Sinoatrial Node Dysfunction and Early Unexpected Death of Mice with a Defect of klotho Gene Expression

Circulation

Volumn 109, Issue 14, 2004, Pages 1776-1782

  Takeshita, Kyosuke ^a   Fujimori, Toshihiko ^b   Kurotaki, Yoko ^b,e   Honjo, Haruo ^c   Tsujikawa, Hiroshi ^b   Yasui, Kenji ^c   Lee, Jong Kook ^c   Kamiya, Kaichiro ^c   Kitaichi, Kiyoyuki ^a   Yamamoto, Koji ^c   Ito, Masafumi ^d   Kondo, Takahisa ^a   Iino, Shigeo ^a   Inden, Yasuya ^a   Hirai, Makoto ^a   Murohara, Toyoaki ^a   Kodama, Itsuo ^c   Nabeshima, Yo Ichi ^b,e,f  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c NAGOYA UNIVERSITY   (Japan)

^d NAGOYA UNIVERSITY HOSPITAL   (Japan)

^e JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^f KYOTO UNIVERSITY   (Japan)

Author keywords

Aging; Death, sudden; Genetics; Sinoatrial node

Indexed keywords

ACETYLCHOLINE; ISOPRENALINE; NORADRENALIN;

ADOLESCENT; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONOTROPISM; CONTROLLED STUDY; EMBRYO; GENE; GENE MUTATION; HEART RATE; IMMUNOHISTOCHEMISTRY; KLOTHO GENE; MOUSE; NONHUMAN; NORADRENALIN BLOOD LEVEL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SINUS NODE DYSFUNCTION; SUDDEN DEATH;

AGING, PREMATURE; ANIMALS; CARDIOTONIC AGENTS; DEATH, SUDDEN; GENE TARGETING; GENES, REPORTER; GLUCURONIDASE; HEART ARREST; HEART RATE; ISOPROTERENOL; LAC OPERON; MALE; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; NOREPINEPHRINE; ORGAN SPECIFICITY; RESTRAINT, PHYSICAL; SINOATRIAL BLOCK; SINOATRIAL NODE; STRESS;

EID: 2342599742     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000124224.48962.32     Document Type: Article

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