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Volumn 122, Issue , 2014, Pages 563-577

Future treatment approaches to multiple sclerosis

Author keywords

Alemtuzumab; Daclizumab; Emerging therapies; Estriol; Laquinimod; Ocrelizumab; Statins; Stem cell transplantation; Vitamin D

Indexed keywords

ALEMTUZUMAB; ANTIINFLAMMATORY AGENT; DACLIZUMAB; ESTRIOL; HORMONE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IMMUNOLOGIC FACTOR; LAQUINIMOD; OCRELIZUMAB; VITAMIN D;

EID: 84893475629     PISSN: 00729752     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-444-52001-2.00024-8     Document Type: Chapter
Times cited : (15)

References (61)
  • 1
    • 59349117317 scopus 로고    scopus 로고
    • Daclizumab in treatment of multiple sclerosis patients
    • Ali E.N., Healy B.C., Stazzone L.A., et al. Daclizumab in treatment of multiple sclerosis patients. Mult Scler 2009, 15:272-274.
    • (2009) Mult Scler , vol.15 , pp. 272-274
    • Ali, E.N.1    Healy, B.C.2    Stazzone, L.A.3
  • 2
    • 41849116363 scopus 로고    scopus 로고
    • Rituximab in relapsing-remitting multiple sclerosis: a 72-week, open-label, phase I trial
    • Bar-Or A., Calabresi P.A., Arnold D., et al. Rituximab in relapsing-remitting multiple sclerosis: a 72-week, open-label, phase I trial. Ann Neurol 2008, 63:395-400.
    • (2008) Ann Neurol , vol.63 , pp. 395-400
    • Bar-Or, A.1    Calabresi, P.A.2    Arnold, D.3
  • 3
    • 0035253377 scopus 로고    scopus 로고
    • Low-dose estrogen therapy ameliorates experimental autoimmune encephalomyelitis in two different inbred mouse strains
    • Bebo B.F., Fyfe-Johnson A., Adlard K., et al. Low-dose estrogen therapy ameliorates experimental autoimmune encephalomyelitis in two different inbred mouse strains. J Immunol 2001, 166:2080-2089.
    • (2001) J Immunol , vol.166 , pp. 2080-2089
    • Bebo, B.F.1    Fyfe-Johnson, A.2    Adlard, K.3
  • 4
    • 2942537826 scopus 로고    scopus 로고
    • Humanized anti-CD25 (daclizumab) inhibits disease activity in multiple sclerosis patients failing to respond to interferon β
    • Bielekova B., Richert N., Howard T., et al. Humanized anti-CD25 (daclizumab) inhibits disease activity in multiple sclerosis patients failing to respond to interferon β. Proc Natl Acad Sci 2004, 101:8705-8708.
    • (2004) Proc Natl Acad Sci , vol.101 , pp. 8705-8708
    • Bielekova, B.1    Richert, N.2    Howard, T.3
  • 5
    • 65249138318 scopus 로고    scopus 로고
    • Effect of anti-CD25 antibody daclizumab in the inhibition of inflammation and stabilization of disease progression in multiple sclerosis
    • Bielekova B., Howard T., Packer A.N., et al. Effect of anti-CD25 antibody daclizumab in the inhibition of inflammation and stabilization of disease progression in multiple sclerosis. Arch Neurol 2009, 66:483-489.
    • (2009) Arch Neurol , vol.66 , pp. 483-489
    • Bielekova, B.1    Howard, T.2    Packer, A.N.3
  • 6
    • 56549086423 scopus 로고    scopus 로고
    • Combining beta interferon and atorvastatin may increase disease activity in multiple sclerosis
    • Birnbaum G., Cree B., Altafullah I., et al. Combining beta interferon and atorvastatin may increase disease activity in multiple sclerosis. Neurology 2008, 71:1390-1395.
    • (2008) Neurology , vol.71 , pp. 1390-1395
    • Birnbaum, G.1    Cree, B.2    Altafullah, I.3
  • 7
    • 0036710356 scopus 로고    scopus 로고
    • The new orally active immunoregulator laquinimod (ABR-215062) effectively inhibits development and relapses in experimental autoimmune encephalomyelitis
    • Brunmark C., Runstrom A., Ohlsson L., et al. The new orally active immunoregulator laquinimod (ABR-215062) effectively inhibits development and relapses in experimental autoimmune encephalomyelitis. J Neuroimmunol 2002, 130:163-172.
    • (2002) J Neuroimmunol , vol.130 , pp. 163-172
    • Brunmark, C.1    Runstrom, A.2    Ohlsson, L.3
  • 8
    • 60049083956 scopus 로고    scopus 로고
    • Autologous non-myeloablative hemopoietic stem cell transplantation in relapsing-remitting multiple sclerosis: a phase I/II study
    • Burt R.K., Loh Y., Cohen B., et al. Autologous non-myeloablative hemopoietic stem cell transplantation in relapsing-remitting multiple sclerosis: a phase I/II study. Lancet Neurol 2009, 8:244-253.
    • (2009) Lancet Neurol , vol.8 , pp. 244-253
    • Burt, R.K.1    Loh, Y.2    Cohen, B.3
  • 9
    • 66149174165 scopus 로고    scopus 로고
    • A phase I/II dose escalation trial of oral vitamin D3 with calcium supplementation in patients with multiple sclerosis
    • Burton J.M., Kimball S., Vieth R., et al. A phase I/II dose escalation trial of oral vitamin D3 with calcium supplementation in patients with multiple sclerosis. Neurology 2008, 70(supp1):A105.
    • (2008) Neurology , vol.70 , Issue.SUPP1
    • Burton, J.M.1    Kimball, S.2    Vieth, R.3
  • 10
    • 54949143968 scopus 로고    scopus 로고
    • Alemtuzumab vs interferon beta-1a in early multiple sclerosis
    • CAMMS223 Trial Investigators
    • CAMMS223 Trial Investigators Alemtuzumab vs interferon beta-1a in early multiple sclerosis. N Engl J Med 2008, 359:1786-1801.
    • (2008) N Engl J Med , vol.359 , pp. 1786-1801
  • 11
    • 33745875004 scopus 로고    scopus 로고
    • Brain atrophy after immunoablation and stem cell transplantation in multiple sclerosis
    • Chen J.T., Collins D.L., Atkins H.L., et al. Brain atrophy after immunoablation and stem cell transplantation in multiple sclerosis. Neurology 2006, 66:1935-1937.
    • (2006) Neurology , vol.66 , pp. 1935-1937
    • Chen, J.T.1    Collins, D.L.2    Atkins, H.L.3
  • 12
    • 84884908632 scopus 로고    scopus 로고
    • Mesenchymal stem cell transplantation in multiple sclerosis
    • Cohen J.A. Mesenchymal stem cell transplantation in multiple sclerosis. J Neurol Sci 2013, 333:43-49.
    • (2013) J Neurol Sci , vol.333 , pp. 43-49
    • Cohen, J.A.1
  • 13
    • 84869492471 scopus 로고    scopus 로고
    • Alemtuzumab versus interferon beta 1a as first-line treatment for patients with relapsing-remitting multiple sclerosis: a randomised controlled phase 3 trial
    • Cohen J.A., Coles A.J., Arnold D.L., et al. Alemtuzumab versus interferon beta 1a as first-line treatment for patients with relapsing-remitting multiple sclerosis: a randomised controlled phase 3 trial. Lancet 2012, 380:1819-1828.
    • (2012) Lancet , vol.380 , pp. 1819-1828
    • Cohen, J.A.1    Coles, A.J.2    Arnold, D.L.3
  • 14
    • 0033552391 scopus 로고    scopus 로고
    • Pulsed monoclonal antibody treatment and autoimmune thyroid disease in multiple sclerosis
    • Coles A.J., Wing M., Smith S., et al. Pulsed monoclonal antibody treatment and autoimmune thyroid disease in multiple sclerosis. Lancet 1999, 354:1691-1695.
    • (1999) Lancet , vol.354 , pp. 1691-1695
    • Coles, A.J.1    Wing, M.2    Smith, S.3
  • 15
    • 2642557746 scopus 로고    scopus 로고
    • Campath-1H treatment of multiple sclerosis: lessons from the bedside for the bench
    • Coles A., Deans J., Compston A. Campath-1H treatment of multiple sclerosis: lessons from the bedside for the bench. Clin Neurol Neurosurg 2004, 106:270-274.
    • (2004) Clin Neurol Neurosurg , vol.106 , pp. 270-274
    • Coles, A.1    Deans, J.2    Compston, A.3
  • 16
    • 84860780657 scopus 로고    scopus 로고
    • Alemtuzumab more effective than interferon-1a at 5-year follow-up of the CAMMS 223 Clinical Trial
    • Coles A.J., Fox E., Vladic A., et al. Alemtuzumab more effective than interferon-1a at 5-year follow-up of the CAMMS 223 Clinical Trial. Neurology 2012, 78:1069-1078.
    • (2012) Neurology , vol.78 , pp. 1069-1078
    • Coles, A.J.1    Fox, E.2    Vladic, A.3
  • 17
    • 84869507357 scopus 로고    scopus 로고
    • Alemtuzumab for patients with relapsing multiple sclerosis after disease-modifying therapy: a randomised controlled phase 3 trial
    • Coles A.J., Twyman C.I., Arnold D.I., et al. Alemtuzumab for patients with relapsing multiple sclerosis after disease-modifying therapy: a randomised controlled phase 3 trial. Lancet 2012, 380:1829-1839.
    • (2012) Lancet , vol.380 , pp. 1829-1839
    • Coles, A.J.1    Twyman, C.I.2    Arnold, D.I.3
  • 18
    • 45249107267 scopus 로고    scopus 로고
    • Effect of laquinimod on MRI-monitored disease activity in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study
    • Comi G., Rovaris M., Abramsky O., et al. Effect of laquinimod on MRI-monitored disease activity in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study. Lancet 2008, 371:2085-2092.
    • (2008) Lancet , vol.371 , pp. 2085-2092
    • Comi, G.1    Rovaris, M.2    Abramsky, O.3
  • 19
    • 84858217865 scopus 로고    scopus 로고
    • Placebo-controlled trial or oral laquinimod for multiple sclerosis
    • Comi G., Jeffery D., Kappos L., et al. Placebo-controlled trial or oral laquinimod for multiple sclerosis. N Engl J Med 2012, 366:1000-1009.
    • (2012) N Engl J Med , vol.366 , pp. 1000-1009
    • Comi, G.1    Jeffery, D.2    Kappos, L.3
  • 20
    • 0032581445 scopus 로고    scopus 로고
    • Rate of pregnancy-related relapse in multiple sclerosis
    • Confavreux C., Hutchinson M., Hours M.M., et al. Rate of pregnancy-related relapse in multiple sclerosis. N Engl J Med 1998, 339:285-291.
    • (1998) N Engl J Med , vol.339 , pp. 285-291
    • Confavreux, C.1    Hutchinson, M.2    Hours, M.M.3
  • 21
    • 84856023693 scopus 로고    scopus 로고
    • Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study
    • Connick P., Lolappan M., Crawley C., et al. Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study. Lancet Neurol 2012, 11:150-156.
    • (2012) Lancet Neurol , vol.11 , pp. 150-156
    • Connick, P.1    Lolappan, M.2    Crawley, C.3
  • 22
    • 16844366404 scopus 로고    scopus 로고
    • An open label study of the effects of rituximab in neuromyelitis optica
    • Cree B., Lamb S., Morgan K., et al. An open label study of the effects of rituximab in neuromyelitis optica. Neurology 2005, 64:1270-1272.
    • (2005) Neurology , vol.64 , pp. 1270-1272
    • Cree, B.1    Lamb, S.2    Morgan, K.3
  • 23
    • 0030714110 scopus 로고    scopus 로고
    • Peripheral blood stem cell transplantation in the treatment of progressive multiple sclerosis: first results of a pilot study
    • Fassas A., Anagnostopoulos A., Kazis A., et al. Peripheral blood stem cell transplantation in the treatment of progressive multiple sclerosis: first results of a pilot study. Bone Marrow Transplant 1997, 20:631-638.
    • (1997) Bone Marrow Transplant , vol.20 , pp. 631-638
    • Fassas, A.1    Anagnostopoulos, A.2    Kazis, A.3
  • 24
    • 79953208669 scopus 로고    scopus 로고
    • Long-term results of stem cell transplantation for MS: a single-center experience
    • Fassas A., Kimiskidis V.K., Sakellari I., et al. Long-term results of stem cell transplantation for MS: a single-center experience. Neurology 2011, 76:1066-1070.
    • (2011) Neurology , vol.76 , pp. 1066-1070
    • Fassas, A.1    Kimiskidis, V.K.2    Sakellari, I.3
  • 25
    • 84879239117 scopus 로고    scopus 로고
    • Daclizumab high-yield process in relapsing-remitting multiple sclerosis (SELECT): a randomised, double-blind, placebo-controlled trial
    • Gold R., Giovannoni G., Selmaj K., et al. Daclizumab high-yield process in relapsing-remitting multiple sclerosis (SELECT): a randomised, double-blind, placebo-controlled trial. Lancet 2013, 381:2167-2175.
    • (2013) Lancet , vol.381 , pp. 2167-2175
    • Gold, R.1    Giovannoni, G.2    Selmaj, K.3
  • 26
    • 39049142995 scopus 로고    scopus 로고
    • B-cell depletion with rituximab in relapsing-remitting multiple sclerosis
    • Hauser S.L., Waubant E., Arnold D.L., et al. B-cell depletion with rituximab in relapsing-remitting multiple sclerosis. N Engl J Med 2008, 358:676-688.
    • (2008) N Engl J Med , vol.358 , pp. 676-688
    • Hauser, S.L.1    Waubant, E.2    Arnold, D.L.3
  • 27
    • 85008356874 scopus 로고    scopus 로고
    • Efficacy and safety of rituximab in patients with primary progressive MS: results of a randomized double-blind placebo-controlled multicenter trial
    • Hawker K., O'Connor P., Freedman M., et al. Efficacy and safety of rituximab in patients with primary progressive MS: results of a randomized double-blind placebo-controlled multicenter trial. Ann Neurol 2009, 72(Suppl 3):A254.
    • (2009) Ann Neurol , vol.72 , Issue.SUPPL. 3
    • Hawker, K.1    O'Connor, P.2    Freedman, M.3
  • 28
    • 55949127730 scopus 로고    scopus 로고
    • Treatment of neuromyelitis optica with rituximab retrospective analysis of 25 patients
    • Jacob A., Weinshenker B.G., Violich I., et al. Treatment of neuromyelitis optica with rituximab retrospective analysis of 25 patients. Arch Neurol 2008, 65:1443-1448.
    • (2008) Arch Neurol , vol.65 , pp. 1443-1448
    • Jacob, A.1    Weinshenker, B.G.2    Violich, I.3
  • 29
    • 0027991759 scopus 로고
    • Estrogen induces a potent suppression of experimental autoimmune encephalomyelitis and collagen-induced arthritis in mice
    • Jansson L., Olsson T., Holmdahl R. Estrogen induces a potent suppression of experimental autoimmune encephalomyelitis and collagen-induced arthritis in mice. J Neuroimmunol 1994, 53:203-207.
    • (1994) J Neuroimmunol , vol.53 , pp. 203-207
    • Jansson, L.1    Olsson, T.2    Holmdahl, R.3
  • 30
    • 84868195949 scopus 로고    scopus 로고
    • Atorvastatin added to interferon beta for relapsing multiple sclerosis: a randomized controlled trial
    • Kamm C.P., El-Koussy M., Humpert S., et al. Atorvastatin added to interferon beta for relapsing multiple sclerosis: a randomized controlled trial. J Neurol 2012, 259:2401-2413.
    • (2012) J Neurol , vol.259 , pp. 2401-2413
    • Kamm, C.P.1    El-Koussy, M.2    Humpert, S.3
  • 31
    • 81555202418 scopus 로고    scopus 로고
    • Ocrelizumab in relapsing-remitting multiple sclerosis: a phase 2, randomised, placebeo-controlled, multicentre trial
    • Kappos L., Li D., Calabresi P., et al. Ocrelizumab in relapsing-remitting multiple sclerosis: a phase 2, randomised, placebeo-controlled, multicentre trial. Lancet 2011, 378:1779-1787.
    • (2011) Lancet , vol.378 , pp. 1779-1787
    • Kappos, L.1    Li, D.2    Calabresi, P.3
  • 32
    • 77957964299 scopus 로고    scopus 로고
    • Safety and immunological effects of mesenchymal stem cell transplantation in patients with multiple sclerosis and amyotrophic lateral sclerosis
    • Karussis D., Karageorgiou C., Vaknin-Dembinsky A., et al. Safety and immunological effects of mesenchymal stem cell transplantation in patients with multiple sclerosis and amyotrophic lateral sclerosis. Arch Neurol 2010, 67:1187-1194.
    • (2010) Arch Neurol , vol.67 , pp. 1187-1194
    • Karussis, D.1    Karageorgiou, C.2    Vaknin-Dembinsky, A.3
  • 33
    • 79551663526 scopus 로고    scopus 로고
    • Bone marrow mesenchymal stem cells: agents of immunomodulation and neuroprotection
    • Kassis I., Vaknin-Dembinsky A., Karussis D. Bone marrow mesenchymal stem cells: agents of immunomodulation and neuroprotection. Curr Stem Cell Res Ther 2013, 6:63-68.
    • (2013) Curr Stem Cell Res Ther , vol.6 , pp. 63-68
    • Kassis, I.1    Vaknin-Dembinsky, A.2    Karussis, D.3
  • 34
    • 0032952297 scopus 로고    scopus 로고
    • Estriol ameliorates autoimmune demyelinating disease implications for multiple sclerosis
    • Kim S., Liva S.M., Dalal M.A., et al. Estriol ameliorates autoimmune demyelinating disease implications for multiple sclerosis. Neurology 1999, 52:1230-1238.
    • (1999) Neurology , vol.52 , pp. 1230-1238
    • Kim, S.1    Liva, S.M.2    Dalal, M.A.3
  • 35
    • 0029119711 scopus 로고
    • Effect of pravastatin on outcomes after cardiac transplantation
    • Kobashigawa J.A., Katznelson S., Laks H., et al. Effect of pravastatin on outcomes after cardiac transplantation. N Engl J Med 1995, 333:621-627.
    • (1995) N Engl J Med , vol.333 , pp. 621-627
    • Kobashigawa, J.A.1    Katznelson, S.2    Laks, H.3
  • 36
    • 58149096526 scopus 로고    scopus 로고
    • Higher levels of 25-hydroxyvitamin D are associated with a lower incidence of multiple sclerosis only in women
    • Kragt J.J., van Amerongen B.M., Killestein J., et al. Higher levels of 25-hydroxyvitamin D are associated with a lower incidence of multiple sclerosis only in women. Mult Scler 2009, 15:9-15.
    • (2009) Mult Scler , vol.15 , pp. 9-15
    • Kragt, J.J.1    van Amerongen, B.M.2    Killestein, J.3
  • 37
    • 67650073013 scopus 로고    scopus 로고
    • Combining beta interferon and atorvastatin may increase disease activity in multiple sclerosis
    • Markovic-Plese S., Jewwells V., Speer D. Combining beta interferon and atorvastatin may increase disease activity in multiple sclerosis. Neurology 2009, 72:1965.
    • (2009) Neurology , vol.72 , pp. 1965
    • Markovic-Plese, S.1    Jewwells, V.2    Speer, D.3
  • 38
    • 84893442744 scopus 로고    scopus 로고
    • Vitamin D levels and risk of multiple sclerosis in patients with clinically isolated syndromes
    • Martinelli V., Costa G.D., Colombo B., et al. Vitamin D levels and risk of multiple sclerosis in patients with clinically isolated syndromes. Mult Scleros J 2013, 1-9.
    • (2013) Mult Scleros J , pp. 1-9
    • Martinelli, V.1    Costa, G.D.2    Colombo, B.3
  • 39
    • 39049115197 scopus 로고    scopus 로고
    • The B cell - old player, new position on the team
    • McFarland H.F. The B cell - old player, new position on the team. N Engl J Med 2008, 358:664-665.
    • (2008) N Engl J Med , vol.358 , pp. 664-665
    • McFarland, H.F.1
  • 40
    • 0345830740 scopus 로고    scopus 로고
    • Vitamin D intake and incidence of multiple sclerosis
    • Munger K.L., Zhang S.M., O'Reilly E., et al. Vitamin D intake and incidence of multiple sclerosis. Neurology 2004, 62:60-65.
    • (2004) Neurology , vol.62 , pp. 60-65
    • Munger, K.L.1    Zhang, S.M.2    O'Reilly, E.3
  • 41
    • 33845720114 scopus 로고    scopus 로고
    • Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis
    • Munger K.L., Levin L.I., Hollis B.W., et al. Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. JAMA 2006, 296:2832-2838.
    • (2006) JAMA , vol.296 , pp. 2832-2838
    • Munger, K.L.1    Levin, L.I.2    Hollis, B.W.3
  • 42
    • 34248352687 scopus 로고    scopus 로고
    • Evaluation of atrovastatin and simvastatin for treatment of multiple sclerosis
    • Neuhaus O., Hartung H.P. Evaluation of atrovastatin and simvastatin for treatment of multiple sclerosis. Expert Rev Neurother 2007, 7:547-556.
    • (2007) Expert Rev Neurother , vol.7 , pp. 547-556
    • Neuhaus, O.1    Hartung, H.P.2
  • 43
    • 15244353263 scopus 로고    scopus 로고
    • Treatment with laquinimod reduces development of active MRI lesions in relapsing MS
    • Polman C., Barkhof F., Sandberg-Wollheim M., et al. Treatment with laquinimod reduces development of active MRI lesions in relapsing MS. Neurology 2005, 64:987-991.
    • (2005) Neurology , vol.64 , pp. 987-991
    • Polman, C.1    Barkhof, F.2    Sandberg-Wollheim, M.3
  • 44
    • 1542358942 scopus 로고    scopus 로고
    • Rituximab: expanding role in therapy for lymphomas and autoimmune diseases
    • Rastetter W., Molina A., White C.A. Rituximab: expanding role in therapy for lymphomas and autoimmune diseases. Annu Rev Med 2004, 55:477-503.
    • (2004) Annu Rev Med , vol.55 , pp. 477-503
    • Rastetter, W.1    Molina, A.2    White, C.A.3
  • 45
    • 9644265478 scopus 로고    scopus 로고
    • Treatment of multiple sclerosis with an anti-interleukin-2 receptor monoclonal antibody
    • Rose J.W., Watt H.E., White A.T., et al. Treatment of multiple sclerosis with an anti-interleukin-2 receptor monoclonal antibody. Ann Neurol 2004, 56:864-867.
    • (2004) Ann Neurol , vol.56 , pp. 864-867
    • Rose, J.W.1    Watt, H.E.2    White, A.T.3
  • 46
    • 34548142973 scopus 로고    scopus 로고
    • Daclizumab phase II trial in relapsing and remitting multiple sclerosis MRI and clinical results
    • Rose J.W., Burns J.B., Bjorklund J., et al. Daclizumab phase II trial in relapsing and remitting multiple sclerosis MRI and clinical results. Neurology 2007, 69:785-789.
    • (2007) Neurology , vol.69 , pp. 785-789
    • Rose, J.W.1    Burns, J.B.2    Bjorklund, J.3
  • 47
    • 67649488058 scopus 로고    scopus 로고
    • Effect of statins on clinical and molecular responses to intramuscular interferon beta-1a
    • Rudick R.A., Pace A., Rani M.R.S., et al. Effect of statins on clinical and molecular responses to intramuscular interferon beta-1a. Neurology 2009, 72:1989-1993.
    • (2009) Neurology , vol.72 , pp. 1989-1993
    • Rudick, R.A.1    Pace, A.2    Rani, M.R.S.3
  • 48
    • 84866126261 scopus 로고    scopus 로고
    • Lower serum vitamin D levels are associated with a higher relapse risk in multiple sclerosis
    • Runia T.F., Hop W.C.J., de Rijke Y.B., et al. Lower serum vitamin D levels are associated with a higher relapse risk in multiple sclerosis. Neurology 2012, 79:261-266.
    • (2012) Neurology , vol.79 , pp. 261-266
    • Runia, T.F.1    Hop, W.C.J.2    de Rijke, Y.B.3
  • 49
    • 33644936033 scopus 로고    scopus 로고
    • Inhibition of the development of chronic experimental autoimmune encephalomyelitis by laquinimod (ABR-215062) in IFN-β k.o. and wild type mice
    • Runstrom A., Leanderson T., Ohlsson L., et al. Inhibition of the development of chronic experimental autoimmune encephalomyelitis by laquinimod (ABR-215062) in IFN-β k.o. and wild type mice. J Neuroimmunol 2006, 173:6978.
    • (2006) J Neuroimmunol , vol.173 , pp. 6978
    • Runstrom, A.1    Leanderson, T.2    Ohlsson, L.3
  • 50
    • 0036791912 scopus 로고    scopus 로고
    • Treatment of multiple sclerosis with the pregnancy hormone estriol
    • Sicotte N.L., Liva S.M., Klutch R., et al. Treatment of multiple sclerosis with the pregnancy hormone estriol. Ann Neurol 2002, 52:421-428.
    • (2002) Ann Neurol , vol.52 , pp. 421-428
    • Sicotte, N.L.1    Liva, S.M.2    Klutch, R.3
  • 51
    • 39849095055 scopus 로고    scopus 로고
    • Vitamin D as an immune modulator in multiple sclerosis, a review
    • Smolders J., Damoiseaux J., Menheere P., et al. Vitamin D as an immune modulator in multiple sclerosis, a review. J Neuroimmunol 2008, 194:7-17.
    • (2008) J Neuroimmunol , vol.194 , pp. 7-17
    • Smolders, J.1    Damoiseaux, J.2    Menheere, P.3
  • 52
    • 84859612741 scopus 로고    scopus 로고
    • A randomised, double blind, placebo controlled trial with vitamin D3 as an add on treatment to interferon-1b in patients with multiple sclerosis
    • Soilu-Hanninen M., Aivo J., Lindstrom B.M., et al. A randomised, double blind, placebo controlled trial with vitamin D3 as an add on treatment to interferon-1b in patients with multiple sclerosis. J Neurol Neurosurg Psychiatry 2012, 83:565-571.
    • (2012) J Neurol Neurosurg Psychiatry , vol.83 , pp. 565-571
    • Soilu-Hanninen, M.1    Aivo, J.2    Lindstrom, B.M.3
  • 53
    • 0344153820 scopus 로고    scopus 로고
    • Immune modulation in multiple sclerosis patients treated with the pregnancy hormone estriol
    • Soldan S.S., Alvarez Retuerto A.I., Sicotte N.L., et al. Immune modulation in multiple sclerosis patients treated with the pregnancy hormone estriol. J Immunol 2003, 171:6267-6274.
    • (2003) J Immunol , vol.171 , pp. 6267-6274
    • Soldan, S.S.1    Alvarez Retuerto, A.I.2    Sicotte, N.L.3
  • 54
    • 79960341237 scopus 로고    scopus 로고
    • Simvastatin as add-on therapy to interferon beta 1-a for relapsing-remitting multiple sclerosis (SIMCOMBIN study): a placebo-controlled ransomised phase 4 trial
    • SIMCOMBIN study investigators
    • Sorensen P.S., Lycke J.N., Eralinna J.P., et al. Simvastatin as add-on therapy to interferon beta 1-a for relapsing-remitting multiple sclerosis (SIMCOMBIN study): a placebo-controlled ransomised phase 4 trial. Lancet Neurol 2011, 10:691-701. SIMCOMBIN study investigators.
    • (2011) Lancet Neurol , vol.10 , pp. 691-701
    • Sorensen, P.S.1    Lycke, J.N.2    Eralinna, J.P.3
  • 55
    • 2442561768 scopus 로고    scopus 로고
    • Oral simvastatin treatment in relapsing-remitting multiple sclerosis
    • Vollmer T., Key L., Durkalski V., et al. Oral simvastatin treatment in relapsing-remitting multiple sclerosis. Lancet 2004, 363:1607-1608.
    • (2004) Lancet , vol.363 , pp. 1607-1608
    • Vollmer, T.1    Key, L.2    Durkalski, V.3
  • 57
    • 77951473224 scopus 로고    scopus 로고
    • Atorvastatin therapy in patients with clinically isolated syndrome and high-risk for conversion to multiple sclerosis: the STAyCIS study
    • Waubant E., Pelletier D., Mass M., et al. Atorvastatin therapy in patients with clinically isolated syndrome and high-risk for conversion to multiple sclerosis: the STAyCIS study. Mult Scler 2009, 15:S272.
    • (2009) Mult Scler , vol.15
    • Waubant, E.1    Pelletier, D.2    Mass, M.3
  • 59
    • 77949301468 scopus 로고    scopus 로고
    • Daclizumab in active relapsing multiple sclerosis (CHOICE study): a phase 2, randomised, double-blind, placebo-controlled, add-on trial with interferon beta
    • Wynn D., Kaufman M., Montalban X., et al. Daclizumab in active relapsing multiple sclerosis (CHOICE study): a phase 2, randomised, double-blind, placebo-controlled, add-on trial with interferon beta. Lancet Neurol 2010, 9:381-390.
    • (2010) Lancet Neurol , vol.9 , pp. 381-390
    • Wynn, D.1    Kaufman, M.2    Montalban, X.3
  • 60
    • 77956651196 scopus 로고    scopus 로고
    • Bone marrow mesenchymal stem cell transplantation in patients with multiple sclerosis: a pilot study
    • Yamout B., Hourani R., Salti H., et al. Bone marrow mesenchymal stem cell transplantation in patients with multiple sclerosis: a pilot study. J Neuroimmunol 2010, 227:185-189.
    • (2010) J Neuroimmunol , vol.227 , pp. 185-189
    • Yamout, B.1    Hourani, R.2    Salti, H.3
  • 61
    • 4744340401 scopus 로고    scopus 로고
    • Laquinimod (ABR-215062) suppresses the development of experimental autoimmune encephalomyelitis, modulates the Th1/Th2 balance and induces the Th3 cytokine TGF-β in Lewis rats
    • Yang J.S., Xu L.Y., Xio B.G., et al. Laquinimod (ABR-215062) suppresses the development of experimental autoimmune encephalomyelitis, modulates the Th1/Th2 balance and induces the Th3 cytokine TGF-β in Lewis rats. J Neuroimmunol 2004, 156:3-9.
    • (2004) J Neuroimmunol , vol.156 , pp. 3-9
    • Yang, J.S.1    Xu, L.Y.2    Xio, B.G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.