
-
-
0010045614
-
Extension of life-span by introduction of telomerase into normal human cells
-
Bodnar A, Ouellette M, Frolkis M, Holt S, Chiu C, Morin G, Harley C, Shay J, Lichtsteiner S, Wright W (1998) Extension of life-span by introduction of telomerase into normal human cells. Science 279(5349):349-352
-
(1998)
Science
, vol.279
, Issue.5349
, pp. 349-352
-
-
Bodnar, A.1
Ouellette, M.2
Frolkis, M.3
Holt, S.4
Chiu, C.5
Morin, G.6
Harley, C.7
Shay, J.8
Lichtsteiner, S.9
Wright, W.10
-
26
-
-
0042195820
-
Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts
-
Parrinello S, Samper E, Krtolica A, Goldstein J, Melov S, Campisi J (2003) Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts. Nat Cell Biol 5(8):741-747
-
(2003)
Nat Cell Biol
, vol.5
, Issue.8
, pp. 741-747
-
-
Parrinello, S.1
Samper, E.2
Krtolica, A.3
Goldstein, J.4
Melov, S.5
Campisi, J.6
-
27
-
-
0026043444
-
In vivo loss of telomeric repeats with age in humans
-
Lindsey J, McGill N, Lindsey L, Green D, Cooke H (1991) In vivo loss of telomeric repeats with age in humans. Mutat Res 256(1):45-48
-
(1991)
Mutat Res
, vol.256
, Issue.1
, pp. 45-48
-
-
Lindsey, J.1
McGill, N.2
Lindsey, L.3
Green, D.4
Cooke, H.5
-
28
-
-
36549024516
-
Accelerated telomere shortening and replicative senescence in human fibroblasts overexpressing mutant and wildtype lamin A
-
Huang S, Risques R, Martin G, Rabinovitch P, Oshima J (2008) Accelerated telomere shortening and replicative senescence in human fibroblasts overexpressing mutant and wildtype lamin A. Exp Cell Res 314(1):82-91
-
(2008)
Exp Cell Res
, vol.314
, Issue.1
, pp. 82-91
-
-
Huang, S.1
Risques, R.2
Martin, G.3
Rabinovitch, P.4
Oshima, J.5
-
29
-
-
59449095581
-
Suppression of proliferative defects associated with processing-defective lamin A mutants by hTERT or inactivation of p53
-
Kudlow B, Stanfel M, Burtner C, Johnston E, Kennedy B (2008) Suppression of proliferative defects associated with processing-defective lamin A mutants by hTERT or inactivation of p53. Mol Biol Cell 19(12):5238-5248
-
(2008)
Mol Biol Cell
, vol.19
, Issue.12
, pp. 5238-5248
-
-
Kudlow, B.1
Stanfel, M.2
Burtner, C.3
Johnston, E.4
Kennedy, B.5
-
30
-
-
0032168373
-
Relationship between donor age and the replicative lifespan of human cells in culture: A reevaluation
-
Cristofalo V, Allen R, Pignolo R, Martin B, Beck J (1998) Relationship between donor age and the replicative lifespan of human cells in culture: a reevaluation. Proc Natl Acad Sci U S A 95(18):10614-10619
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, Issue.18
, pp. 10614-10619
-
-
Cristofalo, V.1
Allen, R.2
Pignolo, R.3
Martin, B.4
Beck, J.5
-
31
-
-
0018890645
-
Intraclonal variation in proliferative potential of human diploid fibroblasts: Stochastic mechanism for cellular aging
-
Smith J, Whitney R (1980) Intraclonal variation in proliferative potential of human diploid fibroblasts: stochastic mechanism for cellular aging. Science 207(4426):82-84
-
(1980)
Science
, vol.207
, Issue.4426
, pp. 82-84
-
-
Smith, J.1
Whitney, R.2
-
32
-
-
34547958816
-
Mitochondrial fission and fusion mediators, hFis1 and OPA1, modulate cellular senescence
-
Lee S, Jeong S-Y, Lim W-C, Kim S, Park Y-Y, Sun X, Youle R, Cho H (2007) Mitochondrial fission and fusion mediators, hFis1 and OPA1, modulate cellular senescence. J Biol Chem 282(31):22977-22983
-
(2007)
J Biol Chem
, vol.282
, Issue.31
, pp. 22977-22983
-
-
Lee, S.1
Jeong, S.-Y.2
Lim, W.-C.3
Kim, S.4
Park, Y.-Y.5
Sun, X.6
Youle, R.7
Cho, H.8
-
33
-
-
33749265862
-
Formation of elongated giant mitochondria in DFO-induced cellular senescence: Involvement of enhanced fusion process through modulation of Fis1
-
Yoon Y-S, Yoon D-S, Lim I, Yoon S-H, Chung H-Y, Rojo M, Malka F, Jou M-J, Martinou J-C, Yoon G (2006) Formation of elongated giant mitochondria in DFO-induced cellular senescence: involvement of enhanced fusion process through modulation of Fis1. J Cell Physiol 209(2):468-480
-
(2006)
J Cell Physiol
, vol.209
, Issue.2
, pp. 468-480
-
-
Yoon, Y.-S.1
Yoon, D.-S.2
Lim, I.3
Yoon, S.-H.4
Chung, H.-Y.5
Rojo, M.6
Malka, F.7
Jou, M.-J.8
Martinou, J.-C.9
Yoon, G.10
-
34
-
-
77956875648
-
Stress-induced senescence in human and rodent astrocytes
-
Bitto A, Sell C, Crowe E, Lorenzini A, Malaguti M, Hrelia S, Torres C (2010) Stress-induced senescence in human and rodent astrocytes. Exp Cell Res 316(17):2961-2968
-
(2010)
Exp Cell Res
, vol.316
, Issue.17
, pp. 2961-2968
-
-
Bitto, A.1
Sell, C.2
Crowe, E.3
Lorenzini, A.4
Malaguti, M.5
Hrelia, S.6
Torres, C.7
-
35
-
-
0037064011
-
Expression of human telomerase (hTERT) does not prevent stress-induced senescence in normal human fibroblasts but protects the cells from stress-induced apoptosis and necrosis
-
Gorbunova V, Seluanov A, Pereira-Smith O (2002) Expression of human telomerase (hTERT) does not prevent stress-induced senescence in normal human fibroblasts but protects the cells from stress-induced apoptosis and necrosis. J Biol Chem 277(41):38540-38549
-
(2002)
J Biol Chem
, vol.277
, Issue.41
, pp. 38540-38549
-
-
Gorbunova, V.1
Seluanov, A.2
Pereira-Smith, O.3
-
36
-
-
0033732110
-
Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes
-
Toussaint O, Medrano E, Von Zglinicki T (2000) Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes. Exp Gerontol 35(8):927-945
-
(2000)
Exp Gerontol
, vol.35
, Issue.8
, pp. 927-945
-
-
Toussaint, O.1
Medrano, E.2
Von Zglinicki, T.3
-
37
-
-
0036629255
-
Oxidative stress shortens telomeres
-
Von Zglinicki T (2002) Oxidative stress shortens telomeres. Trends Biochem Sci 27(7):339-344
-
(2002)
Trends Biochem Sci
, vol.27
, Issue.7
, pp. 339-344
-
-
Von Zglinicki, T.1
-
38
-
-
84871302192
-
Senescent cells: A novel therapeutic target for aging and age-related diseases
-
Naylor R, Baker D, Van Deursen J (2013) Senescent cells: a novel therapeutic target for aging and age-related diseases. Clin Pharmacol Ther 93(1):105-116
-
(2013)
Clin Pharmacol Ther
, vol.93
, Issue.1
, pp. 105-116
-
-
Naylor, R.1
Baker, D.2
Van Deursen, J.3
-
39
-
-
45449084795
-
Cellular senescence and organismal aging
-
Jeyapalan J, Sedivy J (2008) Cellular senescence and organismal aging. Mech Ageing Dev 129(7-8):467-541
-
(2008)
Mech Ageing Dev
, vol.129
, Issue.7-8
, pp. 467-541
-
-
Jeyapalan, J.1
Sedivy, J.2
-
40
-
-
33644692330
-
Cellular senescence in aging primates
-
Herbig U, Ferreira M, Condel L, Carey D, Sedivy J (2006) Cellular senescence in aging primates. Science 311(5765):1257
-
(2006)
Science
, vol.311
, Issue.5765
, pp. 1257
-
-
Herbig, U.1
Ferreira, M.2
Condel, L.3
Carey, D.4
Sedivy, J.5
-
41
-
-
33846090789
-
Accumulation of senescent cells in mitotic tissue of aging primates
-
Jeyapalan J, Ferreira M, Sedivy J, Herbig U (2007) Accumulation of senescent cells in mitotic tissue of aging primates. Mech Ageing Dev 128(1):36-44
-
(2007)
Mech Ageing Dev
, vol.128
, Issue.1
, pp. 36-44
-
-
Jeyapalan, J.1
Ferreira, M.2
Sedivy, J.3
Herbig, U.4
-
42
-
-
79952609648
-
Age-associated increase in heterochromatic marks in murine and primate tissues
-
Kreiling J, Tamamori-Adachi M, Sexton A, Jeyapalan J, Munoz-Najar U, Peterson A, Manivannan J, Rogers E, Pchelintsev N, Adams P, Sedivy J (2011) Age-associated increase in heterochromatic marks in murine and primate tissues. Aging Cell 10(2):292-304
-
(2011)
Aging Cell
, vol.10
, Issue.2
, pp. 292-304
-
-
Kreiling, J.1
Tamamori-Adachi, M.2
Sexton, A.3
Jeyapalan, J.4
Munoz-Najar, U.5
Peterson, A.6
Manivannan, J.7
Rogers, E.8
Pchelintsev, N.9
Adams, P.10
Sedivy, J.11
-
43
-
-
84900969225
-
Ink4a/Arf expression is a biomarker of aging
-
Krishnamurthy J, Torrice C, Ramsey M, Kovalev G, Al-Regaiey K, Su L, Sharpless N (2004) Ink4a/Arf expression is a biomarker of aging. J Clin Invest 114(9):1299-1307
-
(2004)
J Clin Invest
, vol.114
, Issue.9
, pp. 1299-1307
-
-
Krishnamurthy, J.1
Torrice, C.2
Ramsey, M.3
Kovalev, G.4
Al-Regaiey, K.5
Su, L.6
Sharpless, N.7
-
44
-
-
33748327046
-
P16INK4A is a robust in vivo biomarker of cellular aging in human skin
-
Ressler S, Bartkova J, Niederegger H, Bartek J, Scharffetter-Kochanek K, Jansen-Dürr P, Wlaschek M (2006) p16INK4A is a robust in vivo biomarker of cellular aging in human skin. Aging Cell 5(5):379-389
-
(2006)
Aging Cell
, vol.5
, Issue.5
, pp. 379-389
-
-
Ressler, S.1
Bartkova, J.2
Niederegger, H.3
Bartek, J.4
Scharffetter-Kochanek, K.5
Jansen-Dürr, P.6
Wlaschek, M.7
-
45
-
-
84866316014
-
Astrocyte senescence as a component of Alzheimer's disease
-
Bhat R, Crowe E, Bitto A, Moh M, Katsetos C, Garcia F, Johnson F, Trojanowski J, Sell C, Torres C (2012) Astrocyte senescence as a component of Alzheimer's disease. PLoS One 7(9):e45069
-
(2012)
PLoS One
, vol.7
, Issue.9
-
-
Bhat, R.1
Crowe, E.2
Bitto, A.3
Moh, M.4
Katsetos, C.5
Garcia, F.6
Johnson, F.7
Trojanowski, J.8
Sell, C.9
Torres, C.10
-
46
-
-
79151486394
-
Expression of Chr9p21 genes CDKN2B (p15 (INK4b)), CDKN2A (p16 (INK4a), p14 (ARF)) and MTAP in human atherosclerotic plaque
-
Holdt L, Sass K, Gäbel G, Bergert H, Thiery J, Teupser D (2011) Expression of Chr9p21 genes CDKN2B (p15 (INK4b)), CDKN2A (p16 (INK4a), p14 (ARF)) and MTAP in human atherosclerotic plaque. Atherosclerosis 214(2):264-270
-
(2011)
Atherosclerosis
, vol.214
, Issue.2
, pp. 264-270
-
-
Holdt, L.1
Sass, K.2
Gäbel, G.3
Bergert, H.4
Thiery, J.5
Teupser, D.6
-
47
-
-
46449122575
-
Hypertension induces somatic cellular senescence in rats and humans by induction of cell cycle inhibitor p16INK4a
-
Westhoff J, Hilgers K, Steinbach M, Hartner A, Klanke B, Amann K, Melk A (2008) Hypertension induces somatic cellular senescence in rats and humans by induction of cell cycle inhibitor p16INK4a. Hypertension 52(1):123-129
-
(2008)
Hypertension
, vol.52
, Issue.1
, pp. 123-129
-
-
Westhoff, J.1
Hilgers, K.2
Steinbach, M.3
Hartner, A.4
Klanke, B.5
Amann, K.6
Melk, A.7
-
48
-
-
77956672577
-
Ionizing radiation-induced long-term expression of senescence markers in mice is independent of p53 and immune status
-
Le ON, Rodier F, Fontaine F, Coppe JP, Campisi J, De Gregori J, Laverdiere C, Kokta V, Haddad E, Beausejour CM (2010) Ionizing radiation-induced long-term expression of senescence markers in mice is independent of p53 and immune status. Aging Cell 9(3):398-409
-
(2010)
Aging Cell
, vol.9
, Issue.3
, pp. 398-409
-
-
Le, O.N.1
Rodier, F.2
Fontaine, F.3
Coppe, J.P.4
Campisi, J.5
De Gregori, J.6
Laverdiere, C.7
Kokta, V.8
Haddad, E.9
Beausejour, C.M.10
-
49
-
-
9744272376
-
Cigarette smoke induces senescence in alveolar epithelial cells
-
Tsuji T, Aoshiba K, Nagai A (2004) Cigarette smoke induces senescence in alveolar epithelial cells. Am J Respir Cell Mol Biol 31(6):643-649
-
(2004)
Am J Respir Cell Mol Biol
, vol.31
, Issue.6
, pp. 643-649
-
-
Tsuji, T.1
Aoshiba, K.2
Nagai, A.3
-
50
-
-
0035834121
-
Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging
-
Krtolica A, Parrinello S, Lockett S, Desprez P, Campisi J (2001) Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging. Proc Natl Acad Sci U S A 98(21):12072-12077
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, Issue.21
, pp. 12072-12077
-
-
Krtolica, A.1
Parrinello, S.2
Lockett, S.3
Desprez, P.4
Campisi, J.5
-
51
-
-
80855138775
-
Clearance of p16 (Ink4a) - Positive senescent cells delays ageing-associated disorders
-
Baker D, Wijshake T, Tchkonia T, Lebrasseur N, Childs B, Van De Sluis B, Kirkland J, Van Deursen J (2011) Clearance of p16 (Ink4a) - positive senescent cells delays ageing-associated disorders. Nature 479:232-236
-
(2011)
Nature
, vol.479
, pp. 232-236
-
-
Baker, D.1
Wijshake, T.2
Tchkonia, T.3
Lebrasseur, N.4
Childs, B.5
Van De Sluis, B.6
Kirkland, J.7
Van Deursen, J.8
-
52
-
-
84863667325
-
Aging and atherosclerosis: Mechanisms, functional consequences, and potential therapeutics for cellular senescence
-
Wang J, Bennett M (2012) Aging and atherosclerosis: mechanisms, functional consequences, and potential therapeutics for cellular senescence. Circ Res 111(2):245-259
-
(2012)
Circ Res
, vol.111
, Issue.2
, pp. 245-259
-
-
Wang, J.1
Bennett, M.2
-
54
-
-
78349299099
-
Fat tissue, aging, and cellular senescence
-
Tchkonia T, Morbeck D, Von Zglinicki T, Van Deursen J, Lustgarten J, Scrable H, Khosla S, Jensen M, Kirkland J (2010) Fat tissue, aging, and cellular senescence. Aging Cell 9(5):667-684
-
(2010)
Aging Cell
, vol.9
, Issue.5
, pp. 667-684
-
-
Tchkonia, T.1
Morbeck, D.2
Von Zglinicki, T.3
Van Deursen, J.4
Lustgarten, J.5
Scrable, H.6
Khosla, S.7
Jensen, M.8
Kirkland, J.9
-
55
-
-
33749549246
-
Secretion of vascular endothelial growth factor by primary human fibroblasts at senescence
-
Coppe JP, Kauser K, Campisi J, Beausejour CM (2006) Secretion of vascular endothelial growth factor by primary human fibroblasts at senescence. J Biol Chem 281(40):29568-29574
-
(2006)
J Biol Chem
, vol.281
, Issue.40
, pp. 29568-29574
-
-
Coppe, J.P.1
Kauser, K.2
Campisi, J.3
Beausejour, C.M.4
-
56
-
-
31544479046
-
The gene expression program of prostate fibroblast senescence modulates neoplastic epithelial cell proliferation through paracrine mechanisms
-
Bavik C, Coleman I, Dean J, Knudsen B, Plymate S, Nelson P (2006) The gene expression program of prostate fibroblast senescence modulates neoplastic epithelial cell proliferation through paracrine mechanisms. Cancer Res 66(2):794-802
-
(2006)
Cancer Res
, vol.66
, Issue.2
, pp. 794-802
-
-
Bavik, C.1
Coleman, I.2
Dean, J.3
Knudsen, B.4
Plymate, S.5
Nelson, P.6
-
57
-
-
13944260728
-
Stromal-epithelial interactions in aging and cancer: Senescent fibroblasts alter epithelial cell differentiation
-
Parrinello S, Coppe JP, Krtolica A, Campisi J (2005) Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation. J Cell Sci 118(Pt 3):485-496
-
(2005)
J Cell Sci
, vol.118
, Issue.PART 3
, pp. 485-496
-
-
Parrinello, S.1
Coppe, J.P.2
Krtolica, A.3
Campisi, J.4
-
58
-
-
84881399206
-
A complex secretory program orchestrated by the inflammasome controls paracrine senescence
-
Acosta JC, Banito A, Wuestefeld T, Georgilis A, Janich P, Morton JP, Athineos D, Kang TW, Lasitschka F, Andrulis M, Pascual G, Morris KJ, Khan S, Jin H, Dharmalingam G, Snijders AP, Carroll T, Capper D, Pritchard C, Inman GJ, Longerich T, Sansom OJ, Benitah SA, Zender L, Gil J (2013) A complex secretory program orchestrated by the inflammasome controls paracrine senescence. Nat Cell Biol 15(8):978-990
-
(2013)
Nat Cell Biol
, vol.15
, Issue.8
, pp. 978-990
-
-
Acosta, J.C.1
Banito, A.2
Wuestefeld, T.3
Georgilis, A.4
Janich, P.5
Morton, J.P.6
Athineos, D.7
Kang, T.W.8
Lasitschka, F.9
Andrulis, M.10
Pascual, G.11
Morris, K.J.12
Khan, S.13
Jin, H.14
Dharmalingam, G.15
Snijders, A.P.16
Carroll, T.17
Capper, D.18
Pritchard, C.19
Inman, G.J.20
Longerich, T.21
Sansom, O.J.22
Benitah, S.A.23
Zender, L.24
Gil, J.25
more..
-
59
-
-
34547908461
-
Augmented Wnt signaling in a mammalian model of accelerated aging
-
Liu H, Fergusson M, Castilho R, Liu J, Cao L, Chen J, Malide D, Rovira I, Schimel D, Kuo C, Gutkind J, Hwang P, Finkel T (2007) Augmented Wnt signaling in a mammalian model of accelerated aging. Science 317(5839):803-806
-
(2007)
Science
, vol.317
, Issue.5839
, pp. 803-806
-
-
Liu, H.1
Fergusson, M.2
Castilho, R.3
Liu, J.4
Cao, L.5
Chen, J.6
Malide, D.7
Rovira, I.8
Schimel, D.9
Kuo, C.10
Gutkind, J.11
Hwang, P.12
Finkel, T.13
-
60
-
-
79959340540
-
Wnt/ß-catenin signaling induces the aging of mesenchymal stem cells through the DNA damage response and the p53/p21 pathway
-
D-y Z, H-j W, Y-z T
-
D-y Z, H-j W, Y-z T (2011) Wnt/ß-catenin signaling induces the aging of mesenchymal stem cells through the DNA damage response and the p53/p21 pathway. PLoS One 6(6):e21397
-
(2011)
PLoS One
, vol.6
, Issue.6
-
-
-
61
-
-
84876480332
-
Telomere protection and TRF2 expression are enhanced by the canonical Wnt signalling pathway
-
Diala I, Wagner N, Magdinier F, Shkreli M, Sirakov M, Bauwens S, Schluth-Bolard C, Simonet T, Renault V, Ye J, Djerbi A, Pineau P, Choi J, Artandi S, Dejean A, Plateroti M, Gilson E (2013) Telomere protection and TRF2 expression are enhanced by the canonical Wnt signalling pathway. EMBO Rep 14(4):356-363
-
(2013)
EMBO Rep
, vol.14
, Issue.4
, pp. 356-363
-
-
Diala, I.1
Wagner, N.2
Magdinier, F.3
Shkreli, M.4
Sirakov, M.5
Bauwens, S.6
Schluth-Bolard, C.7
Simonet, T.8
Renault, V.9
Ye, J.10
Djerbi, A.11
Pineau, P.12
Choi, J.13
Artandi, S.14
Dejean, A.15
Plateroti, M.16
Gilson, E.17
-
62
-
-
84878636704
-
Elevated SOCS3 and altered IL-6 signaling is associated with age-related human muscle stem cell dysfunction
-
McKay B, Ogborn D, Baker J, Toth K, Tarnopolsky M, Parise G (2013) Elevated SOCS3 and altered IL-6 signaling is associated with age-related human muscle stem cell dysfunction. Am J Physiol Cell Physiol 304(8):C717-C728
-
(2013)
Am J Physiol Cell Physiol
, vol.304
, Issue.8
-
-
McKay, B.1
Ogborn, D.2
Baker, J.3
Toth, K.4
Tarnopolsky, M.5
Parise, G.6
-
63
-
-
84891372479
-
The role of IL-6 in bone marrow (BM)-derived mesenchymal stem cells (MSCs) proliferation and chondrogenesis
-
Wei H, Shen G, Deng X, Lou D, Sun B, Wu H, Long L, Ding T, Zhao J (2013) The role of IL-6 in bone marrow (BM)-derived mesenchymal stem cells (MSCs) proliferation and chondrogenesis. Cell Tissue Bank 14(4):699-706
-
(2013)
Cell Tissue Bank
, vol.14
, Issue.4
, pp. 699-706
-
-
Wei, H.1
Shen, G.2
Deng, X.3
Lou, D.4
Sun, B.5
Wu, H.6
Long, L.7
Ding, T.8
Zhao, J.9
-
64
-
-
84868685839
-
Wnt antagonist SFRP1 functions as a secreted mediator of senescence
-
Elzi D, Song M, Hakala K, Weintraub S, Shiio Y (2012) Wnt antagonist SFRP1 functions as a secreted mediator of senescence. Mol Cell Biol 32(21):4388-4399
-
(2012)
Mol Cell Biol
, vol.32
, Issue.21
, pp. 4388-4399
-
-
Elzi, D.1
Song, M.2
Hakala, K.3
Weintraub, S.4
Shiio, Y.5
-
65
-
-
41549149451
-
Cellular senescence in vivo: A barrier to tumorigenesis
-
Prieur A, Peeper D (2008) Cellular senescence in vivo: a barrier to tumorigenesis. Curr Opin Cell Biol 20(2):150-155
-
(2008)
Curr Opin Cell Biol
, vol.20
, Issue.2
, pp. 150-155
-
-
Prieur, A.1
Peeper, D.2
-
66
-
-
81855169964
-
Senescence surveillance of pre-malignant hepatocytes limits liver cancer development
-
Kang T-W, Yevsa T, Woller N, Hoenicke L, Wuestefeld T, Dauch D, Hohmeyer A, Gereke M, Rudalska R, Potapova A, Iken M, Vucur M, Weiss S, Heikenwalder M, Khan S, Gil J, Bruder D, Manns M, Schirmacher P, Tacke F, Ott M, Luedde T, Longerich T, Kubicka S, Zender L (2011) Senescence surveillance of pre-malignant hepatocytes limits liver cancer development. Nature 479(7374):547-551
-
(2011)
Nature
, vol.479
, Issue.7374
, pp. 547-551
-
-
Kang, T.-W.1
Yevsa, T.2
Woller, N.3
Hoenicke, L.4
Wuestefeld, T.5
Dauch, D.6
Hohmeyer, A.7
Gereke, M.8
Rudalska, R.9
Potapova, A.10
Iken, M.11
Vucur, M.12
Weiss, S.13
Heikenwalder, M.14
Khan, S.15
Gil, J.16
Bruder, D.17
Manns, M.18
Schirmacher, P.19
Tacke, F.20
Ott, M.21
Luedde, T.22
Longerich, T.23
Kubicka, S.24
Zender, L.25
more..
-
67
-
-
77954243065
-
The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing
-
Jun. J-I, Lau L (2010) The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing. Nat Cell Biol 12(7):676-685
-
(2010)
Nat Cell Biol
, vol.12
, Issue.7
, pp. 676-685
-
-
Jun, J.-I.1
Lau, L.2
-
68
-
-
2442595111
-
Understanding the role of immune regulation in wound healing
-
Park J, Barbul A (2004) Understanding the role of immune regulation in wound healing. Am J Surg 187(5A):11S-16S
-
(2004)
Am J Surg
, vol.187
, Issue.5 A
-
-
Park, J.1
Barbul, A.2
-
69
-
-
49749145668
-
Senescence of activated stellate cells limits liver fibrosis
-
Krizhanovsky V, Yon M, Dickins R, Hearn S, Simon J, Miething C, Yee H, Zender L, Lowe S (2008) Senescence of activated stellate cells limits liver fibrosis. Cell 134(4):657-667
-
(2008)
Cell
, vol.134
, Issue.4
, pp. 657-667
-
-
Krizhanovsky, V.1
Yon, M.2
Dickins, R.3
Hearn, S.4
Simon, J.5
Miething, C.6
Yee, H.7
Zender, L.8
Lowe, S.9
-
70
-
-
77955664688
-
Aging of the innate immune system
-
Shaw A, Joshi S, Greenwood H, Panda A, Lord J (2010) Aging of the innate immune system. Curr Opin Immunol 22(4):507-513
-
(2010)
Curr Opin Immunol
, vol.22
, Issue.4
, pp. 507-513
-
-
Shaw, A.1
Joshi, S.2
Greenwood, H.3
Panda, A.4
Lord, J.5
-
71
-
-
84876732591
-
T cell replicative senescence in human aging
-
Chou J, Effros R (2012) T cell replicative senescence in human aging. Curr Pharm Des 19(9):1680-1698
-
(2012)
Curr Pharm des
, vol.19
, Issue.9
, pp. 1680-1698
-
-
Chou, J.1
Effros, R.2
-
72
-
-
0027332123
-
Altered regulation of G1 cyclins in senescent human diploid fibroblasts: Accumulation of inactive cyclin E-Cdk2 and cyclin D1-Cdk2 complexes
-
Dulic V, Drullinger LF, Lees E, Reed SI, Stein GH (1993) Altered regulation of G1 cyclins in senescent human diploid fibroblasts: accumulation of inactive cyclin E-Cdk2 and cyclin D1-Cdk2 complexes. Proc Natl Acad Sci U S A 90(23):11034-11038
-
(1993)
Proc Natl Acad Sci U S A
, vol.90
, Issue.23
, pp. 11034-11038
-
-
Dulic, V.1
Drullinger, L.F.2
Lees, E.3
Reed, S.I.4
Stein, G.H.5
-
73
-
-
0017615459
-
Characterization of the cell cycle of cultured human diploid cells: Effects of aging and hydrocortisone
-
Grove GL, Cristofalo VJ (1977) Characterization of the cell cycle of cultured human diploid cells: effects of aging and hydrocortisone. J Cell Physiol 90(3):415-422
-
(1977)
J Cell Physiol
, vol.90
, Issue.3
, pp. 415-422
-
-
Grove, G.L.1
Cristofalo, V.J.2
-
74
-
-
0022257331
-
Reinitiation of cellular DNA synthesis in BrdU-selected nondividing senescent WI-38 cells by simian virus 40 infection
-
Gorman SD, Cristofalo VJ (1985) Reinitiation of cellular DNA synthesis in BrdU-selected nondividing senescent WI-38 cells by simian virus 40 infection. J Cell Physiol 125(1):122-126
-
(1985)
J Cell Physiol
, vol.125
, Issue.1
, pp. 122-126
-
-
Gorman, S.D.1
Cristofalo, V.J.2
-
75
-
-
33845269825
-
Oncogeneinduced senescence is a DNA damage response triggered by DNA hyper-replication
-
Di Micco R, Fumagalli M, Cicalese A, Piccinin S, Gasparini P, Luise C, Schurra C, Garre M, Nuciforo PG, Bensimon A, Maestro R, Pelicci PG, D'Adda Di Fagagna F (2006) Oncogeneinduced senescence is a DNA damage response triggered by DNA hyper-replication. Nature 444(7119):638-642
-
(2006)
Nature
, vol.444
, Issue.7119
, pp. 638-642
-
-
Di Micco, R.1
Fumagalli, M.2
Cicalese, A.3
Piccinin, S.4
Gasparini, P.5
Luise, C.6
Schurra, C.7
Garre, M.8
Nuciforo, P.G.9
Bensimon, A.10
Maestro, R.11
Pelicci, P.G.12
D'Adda Di Fagagna, F.13
-
76
-
-
0029818858
-
Expression of p21 is not required for senescence of human fibroblasts
-
Medcalf AS, Klein-Szanto AJ, Cristofalo VJ (1996) Expression of p21 is not required for senescence of human fibroblasts. Cancer Res 56(20):4582-4585
-
(1996)
Cancer Res
, vol.56
, Issue.20
, pp. 4582-4585
-
-
Medcalf, A.S.1
Klein-Szanto, A.J.2
Cristofalo, V.J.3
-
77
-
-
0030609861
-
Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts
-
Brown JP, Wei W, Sedivy JM (1997) Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts. Science 277(5327):831-834
-
(1997)
Science
, vol.277
, Issue.5327
, pp. 831-834
-
-
Brown, J.P.1
Wei, W.2
Sedivy, J.M.3
-
78
-
-
81855209312
-
53BP1 contributes to a robust genomic stability in human fibroblasts
-
Fink LS, Roell M, Caiazza E, Lerner C, Stamato T, Hrelia S, Lorenzini A, Sell C (2011) 53BP1 contributes to a robust genomic stability in human fibroblasts. Aging 3(9):836-845
-
(2011)
Aging
, vol.3
, Issue.9
, pp. 836-845
-
-
Fink, L.S.1
Roell, M.2
Caiazza, E.3
Lerner, C.4
Stamato, T.5
Hrelia, S.6
Lorenzini, A.7
Sell, C.8
-
79
-
-
81855189618
-
The disposable soma theory revisited: Time as a resource in the theories of aging
-
Lorenzini A, Stamato T, Sell C (2011) The disposable soma theory revisited: time as a resource in the theories of aging. Cell Cycle 10(22):3853-3856
-
(2011)
Cell Cycle
, vol.10
, Issue.22
, pp. 3853-3856
-
-
Lorenzini, A.1
Stamato, T.2
Sell, C.3
-
80
-
-
33646946746
-
Senescence-associated betagalactosidase is lysosomal beta-galactosidase
-
Lee BY, Han JA, Im JS, Morrone A, Johung K, Goodwin EC, Kleijer WJ, Di Maio D, Hwang ES (2006) Senescence-associated betagalactosidase is lysosomal beta-galactosidase. Aging Cell 5(2):187-195
-
(2006)
Aging Cell
, vol.5
, Issue.2
, pp. 187-195
-
-
Lee, B.Y.1
Han, J.A.2
Im, J.S.3
Morrone, A.4
Johung, K.5
Goodwin, E.C.6
Kleijer, W.J.7
Di Maio, D.8
Hwang, E.S.9
-
81
-
-
0033572894
-
Differentiation between senescence (M1) and crisis (M2) in human fibroblast cultures
-
Wei W, Sedivy JM (1999) Differentiation between senescence (M1) and crisis (M2) in human fibroblast cultures. Exp Cell Res 253(2):519-522
-
(1999)
Exp Cell Res
, vol.253
, Issue.2
, pp. 519-522
-
-
Wei, W.1
Sedivy, J.M.2
-
82
-
-
19944427674
-
Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA
-
Zhang R, Poustovoitov MV, Ye X, Santos HA, Chen W, Daganzo SM, Erzberger JP, Serebriiskii IG, Canutescu AA, Dunbrack RL, Pehrson JR, Berger JM, Kaufman PD, Adams PD (2005) Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA. Dev Cell 8(1):19-30
-
(2005)
Dev Cell
, vol.8
, Issue.1
, pp. 19-30
-
-
Zhang, R.1
Poustovoitov, M.V.2
Ye, X.3
Santos, H.A.4
Chen, W.5
Daganzo, S.M.6
Erzberger, J.P.7
Serebriiskii, I.G.8
Canutescu, A.A.9
Dunbrack, R.L.10
Pehrson, J.R.11
Berger, J.M.12
Kaufman, P.D.13
Adams, P.D.14
-
83
-
-
33947236204
-
Molecular dissection of formation of senescence-associated heterochromatin foci
-
Zhang R, Chen W, Adams PD (2007) Molecular dissection of formation of senescence-associated heterochromatin foci. Mol Cell Biol 27(6):2343-2358
-
(2007)
Mol Cell Biol
, vol.27
, Issue.6
, pp. 2343-2358
-
-
Zhang, R.1
Chen, W.2
Adams, P.D.3
|