HMG-CoA reductase inhibitors up-regulate anti-aging klotho mRNA via RhoA inactivation in IMCD3 cells

Cardiovascular Research

Volumn 64, Issue 2, 2004, Pages 331-336

  Narumiya, Hiromichi ^a   Sasaki, Susumu ^a   Kuwahara, Noriko ^a   Irie, Hidekazu ^a   Kusaba, Tetsuro ^a   Kameyama, Hisako ^a   Tamagaki, Keiichi ^a   Hatta, Tsuguru ^a   Takeda, Kazuo ^a   Matsubara, Hiroaki ^a  

^a KYOTO PREFECTURAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

HMG CoA reductase inhibitors; Klotho; Real time RT PCR; RhoA

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ANGIOTENSIN; ATORVASTATIN; FARNESYL DIPHOSPHATE; GERANYLGERANYL PYROPHOSPHATE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MESSENGER RNA; MEVALONIC ACID; PITAVASTATIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; ENZYME INHIBITION; EVALUATION; GENE; GENE EXPRESSION; GENE OVEREXPRESSION; INHIBITION KINETICS; ISOPRENYLATION; KLOTHO GENE; MOLECULE; MORPHOLOGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS; STIMULATION; UPREGULATION;

AMIDES; ANALYSIS OF VARIANCE; ANGIOTENSIN II; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; GLUCURONIDASE; HEPTANOIC ACIDS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; KIDNEY TUBULES; MEMBRANE PROTEINS; PYRIDINES; PYRROLES; QUINOLINES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RHOA GTP-BINDING PROTEIN; RNA, MESSENGER;

EID: 5444269240     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cardiores.2004.07.011     Document Type: Article

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